Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein kinase c iota type | 0.0521 | 0.9375 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0046 | 0.0239 | 0.028 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0046 | 0.0239 | 0.0261 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.1971 | 0.1896 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0244 | 0.4038 | 0.4159 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.1776 | 0.1683 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0105 | 0.1375 | 0.1244 |
Echinococcus granulosus | thymidine kinase | 0.0244 | 0.4038 | 0.4159 |
Onchocerca volvulus | 0.0156 | 0.2359 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0078 | 0.0863 | 0.0649 |
Echinococcus granulosus | thymidine kinase | 0.0244 | 0.4038 | 0.4159 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0078 | 0.0863 | 0.0683 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.0785 | 0.1436 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.0239 | 0.028 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0239 | 0.0025 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0046 | 0.0239 | 0.001 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0239 | 0.0025 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0046 | 0.0239 | 0.0261 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0074 | 0.0785 | 0.2608 |
Echinococcus granulosus | thymidylate synthase | 0.0156 | 0.2359 | 0.2321 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2359 | 1 |
Giardia lamblia | Thymidine kinase | 0.025 | 0.4154 | 0.5327 |
Trichomonas vaginalis | thymidine kinase, putative | 0.025 | 0.4154 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.025 | 0.4154 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.025 | 0.4154 | 1 |
Brugia malayi | protein kinase C3,putative | 0.0476 | 0.8511 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0105 | 0.1375 | 0.1616 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0046 | 0.0239 | 0.0261 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0244 | 0.4038 | 0.4159 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.1971 | 0.1782 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.0239 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0239 | 0.0261 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0046 | 0.0239 | 0.001 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0105 | 0.1375 | 0.1244 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0078 | 0.0863 | 0.0683 |
Trypanosoma cruzi | thymidine kinase, putative | 0.025 | 0.4154 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0105 | 0.1375 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0239 | 0.0025 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2359 | 0.4672 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.0239 | 0.028 |
Echinococcus multilocularis | thymidine kinase | 0.0244 | 0.4038 | 0.4159 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0078 | 0.0863 | 0.0944 |
Brugia malayi | protein kinase C II. | 0.0078 | 0.0863 | 0.1014 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0156 | 0.2359 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.1776 | 0.1584 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.1375 | 0.1173 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0156 | 0.2359 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.0244 | 0.4038 | 0.4159 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Echinococcus granulosus | glycogen phosphorylase | 0.0105 | 0.1375 | 0.1244 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0078 | 0.0863 | 0.0649 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2359 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.035 | 0.0124 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2359 | 0.218 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0046 | 0.0239 | 0.0261 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0046 | 0.0239 | 0.0261 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0105 | 0.1375 | 0.1244 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0046 | 0.0239 | 0.001 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0105 | 0.1375 | 0.1505 |
Loa Loa (eye worm) | thymidylate synthase | 0.0156 | 0.2359 | 0.2582 |
Entamoeba histolytica | protein kinase, putative | 0.0046 | 0.0239 | 0.0025 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0105 | 0.1375 | 0.292 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0105 | 0.1375 | 0.5829 |
Schistosoma mansoni | serine/threonine kinase | 0.0046 | 0.0239 | 0.001 |
Entamoeba histolytica | thymidine kinase, putative | 0.025 | 0.4154 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.2359 | 0.5415 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0156 | 0.2359 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0105 | 0.1375 | 0.292 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.1971 | 0.1782 |
Echinococcus granulosus | glycogen phosphorylase | 0.0105 | 0.1375 | 0.1244 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0105 | 0.1375 | 0.2937 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0078 | 0.0863 | 0.0683 |
Echinococcus multilocularis | protein kinase c iota type | 0.0521 | 0.9375 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0046 | 0.0239 | 0.0261 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0078 | 0.0863 | 0.0649 |
Giardia lamblia | Deoxynucleoside kinase | 0.0376 | 0.6592 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0046 | 0.0239 | 0.0261 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.1776 | 0.1683 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.1375 | 0.1173 |
Brugia malayi | thymidylate synthase | 0.0156 | 0.2359 | 0.2772 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0509 | 0.9136 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Trichomonas vaginalis | thymidine kinase, putative | 0.025 | 0.4154 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0105 | 0.1375 | 0.2937 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0078 | 0.0863 | 0.0683 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Echinococcus multilocularis | thymidylate synthase | 0.0156 | 0.2359 | 0.2321 |
Trichomonas vaginalis | AGC family protein kinase | 0.0046 | 0.0239 | 0.0048 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0105 | 0.1375 | 0.1244 |
Schistosoma mansoni | thymidine kinase | 0.0244 | 0.4038 | 0.3899 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0785 | 0.0922 |
Brugia malayi | Hr1 repeat family protein | 0.0046 | 0.0239 | 0.028 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0046 | 0.0239 | 0.001 |
Mycobacterium ulcerans | thymidylate synthase | 0.0156 | 0.2359 | 1 |
Leishmania major | thymidine kinase, putative | 0.025 | 0.4154 | 1 |
Trypanosoma brucei | thymidine kinase | 0.025 | 0.4154 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 50 % | Inhibition of carnitine-dependent oxidation of [1-14C]-palmitate to 14CO2 in rat liver mitochondria was measured in vitro at 2 nM concentration | ChEMBL. | 3612690 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.