TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.441 | Formula: C21H24N4O
H donors: 2 H acceptors: 2 LogP: 3.01 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccc2c1nc1ccccc1c2N)NCCN1CCCCC1
InChi: 1S/C21H24N4O/c22-19-15-7-2-3-10-18(15)24-20-16(19)8-6-9-17(20)21(26)23-11-14-25-12-4-1-5-13-25/h2-3,6-10H,1,4-5,11-14H2,(H2,22,24)(H,23,26)
InChiKey: XUSGYXPYASDERJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cysteine protease	0.0313	0.1543	0.3203
Schistosoma mansoni	cathepsin C	0.0127	0.046	0.0915
Echinococcus multilocularis	cathepsin L	0.0127	0.046	0.085
Loa Loa (eye worm)	hypothetical protein	0.0127	0.046	0.0983
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Brugia malayi	Cathepsin L-like precursor	0.0587	0.3132	0.6677
Trypanosoma cruzi	cysteine peptidase, putative	0.1769	1	1
Loa Loa (eye worm)	cathepsin B	0.0351	0.1763	0.3772
Entamoeba histolytica	cysteine proteinase 2	0.0313	0.1543	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Echinococcus granulosus	cathepsin b	0.0852	0.4674	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0059	0.0068	0.0071
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0587	0.3132	1
Brugia malayi	Cathepsin L-like precursor	0.0587	0.3132	0.6677
Toxoplasma gondii	cathepsin CPL	0.0587	0.3132	1
Onchocerca volvulus		0.0587	0.3132	1
Onchocerca volvulus	Cathepsin L homolog	0.0587	0.3132	1
Leishmania major	cathepsin L-like protease	0.0587	0.3132	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0587	0.3132	0.6702
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Onchocerca volvulus	Cathepsin L homolog	0.0587	0.3132	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0587	0.3132	0.6653
Brugia malayi	fibroinase precursor	0.0127	0.046	0.0915
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Echinococcus multilocularis	cysteine protease	0.0587	0.3132	0.6653
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0808	0.1729
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Leishmania major	cathepsin L-like protease	0.0587	0.3132	0.1662
Onchocerca volvulus	Cathepsin F homolog	0.0587	0.3132	1
Brugia malayi	Cathepsin L-like precursor	0.0587	0.3132	0.6677
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Echinococcus multilocularis	cathepsin L	0.0313	0.1543	0.3203
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Giardia lamblia	Cathepsin B precursor	0.0351	0.1763	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Onchocerca volvulus		0.0587	0.3132	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0587	0.3132	0.2802
Trypanosoma cruzi	cysteine peptidase, putative	0.0187	0.0808	0.0365
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Brugia malayi	cathepsin L-like precursor	0.04	0.2049	0.4341
Entamoeba histolytica	cysteine proteinase, putative	0.0313	0.1543	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0313	0.1543	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0587	0.3132	1
Giardia lamblia	Cathepsin B precursor	0.0351	0.1763	1
Brugia malayi	Cathepsin L-like precursor	0.0187	0.0808	0.1666
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0059	0.0068	0.0071
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0587	0.3132	1
Brugia malayi	Cathepsin L-like precursor	0.0587	0.3132	0.6677
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0127	0.046	0.0915
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.046	0.0915
Leishmania major	cysteine peptidase A (CPA)	0.0587	0.3132	0.1662
Brugia malayi	Papain family cysteine protease containing protein	0.0313	0.1543	0.3251
Entamoeba histolytica	cysteine proteinase, putative	0.0587	0.3132	1
Entamoeba histolytica	cysteine proteinase, putative	0.0313	0.1543	0.4054
Onchocerca volvulus		0.0587	0.3132	1
Brugia malayi	cathepsin L precursor	0.0127	0.046	0.0915
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0127	0.046	0.0983
Plasmodium vivax	vivapain-2	0.0587	0.3132	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0587	0.3132	0.6653
Echinococcus granulosus	cathepsin L	0.0127	0.046	0.085
Echinococcus granulosus	cathepsin L cysteine protease	0.0313	0.1543	0.3203
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Echinococcus multilocularis	cysteine protease	0.0587	0.3132	0.6653
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0127	0.046	0.0915
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0852	0.4674	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1769	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0127	0.046	0.0915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1769	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0587	0.3132	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0587	0.3132	0.6653
Loa Loa (eye worm)	ctsf protein	0.0587	0.3132	0.6702
Loa Loa (eye worm)	hypothetical protein	0.0127	0.046	0.0983
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0127	0.046	0.0983
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1543	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.0313	0.1543	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0852	0.4674	1
Giardia lamblia	Cathepsin B precursor	0.0351	0.1763	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0587	0.3132	0.6702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.04	0.2049	0.5946
Echinococcus granulosus	calpain A	0.0059	0.0069	0.0003
Loa Loa (eye worm)	hypothetical protein	0.04	0.2049	0.4383
Entamoeba histolytica	cysteine protease, putative	0.0587	0.3132	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0127	0.046	0.0983
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0587	0.3132	0.6677
Echinococcus multilocularis	cathepsin b	0.0852	0.4674	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0852	0.4674	0.4418
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0313	0.1543	0.3251
Brugia malayi	cathepsin F-like cysteine proteinase	0.0127	0.046	0.0915
Onchocerca volvulus		0.0587	0.3132	1
Onchocerca volvulus		0.0587	0.3132	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0313	0.1543	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0313	0.1543	0.1136
Brugia malayi	Papain family cysteine protease containing protein	0.0313	0.1543	0.3251
Loa Loa (eye worm)	hypothetical protein	0.0127	0.046	0.0983
Schistosoma mansoni	cathepsin s	0.0187	0.0808	0.1666
Schistosoma mansoni	cathepsin F (C01 family)	0.04	0.2049	0.4341
Echinococcus granulosus	cathepsin L	0.0313	0.1543	0.3203
Loa Loa (eye worm)	hypothetical protein	0.04	0.2049	0.4383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0187	0.0808	0.1666
Echinococcus granulosus	cathepsin l1	0.04	0.2049	0.43
Leishmania major	cathepsin L-like protease	0.0587	0.3132	0.1662
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0127	0.046	0.0915
Echinococcus granulosus	cathepsin b	0.0852	0.4674	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0127	0.046	0.0915
Loa Loa (eye worm)	fibroinase	0.0587	0.3132	0.6702
Brugia malayi	Cathepsin L-like precursor	0.0587	0.3132	0.6677
Trypanosoma cruzi	major cysteine proteinase, putative	0.1309	0.7327	0.7198
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Loa Loa (eye worm)	hypothetical protein	0.0127	0.046	0.0983
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0351	0.1763	0.4877
Trypanosoma cruzi	cysteine peptidase, putative	0.1769	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.04	0.2049	0.4341
Plasmodium vivax	vivapain-3	0.0313	0.1543	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.04	0.2049	0.5946
Schistosoma mansoni	cathepsin F (C01 family)	0.0587	0.3132	0.6677
Entamoeba histolytica	cysteine proteinase, putative	0.04	0.2049	0.5946
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0127	0.046	0.0915
Trypanosoma cruzi	cysteine peptidase, putative	0.0313	0.1543	0.1136
Loa Loa (eye worm)	hypothetical protein	0.04	0.2049	0.4383
Echinococcus multilocularis	calpain A	0.0059	0.0069	0.0003
Schistosoma mansoni	cathepsin B (C01 family)	0.0127	0.046	0.0915
Brugia malayi	cathepsin B-like cysteine proteinase	0.0852	0.4674	1
Toxoplasma gondii	cathepsin B	0.0351	0.1763	0.4877
Brugia malayi	Cathepsin L-like precursor	0.04	0.2049	0.4341
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0313	0.1543	0.1136
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0127	0.046	0.0915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0313	0.1543	0.3251
Entamoeba histolytica	cysteine proteinase, putative	0.0313	0.1543	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0127	0.046	0.0915
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0127	0.046	0.0915
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0187	0.0808	0.1729
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0587	0.3132	1
Brugia malayi	Cathepsin L-like precursor	0.0587	0.3132	0.6677
Onchocerca volvulus		0.04	0.2049	0.5946
Leishmania major	cathepsin L-like protease	0.1769	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0587	0.3132	1
Plasmodium vivax	vivapain-2	0.0587	0.3132	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0127	0.046	0.0915
Plasmodium vivax	unspecified product	0.0313	0.1543	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Loa Loa (eye worm)	calpain family protein 1	0.0054	0.0035	0.0075
Echinococcus granulosus	cathepsin l1	0.0587	0.3132	0.6653
Loa Loa (eye worm)	hypothetical protein	0.0127	0.046	0.0983
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.046	0.0915
Plasmodium vivax	vivapain-1	0.0313	0.1543	0.4054
Leishmania major	cathepsin L-like protease	0.0587	0.3132	0.1662
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0127	0.046	0.0915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0852	0.4674	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0852	0.4674	1
Echinococcus multilocularis	cathepsin b	0.0852	0.4674	1
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.046	0.0915
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0313	0.1543	0.3251
Onchocerca volvulus		0.0587	0.3132	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0808	0.1729
Trypanosoma cruzi	cruzipain precursor, putative	0.0187	0.0808	0.0365
Echinococcus multilocularis	cathepsin L cysteine protease	0.0587	0.3132	0.6653
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0313	0.1543	0.1136
Plasmodium vivax	unspecified product	0.0187	0.0808	0.1303
Leishmania major	cathepsin L-like protease	0.0587	0.3132	0.1662
Brugia malayi	Papain family cysteine protease containing protein	0.0587	0.3132	0.6677
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0587	0.3132	0.6653
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase	0.0127	0.046	0.0915
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0187	0.0808	0.1666
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0808	0.1729
Schistosoma mansoni	cathepsin S (C01 family)	0.0127	0.046	0.0915
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0852	0.4674	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0313	0.1543	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0351	0.1763	0.026
Trypanosoma cruzi	cysteine proteinase, putative	0.0313	0.1543	0.1136
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0587	0.3132	0.6653
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0351	0.1763	0.1366
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0587	0.3132	0.6702
Onchocerca volvulus		0.0587	0.3132	1
Loa Loa (eye worm)	cysteine protease	0.0587	0.3132	0.6702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0035	0.0075
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1583	0.8916	0.8864
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0587	0.3132	1
Leishmania major	cathepsin L-like protease	0.1769	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0351	0.1763	0.3725
Entamoeba histolytica	cysteine protease, putative	0.0313	0.1543	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0587	0.3132	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0127	0.046	0.0915
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1769	1	1
Brugia malayi	Cathepsin L-like precursor	0.04	0.2049	0.4341
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0127	0.046	0.0983

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	= 102 nM	Concentration required for 50% reduction of counted L1210 cells upon exposure for a period of 70h	ChEMBL.	6492078
ID50 (functional)	= 102 nM	Concentration required for 50% reduction of counted L1210 cells upon exposure for a period of 70h	ChEMBL.	6492078
ID50 (functional)	= 380 nM	Concentration of the compound required for 50% reduction of counted HCT-8 cells upon exposure for a period of 70h	ChEMBL.	6492078
ID50 (functional)	= 380 nM	Concentration of the compound required for 50% reduction of counted HCT-8 cells upon exposure for a period of 70h	ChEMBL.	6492078
ILS (functional)	= 33 %	Percentage increase in lifespan of treated animals over that of animals injected with tumor (10e6 P388 leukemia cells), at the optimal dose of 2.6 mg/(kg day)	ChEMBL.	6492078
ILS (functional)	= 33 %	Percentage increase in lifespan of treated animals over that of animals injected with tumor (10e6 P388 leukemia cells), at the optimal dose of 2.6 mg/(kg day)	ChEMBL.	6492078
Log K (ADMET)	= 7.1	Logarithmic association constant determined by ethidium displacement from DNA co-polymers (G + C)	ChEMBL.	6492078
Log K (ADMET)	= 7.12	Logarithmic association constant determined by ethidium displacement from DNA co-polymers (adenine & thymine)	ChEMBL.	6492078
pKa	= 8.9	pKa value for the side-chain cationic center	ChEMBL.	6492078
Rm	= -0.7	Lipophilicity (Rm) (RP-TLC)	ChEMBL.	6492078

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL34609

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 49099