Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0129 | 0.2988 | 0.3727 |
Echinococcus multilocularis | serotonin transporter | 0.0152 | 0.3663 | 0.4569 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0255 | 0.6652 | 0.8297 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0483 | 0.0483 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0157 | 0.3802 | 0.4743 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0157 | 0.3802 | 0.4743 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0483 | 0.0483 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0053 | 0.0777 | 0.097 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0371 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0113 | 0.2539 | 0.3167 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0053 | 0.0777 | 0.097 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0157 | 0.3802 | 0.4743 |
Echinococcus granulosus | glutamate receptor 2 | 0.0157 | 0.3802 | 0.4743 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0483 | 0.0483 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0483 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0483 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0483 | 0.0483 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0371 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.0204 | 0.0254 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0129 | 0.2988 | 0.3727 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0483 | 0.0603 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0371 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0483 | 0.0603 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0053 | 0.0777 | 0.097 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0152 | 0.3663 | 0.3663 |
Echinococcus granulosus | muscleblind protein | 0.0176 | 0.4362 | 0.5441 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0255 | 0.6652 | 0.6652 |
Plasmodium falciparum | amino acid transporter, putative | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0053 | 0.0777 | 0.097 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0113 | 0.2539 | 0.3167 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0033 | 0.0204 | 0.0254 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0124 | 0.2841 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4362 | 0.4362 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0302 | 0.8017 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0483 | 0.5 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0053 | 0.0777 | 0.097 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0142 | 0.3376 | 0.4211 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0233 | 0.6012 | 0.75 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0483 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0483 | 0.0483 |
Schistosoma mansoni | glutamate receptor kainate | 0.0142 | 0.3376 | 0.4211 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0082 | 0.1617 | 0.2017 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0113 | 0.2539 | 0.2539 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.3663 | 0.3663 |
Onchocerca volvulus | 0.0042 | 0.0483 | 0.1319 | |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0152 | 0.3663 | 0.3663 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0176 | 0.4362 | 0.5441 |
Brugia malayi | hypothetical protein | 0.0117 | 0.2654 | 0.2654 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0082 | 0.1617 | 0.2017 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0483 | 0.0483 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0082 | 0.1617 | 0.2017 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0483 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1617 | 0.1617 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0483 | 0.0483 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0091 | 0.1888 | 0.2355 |
Onchocerca volvulus | 0.0042 | 0.0483 | 0.1319 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0152 | 0.3663 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0204 | 0.0204 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0142 | 0.3376 | 0.4211 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0104 | 0.2276 | 0.2839 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0255 | 0.6652 | 0.8297 |
Echinococcus multilocularis | muscleblind protein | 0.0176 | 0.4362 | 0.5441 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0091 | 0.1888 | 0.2355 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4362 | 0.4362 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0483 | 0.0483 |
Onchocerca volvulus | Putative nachr subunit | 0.0082 | 0.1617 | 0.4415 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0142 | 0.3376 | 0.3376 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0076 | 0.1461 | 0.1823 |
Echinococcus granulosus | serotonin transporter | 0.0152 | 0.3663 | 0.4569 |
Brugia malayi | Muscleblind-like protein | 0.0176 | 0.4362 | 0.4362 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0483 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0157 | 0.3802 | 0.4743 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0082 | 0.1617 | 0.2017 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0033 | 0.0204 | 0.0254 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0157 | 0.3802 | 0.4743 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0053 | 0.0777 | 0.097 |
Plasmodium falciparum | transporter, putative | 0.0026 | 0 | 0.5 |
Onchocerca volvulus | 0.0152 | 0.3663 | 1 | |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0302 | 0.8017 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0142 | 0.3376 | 0.3376 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0157 | 0.3802 | 0.4743 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0483 | 0.0483 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0106 | 0.2323 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0302 | 0.8017 | 1 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0053 | 0.0777 | 0.097 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0152 | 0.3663 | 0.4569 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0483 | 0.0483 |
Echinococcus multilocularis | NMDA receptor | 0.0053 | 0.0777 | 0.097 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0483 | 0.0603 |
Schistosoma mansoni | glutamate receptor kainate | 0.0142 | 0.3376 | 0.4211 |
Echinococcus granulosus | voltage gated potassium channel | 0.0033 | 0.0204 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.3663 | 0.3663 |
Onchocerca volvulus | 0.0042 | 0.0483 | 0.1319 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.0204 | 0.0254 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0777 | 0.097 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0142 | 0.3376 | 0.3376 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0152 | 0.3663 | 0.4569 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0076 | 0.1461 | 0.1823 |
Echinococcus granulosus | glutamate receptor 2 | 0.0104 | 0.2276 | 0.2839 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0483 | 0.0603 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0033 | 0.0204 | 0.0204 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0157 | 0.3802 | 0.4743 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0053 | 0.0777 | 0.097 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0157 | 0.3802 | 0.4743 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0483 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0113 | 0.2539 | 0.2539 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0483 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0142 | 0.3376 | 0.3376 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0142 | 0.3376 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0483 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.4745 | 0.4745 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0082 | 0.1617 | 0.1617 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0082 | 0.1617 | 0.1617 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0271 | 0.7121 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0082 | 0.1617 | 0.2017 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0152 | 0.3663 | 0.3663 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0033 | 0.0204 | 0.0254 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0157 | 0.3802 | 0.4743 |
Loa Loa (eye worm) | serotonin transporter b | 0.0152 | 0.3663 | 0.3663 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0082 | 0.1617 | 0.2017 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0255 | 0.6652 | 0.8297 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.3663 | 0.3663 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0026 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0483 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0106 | 0.2323 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0124 | 0.2841 | 0.3544 |
Schistosoma mansoni | glutamate receptor kainate | 0.0142 | 0.3376 | 0.4211 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0142 | 0.3376 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2105 | 0.2105 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative potency (functional) | = 0.29 | The compound was tested for it's ability to prevent the reserpine induced hypothermia in mice | ChEMBL. | 7205881 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.