Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0117 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0117 | 0.0478 | 0.0478 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0117 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0619 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.0955 | 0.0955 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0117 | 0.0478 | 0.0542 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0557 | 0.8827 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0117 | 0.0478 | 0.0478 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0117 | 0.0478 | 0.0478 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0117 | 0.0478 | 0.0542 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0117 | 0.0478 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0117 | 0.0478 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0117 | 0.0478 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0117 | 0.0478 | 0.0542 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0117 | 0.0478 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0117 | 0.0478 | 0.0542 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0117 | 0.0478 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0117 | 0.0478 | 0.0478 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0117 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | nuclear hormone receptor | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0117 | 0.0478 | 0.0478 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0117 | 0.0478 | 0.0478 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0117 | 0.0478 | 0.0478 |
Trypanosoma brucei | RNA helicase, putative | 0.0142 | 0.0955 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0117 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0117 | 0.0478 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0117 | 0.0478 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0117 | 0.0478 | 0.0478 |
Onchocerca volvulus | 0.0117 | 0.0478 | 1 | |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0117 | 0.0478 | 0.0542 |
Brugia malayi | ecdysteroid receptor | 0.0117 | 0.0478 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0117 | 0.0478 | 0.0478 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0117 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0478 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0117 | 0.0478 | 0.0542 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0117 | 0.0478 | 1 |
Brugia malayi | steroid hormone receptor | 0.0117 | 0.0478 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0117 | 0.0478 | 0.0478 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0117 | 0.0478 | 0.0542 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0117 | 0.0478 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0117 | 0.0478 | 0.0542 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0117 | 0.0478 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0117 | 0.0478 | 0.0478 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0117 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0117 | 0.0478 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 32 ug ml-1 | Minimum inhibitory concentration against Neisseria meningitides 69480 | ChEMBL. | 14998336 |
MIC (functional) | = 128 ug ml-1 | Minimum inhibitory concentration against Micrococcus luteus ATCC8340 | ChEMBL. | 14998336 |
MNEC (binding) | = 1 ug ml-1 | Maximum noneffective concentration of the compound against E. coli DNA gyrase | ChEMBL. | 14998336 |
MNEC (binding) | = 1 ug ml-1 | Maximum noneffective concentration of the compound against E. coli DNA gyrase | ChEMBL. | 14998336 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.