Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Onchocerca volvulus | 0.0157 | 0 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1248 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0634 | 0.4372 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1248 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1248 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0634 | 0.4372 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.066 | 0.066 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1248 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1248 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1248 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1248 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1248 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1248 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 18 % | In vitro binding affinity towards human adenosine A2B receptor by [3H]-DPCPX displacement at 10 uM. | ChEMBL. | 12672250 |
Ki (binding) | = 20 nM | In vitro binding affinity towards human adenosine A1 receptor by [3H]-DPCPX displacement. | ChEMBL. | 12672250 |
Ki (binding) | = 81 nM | Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptor | ChEMBL. | 12672250 |
Ki (binding) | = 125 nM | Tested for binding affinity towards human adenosine A2A receptor using [3H]-ZM-241,385 as radioligand | ChEMBL. | 12672250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.