Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0033 | 0.0526 | 0.0526 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0033 | 0.0526 | 0.0526 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0081 | 0.2156 | 0.6459 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0081 | 0.2156 | 0.2156 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0081 | 0.2156 | 0.6459 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.003 | 0.0414 | 0.0414 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0033 | 0.0526 | 0.0526 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.011 | 0.3111 | 0.2813 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0033 | 0.0526 | 0.0526 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0081 | 0.2156 | 0.1817 |
Echinococcus multilocularis | protein kinase c iota type | 0.0117 | 0.3363 | 0.3363 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0314 | 1 | 1 |
Leishmania major | farnesyltransferase beta subunit | 0.011 | 0.3111 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0278 | 0.8775 | 0.8775 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0033 | 0.0526 | 0.0526 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0033 | 0.0526 | 0.0526 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.011 | 0.3111 | 0.2813 |
Brugia malayi | nuclear hormone receptor | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0033 | 0.0526 | 0.0526 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.003 | 0.0414 | 0.0414 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.011 | 0.3111 | 1 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.011 | 0.3111 | 0.3111 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | protein kinase C II. | 0.0018 | 0.0005 | 0.0005 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.8712 | 0.8712 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.003 | 0.0414 | 0.0414 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.011 | 0.3111 | 0.3942 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.003 | 0.0414 | 0.0414 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0308 | 0.9793 | 0.9793 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0081 | 0.2156 | 0.2156 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0081 | 0.2156 | 0.6459 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.003 | 0.0414 | 0.0414 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0314 | 1 | 1 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0081 | 0.2156 | 0.6459 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0526 | 0.0526 |
Toxoplasma gondii | hypothetical protein | 0.0233 | 0.7255 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0018 | 0.0005 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0275 | 0.8677 | 0.8677 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0314 | 1 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0117 | 0.3363 | 0.3363 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.008 | 0.2107 | 0.1766 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0033 | 0.0526 | 0.0526 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0081 | 0.2156 | 0.2156 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0033 | 0.0526 | 0.0526 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0081 | 0.2156 | 0.6459 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0081 | 0.2156 | 0.6459 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0018 | 0.0005 | 0.0005 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.011 | 0.3111 | 0.2813 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0293 | 0.9302 | 0.9302 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0081 | 0.2156 | 0.2156 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0081 | 0.2156 | 0.2156 |
Echinococcus granulosus | FTZ F1 alpha | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0033 | 0.0526 | 0.0526 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.003 | 0.0414 | 0.0414 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0114 | 0.3269 | 0.3269 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0033 | 0.0526 | 0.0526 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0018 | 0.0005 | 0.0005 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0314 | 1 | 1 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.011 | 0.3111 | 0.2813 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.011 | 0.3111 | 0.2813 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.011 | 0.3111 | 0.3111 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0278 | 0.8775 | 0.8775 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0314 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0.0526 | 0.0526 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.003 | 0.0414 | 0.5 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.011 | 0.3111 | 0.3111 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0.0526 | 0.0526 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0018 | 0.0005 | 0.0005 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0005 | 0.0005 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | protein kinase C3,putative | 0.0107 | 0.3022 | 0.3022 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.011 | 0.3111 | 0.3111 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0314 | 1 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0314 | 1 | 1 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0081 | 0.2156 | 0.6459 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.011 | 0.3111 | 0.2813 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0033 | 0.0526 | 0.0526 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0033 | 0.0526 | 0.0526 |
Toxoplasma gondii | hypothetical protein | 0.0081 | 0.2156 | 0.2546 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.011 | 0.3111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | steroid hormone receptor | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0018 | 0.0005 | 0.0005 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0081 | 0.2156 | 0.1817 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0081 | 0.2156 | 0.2156 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0526 | 0.0526 |
Giardia lamblia | Prenyltransferase | 0.011 | 0.3111 | 0.2813 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.003 | 0.0414 | 0.0414 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0033 | 0.0526 | 0.0526 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.011 | 0.3111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0033 | 0.0526 | 0.0526 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0081 | 0.2156 | 0.6459 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | ecdysteroid receptor | 0.0033 | 0.0526 | 0.0526 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.003 | 0.0414 | 0.0414 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0278 | 0.8775 | 0.8775 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.003 | 0.0414 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0414 | 0.0414 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0081 | 0.2156 | 0.1817 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.011 | 0.3111 | 0.2813 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | thyroid hormone receptor | 0.0308 | 0.9793 | 0.9793 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0081 | 0.2156 | 0.2156 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0414 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0526 | 0.0526 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.011 | 0.3111 | 0.2813 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0081 | 0.2156 | 0.1817 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0314 | 1 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0275 | 0.8677 | 0.8677 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0081 | 0.2156 | 0.6459 |
Onchocerca volvulus | 0.0081 | 0.2156 | 1 | |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.011 | 0.3111 | 0.2813 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0314 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0081 | 0.2156 | 0.6459 |
Schistosoma mansoni | nuclear hormone receptor | 0.0033 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0033 | 0.0526 | 0.0526 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0033 | 0.0526 | 0.0526 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0275 | 0.8677 | 0.8677 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0005 | 0.0005 |
Schistosoma mansoni | coup transcription factor | 0.0033 | 0.0526 | 0.0526 |
Schistosoma mansoni | thyroid hormone receptor | 0.0308 | 0.9793 | 0.9793 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0081 | 0.2156 | 0.1817 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0005 | 0.0005 |
Brugia malayi | nuclear receptor NHR-88 | 0.0033 | 0.0526 | 0.0526 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.011 | 0.3111 | 0.3111 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0233 | 0.7255 | 0.7136 |
Schistosoma mansoni | atypical protein kinase C | 0.0124 | 0.3609 | 0.3609 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 135 nM | Ability to displace [3H]-clonidine from alpha-2 adrenergic receptor in rat brain homogenates in vitro | ChEMBL. | 3039138 |
pA2 (functional) | = 7.22 | In vitro antagonistic activity against alpha-2 adrenergic receptor in isolated electrically stimulated rat vas deferens(clonidine-induced decrease in twitch height) | ChEMBL. | 3039138 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.