Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.1196 | 0.5513 | 0.5513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1611 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1611 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0692 | 0.0049 | 0.0049 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0692 | 0.0049 | 0.0049 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Leishmania major | cathepsin L-like protease | 0.1196 | 0.5513 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0692 | 0.0049 | 0.009 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1196 | 0.5513 | 0.549 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1196 | 0.5513 | 0.5513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0692 | 0.0049 | 0.0049 |
Onchocerca volvulus | 0.1196 | 0.5513 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1611 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0688 | 0 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.1196 | 0.5513 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.1196 | 0.5513 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1196 | 0.5513 | 1 |
Onchocerca volvulus | 0.1196 | 0.5513 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.1196 | 0.5513 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.1196 | 0.5513 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1196 | 0.5513 | 0.549 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1196 | 0.5513 | 0.5513 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1196 | 0.5513 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1196 | 0.5513 | 0.5513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0779 | 0.0986 | 0.0941 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1196 | 0.5513 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1196 | 0.5513 | 0.549 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1196 | 0.5513 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1196 | 0.5513 | 0.5513 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1196 | 0.5513 | 0.549 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1611 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1611 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1611 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1611 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0779 | 0.0986 | 0.0986 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0692 | 0.0049 | 0.0049 |
Plasmodium vivax | vivapain-2 | 0.1196 | 0.5513 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1196 | 0.5513 | 0.5513 |
Brugia malayi | cathepsin L-like precursor | 0.0779 | 0.0986 | 0.0941 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0779 | 0.0986 | 0.1714 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1196 | 0.5513 | 1 |
Leishmania major | cathepsin L-like protease | 0.1196 | 0.5513 | 1 |
Onchocerca volvulus | 0.1196 | 0.5513 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0692 | 0.0049 | 0.009 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0692 | 0.0049 | 0.009 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0779 | 0.0986 | 0.1788 |
Leishmania major | cathepsin L-like protease | 0.1196 | 0.5513 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1196 | 0.5513 | 0.549 |
Onchocerca volvulus | 0.1196 | 0.5513 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.1196 | 0.5513 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1196 | 0.5513 | 0.5513 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1196 | 0.5513 | 0.5513 |
Leishmania major | cathepsin L-like protease | 0.1196 | 0.5513 | 1 |
Onchocerca volvulus | 0.1196 | 0.5513 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1611 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1196 | 0.5513 | 0.549 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0692 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0779 | 0.0986 | 0.0986 |
Onchocerca volvulus | 0.1196 | 0.5513 | 1 | |
Onchocerca volvulus | 0.1196 | 0.5513 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0779 | 0.0986 | 0.0941 |
Leishmania major | cathepsin L-like protease | 0.1196 | 0.5513 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1196 | 0.5513 | 0.549 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0692 | 0.0049 | 0.009 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1196 | 0.5513 | 0.5513 |
Giardia lamblia | Cathepsin B precursor | 0.0688 | 0 | 0.5 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0692 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | fibroinase | 0.1196 | 0.5513 | 0.5513 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0692 | 0.0049 | 0.0049 |
Echinococcus granulosus | cathepsin l1 | 0.1196 | 0.5513 | 0.549 |
Entamoeba histolytica | cysteine protease, putative | 0.1196 | 0.5513 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1196 | 0.5513 | 0.5513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1196 | 0.5513 | 0.549 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1196 | 0.5513 | 0.549 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1196 | 0.5513 | 0.549 |
Brugia malayi | Cathepsin L-like precursor | 0.0779 | 0.0986 | 0.0941 |
Loa Loa (eye worm) | hypothetical protein | 0.0779 | 0.0986 | 0.0986 |
Brugia malayi | Cathepsin L-like precursor | 0.1196 | 0.5513 | 0.549 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1196 | 0.5513 | 0.5513 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1611 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0779 | 0.0986 | 0.0986 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0692 | 0.0049 | 0.0049 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1196 | 0.5513 | 0.549 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0779 | 0.0986 | 0.0986 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0779 | 0.0986 | 0.0941 |
Plasmodium vivax | vivapain-2 | 0.1196 | 0.5513 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1196 | 0.5513 | 0.549 |
Brugia malayi | Cathepsin L-like precursor | 0.1196 | 0.5513 | 0.549 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0779 | 0.0986 | 0.1788 |
Onchocerca volvulus | Cathepsin F homolog | 0.1196 | 0.5513 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1196 | 0.5513 | 0.549 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1196 | 0.5513 | 0.5513 |
Giardia lamblia | Cathepsin B precursor | 0.0688 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1196 | 0.5513 | 1 |
Echinococcus granulosus | cathepsin b | 0.1611 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Leishmania major | cathepsin L-like protease | 0.1196 | 0.5513 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1196 | 0.5513 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 28 % | In vitro inhibition of Aldose reductase in partially purified bovine lens preparation at a concentration of 4*10e -8M. | ChEMBL. | 1901912 |
Inhibition (binding) | = 28 % | In vitro inhibition of Aldose reductase in partially purified bovine lens preparation at a concentration of 4*10e -8M. | ChEMBL. | 1901912 |
Inhibition (binding) | = 42 % | In vitro inhibition of Aldose reductase in partially purified bovine lens preparation at a concentration of 10e -7M. | ChEMBL. | 1901912 |
Inhibition (binding) | = 42 % | In vitro inhibition of Aldose reductase in partially purified bovine lens preparation at a concentration of 10e -7M. | ChEMBL. | 1901912 |
Lowering (functional) | = 25 % | In vivo inhibition of galactitol accumulation in the sciatic nerve of rats fed 20% galactose for 4 day at 96 mg/kg/day dose | ChEMBL. | 1901912 |
Lowering (functional) | = 51 % | In vivo inhibition of galactitol accumulation in the diaphragm of rats fed 20% galactose for 4 day at 96 mg/kg/day dose | ChEMBL. | 1901912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.