Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0319 | 1 | 1 |
Plasmodium falciparum | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase, decarboxylating Gnd2 | 0.0124 | 0.3099 | 0.7333 |
Trypanosoma brucei | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0124 | 0.3099 | 0.3355 |
Chlamydia trachomatis | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.9386 |
Schistosoma mansoni | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Giardia lamblia | Glucosamine-6-phosphate deaminase | 0.0038 | 0.0046 | 0.0046 |
Echinococcus multilocularis | 6 phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0156 | 0.4226 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0297 | 0.9238 | 1 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Trypanosoma cruzi | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0049 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Chlamydia trachomatis | 6-phosphogluconolactonase | 0.013 | 0.3301 | 1 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0297 | 0.9238 | 1 |
Trypanosoma brucei | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0049 |
Brugia malayi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Leishmania major | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0049 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0124 | 0.3099 | 0.3099 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0297 | 0.9238 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0038 | 0.0046 | 0.0049 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Echinococcus multilocularis | 6 phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0297 | 0.9238 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0297 | 0.9238 | 1 |
Schistosoma mansoni | transcription initiation factor iia (tfiia) gamma chain | 0.005 | 0.0485 | 0.0525 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0038 | 0.0046 | 0.0049 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0297 | 0.9238 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Leishmania major | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0046 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.013 | 0.3301 | 0.3574 |
Trichomonas vaginalis | 3-hydroxyisobutyrate dehydrogenase, putative | 0.0124 | 0.3099 | 0.3099 |
Leishmania major | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0038 | 0.0046 | 0.0046 |
Echinococcus granulosus | 6 phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Schistosoma mansoni | glucosamine-6-phosphate isomerase | 0.0038 | 0.0046 | 0.0049 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Loa Loa (eye worm) | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.7333 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Giardia lamblia | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0124 | 0.3099 | 0.3099 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0124 | 0.3099 | 0.3099 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0297 | 0.9238 | 1 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.7333 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0156 | 0.4226 | 1 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Mycobacterium leprae | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.013 | 0.3301 | 0.7812 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0038 | 0.0046 | 0.0046 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0319 | 1 | 1 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.005 | 0.0485 | 0.0525 |
Brugia malayi | 6-phosphogluconolactonase family protein | 0.013 | 0.3301 | 0.3574 |
Echinococcus granulosus | 6 phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Giardia lamblia | Glucosamine-6-phosphate deaminase | 0.0038 | 0.0046 | 0.0046 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0074 | 0.1325 | 0.1434 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0156 | 0.4226 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Plasmodium vivax | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0124 | 0.3099 | 0.3355 |
Loa Loa (eye worm) | pgd protein | 0.0124 | 0.3099 | 0.3355 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1 | 0.0124 | 0.3099 | 0.7333 |
Trypanosoma brucei | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.3574 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0046 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0046 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0297 | 0.9238 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.013 | 0.3301 | 0.3574 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0319 | 1 | 1 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0297 | 0.9238 | 1 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.013 | 0.3301 | 0.0294 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0038 | 0.0046 | 0.0049 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0124 | 0.3099 | 0.3355 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase Gnd1 | 0.0124 | 0.3099 | 0.7333 |
Mycobacterium ulcerans | 6-phosphogluconolactonase | 0.013 | 0.3301 | 0.7812 |
Mycobacterium tuberculosis | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0092 | 0.1968 | 0.4656 |
Trypanosoma cruzi | glucosamine-6-phosphate isomerase, putative | 0.0038 | 0.0046 | 0.0049 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HACU improvement (functional) | = 5 % | Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-5 M | ChEMBL. | No reference |
HACU improvement (functional) | = 10 % | Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-6 M | ChEMBL. | No reference |
HACU improvement (functional) | = 26 % | Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-7 M | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.