Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0223 | 0.0701 | 0.0701 |
Echinococcus multilocularis | nAChR subunit | 0.0387 | 0.1639 | 0.5782 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0179 | 0.0446 | 0.0446 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0596 | 0.2835 | 0.2835 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0387 | 0.1639 | 0.1639 |
Entamoeba histolytica | hypothetical protein | 0.0209 | 0.0617 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0387 | 0.1639 | 0.1639 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0387 | 0.1639 | 0.1639 |
Onchocerca volvulus | 0.0179 | 0.0446 | 0.0446 | |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | nAChR subunit | 0.0209 | 0.0617 | 0.2177 |
Schistosoma mansoni | nAChR subunit | 0.0387 | 0.1639 | 0.1639 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0387 | 0.1639 | 0.5782 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0387 | 0.1639 | 0.5782 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0209 | 0.0617 | 0.0617 |
Onchocerca volvulus | 0.0387 | 0.1639 | 0.1639 | |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0387 | 0.1639 | 0.1639 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0387 | 0.1639 | 0.1639 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0101 | 0 | 0.5 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0179 | 0.0446 | 0.0446 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0617 | 0.0617 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0387 | 0.1639 | 0.5782 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0179 | 0.0446 | 0.1572 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0596 | 0.2835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0387 | 0.1639 | 0.5782 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | hypothetical protein | 0.1669 | 0.8978 | 0.8978 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0101 | 0 | 0.5 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0179 | 0.0446 | 0.1572 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0179 | 0.0446 | 0.0446 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.1848 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0387 | 0.1639 | 0.1639 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0387 | 0.1639 | 0.1639 |
Onchocerca volvulus | 0.0179 | 0.0446 | 0.0446 | |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0387 | 0.1639 | 0.5782 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0387 | 0.1639 | 0.5782 |
Onchocerca volvulus | 0.0209 | 0.0617 | 0.0617 | |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0387 | 0.1639 | 0.5782 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0101 | 0 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0387 | 0.1639 | 0.5782 |
Schistosoma mansoni | nAChR subunit | 0.0387 | 0.1639 | 0.1639 |
Onchocerca volvulus | 0.1848 | 1 | 1 | |
Echinococcus multilocularis | nAChR subunit | 0.0209 | 0.0617 | 0.2177 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0209 | 0.0617 | 0.0617 |
Onchocerca volvulus | 0.0387 | 0.1639 | 0.1639 | |
Brugia malayi | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0532 | 0.0532 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0387 | 0.1639 | 0.1639 |
Onchocerca volvulus | Putative nachr subunit | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | acetylcholinesterase | 0.0596 | 0.2835 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.2835 | 0.2835 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0209 | 0.0617 | 0.0617 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Onchocerca volvulus | 0.0209 | 0.0617 | 0.0617 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0244 | 0.0818 | 0.0818 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0179 | 0.0446 | 0.0446 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0223 | 0.0701 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0387 | 0.1639 | 0.5782 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0101 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0617 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0387 | 0.1639 | 0.5782 |
Schistosoma mansoni | nAChR subunit | 0.0179 | 0.0446 | 0.0446 |
Onchocerca volvulus | 0.1848 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | ACC-1 protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0208 | 0.0617 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0179 | 0.0446 | 0.0446 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0387 | 0.1639 | 0.1639 |
Onchocerca volvulus | 0.0179 | 0.0446 | 0.0446 | |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Schistosoma mansoni | nAChR subunit | 0.0179 | 0.0446 | 0.0446 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | LGC-31 protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0223 | 0.0701 | 0.2472 |
Brugia malayi | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.1848 | 1 | 1 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0617 | 0.0617 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0209 | 0.0617 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.2835 | 0.2835 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0387 | 0.1639 | 0.1639 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0387 | 0.1639 | 0.5782 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0209 | 0.0617 | 0.0617 |
Brugia malayi | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0387 | 0.1639 | 0.5782 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0223 | 0.0701 | 0.2472 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0387 | 0.1639 | 0.5782 |
Echinococcus granulosus | acetylcholinesterase | 0.0596 | 0.2835 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0596 | 0.2835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0387 | 0.1639 | 0.1639 |
Echinococcus multilocularis | acetylcholinesterase | 0.0596 | 0.2835 | 1 |
Brugia malayi | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0179 | 0.0446 | 0.0446 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0617 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0617 | 0.0617 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0387 | 0.1639 | 0.1639 |
Schistosoma mansoni | nAChR subunit | 0.0387 | 0.1639 | 0.1639 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0244 | 0.0818 | 0.0818 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0179 | 0.0446 | 0.1572 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.1848 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0387 | 0.1639 | 0.1639 |
Schistosoma mansoni | nAChR subunit | 0.0387 | 0.1639 | 0.1639 |
Brugia malayi | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0387 | 0.1639 | 0.5782 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0179 | 0.0446 | 0.1572 |
Brugia malayi | Cation transporter family protein | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0179 | 0.0446 | 0.1572 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0617 | 0.0617 |
Echinococcus granulosus | carboxylesterase 5A | 0.0596 | 0.2835 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0179 | 0.0446 | 0.0446 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0387 | 0.1639 | 0.5782 |
Brugia malayi | Carboxylesterase family protein | 0.0596 | 0.2835 | 0.2835 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | nAChR subunit | 0.0387 | 0.1639 | 0.5782 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0179 | 0.0446 | 0.0446 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Schistosoma mansoni | nAChR subunit | 0.0387 | 0.1639 | 0.1639 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0209 | 0.0617 | 0.0617 |
Brugia malayi | Carboxylesterase family protein | 0.0596 | 0.2835 | 0.2835 |
Loa Loa (eye worm) | carboxylesterase | 0.0596 | 0.2835 | 0.2835 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0387 | 0.1639 | 0.1639 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0596 | 0.2835 | 0.2835 |
Brugia malayi | Cation transporter family protein | 0.0387 | 0.1639 | 0.1639 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0387 | 0.1639 | 0.5782 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0617 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.0446 | 0.0446 |
Onchocerca volvulus | 0.1848 | 1 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0209 | 0.0617 | 0.0617 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0387 | 0.1639 | 0.1639 |
Schistosoma mansoni | nAChR subunit | 0.0387 | 0.1639 | 0.1639 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.1848 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0617 | 0.0617 |
Onchocerca volvulus | 0.0387 | 0.1639 | 0.1639 | |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0208 | 0.0617 | 1 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0209 | 0.0617 | 0.0617 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.2 p.p.m. | Inhibitory activity against second generation merozoids of Eimeria tenella in chick hepatocyte assay; value given as 0.2-1.0 | ChEMBL. | 9873375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.