Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0375 | 0.1015 | 0.1015 |
Brugia malayi | Carboxylesterase family protein | 0.0375 | 0.1015 | 0.0802 |
Loa Loa (eye worm) | carboxylesterase | 0.0375 | 0.1015 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0231 | 0.0149 |
Echinococcus granulosus | acetylcholinesterase | 0.2218 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0375 | 0.1015 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.1015 | 0.0939 |
Loa Loa (eye worm) | carboxylesterase | 0.0375 | 0.1015 | 0.0939 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0375 | 0.1015 | 0.1015 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0375 | 0.1015 | 0.1015 |
Loa Loa (eye worm) | carboxylesterase | 0.2218 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0375 | 0.1015 | 0.0802 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0459 | 0.1427 | 0.1427 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.1015 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.0231 | 0.0149 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0375 | 0.1015 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0375 | 0.1015 | 0.1015 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2218 | 1 | 1 |
Onchocerca volvulus | 0.0375 | 0.1015 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0375 | 0.1015 | 0.1015 |
Onchocerca volvulus | 0.0375 | 0.1015 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.2218 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0214 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.1015 | 0.0939 |
Echinococcus granulosus | acetylcholinesterase | 0.2218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.1015 | 0.0939 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0375 | 0.1015 | 0.1015 |
Onchocerca volvulus | 0.0375 | 0.1015 | 1 | |
Echinococcus multilocularis | neuropeptide s receptor | 0.0459 | 0.1427 | 0.1427 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2218 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0375 | 0.1015 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0375 | 0.1015 | 0.1015 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0375 | 0.1015 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0375 | 0.1015 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0375 | 0.1015 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0375 | 0.1015 | 0.1015 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0214 | 0.0231 | 0.0231 |
Echinococcus granulosus | carboxylesterase 5A | 0.2218 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0375 | 0.1015 | 0.0802 |
Onchocerca volvulus | 0.0375 | 0.1015 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0375 | 0.1015 | 0.0802 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0459 | 0.1427 | 0.1427 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0375 | 0.1015 | 0.1015 |
Echinococcus multilocularis | acetylcholinesterase | 0.2218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.1015 | 0.0939 |
Onchocerca volvulus | 0.0375 | 0.1015 | 1 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0375 | 0.1015 | 0.1015 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0375 | 0.1015 | 0.1015 |
Echinococcus granulosus | neuropeptide s receptor | 0.0459 | 0.1427 | 0.1427 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0375 | 0.1015 | 0.1015 |
Echinococcus multilocularis | acetylcholinesterase | 0.2218 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0375 | 0.1015 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.1015 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.1015 | 0.0939 |
Brugia malayi | hypothetical protein | 0.0375 | 0.1015 | 0.0802 |
Echinococcus granulosus | neuroligin | 0.0375 | 0.1015 | 0.1015 |
Echinococcus multilocularis | neuroligin | 0.0375 | 0.1015 | 0.1015 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED1.5 (functional) | NT 0 mg kg-1 | Effective dose required to produce an increase in dP/dt5 by 1500 mmHg/s in cats;NT means not tested. | ChEMBL. | 2544724 |
ED1.5 (functional) | NT 0 mg kg-1 | Effective dose required to produce an increase in dP/dt5 by 1500 mmHg/s in dogs;NT means not tested. | ChEMBL. | 2544724 |
ED1.5 (functional) | > 3 mg kg-1 | Effective dose required to produce an increase in dP/dt5 by 1500 mmHg/s in rats | ChEMBL. | 2544724 |
Max (functional) | NO 0 mmHg s-1 | Maximum increase in dP/dt when administered intravenously in rats. | ChEMBL. | 2544724 |
Max (functional) | ND 0 mmHg s-1 | Maximum increase in dP/dt when administered intravenously in cats. | ChEMBL. | 2544724 |
Max (functional) | ND 0 mmHg s-1 | Maximum increase in dP/dt when administered intravenously in dogs. | ChEMBL. | 2544724 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.