Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.3151 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.6422 | 0.4775 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.6422 | 0.4775 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.3151 | 0.3151 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.3151 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.3151 | 0.3151 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.6422 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.3151 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3151 | 0.1904 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.3151 | 0.3151 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.3151 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.3151 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.3151 | 0.3151 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.3151 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.3151 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.3151 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.3151 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3151 | 0.1904 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3151 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antioxidant activity assessed as superoxide radical anion scavenging activity at 0.2 mg/ml by hypoxanthine NBT method | ChEMBL. | 17890083 |
Activity (functional) | = 95.79 % | Antioxidant activity assessed as superoxide radical anion scavenging activity at 0.5 mg/ml by hypoxanthine NBT method | ChEMBL. | 17890083 |
IC50 (functional) | = 0.14 mg/ml | Antioxidant activity assessed as superoxide radical anion scavenging activity by hypoxanthine NBT method | ChEMBL. | 17890083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.