Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.5 nM | Inhibition of cholesterol synthesis in rat hepatocytes | ChEMBL. | 17764936 |
IC50 (binding) | = 37 nM | Inhibition of HMG-CoA reductase in rat liver microsomes | ChEMBL. | 17764936 |
IC50 (binding) | = 37 nM | Inhibition of HMG-CoA reductase in rat liver microsomes | ChEMBL. | 17764936 |
IC50 (functional) | = 18500 nM | Inhibition of cholesterol synthesis in L6 myocytes | ChEMBL. | 17764936 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.