Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.5436 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.5436 | 0.3662 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.5436 | 0.3662 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0239 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.5436 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0239 | 1 | 1 |
Onchocerca volvulus | 0.0239 | 1 | 0.5 | |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.5436 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.5436 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0239 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0239 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.5436 | 0.3662 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.5436 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0239 | 1 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0239 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.5436 | 0.3662 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0239 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8 nM | Inhibition of cholesterol synthesis in rat hepatocytes | ChEMBL. | 17764936 |
IC50 (binding) | = 14 nM | Inhibition of HMG-CoA reductase in rat liver microsomes | ChEMBL. | 17764936 |
IC50 (binding) | = 14 nM | Inhibition of HMG-CoA reductase in rat liver microsomes | ChEMBL. | 17764936 |
IC50 (functional) | = 4340 nM | Inhibition of cholesterol synthesis in L6 myocytes | ChEMBL. | 17764936 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.