Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0114 | 0.3115 | 0.591 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.014 | 0.4181 | 0.799 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 0.4181 | 0.799 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.5212 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.004 | 0.0085 | 0.0085 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.5212 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1238 | 0.2249 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1626 | 0.1554 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.5212 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.008 | 0.1741 | 0.3229 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.008 | 0.1741 | 0.3229 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.1238 | 0.2249 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.004 | 0.0085 | 0.0085 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.1238 | 0.2249 |
Onchocerca volvulus | 0.008 | 0.1741 | 0.5 | |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.5212 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0282 | 1 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.014 | 0.0056 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.1626 | 0.1626 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.1238 | 0.2249 |
Schistosoma mansoni | lipoxygenase | 0.0114 | 0.3115 | 0.591 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.008 | 0.1741 | 0.3229 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.5212 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 0.4181 | 0.799 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.1238 | 0.2249 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.014 | 0.0056 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0114 | 0.3115 | 0.591 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.1238 | 0.1163 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.014 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.5212 | 1 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.1713 | 0.3176 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.1238 | 0.2249 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 0.4181 | 0.799 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0 | 0.5 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.5212 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1626 | 0.1554 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0138 | 0.4096 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.014 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.5212 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.5212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.5212 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0138 | 0.4096 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.4021 | 0.7676 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.1238 | 0.2249 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1741 | 0.3229 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.014 | 0.0108 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.1238 | 0.2249 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.1238 | 0.2249 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1626 | 0.1554 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.008 | 0.1741 | 0.3229 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.1238 | 0.2249 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0282 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.1238 | 0.2249 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.014 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.1238 | 0.2249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 | Inhibition of cholesterol synthesis in L6 myocytes | ChEMBL. | 17764936 |
IC50 (functional) | = 7.5 nM | Inhibition of cholesterol synthesis in rat hepatocytes | ChEMBL. | 17764936 |
IC50 (binding) | = 25 nM | Inhibition of HMG-CoA reductase in rat liver microsomes | ChEMBL. | 17764936 |
IC50 (binding) | = 25 nM | Inhibition of HMG-CoA reductase in rat liver microsomes | ChEMBL. | 17764936 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.