Detailed information for compound 500128

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.544 | Formula: C29H26N4
  • H donors: 0 H acceptors: 3 LogP: 7.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ncc2c(n1)n(CC(C)(C)C)c(c2)Cc1ccc(cc1)c1ccc2c(c1)cccc2
  • InChi: 1S/C29H26N4/c1-29(2,3)19-33-26(16-25-18-31-27(17-30)32-28(25)33)14-20-8-10-22(11-9-20)24-13-12-21-6-4-5-7-23(21)15-24/h4-13,15-16,18H,14,19H2,1-3H3
  • InChiKey: GRQUVURBHNCPFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0204 0.1038 0.094
Schistosoma mansoni steroid hormone receptor ad4bp 0.0204 0.1038 0.1038
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0355 0.2043 0.1956
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Echinococcus granulosus death domain containing protein 0.0075 0.017 0.0063
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1271 0.1176
Plasmodium falciparum LCCL domain-containing protein 0.0293 0.1629 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.037 0.0871
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1271 0.1176
Loa Loa (eye worm) hypothetical protein 0.0204 0.1038 0.2699
Loa Loa (eye worm) hypothetical protein 0.0101 0.0344 0.0798
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0075 0.0175 0.0175
Loa Loa (eye worm) cytochrome P450 family protein 0.0102 0.035 0.0817
Treponema pallidum sodium- and chloride- dependent transporter 0.0265 0.144 0.5
Brugia malayi ecdysone receptor 0.0096 0.0316 0.0852
Entamoeba histolytica hypothetical protein 0.0112 0.0417 1
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0131 0.0353
Loa Loa (eye worm) hypothetical protein 0.0204 0.1038 0.2699
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0549 0.148
Loa Loa (eye worm) hypothetical protein 0.0204 0.1038 0.2699
Echinococcus multilocularis thyroid hormone receptor alpha 0.0342 0.1959 0.1872
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0328 0.1864 0.4961
Brugia malayi Peroxidasin 0.017 0.081 0.2185
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0204 0.1038 0.2802
Schistosoma mansoni lipoxygenase 0.1017 0.6475 0.6475
Schistosoma mansoni nuclear receptor nhr-48 0.0096 0.0316 0.0316
Brugia malayi Cathepsin L-like precursor 0.0071 0.0145 0.0391
Brugia malayi Animal haem peroxidase family protein 0.017 0.081 0.2185
Echinococcus granulosus serotonin transporter 0.0265 0.144 0.1347
Echinococcus granulosus peroxidasin 0.017 0.081 0.0709
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0204 0.1038 0.1038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) animal heme peroxidase 0.017 0.081 0.2074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Onchocerca volvulus Peroxidasin homolog 0.017 0.081 0.4478
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0144 0.0633 0.3288
Echinococcus granulosus RUN 0.0293 0.1629 0.1538
Brugia malayi Steroid receptor seven-up type 2 0.0204 0.1038 0.2802
Onchocerca volvulus Peroxidase homolog 0.017 0.081 0.4478
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0853 0.5372 1
Loa Loa (eye worm) norepinephrine transporter 0.0265 0.144 0.3801
Brugia malayi MH2 domain containing protein 0.0127 0.0522 0.1408
Brugia malayi orphan nuclear receptor NR2E1 0.0096 0.0316 0.0852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Brugia malayi tailless protein 0.0096 0.0316 0.0852
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0446 0.265 0.265
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.4129 0.4129
Echinococcus granulosus jun protein 0.0355 0.2043 0.1956
Schistosoma mansoni peroxidasin 0.017 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0265 0.144 0.3801
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0115 0.0115
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0376 0.2187 0.3949
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.0463 0.6948
Schistosoma mansoni tyrosinase precursor 0.0105 0.037 0.037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0204 0.1038 0.2802
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0096 0.0316 0.021
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Loa Loa (eye worm) hypothetical protein 0.0204 0.1038 0.2699
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0204 0.1038 0.1038
Loa Loa (eye worm) hypothetical protein 0.0204 0.1038 0.2699
Brugia malayi Death domain containing protein 0.0075 0.017 0.046
Loa Loa (eye worm) nuclear hormone receptor 0.0096 0.0316 0.0722
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0549 0.0549
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0417 0.0313
Schistosoma mansoni dihydrofolate reductase 0.0376 0.2187 0.2187
Onchocerca volvulus 0.017 0.081 0.4478
Brugia malayi Nuclear hormone receptor E75 0.0096 0.0316 0.0852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0204 0.1038 0.2802
Loa Loa (eye worm) hypothetical protein 0.0345 0.1978 0.5272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0204 0.1038 0.2699
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0204 0.1038 0.094
Loa Loa (eye worm) hypothetical protein 0.0108 0.0393 0.0934
Schistosoma mansoni nuclear hormone receptor 0.0096 0.0316 0.0316
Chlamydia trachomatis dihydrofolate reductase 0.0376 0.2187 0.5
Brugia malayi Cathepsin L-like precursor 0.0071 0.0145 0.0391
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0071 0.0145 0.0037
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0144 0.0633 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0204 0.1038 0.2699
Brugia malayi Nuclear hormone receptor-like 1 0.0108 0.0393 0.1061
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1545 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Brugia malayi hypothetical protein 0.0108 0.0393 0.1061
Loa Loa (eye worm) DR-78 0.0096 0.0316 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0204 0.1038 0.2802
Brugia malayi nuclear hormone receptor family member odr-7 0.0096 0.0316 0.0852
Brugia malayi steroid hormone receptor 0.0204 0.1038 0.2802
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0204 0.1038 0.2699
Brugia malayi nuclear hormone receptor family member nhr-6 0.0096 0.0316 0.0852
Brugia malayi Animal haem peroxidase family protein 0.017 0.081 0.2185
Schistosoma mansoni thyroid hormone receptor 0.0342 0.1959 0.1959
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0204 0.1038 0.094
Schistosoma mansoni tyrosinase precursor 0.0105 0.037 0.037
Brugia malayi Animal haem peroxidase family protein 0.017 0.081 0.2185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Echinococcus multilocularis jun protein 0.0355 0.2043 0.1956
Echinococcus multilocularis peroxidasin 0.017 0.081 0.0709
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0105 0.037 0.0999
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0522 0.1285
Brugia malayi nuclear hormone receptor 0.0096 0.0316 0.0852
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0265 0.144 0.144
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0071 0.0145 0.0254
Schistosoma mansoni jun-related protein 0.0288 0.1599 0.1599
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0145 0.0391
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0204 0.1038 0.2802
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Brugia malayi hypothetical protein 0.0108 0.0393 0.1061
Loa Loa (eye worm) hypothetical protein 0.0204 0.1038 0.2699
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0138 0.0592 0.049
Plasmodium vivax multidomain scavenger receptor, putative 0.0293 0.1629 1
Schistosoma mansoni coup transcription factor 0.0204 0.1038 0.1038
Echinococcus granulosus Ankyrin 0.0075 0.0175 0.0068
Onchocerca volvulus 0.0105 0.037 0.1519
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0145 0.1224
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0549 0.0445
Brugia malayi hypothetical protein 0.0293 0.1629 0.4398
Echinococcus granulosus netrin receptor unc 5 0.0075 0.017 0.0063
Loa Loa (eye worm) hypothetical protein 0.0105 0.037 0.0871
Brugia malayi bZIP transcription factor family protein 0.0355 0.2043 0.5514
Brugia malayi hypothetical protein 0.017 0.081 0.2185
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0075 0.017 0.0063
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.4129 0.4065
Loa Loa (eye worm) serotonin transporter b 0.0265 0.144 0.3801
Onchocerca volvulus Chorion peroxidase homolog 0.017 0.081 0.4478
Brugia malayi RNA binding protein 0.0131 0.0549 0.148
Schistosoma mansoni hypothetical protein 0.0069 0.0131 0.0131
Echinococcus multilocularis lipoxygenase domain containing protein 0.0293 0.1629 0.1538
Loa Loa (eye worm) cysteine protease 0.0071 0.0145 0.0254
Schistosoma mansoni hypothetical protein 0.0171 0.0811 0.0811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0108 0.0393 0.0934
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0095 0.0306 0.4131
Loa Loa (eye worm) hypothetical protein 0.0239 0.1271 0.3336
Brugia malayi nuclear receptor NHR-88 0.0096 0.0316 0.0852
Brugia malayi Animal haem peroxidase family protein 0.017 0.081 0.2185
Brugia malayi nuclear receptor NHR-88 0.0204 0.1038 0.2802
Echinococcus granulosus Polycystic kidney disease protein 0.0293 0.1629 0.1538
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0138 0.0592 0.049
Schistosoma mansoni nuclear receptor 0.0096 0.0316 0.0316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Mycobacterium ulcerans proteasome PrcA 0.0853 0.5372 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0376 0.2187 0.3949
Brugia malayi Doublecortin family protein 0.0293 0.1629 0.4398
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0105 0.037 0.0999
Brugia malayi Cytochrome P450 family protein 0.0102 0.035 0.0946
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0204 0.1038 0.6018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) animal heme peroxidase 0.017 0.081 0.2074
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0071 0.0145 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0204 0.1038 0.2802
Onchocerca volvulus 0.017 0.081 0.4478
Echinococcus granulosus nuclear factor of activated T cells 5 0.0383 0.223 0.2145
Schistosoma mansoni RAR-like nuclear receptor 0.0204 0.1038 0.1038
Schistosoma mansoni cathepsin F (C01 family) 0.0071 0.0145 0.0145
Brugia malayi hypothetical protein 0.0112 0.0417 0.1126
Schistosoma mansoni nuclear hormone receptor 0.0204 0.1038 0.1038
Leishmania major cathepsin L-like protease 0.0071 0.0145 0.0702
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Echinococcus multilocularis RUN 0.0293 0.1629 0.1538
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0108 0.0393 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0071 0.0145 0.5
Onchocerca volvulus 0.0096 0.0316 0.1153
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0265 0.144 0.3888
Brugia malayi Nuclear hormone receptor-like 1 0.0204 0.1038 0.2802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0108 0.0393 0.0288
Brugia malayi hypoxia-induced factor 1 0.0152 0.069 0.1861
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0204 0.1038 0.094
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0204 0.1038 0.1038
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0196 0.0983 0.0884
Loa Loa (eye worm) hypothetical protein 0.0069 0.0131 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0549 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Echinococcus granulosus snurportin 1 0.0328 0.1864 0.1775
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0096 0.0316 0.021
Onchocerca volvulus Protein ultraspiracle homolog 0.0204 0.1038 0.6018
Echinococcus multilocularis cathepsin L cysteine protease 0.0071 0.0145 0.0037
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0304 0.1705 0.1615
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0204 0.1038 0.2802
Brugia malayi Nuclear hormone receptor-like 1 0.0108 0.0393 0.1061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0204 0.1038 0.094
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.0145 0.0254
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0096 0.0316 0.0316
Entamoeba histolytica hypothetical protein 0.0112 0.0417 1
Echinococcus granulosus tm gpcr rhodopsin 0.0909 0.5749 0.5702
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0549 0.0549
Loa Loa (eye worm) fibroinase 0.0071 0.0145 0.0254
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0288 0.1599 0.1599
Schistosoma mansoni polycystin 1-related 0.0293 0.1629 0.1629
Leishmania major cathepsin L-like protease 0.0071 0.0145 0.0702
Loa Loa (eye worm) tyrosinase 1 0.0105 0.037 0.0871
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0204 0.1038 0.1038
Brugia malayi hypothetical protein 0.0239 0.1271 0.343
Onchocerca volvulus 0.0105 0.037 0.1519
Brugia malayi Common central domain of tyrosinase family protein 0.0105 0.037 0.0999
Echinococcus granulosus lipoxygenase domain containing protein 0.0293 0.1629 0.1538
Echinococcus granulosus thyroid hormone receptor alpha 0.0096 0.0316 0.021
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0096 0.0316 0.1153
Echinococcus multilocularis cysteine protease 0.0071 0.0145 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0355 0.2043 0.1956
Echinococcus granulosus cathepsin l cysteine peptidase 0.0071 0.0145 0.0037
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0204 0.1038 0.094
Leishmania major cathepsin L-like protease 0.0071 0.0145 0.0702
Brugia malayi nuclear receptor NHR-67 0.0096 0.0316 0.0852
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0204 0.1038 0.2802
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0204 0.1038 0.2699
Onchocerca volvulus 0.0293 0.1629 1
Brugia malayi ShTK domain containing protein 0.0105 0.037 0.0999
Echinococcus granulosus tar DNA binding protein 0.0131 0.0549 0.0445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.017 0.046
Brugia malayi hypothetical protein 0.0096 0.0316 0.0852
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0144 0.0633 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.0775 0.1979
Echinococcus multilocularis lipoxygenase domain containing protein 0.0293 0.1629 0.1538
Brugia malayi Animal haem peroxidase family protein 0.017 0.081 0.2185
Brugia malayi small heat shock protein 0.0603 0.3705 1
Loa Loa (eye worm) dihydrofolate reductase 0.0376 0.2187 0.5844
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0909 0.5749 0.5702
Onchocerca volvulus 0.0265 0.144 0.8728
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Loa Loa (eye worm) hypothetical protein 0.0108 0.0393 0.0934
Loa Loa (eye worm) animal heme peroxidase 0.017 0.081 0.2074
Loa Loa (eye worm) hypothetical protein 0.0293 0.1629 0.4318
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0115 0.014
Echinococcus multilocularis cysteine protease 0.0071 0.0145 0.0037
Loa Loa (eye worm) hypothetical protein 0.0204 0.1038 0.2699
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0344 0.0798
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0383 0.223 0.2145
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0344 0.0927
Brugia malayi hypothetical protein 0.0293 0.1629 0.4398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) hypothetical protein 0.0293 0.1629 0.4318
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0549 0.0549
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0075 0.017 0.0324
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0204 0.1038 0.1038
Loa Loa (eye worm) hypothetical protein 0.0108 0.0393 0.0934
Brugia malayi Cathepsin L-like precursor 0.0071 0.0145 0.0391
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0096 0.0316 0.0852
Brugia malayi Protein kinase domain containing protein 0.0075 0.017 0.046
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0204 0.1038 0.2802
Loa Loa (eye worm) hypothetical protein 0.0075 0.0175 0.0336
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0096 0.0316 0.021
Entamoeba histolytica hypothetical protein 0.0112 0.0417 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0204 0.1038 0.094
Brugia malayi hypothetical protein 0.0165 0.0775 0.2092
Brugia malayi dihydrofolate reductase family protein 0.0376 0.2187 0.5902
Schistosoma mansoni thyroid hormone receptor 0.0342 0.1959 0.1959
Onchocerca volvulus Dual oxidase homolog 0.017 0.081 0.4478
Loa Loa (eye worm) animal heme peroxidase 0.017 0.081 0.2074
Schistosoma mansoni ankyrin 23/unc44 0.0075 0.017 0.017
Onchocerca volvulus 0.0105 0.037 0.1519
Loa Loa (eye worm) ShTK domain-containing protein 0.0105 0.037 0.0871
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Brugia malayi Uncoordinated protein 44 0.0075 0.017 0.046
Loa Loa (eye worm) hypothetical protein 0.0108 0.0393 0.0934
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0105 0.037 0.0999
Echinococcus granulosus Nuclear hormone receptor HR96 0.0096 0.0316 0.021
Onchocerca volvulus 0.017 0.081 0.4478
Schistosoma mansoni retinoic acid receptor RXR 0.0304 0.1705 0.1705
Loa Loa (eye worm) blistered cuticle protein 3 0.017 0.081 0.2074
Brugia malayi conserved hypotetical protein 0.0096 0.0316 0.0852
Leishmania major cathepsin L-like protease 0.0118 0.0463 0.6766
Schistosoma mansoni hypothetical protein 0.0328 0.1864 0.1864
Schistosoma mansoni netrin receptor unc5 0.0075 0.017 0.017
Schistosoma mansoni cathepsin F (C01 family) 0.0071 0.0145 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.0463 0.6948
Echinococcus granulosus Nuclear hormone receptor HR96 0.0096 0.0316 0.021
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0204 0.1038 0.094
Loa Loa (eye worm) steroid hormone receptor 0.0204 0.1038 0.2699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) nuclear receptor NHR-67 0.0096 0.0316 0.0722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0204 0.1038 0.094
Trypanosoma cruzi cruzipain precursor, putative 0.0118 0.0463 0.6948
Schistosoma mansoni hypothetical protein 0.0293 0.1629 0.1629
Loa Loa (eye worm) hypothetical protein 0.0075 0.017 0.0324
Brugia malayi RNA, U transporter 1 0.0087 0.0255 0.0689
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.0316 0.021
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0417 0.0313
Onchocerca volvulus Bile acid receptor homolog 0.0204 0.1038 0.6018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0204 0.1038 0.094
Loa Loa (eye worm) solute carrier family 6 member 4 0.0265 0.144 0.3801
Brugia malayi hypothetical protein 0.0096 0.0316 0.0852
Echinococcus multilocularis Ankyrin 0.0075 0.0175 0.0068
Echinococcus multilocularis Polycystic kidney disease protein 0.0293 0.1629 0.1538
Schistosoma mansoni hypothetical protein 0.0138 0.0592 0.0592
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0204 0.1038 0.2802
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0071 0.0145 0.5
Brugia malayi nuclear receptor RXR 0.0108 0.0393 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0204 0.1038 0.2802
Brugia malayi photoreceptor-specific nuclear receptor 0.0204 0.1038 0.2802
Loa Loa (eye worm) hypothetical protein 0.0204 0.1038 0.2699
Onchocerca volvulus Peroxidasin homolog 0.017 0.081 0.4478
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Schistosoma mansoni hypothetical protein 0.0112 0.0417 0.0417
Toxoplasma gondii cathepsin CPL 0.0071 0.0145 0.057
Brugia malayi nuclear receptor RXR 0.0096 0.0316 0.0852
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.0316 0.021
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0549 0.1359
Brugia malayi Cathepsin L-like precursor 0.0071 0.0145 0.0391
Leishmania major cathepsin L-like protease 0.0118 0.0463 0.6766
Schistosoma mansoni nuclear receptor 0.0096 0.0316 0.0316
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0071 0.0145 0.0037
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0108 0.0393 0.0393
Echinococcus multilocularis geminin 0.0171 0.0811 0.0711
Loa Loa (eye worm) ShTK domain-containing protein 0.0105 0.037 0.0871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Echinococcus granulosus dihydrofolate reductase 0.0376 0.2187 0.2102
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.0463 0.6948
Onchocerca volvulus Netrin receptor homolog 0.0075 0.017 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Echinococcus multilocularis netrin receptor unc 5 0.0075 0.017 0.0063
Onchocerca volvulus 0.0096 0.0316 0.1153
Echinococcus multilocularis nuclear receptor nhr 48 0.0096 0.0316 0.021
Loa Loa (eye worm) ctsf protein 0.0071 0.0145 0.0254
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Echinococcus multilocularis serotonin transporter 0.0265 0.144 0.1347
Echinococcus multilocularis snurportin 1 0.0328 0.1864 0.1775
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0115 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0204 0.1038 0.2802
Loa Loa (eye worm) hypothetical protein 0.0603 0.3705 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.069 0.1745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0204 0.1038 0.2699
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Echinococcus multilocularis ecdysone induced protein 78C 0.0204 0.1038 0.094
Echinococcus multilocularis dihydrofolate reductase 0.0376 0.2187 0.2102
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0144 0.0633 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0204 0.1038 0.094
Loa Loa (eye worm) doublecortin family protein 0.0293 0.1629 0.4318
Schistosoma mansoni lipoxygenase 0.1545 1 1
Brugia malayi TAR-binding protein 0.0131 0.0549 0.148
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.0108 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0115 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Leishmania major cysteine peptidase A (CPA) 0.0071 0.0145 0.0702
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) hypothetical protein 0.0265 0.144 0.3801
Schistosoma mansoni hypothetical protein 0.0075 0.017 0.017
Echinococcus granulosus nuclear receptor nhr 48 0.0096 0.0316 0.021
Brugia malayi Dihydrofolate reductase 0.0376 0.2187 0.5902
Leishmania major cathepsin L-like protease 0.0071 0.0145 0.0702
Entamoeba histolytica hypothetical protein 0.0112 0.0417 1
Brugia malayi nuclear hormone receptor 0.0204 0.1038 0.2802
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0144 0.0633 1
Onchocerca volvulus Peroxidase homolog 0.017 0.081 0.4478
Brugia malayi hypothetical protein 0.0279 0.1534 0.4139
Brugia malayi Cathepsin L-like precursor 0.0071 0.0145 0.0391
Echinococcus granulosus lipoxygenase domain containing protein 0.0293 0.1629 0.1538
Echinococcus multilocularis cathepsin L cysteine protease 0.0071 0.0145 0.0037
Echinococcus granulosus cathepsin l1 0.0071 0.0145 0.0037
Echinococcus multilocularis FTZ F1 alpha 0.0204 0.1038 0.094
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0344 0.0927
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0108 0.0291
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0115 0.0014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0108 0.0393 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0204 0.1038 0.2699
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0549 0.1359
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0204 0.1038 0.1038
Brugia malayi Nuclear hormone receptor E75 0.0096 0.0316 0.0852
Brugia malayi ecdysteroid receptor 0.0204 0.1038 0.2802
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0204 0.1038 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0145 0.5
Loa Loa (eye worm) RNA binding protein 0.0131 0.0549 0.1359
Echinococcus granulosus FTZ F1 alpha 0.0204 0.1038 0.094
Loa Loa (eye worm) hypothetical protein 0.017 0.081 0.2074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0115 0.0014
Onchocerca volvulus 0.0293 0.1629 1
Schistosoma mansoni rab6-interacting 0.0293 0.1629 0.1629
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0722
Schistosoma mansoni sodium/chloride dependent transporter 0.0265 0.144 0.144
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0115 0.0014
Echinococcus granulosus ecdysone induced protein 78C 0.0204 0.1038 0.094
Schistosoma mansoni rab6-interacting 0.0293 0.1629 0.1629
Echinococcus granulosus microtubule associated protein 2 0.0667 0.4129 0.4065
Onchocerca volvulus 0.0105 0.037 0.1519
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0105 0.037 0.0999
Echinococcus granulosus cathepsin L cysteine proteinase 0.0071 0.0145 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0145 0.5
Leishmania major cathepsin L-like protease 0.0118 0.0463 0.6766
Loa Loa (eye worm) hypothetical protein 0.0108 0.0393 0.0934
Leishmania major cathepsin L-like protease 0.0071 0.0145 0.0702
Brugia malayi Cathepsin L-like precursor 0.0071 0.0145 0.0391
Onchocerca volvulus 0.0279 0.1534 0.9355
Schistosoma mansoni loxhd1 0.0293 0.1629 0.1629
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0522 0.1285
Loa Loa (eye worm) hypothetical protein 0.0265 0.144 0.3801
Onchocerca volvulus 0.0204 0.1038 0.6018
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0096 0.0316 0.1153
Brugia malayi Blistered cuticle protein 3 0.017 0.081 0.2185
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0204 0.1038 0.2802
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0096 0.0316 0.0722
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0115 0.0007
Schistosoma mansoni peroxidasin 0.017 0.081 0.081
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0096 0.0316 0.021
Schistosoma mansoni zinc finger protein 0.0096 0.0316 0.0316
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0144 0.0633 0.3288
Schistosoma mansoni nuclear hormone receptor 0.0096 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.0171 0.0811 0.0811
Echinococcus granulosus geminin 0.0171 0.0811 0.0711
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0075 0.017 0.0063
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0853 0.5372 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0204 0.1038 0.2699

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) < 1 nM Inhibition of cathepsin K by fluorescence assay ChEMBL. 17911019
IC50 (binding) < 1 nM Inhibition of cathepsin K by fluorescence assay ChEMBL. 17911019
IC50 (binding) = 520 nM Inhibition of cathepsin L by fluorescence assay ChEMBL. 17911019
IC50 (binding) > 1000 nM Inhibition of cathepsin S by fluorescence assay ChEMBL. 17911019
IC50 (binding) > 1000 nM Inhibition of cathepsin S by fluorescence assay ChEMBL. 17911019

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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