Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0.3469 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.3469 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2067 | 0.5959 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.3469 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.3469 | 0.5 |
Echinococcus multilocularis | protein kinase shaggy | 0.0058 | 0.3469 | 0.3975 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0058 | 0.3469 | 0.3469 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2067 | 0.2067 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2067 | 0.2368 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2067 | 0.2067 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.011 | 0.8727 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2067 | 0.5959 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0058 | 0.3469 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0.3469 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2067 | 0.2067 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0058 | 0.3469 | 0.3975 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2067 | 0.2368 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0058 | 0.3469 | 0.3469 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0058 | 0.3469 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.3469 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.3469 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0.3469 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0123 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2067 | 0.2067 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0.3469 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0058 | 0.3469 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2067 | 0.2067 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.3469 | 0.5 |
Echinococcus granulosus | protein kinase shaggy | 0.0058 | 0.3469 | 0.3469 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.3469 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.3469 | 0.5 |
Brugia malayi | intracellular kinase | 0.0058 | 0.3469 | 1 |
Onchocerca volvulus | 0.0058 | 0.3469 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.008 uM | Inhibition of human CDK2/cyclin A | ChEMBL. | 17904841 |
IC50 (binding) | = 2 uM | Inhibition of human MAPK | ChEMBL. | 17904841 |
IC50 (binding) | = 2.8 uM | Inhibition of human GSK3beta | ChEMBL. | 17904841 |
IC50 (binding) | = 2.8 uM | Inhibition of human GSK3beta | ChEMBL. | 17904841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.