TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 347.437 | Formula: C19H17N5S
H donors: 1 H acceptors: 3 LogP: 3.24 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CSc1cnn2c1nc(cc2NCc1cccnc1)c1ccccc1
InChi: 1S/C19H17N5S/c1-25-17-13-22-24-18(21-12-14-6-5-9-20-11-14)10-16(23-19(17)24)15-7-3-2-4-8-15/h2-11,13,21H,12H2,1H3
InChiKey: UZUBZLWMXKGJJE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.0081	0.3894	0.3869
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0026	0.065	0.0902
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0831	0.2134
Echinococcus multilocularis	FTZ F1 alpha	0.0054	0.2337	0.2306
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2337	0.5961
Schistosoma mansoni	hypothetical protein	0.0109	0.5571	0.5553
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.004	0.0103
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0054	0.2337	0.2306
Echinococcus granulosus	ecdysone induced protein 78C	0.0054	0.2337	0.3395
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.3361	0.3335
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Echinococcus granulosus	thyroid hormone receptor alpha	0.0026	0.065	0.0902
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.2621	0.6553
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0054	0.2337	0.3395
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0026	0.065	0.0902
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0054	0.2337	0.6003
Brugia malayi	orphan nuclear receptor NR2E1	0.0026	0.065	0.167
Echinococcus granulosus	NADH dehydrogenase ubiquinone flavoprotein 1	0.0081	0.3894	0.5695
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.2621	0.3815
Schistosoma mansoni	zinc finger protein	0.0026	0.065	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Brugia malayi	hypothetical protein	0.0026	0.065	0.167
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0026	0.065	0.0613
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.2621	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0054	0.2337	0.2306
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0054	0.2337	0.2306
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0054	0.2337	0.6003
Schistosoma mansoni	nuclear receptor	0.0026	0.065	0.0613
Brugia malayi	hypothetical protein	0.0037	0.1334	0.3426
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0054	0.2337	0.3395
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0054	0.2337	0.5961
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2337	0.5961
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0054	0.2337	0.3395
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.2621	0.6553
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1976	0.5024
Schistosoma mansoni	hypothetical protein	0.0033	0.108	0.1044
Brugia malayi	hypothetical protein	0.0029	0.0831	0.2134
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.108	0.2774
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0026	0.065	0.0902
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.2621	0.2592
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0081	0.3894	1
Brugia malayi	Nuclear hormone receptor E75	0.0026	0.065	0.167
Onchocerca volvulus		0.0058	0.2556	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.1334	0.1299
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0058	0.2556	0.2526
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.013	0.6807	0.6794
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)	0.0081	0.3894	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0054	0.2337	0.2306
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2337	0.5961
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0054	0.2337	0.3395
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0054	0.2337	0.6003
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0054	0.2337	0.6003
Brugia malayi	Nuclear hormone receptor E75	0.0026	0.065	0.167
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0026	0.065	0.167
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0026	0.065	0.0613
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0054	0.2337	0.5961
Loa Loa (eye worm)	hypothetical protein	0.0033	0.108	0.2699
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.013	0.6807	1
Brugia malayi	nuclear receptor NHR-67	0.0026	0.065	0.167
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2337	0.5961
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.2556	0.653
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.065	0.0613
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0026	0.065	0.0613
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0026	0.065	0.167
Brugia malayi	nuclear hormone receptor	0.0026	0.065	0.167
Leishmania major	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0081	0.3894	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0054	0.2337	0.2306
Brugia malayi	conserved hypotetical protein	0.0026	0.065	0.167
Brugia malayi	intracellular kinase	0.0058	0.2556	0.6565
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0054	0.2337	0.6003
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2337	0.5961
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.065	0.0613
Brugia malayi	nuclear hormone receptor	0.0054	0.2337	0.6003
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.2621	0.6553
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0831	0.2052
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0831	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0831	0.2052
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0054	0.2337	0.6003
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2337	0.5961
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0054	0.2337	0.2306
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0054	0.2337	0.2306
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0026	0.065	0.0902
Echinococcus multilocularis	nuclear receptor nhr 48	0.0026	0.065	0.0613
Brugia malayi	Steroid receptor seven-up type 2	0.0054	0.2337	0.6003
Brugia malayi	nuclear hormone receptor family member odr-7	0.0026	0.065	0.167
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0054	0.2337	0.2306
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1976	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.2556	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.2621	0.2592
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0831	0.2052
Echinococcus granulosus	nuclear receptor nhr 48	0.0026	0.065	0.0902
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative	0.0081	0.3894	1
Schistosoma mansoni	thyroid hormone receptor	0.0185	1	1
Schistosoma mansoni	hypothetical protein	0.0037	0.1334	0.1299
Echinococcus multilocularis	ecdysone induced protein 78C	0.0054	0.2337	0.2306
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase I subunit F	0.0081	0.3894	0.5
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0058	0.2556	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.2556	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0054	0.2337	0.2306
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0029	0.0831	0.2052
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1976	0.5075
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0029	0.0831	0.0794
Schistosoma mansoni	nuclear hormone receptor	0.0054	0.2337	0.2306
Schistosoma mansoni	thyroid hormone receptor	0.0185	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2337	0.5961
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.2556	0.5
Brugia malayi	steroid hormone receptor	0.0054	0.2337	0.6003
Brugia malayi	tailless protein	0.0026	0.065	0.167
Echinococcus granulosus	FTZ F1 alpha	0.0054	0.2337	0.3395
Schistosoma mansoni	NADH-ubiquinone oxidoreductase	0.0081	0.3894	0.3869
Brugia malayi	NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor	0.0081	0.3894	1
Schistosoma mansoni	nuclear receptor	0.0026	0.065	0.0613
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0081	0.3894	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0054	0.2337	0.6003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0054	0.2337	0.5961
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0026	0.065	0.0613
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0054	0.2337	0.5961
Echinococcus granulosus	protein kinase shaggy	0.0058	0.2556	0.3719
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0029	0.0831	0.1169
Loa Loa (eye worm)	nuclear hormone receptor	0.0026	0.065	0.1583
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0026	0.065	0.1583
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0.0081	0.3894	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0054	0.2337	0.6003
Brugia malayi	hypothetical protein	0.0029	0.0831	0.2134
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0054	0.2337	0.2306
Loa Loa (eye worm)	DR-78	0.0026	0.065	0.1583
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0054	0.2337	0.2306
Entamoeba histolytica	protein kinase, putative	0.0058	0.2556	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0026	0.065	0.0613
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.2621	0.2592
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.2621	0.6553
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0054	0.2337	0.3395
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0058	0.2556	0.3719
Onchocerca volvulus	Bile acid receptor homolog	0.0054	0.2337	0.885
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Mycobacterium ulcerans	NADH dehydrogenase I subunit F	0.0081	0.3894	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0054	0.2337	0.2306
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1976	0.5024
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0054	0.2337	0.6003
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.3361	0.4908
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0054	0.2337	0.6003
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0029	0.0831	0.0794
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.004	0.0103
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.0081	0.3894	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0026	0.065	0.1583
Schistosoma mansoni	hypothetical protein	0.013	0.6807	0.6794
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0058	0.2556	0.2526
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.0081	0.3894	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0054	0.2337	0.885
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0054	0.2337	0.5961
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0054	0.2337	0.6003
Brugia malayi	ecdysteroid receptor	0.0054	0.2337	0.6003
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.2556	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0054	0.2337	0.5961
Onchocerca volvulus	Protein ultraspiracle homolog	0.0054	0.2337	0.885
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0054	0.2337	0.5961
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.2556	0.653
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Loa Loa (eye worm)	hypothetical protein	0.0026	0.065	0.1583
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0029	0.0831	0.0794
Loa Loa (eye worm)	NADH-ubiquinone oxidoreductase 51 kDa subunit	0.0081	0.3894	1
Onchocerca volvulus		0.0054	0.2337	0.885
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.2621	0.0486
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0026	0.065	0.0613
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0026	0.065	0.0613
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.1334	0.1912
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0054	0.2337	0.3395
Brugia malayi	hypothetical protein	0.0026	0.065	0.167
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0054	0.2337	0.6003
Loa Loa (eye worm)	steroid hormone receptor	0.0054	0.2337	0.5961
Brugia malayi	nuclear receptor NHR-88	0.0026	0.065	0.167
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0054	0.2337	0.2306
Onchocerca volvulus	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog	0.0043	0.169	0.5454
Brugia malayi	nuclear receptor RXR	0.0026	0.065	0.167
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0054	0.2337	0.6003
Brugia malayi	nuclear receptor RXR	0.0029	0.0831	0.2134
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0831	0.2052
Brugia malayi	nuclear receptor NHR-88	0.0054	0.2337	0.6003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0054	0.2337	0.3395
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0026	0.065	0.0613
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0054	0.2337	0.6003
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0054	0.2337	0.2306
Schistosoma mansoni	retinoic acid receptor RXR	0.0054	0.2337	0.2306
Treponema pallidum	nitrogen fixation protein (rnfC)	0.0018	0.0203	0.5
Brugia malayi	ecdysone receptor	0.0026	0.065	0.167
Schistosoma mansoni	coup transcription factor	0.0054	0.2337	0.2306
Plasmodium falciparum	glycogen synthase kinase 3	0.0058	0.2556	0.5
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0831	0.2052
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.1334	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0054	0.2337	0.5961
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0054	0.2337	0.6003
Echinococcus multilocularis	protein kinase shaggy	0.0058	0.2556	0.2526

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.007 uM	Inhibition of human CDK2/cyclin A	ChEMBL.	17904841
IC50 (binding)	= 0.9 uM	Inhibition of human MAPK	ChEMBL.	17904841
IC50 (binding)	= 1.8 uM	Inhibition of human GSK3beta	ChEMBL.	17904841
IC50 (binding)	= 1.8 uM	Inhibition of human GSK3beta	ChEMBL.	17904841

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL399287

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 500296