Detailed information for compound 500317

Basic information

Technical information
  • TDR Targets ID: 500317
  • Name: 3-bromo-5-propan-2-yl-N-(pyridin-3-ylmethyl)p yrazolo[1,5-a]pyrimidin-7-amine
  • MW: 346.225 | Formula: C15H16BrN5
  • H donors: 1 H acceptors: 3 LogP: 2.92 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1cc(NCc2cccnc2)n2c(n1)c(Br)cn2)C
  • InChi: 1S/C15H16BrN5/c1-10(2)13-6-14(18-8-11-4-3-5-17-7-11)21-15(20-13)12(16)9-19-21/h3-7,9-10,18H,8H2,1-2H3
  • InChiKey: MMWMWUIAVIIWKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-bromo-5-isopropyl-N-(3-pyridylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine
  • 3-bromo-5-isopropyl-N-(3-pyridylmethyl)-7-pyrazolo[1,5-a]pyrimidinamine
  • (3-bromo-5-isopropyl-pyrazolo[1,5-a]pyrimidin-7-yl)-(3-pyridylmethyl)amine
  • 3-bromo-5-propan-2-yl-N-(pyridin-3-ylmethyl)pyrazolo[5,1-b]pyrimidin-7-amine
  • 3-bromo-5-isopropyl-N-(3-pyridylmethyl)pyrazolo[5,1-b]pyrimidin-7-amine
  • 3-bromo-5-isopropyl-N-(3-pyridylmethyl)-7-pyrazolo[5,1-b]pyrimidinamine
  • (3-bromo-5-isopropyl-pyrazolo[5,1-b]pyrimidin-7-yl)-(3-pyridylmethyl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0072 0.0853 0.1119
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0175 0.0151
Schistosoma mansoni laminin gamma-3 chain 0.0066 0.0772 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0161 0.2053 0.2693
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0041 0.0422 1
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0304 0.1616
Brugia malayi hypothetical protein 0.0085 0.1024 0.1343
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0222 0.0221
Brugia malayi Serotonin receptor 0.0026 0.0222 0.0291
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0354 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0222 0.0221
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0099 0.0098
Loa Loa (eye worm) abnormal epIthelia family member 0.005 0.0544 0.0711
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Schistosoma mansoni tyrosine kinase 0.0079 0.0936 0.092
Loa Loa (eye worm) serotonin transporter b 0.024 0.3117 0.4087
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0099 0.0098
Toxoplasma gondii hypothetical protein 0.0041 0.0422 0.3674
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0304 0.1616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0161 0.2053 0.2691
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0853 0.127
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0224 0.0471
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0757 0.0742
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0853 0.7421
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0222 0.0221
Brugia malayi larval opioid receptor 0.0026 0.0222 0.0291
Brugia malayi intermediate filament protein 0.0053 0.0595 0.0781
Schistosoma mansoni nuclear receptor 0.0076 0.0901 0.0885
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0222 0.0221
Brugia malayi ecdysone receptor 0.0076 0.0901 0.1181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.0083
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0083 0.0604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0304 0.0364
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0109 0.0042
Loa Loa (eye worm) carboxylesterase 0.0022 0.0175 0.0227
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0222 0.0221
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0577 0.0755
Brugia malayi hypothetical protein 0.0136 0.1716 0.225
Echinococcus multilocularis geminin 0.0379 0.5007 0.5006
Plasmodium vivax glutathione reductase, putative 0.0092 0.1121 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0222 0.0221
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0577 0.0755
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.0422 0.0406
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Schistosoma mansoni notch 0.0017 0.0099 0.0083
Onchocerca volvulus 0.0026 0.0222 0.0407
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0161 0.2053 0.2052
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0577 0.0757
Loa Loa (eye worm) hypothetical protein 0.0133 0.1669 0.2186
Schistosoma mansoni notch 0.0017 0.0099 0.0083
Brugia malayi Cytochrome P450 family protein 0.0055 0.0621 0.0815
Echinococcus multilocularis serotonin transporter 0.024 0.3117 0.3116
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0222 0.0291
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0126 0.1574 0.2062
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0222 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0109 0.0042
Schistosoma mansoni kinase 0.0053 0.059 0.0574
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0436 0.5781 0.758
Entamoeba histolytica hypothetical protein 0.0036 0.0354 0.2432
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0304 0.1616
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0189 0.0248
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0221 0.0287
Schistosoma mansoni amine GPCR 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Mycobacterium tuberculosis Conserved protein 0.0072 0.0853 0.127
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1271 0.3481
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.0901 0.0899
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Brugia malayi Thioredoxin reductase 0.0092 0.1121 0.1469
Onchocerca volvulus 0.0026 0.0222 0.0407
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0076 0.0901 0.0899
Brugia malayi Peroxidasin 0.0052 0.0577 0.0757
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0161 0.2053 0.2693
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0356
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.1024 0.1343
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0304 0.1616
Echinococcus granulosus FTZ F1 alpha 0.0161 0.2053 0.2052
Plasmodium falciparum glutathione reductase 0.0032 0.0304 0.2604
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0175 0.0173
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0222 0.0407
Loa Loa (eye worm) hypothetical protein 0.0085 0.1024 0.1341
Schistosoma mansoni lipoxygenase 0.0121 0.1508 0.1493
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0161 0.2053 0.2052
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0083 0.0158
Onchocerca volvulus 0.0076 0.0901 0.2655
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0161 0.2053 0.2693
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0422 0.0406
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Echinococcus multilocularis microtubule associated protein 2 0.0748 1 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0017 0.0015
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.0422 0.0552
Brugia malayi Death domain containing protein 0.003 0.0273 0.0358
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0577 0.0757
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0222 0.0221
Onchocerca volvulus 0.0022 0.0175 0.0251
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0665 0.5611
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0161 0.2053 0.2693
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0304 0.1616
Schistosoma mansoni tyrosine kinase 0.0079 0.0947 0.0932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0621 0.0813
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0853 0.0838
Schistosoma mansoni cpg binding protein 0.0033 0.0317 0.0301
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0757 0.5759
Echinococcus granulosus sex peptide receptor 0.0026 0.0222 0.0221
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0109 0.0042
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0552
Brugia malayi ecdysteroid receptor 0.0161 0.2053 0.2693
Schistosoma mansoni DNA polymerase eta 0.0021 0.0155 0.0138
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0595 0.0779
Brugia malayi beta-lactamase 0.0072 0.0853 0.1119
Loa Loa (eye worm) hypothetical protein 0.0161 0.2053 0.2691
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0552
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0155 0.0784
Leishmania major trypanothione reductase 0.0092 0.1121 0.7006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Entamoeba histolytica hypothetical protein 0.0036 0.0354 0.2432
Brugia malayi Melatonin receptor type 1A 0.0026 0.0222 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0109 0.0042
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.005 0.0544 0.0713
Treponema pallidum sodium- and chloride- dependent transporter 0.024 0.3117 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1271 0.1257
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0511 0.0509
Echinococcus multilocularis neurogenic locus notch protein 0.005 0.0544 0.0542
Schistosoma mansoni hypothetical protein 0.0258 0.3361 0.335
Brugia malayi GnHR receptor homolog 0.0026 0.0222 0.0291
Onchocerca volvulus Protein ultraspiracle homolog 0.0161 0.2053 0.6475
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0668 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0161 0.2053 0.2693
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0109 0.0042
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0155 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Onchocerca volvulus 0.0026 0.0222 0.0407
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0222 0.0221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0765 0.075
Loa Loa (eye worm) hypothetical protein 0.0161 0.2053 0.2691
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0161 0.2053 0.2691
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Leishmania major hypothetical protein, conserved 0.0072 0.0853 0.524
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Brugia malayi Nuclear hormone receptor E75 0.0076 0.0901 0.1181
Echinococcus granulosus cpg binding protein 0.0033 0.0317 0.0315
Schistosoma mansoni microtubule-associated protein tau 0.0748 1 1
Brugia malayi glutathione reductase 0.0092 0.1121 0.1469
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0595 0.0781
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0304 0.2604
Schistosoma mansoni hypothetical protein 0.0018 0.0109 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0222 0.0221
Brugia malayi hypothetical protein 0.0076 0.0901 0.1181
Loa Loa (eye worm) hypothetical protein 0.0072 0.0853 0.1117
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0853 0.2279
Schistosoma mansoni hypothetical protein 0.0026 0.0222 0.0206
Schistosoma mansoni tyrosine kinase 0.0148 0.1873 0.186
Mycobacterium tuberculosis Conserved protein 0.0072 0.0853 0.127
Schistosoma mansoni opsin-like receptor 0.0026 0.0222 0.0206
Echinococcus granulosus g protein coupled receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis thyroid hormone receptor alpha 0.0419 0.5544 0.5543
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1271 0.3481
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0161 0.2053 0.2693
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0463 0.6144 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0222 0.0289
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.1271 0.3884
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.2721 0.4352
Echinococcus multilocularis carboxylesterase 5A 0.0133 0.1669 0.1667
Schistosoma mansoni tyrosine kinase 0.0047 0.0511 0.0495
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0083 0.0158
Loa Loa (eye worm) hypothetical protein 0.0131 0.1645 0.2155
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0222 0.0221
Brugia malayi photoreceptor-specific nuclear receptor 0.0161 0.2053 0.2693
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0436 0.5781 0.758
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0227
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0126 0.1574 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0161 0.2053 0.204
Echinococcus granulosus neuroligin 0.0022 0.0175 0.0173
Echinococcus granulosus peroxidasin 0.0052 0.0577 0.0576
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0161 0.2053 0.2052
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0222 0.0206
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0173 0.222 0.2219
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0085 0.1024 0.1341
Echinococcus multilocularis lamin dm0 0.0053 0.0595 0.0594
Brugia malayi Uncoordinated protein 44 0.003 0.0273 0.0358
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.1574 0.1572
Plasmodium falciparum amino acid transporter, putative 0.0041 0.0422 0.3674
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0041 0.0422 0.0554
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.1574 0.1572
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.1271 0.1667
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0853 0.127
Schistosoma mansoni notch 0.0017 0.0099 0.0083
Loa Loa (eye worm) hypothetical protein 0.0053 0.0595 0.0779
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0085 0.1024 0.1009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Brugia malayi nuclear receptor NHR-67 0.0076 0.0901 0.1181
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0259 0.034
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0853 0.2279
Brugia malayi Steroid receptor seven-up type 2 0.0161 0.2053 0.2693
Echinococcus granulosus thyroid hormone receptor alpha 0.0076 0.0901 0.0899
Echinococcus multilocularis somatostatin receptor 0.0026 0.0222 0.0221
Brugia malayi steroid hormone receptor 0.0161 0.2053 0.2693
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Echinococcus multilocularis fibropellin Ia 0.0017 0.0099 0.0098
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0175 0.0159
Loa Loa (eye worm) nuclear receptor NHR-67 0.0076 0.0901 0.1179
Mycobacterium tuberculosis Probable oxidoreductase 0.0234 0.3039 0.4877
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0222 0.0289
Echinococcus granulosus muscleblind protein 0.0162 0.2064 0.2062
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.0422 0.0421
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0076 0.0901 0.0899
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0304 0.0288
Mycobacterium ulcerans beta-lactamase 0.0072 0.0853 0.2168
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.067 0.5917
Brugia malayi EGF-like domain containing protein 0.0017 0.0099 0.013
Leishmania major cytochrome p450-like protein 0.0026 0.0226 0.1102
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0083 0.0082
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0083 0.0158
Loa Loa (eye worm) hypothetical protein 0.0021 0.0155 0.02
Loa Loa (eye worm) hypothetical protein 0.0072 0.0853 0.1117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0901 0.0899
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0853 0.2168
Plasmodium vivax amine transporter, putative 0.0041 0.0422 0.3268
Schistosoma mansoni notch 0.0017 0.0099 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0668 0.5022
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0222 0.0206
Brugia malayi nuclear receptor NHR-88 0.0161 0.2053 0.2693
Echinococcus granulosus carboxylesterase 5A 0.0133 0.1669 0.1667
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0083 0.0082
Echinococcus granulosus dna polymerase kappa 0.0021 0.0155 0.0153
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0222 0.0221
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0226 0.1102
Loa Loa (eye worm) glutathione reductase 0.0092 0.1121 0.1468
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0226 0.2937 0.2936
Onchocerca volvulus 0.0076 0.0901 0.2655
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Brugia malayi EGF-like domain containing protein 0.0017 0.0099 0.013
Brugia malayi G-protein coupled receptor 0.0026 0.0222 0.0291
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0222 0.0291
Giardia lamblia DINP protein human, muc B family 0.0021 0.0155 0.1098
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Schistosoma mansoni hypothetical protein 0.0059 0.0665 0.065
Onchocerca volvulus 0.0052 0.0577 0.1583
Schistosoma mansoni notch 0.0017 0.0099 0.0083
Schistosoma mansoni hypothetical protein 0.0379 0.5007 0.4999
Brugia malayi putative neuropeptide receptor 0.0026 0.0222 0.0291
Brugia malayi ORL1-like opioid receptor 0.0026 0.0222 0.0291
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0152 0.1931 0.193
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0155 0.0203
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0083 0.0082
Onchocerca volvulus 0.0022 0.0175 0.0251
Schistosoma mansoni cell polarity protein 0.0017 0.0099 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0161 0.2053 0.2691
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0083 0.0604
Onchocerca volvulus Peroxidase homolog 0.0052 0.0577 0.1583
Echinococcus granulosus slit 2 protein 0.0066 0.0772 0.077
Schistosoma mansoni biogenic amine receptor 0.0026 0.0222 0.0206
Schistosoma mansoni hypothetical protein 0.0026 0.0222 0.0206
Schistosoma mansoni cpg binding protein 0.0031 0.0293 0.0277
Loa Loa (eye worm) hypothetical protein 0.0059 0.0665 0.0871
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Brugia malayi hypothetical protein 0.0085 0.1024 0.1343
Entamoeba histolytica hypothetical protein 0.0036 0.0354 0.2432
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1271 0.3481
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0041 0.0422 0.0421
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0222 0.0221
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0222 0.0291
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0304 0.1616
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0222 0.0221
Brugia malayi EGF-like domain containing protein 0.0066 0.0772 0.1012
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0155 0.0627
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0222 0.0221
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0853 0.2279
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0161 0.2053 0.2052
Schistosoma mansoni adenoreceptor 0.0026 0.0222 0.0206
Brugia malayi Cadherin domain containing protein 0.0017 0.0099 0.013
Echinococcus granulosus nuclear factor of activated T cells 5 0.0152 0.1931 0.193
Echinococcus multilocularis netrin receptor unc 5 0.003 0.0273 0.0272
Loa Loa (eye worm) hypothetical protein 0.0072 0.0853 0.1117
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0668 0.4019
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0668 0.5022
Brugia malayi nuclear hormone receptor family member odr-7 0.0076 0.0901 0.1181
Brugia malayi Dopamine receptor protein 1 0.0026 0.0222 0.0291
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0222 0.0221
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0222 0.0221
Brugia malayi hypothetical protein 0.0036 0.0354 0.0465
Loa Loa (eye worm) hypothetical protein 0.0072 0.0853 0.1117
Brugia malayi EGF-like domain containing protein 0.0017 0.0099 0.013
Echinococcus multilocularis acetylcholinesterase 0.0133 0.1669 0.1667
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0277 0.0261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Schistosoma mansoni hypothetical protein 0.0026 0.0222 0.0206
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0304 0.0303
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0304 0.2291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0161 0.2053 0.2691
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0099 0.0098
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0226 0.2937 0.2936
Loa Loa (eye worm) hypothetical protein 0.0161 0.2053 0.2691
Brugia malayi Carboxylesterase family protein 0.0022 0.0175 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0668 0.5902
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0304 0.1616
Mycobacterium tuberculosis Probable reductase 0.021 0.2721 0.4352
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0109 0.0326
Echinococcus granulosus fibropellin Ia 0.0017 0.0099 0.0098
Echinococcus granulosus ecdysone induced protein 78C 0.0161 0.2053 0.2052
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.1271 0.127
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0222 0.0291
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.1271 0.1666
Loa Loa (eye worm) carboxylesterase 0.0022 0.0175 0.0227
Schistosoma mansoni netrin receptor unc5 0.003 0.0273 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.024 0.3117 0.3106
Echinococcus multilocularis protein jagged 2 0.0017 0.0099 0.0098
Echinococcus granulosus mitogen activated protein kinase 11 0.0126 0.1574 0.1572
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0577 0.1583
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0149 0.0133
Echinococcus granulosus jun protein 0.0173 0.222 0.2219
Onchocerca volvulus 0.0026 0.0222 0.0407
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0083 0.0067
Onchocerca volvulus 0.0026 0.0222 0.0407
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0161 0.2053 0.2052
Echinococcus multilocularis acetylcholinesterase 0.0133 0.1669 0.1667
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.1121 0.1711
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0041 0.0422 0.0406
Schistosoma mansoni amine GPCR 0.0026 0.0222 0.0206
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0222 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0853 0.524
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0222 0.0221
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0304 0.2604
Echinococcus multilocularis nuclear receptor nhr 48 0.0076 0.0901 0.0899
Echinococcus multilocularis cpg binding protein 0.0033 0.0317 0.0315
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0099 0.0098
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0155 0.0627
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0161 0.2053 0.204
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0109 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0109 0.0042
Brugia malayi intracellular kinase 0.0059 0.0668 0.0876
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0017 0.00000000060012
Brugia malayi tailless protein 0.0076 0.0901 0.1181
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.0947 0.0945
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.0083
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0222 0.0221
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0226 0.0295
Schistosoma mansoni hypothetical protein 0.0141 0.178 0.1766
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0161 0.2053 0.204
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0757 0.4609
Echinococcus granulosus acetylcholinesterase 0.0133 0.1669 0.1667
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0853 0.127
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0422 0.0406
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Schistosoma mansoni nuclear receptor 0.0076 0.0901 0.0885
Brugia malayi Doublecortin family protein 0.0059 0.0665 0.0873
Onchocerca volvulus 0.0031 0.0293 0.0641
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0304 0.1616
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0222 0.0289
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0665 0.0664
Brugia malayi neuropeptide F receptor 0.0026 0.0222 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0853 0.1117
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0041 0.0422 0.0421
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus multilocularis pikachurin 0.005 0.0544 0.0542
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0174 0.2224 0.2223
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0577 0.0757
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0577 0.0757
Brugia malayi hypothetical protein 0.0022 0.0175 0.0229
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0222 0.0221
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0222 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0109 0.0042
Schistosoma mansoni septate junction protein 0.0017 0.0099 0.0083
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0099 0.000000077249
Echinococcus granulosus g protein coupled receptor 0.0026 0.0222 0.0221
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0083 0.0158
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0109 0.0042
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0304 0.2604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Echinococcus multilocularis epidermal growth factor receptor 0.0148 0.1873 0.1872
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Echinococcus granulosus nuclear receptor nhr 48 0.0076 0.0901 0.0899
Loa Loa (eye worm) hypothetical protein 0.0133 0.1669 0.2186
Brugia malayi nuclear receptor RXR 0.0085 0.1024 0.1343
Entamoeba histolytica protein kinase, putative 0.0059 0.0668 0.5022
Mycobacterium ulcerans glutaminase 0.0271 0.3541 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0422 0.3674
Loa Loa (eye worm) hypothetical protein 0.024 0.3117 0.4087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0224 0.0293
Mycobacterium ulcerans lipase LipD 0.0072 0.0853 0.2168
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0853 0.127
Schistosoma mansoni thyroid hormone receptor 0.0419 0.5544 0.5536
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0222 0.0291
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0017 0.0022
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0422 0.0406
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0853 0.2279
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0155 0.0117
Echinococcus multilocularis peroxidasin 0.0052 0.0577 0.0576
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0222 0.0221
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0222 0.0206
Brugia malayi Muscleblind-like protein 0.0162 0.2064 0.2706
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0222 0.0289
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0041 0.0422 0.0421
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0853 0.254
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.0901 0.0899
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Echinococcus granulosus fmrfamide receptor 0.0026 0.0222 0.0221
Schistosoma mansoni opsin-like receptor 0.0026 0.0222 0.0206
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0304 0.1616
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0161 0.2053 0.2052
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0665 0.0664
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0155 0.0153
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0226 0.1102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Schistosoma mansoni glutaminase 0.0271 0.3541 0.353
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Brugia malayi glutaminase DH11.1 0.0271 0.3541 0.4644
Echinococcus granulosus protein jagged 2 0.0017 0.0099 0.0098
Schistosoma mansoni sodium/chloride dependent transporter 0.0042 0.0441 0.0425
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0304 0.0569
Loa Loa (eye worm) beta-lactamase 0.0072 0.0853 0.1117
Brugia malayi Cadherin domain containing protein 0.0017 0.0099 0.013
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0668 0.0667
Schistosoma mansoni tyrosine kinase 0.0079 0.0936 0.092
Echinococcus granulosus somatostatin receptor 0.0026 0.0222 0.0221
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0155 0.0627
Echinococcus granulosus protein jagged 1 0.0017 0.0099 0.0098
Schistosoma mansoni tyrosine kinase 0.0079 0.0947 0.0932
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0175 0.0159
Brugia malayi Blistered cuticle protein 3 0.0052 0.0577 0.0757
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0224 0.0471
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0222 0.0221
Echinococcus multilocularis RUN 0.0059 0.0665 0.0664
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0099 0.0098
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.1128 0.1126
Brugia malayi CXXC zinc finger family protein 0.0031 0.0293 0.0384
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Echinococcus granulosus orexin receptor type 2 0.0026 0.0222 0.0221
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0099 0.013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0227
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0577 0.1583
Echinococcus granulosus Ankyrin 0.003 0.0277 0.0275
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0099 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0571 0.147
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0109 0.0042
Echinococcus multilocularis slit 2 protein 0.0066 0.0772 0.077
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0175 0.0173
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0258 0.3361 0.336
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0161 0.2053 0.2052
Brugia malayi AKH receptor 0.0026 0.0222 0.0291
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0304 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0161 0.2053 0.2052
Echinococcus granulosus serotonin transporter 0.024 0.3117 0.3116
Loa Loa (eye worm) hypothetical protein 0.0161 0.2053 0.2691
Brugia malayi conserved hypotetical protein 0.0076 0.0901 0.1181
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0076 0.0901 0.1179
Onchocerca volvulus 0.0052 0.0577 0.1583
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0577 0.0755
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1271 0.8003
Echinococcus multilocularis muscleblind protein 0.0162 0.2064 0.2062
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0668 0.0653
Echinococcus multilocularis FTZ F1 alpha 0.0161 0.2053 0.2052
Schistosoma mansoni gliotactin 0.0022 0.0175 0.0159
Brugia malayi isocitrate dehydrogenase 0.0016 0.0083 0.0109
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.0273 0.0272
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0422 0.0406
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0293 0.0382
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0109 0.0042
Brugia malayi G-protein coupled receptor 0.0026 0.0222 0.0291
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0017 0.0022
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0668 0.0874
Brugia malayi Sodium:neurotransmitter symporter family protein 0.024 0.3117 0.4088
Schistosoma mansoni amine GPCR 0.0026 0.0222 0.0206
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.0901 0.2655
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0222 0.0206
Onchocerca volvulus 0.0052 0.0577 0.1583
Echinococcus multilocularis neuroligin 0.0022 0.0175 0.0173
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.1574 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0544 0.0711
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0222 0.0289
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.0901 0.0899
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0222 0.0221
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.005 0.0544 0.0528
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.1574 0.1572
Onchocerca volvulus 0.0026 0.0222 0.0407
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Brugia malayi neuropeptide F receptor 0.0026 0.0222 0.0291
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0853 0.127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0161 0.2053 0.2052
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0901 0.0885
Echinococcus granulosus hypothetical protein 0.0026 0.0222 0.0221
Echinococcus multilocularis insulin receptor 0.0047 0.0511 0.0509
Schistosoma mansoni loxhd1 0.0059 0.0665 0.065
Loa Loa (eye worm) hypothetical protein 0.024 0.3117 0.4087
Onchocerca volvulus 0.0072 0.0853 0.2498
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0109 0.0042
Echinococcus multilocularis 0.0046 0.0491 0.0489
Loa Loa (eye worm) hypothetical protein 0.005 0.0544 0.0711
Trichomonas vaginalis glutaminase, putative 0.0271 0.3541 1
Echinococcus granulosus insulin receptor 0.0047 0.0511 0.0509
Loa Loa (eye worm) hypothetical protein 0.0059 0.0665 0.0871
Onchocerca volvulus 0.0041 0.0422 0.107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0304 0.1616
Echinococcus granulosus mitogen activated protein kinase 14 0.0126 0.1574 0.1572
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0041 0.0422 0.0421
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0222 0.0221
Onchocerca volvulus 0.0136 0.1716 0.5355
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Brugia malayi G protein-coupled receptor 0.0026 0.0222 0.0291
Echinococcus multilocularis Ankyrin 0.003 0.0277 0.0275
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.2721 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0668 0.4019
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0304 0.2129
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0222 0.0221
Onchocerca volvulus 0.0026 0.0222 0.0407
Schistosoma mansoni neuropeptide receptor 0.0026 0.0222 0.0206
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0041 0.0422 0.0552
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0757 0.0991
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0222 0.0206
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0173 0.222 0.2219
Echinococcus multilocularis protein jagged 1 0.0017 0.0099 0.0098
Echinococcus multilocularis musashi 0.0053 0.0595 0.0594
Schistosoma mansoni neuropeptide receptor 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Echinococcus multilocularis dnaJ subfamily B 0.0443 0.5875 0.5874
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis protein jagged 1 0.0017 0.0099 0.0098
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0901 0.0885
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0155 0.0153
Brugia malayi laminin-like protein K08C7.3 precursor 0.005 0.0544 0.0713
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0757 0.0756
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0109 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0161 0.2053 0.2693
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0041 0.0422 0.0406
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0076 0.0901 0.1181
Echinococcus granulosus protein kinase shaggy 0.0059 0.0668 0.0667
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0577 0.1583
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0175 0.0151
Echinococcus multilocularis jun protein 0.0173 0.222 0.2219
Echinococcus granulosus sodium and chloride dependent glycine 0.0041 0.0422 0.0421
Plasmodium falciparum glutathione reductase 0.0092 0.1121 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0161 0.2053 0.2691
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0083 0.0158
Brugia malayi Carboxylesterase family protein 0.0133 0.1669 0.2188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Loa Loa (eye worm) hypothetical protein 0.0072 0.0853 0.1117
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0361
Toxoplasma gondii hypothetical protein 0.0041 0.0422 0.3674
Onchocerca volvulus 0.0026 0.0222 0.0407
Plasmodium falciparum thioredoxin reductase 0.0032 0.0304 0.2604
Onchocerca volvulus 0.0026 0.0222 0.0407
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.1271 0.127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0853 0.0838
Brugia malayi hypothetical protein 0.0059 0.0665 0.0873
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0757 0.0993
Loa Loa (eye worm) hypothetical protein 0.024 0.3117 0.4087
Schistosoma mansoni amine GPCR 0.0026 0.0222 0.0206
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0668 0.1748
Schistosoma mansoni neuropeptide receptor 0.0026 0.0222 0.0206
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0109 0.0042
Echinococcus granulosus serotonin receptor 0.0026 0.0222 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0161 0.2053 0.2693
Schistosoma mansoni cytochrome P450 0.0018 0.0109 0.0092
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0853 0.2168
Schistosoma mansoni neuropeptide receptor 0.0026 0.0222 0.0206
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0304 0.1616
Trypanosoma brucei protein kinase, putative 0.0059 0.0668 0.4019
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0552
Schistosoma mansoni zinc finger protein 0.0076 0.0901 0.0885
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0175 0.0159
Echinococcus granulosus dna polymerase eta 0.0021 0.0155 0.0153
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0222 0.0291
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0354 0.0338
Schistosoma mansoni thyroid hormone receptor 0.0419 0.5544 0.5536
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0109 0.0042
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0757 0.4609
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0109 0.0042
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0273 0.0358
Brugia malayi orphan nuclear receptor NR2E1 0.0076 0.0901 0.1181
Onchocerca volvulus Netrin receptor homolog 0.003 0.0273 0.0577
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0175 0.0332
Brugia malayi Carboxylesterase family protein 0.0022 0.0175 0.0229
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0099 0.0098
Echinococcus multilocularis muscleblind protein 1 0.0162 0.2064 0.2062
Brugia malayi Carboxylesterase family protein 0.0022 0.0175 0.0229
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0304 0.1616
Onchocerca volvulus 0.0022 0.0175 0.0251
Schistosoma mansoni hypothetical protein 0.0379 0.5007 0.4999
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0155 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0162 0.2064 0.2705
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0668 0.5902
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0017 0.0015
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0668 0.5192
Schistosoma mansoni histamine h1 receptor 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0175 0.0151
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0222 0.0221
Echinococcus granulosus neuropeptide receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Loa Loa (eye worm) hypothetical protein 0.0161 0.2053 0.2691
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0222 0.0206
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0161 0.2053 0.2691
Trypanosoma brucei unspecified product 0.0021 0.0155 0.0627
Brugia malayi EGF-like domain containing protein 0.0017 0.0099 0.013
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.0083
Brugia malayi Dopamine receptor protein 2 0.0026 0.0222 0.0291
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.2721 0.4352
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.0422 0.0421
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0107 0.0815
Schistosoma mansoni nuclear hormone receptor 0.0161 0.2053 0.204
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.1121 1
Schistosoma mansoni tyrosine kinase 0.0047 0.0511 0.0495
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0175 0.0159
Onchocerca volvulus Peroxidase homolog 0.0052 0.0577 0.1583
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0083 0.0082
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0668 0.5639
Onchocerca volvulus 0.0059 0.0665 0.1876
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.0422 0.0421
Echinococcus granulosus protein jagged 2 0.0017 0.0099 0.0098
Schistosoma mansoni peroxidasin 0.0052 0.0577 0.0561
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0222 0.0221
Echinococcus granulosus geminin 0.0379 0.5007 0.5006
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0222 0.0291
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0757 0.0756
Schistosoma mansoni lipoxygenase 0.0226 0.2937 0.2925
Loa Loa (eye worm) hypothetical protein 0.0162 0.2064 0.2705
Echinococcus granulosus RUN 0.0059 0.0665 0.0664
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Brugia malayi Dopamine receptor 0.0026 0.0222 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Schistosoma mansoni lamin 0.0053 0.0595 0.058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0552
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0222 0.0206
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0304 0.0569
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis serotonin receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0668 0.0667
Echinococcus granulosus bloom syndrome protein 0.0026 0.0224 0.0222
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0304 0.1616
Loa Loa (eye worm) notch protein 0.0017 0.0099 0.0128
Loa Loa (eye worm) glutaminase 2 0.0271 0.3541 0.4643
Schistosoma mansoni amine GPCR 0.0026 0.0222 0.0206
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) steroid hormone receptor 0.0161 0.2053 0.2691
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0222 0.0221
Trypanosoma brucei unspecified product 0.0014 0.0067 0.0047
Trypanosoma brucei polo-like protein kinase 0.0103 0.1271 0.8003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0207 0.027
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0085 0.1024 0.1023
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0665 0.0871
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0901 0.0899
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0017 0.0015
Schistosoma mansoni polycystin 1-related 0.0059 0.0665 0.065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0161 0.2053 0.2691
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0304 0.0703
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Brugia malayi nuclear hormone receptor family member nhr-6 0.0076 0.0901 0.1181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Schistosoma mansoni sodium/chloride dependent transporter 0.024 0.3117 0.3106
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0577 0.0755
Echinococcus granulosus pikachurin 0.005 0.0544 0.0542
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0222 0.0289
Mycobacterium ulcerans hypothetical protein 0.0072 0.0853 0.2168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0161 0.2053 0.2691
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0222 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1271 0.3481
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0853 0.127
Brugia malayi hypothetical protein 0.0076 0.0901 0.1181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0221 0.0219
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0422 0.0554
Loa Loa (eye worm) glutaminase 0.0271 0.3541 0.4643
Schistosoma mansoni myosin xvIII 0.0026 0.0222 0.0206
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0577 0.0755
Brugia malayi sulfakinin receptor protein 0.0026 0.0222 0.0291
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0222 0.0221
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0099 0.0748
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0109 0.0042
Brugia malayi RE15519p 0.0026 0.0222 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0222 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0175 0.0173
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0161 0.2053 0.2693
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0161 0.2053 0.2693
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0354 0.0353
Echinococcus multilocularis sex peptide receptor 0.0026 0.0222 0.0221
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0273 0.0356
Onchocerca volvulus 0.0059 0.0668 0.1885
Schistosoma mansoni RAR-like nuclear receptor 0.0161 0.2053 0.204
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0511 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0853 0.0852
Brugia malayi small heat shock protein 0.0572 0.7626 1
Brugia malayi Delta serrate ligand family protein 0.0017 0.0099 0.013
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0041 0.0422 0.0421
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0155 0.02
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0665 0.0664
Brugia malayi hypothetical protein 0.0052 0.0577 0.0757
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0227
Echinococcus multilocularis neural cadherin 0.0017 0.0099 0.0098
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0222 0.0206
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0221 0.0219
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0161 0.2053 0.204
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0665 0.0664
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0067 0.0047
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus granulosus death domain containing protein 0.003 0.0273 0.0272
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0161 0.2053 0.2052
Schistosoma mansoni intermediate filament proteins 0.0053 0.0595 0.058
Onchocerca volvulus 0.0022 0.0175 0.0251
Loa Loa (eye worm) hypothetical protein 0.0169 0.2156 0.2825
Onchocerca volvulus 0.0026 0.0222 0.0407
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.0083
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Entamoeba histolytica hypothetical protein 0.0036 0.0354 0.2432
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0109 0.0042
Onchocerca volvulus 0.0026 0.0222 0.0407
Brugia malayi Nuclear hormone receptor-like 1 0.0161 0.2053 0.2693
Trypanosoma brucei trypanothione reductase 0.0092 0.1121 0.7006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0422 0.3674
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0161 0.2053 0.204
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0853 0.524
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0041 0.0422 0.0406
Loa Loa (eye worm) hypothetical protein 0.0085 0.1024 0.1341
Echinococcus granulosus intermediate filament protein 0.0053 0.0595 0.0594
Echinococcus granulosus allatostatin A receptor 0.0026 0.0222 0.0221
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Brugia malayi Carboxylesterase family protein 0.0133 0.1669 0.2188
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0126 0.1574 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0067 0.0047
Schistosoma mansoni hypothetical protein 0.0443 0.5875 0.5868
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Loa Loa (eye worm) cytochrome P450 0.0018 0.0109 0.0141
Echinococcus multilocularis serotonin receptor 0.0026 0.0222 0.0221
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0155 0.0203
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.1024 0.1343
Schistosoma mansoni steroid hormone receptor ad4bp 0.0161 0.2053 0.204
Echinococcus granulosus lamin 0.0053 0.0595 0.0594
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0175 0.0332
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0511 0.0668
Schistosoma mansoni coup transcription factor 0.0161 0.2053 0.204
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0085 0.1024 0.1341
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0227
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0304 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.0901 0.0899
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0234 0.3039 0.4877
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.1121 0.1468
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0155 0.0627
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0259 0.3377 0.3376
Echinococcus granulosus notch 0.0017 0.0099 0.0098
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0226 0.0295
Brugia malayi Cytochrome P450 family protein 0.0026 0.0226 0.0297
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0181 0.1487
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0161 0.2053 0.2693
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0161 0.2053 0.2693
Onchocerca volvulus 0.0072 0.0853 0.2498
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0155 0.0138
Loa Loa (eye worm) acetylcholinesterase 1 0.0133 0.1669 0.2186
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0222 0.0221
Brugia malayi nuclear receptor NHR-88 0.0076 0.0901 0.1181
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0853 0.127
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0222 0.0291
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0161 0.2053 0.6475
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0083 0.0109
Brugia malayi EGF-like domain containing protein 0.0017 0.0099 0.013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0227
Brugia malayi Cytochrome P450 family protein 0.0018 0.0109 0.0143
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0304 0.2129
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0155 0.0133
Loa Loa (eye worm) nuclear hormone receptor 0.0076 0.0901 0.1179
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0099 0.013
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0222 0.0221
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.0947 0.0945
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.0947 0.0945
Schistosoma mansoni hypothetical protein 0.003 0.0273 0.0257
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0595 0.0779
Echinococcus granulosus acetylcholinesterase 0.0133 0.1669 0.1667
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0384 0.0383
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0085 0.1024 0.1023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0207 0.027
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0222 0.0206
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0222 0.0221
Plasmodium falciparum thioredoxin reductase 0.0092 0.1121 1
Schistosoma mansoni retinoic acid receptor RXR 0.0259 0.3377 0.3366
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0571 0.147
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0665 0.5876
Schistosoma mansoni cpg binding protein 0.0033 0.0317 0.0301
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Loa Loa (eye worm) hypothetical protein 0.0066 0.0772 0.101
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0099 0.013
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0222 0.0206
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0304 0.0569
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0422 0.0554
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Loa Loa (eye worm) RecQ helicase 0.0026 0.0224 0.0291
Brugia malayi Serotonin receptor 0.0482 0.6398 0.8391
Onchocerca volvulus 0.024 0.3117 1
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0226 0.1102
Schistosoma mansoni notch 0.0017 0.0103 0.0086
Mycobacterium leprae Probable lipase LipE 0.0072 0.0853 0.254
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0304 0.2604
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0668 0.1748
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0085 0.1024 0.1341
Brugia malayi hypothetical protein 0.0059 0.0665 0.0873
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.2721 0.4352
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0083 0.0604
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0222 0.0291
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0304 0.1616
Schistosoma mansoni biogenic amine receptor 0.0026 0.0222 0.0206
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0384 0.0383
Loa Loa (eye worm) DR-78 0.0076 0.0901 0.1179
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.0273 0.0272
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0109 0.0834
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0109 0.0042
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0234 0.3039 0.4877
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0109 0.0326
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0224 0.0222
Brugia malayi nuclear hormone receptor 0.0161 0.2053 0.2693
Schistosoma mansoni tyrosine kinase 0.0079 0.0936 0.092
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0234 0.3039 1
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0226 0.0295
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0222 0.0407
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0853 0.0852
Giardia lamblia Kinase, PLK 0.0103 0.1271 1
Giardia lamblia High cysteine protein 0.0017 0.0099 0.0658
Onchocerca volvulus 0.0053 0.0595 0.1644
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Brugia malayi Cytochrome P450 family protein 0.0026 0.0226 0.0297
Echinococcus granulosus dnaJ subfamily B 0.0443 0.5875 0.5874
Onchocerca volvulus 0.0041 0.0422 0.107
Loa Loa (eye worm) carboxylesterase 0.0133 0.1669 0.2186
Trichomonas vaginalis esterase, putative 0.0072 0.0853 0.2279
Schistosoma mansoni cell polarity protein 0.005 0.0544 0.0528
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0155 0.0627
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0109 0.0326
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0577 0.0757
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0222 0.0221
Brugia malayi notch-like transmembrane receptor 0.0017 0.0099 0.013
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0222 0.0221
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0175 0.0173
Brugia malayi Furin-like cysteine rich region family protein 0.0148 0.1873 0.2457
Echinococcus granulosus protein jagged 1 0.0017 0.0099 0.0098
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0161 0.2053 0.2052
Brugia malayi Muscle positioning protein 4 0.0017 0.0099 0.013
Echinococcus granulosus neural cadherin 0.0017 0.0099 0.0098
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0041 0.0422 0.0421
Leishmania major DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0175 0.0173
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0109 0.0326
Brugia malayi bZIP transcription factor family protein 0.0173 0.222 0.2911
Loa Loa (eye worm) hypothetical protein 0.0085 0.1024 0.1341
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0222 0.0221
Onchocerca volvulus 0.0026 0.0222 0.0407
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0304 0.0399
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0222 0.0289
Brugia malayi laminin alpha chain 0.005 0.0544 0.0713
Schistosoma mansoni rab6-interacting 0.0059 0.0665 0.065
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0155 0.0627
Echinococcus multilocularis notch 0.0017 0.0099 0.0098
Brugia malayi nuclear receptor RXR 0.0076 0.0901 0.1181
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0222 0.0221
Toxoplasma gondii ABC1 family protein 0.0072 0.0853 0.7577
Schistosoma mansoni lamin 0.0053 0.0595 0.058
Onchocerca volvulus 0.0022 0.0175 0.0251
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1271 0.3481
Toxoplasma gondii thioredoxin reductase 0.0092 0.1121 1
Plasmodium falciparum transporter, putative 0.0041 0.0422 0.3674
Echinococcus multilocularis dna polymerase eta 0.0021 0.0155 0.0153
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0226 0.0343
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Mycobacterium tuberculosis Conserved protein 0.0072 0.0853 0.127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0222 0.0221
Schistosoma mansoni slit 0.0066 0.0772 0.0756
Brugia malayi Nuclear hormone receptor E75 0.0076 0.0901 0.1181
Schistosoma mansoni hypothetical protein 0.0051 0.0566 0.055
Schistosoma mansoni hypothetical protein 0.0026 0.0222 0.0206
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0304 0.0703
Echinococcus granulosus neuropeptide receptor 0.0026 0.0222 0.0221
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0853 0.1119
Brugia malayi Protein kinase domain containing protein 0.0047 0.0511 0.067
Echinococcus granulosus delta-like protein 1 0.0017 0.0099 0.0098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0304 0.1616
Echinococcus granulosus netrin receptor unc 5 0.003 0.0273 0.0272
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0161 0.2053 0.2052
Leishmania major cytochrome p450-like protein 0.0018 0.0109 0.0326
Onchocerca volvulus 0.0053 0.0595 0.1644
Onchocerca volvulus Bile acid receptor homolog 0.0161 0.2053 0.6475
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0099 0.013
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0109 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Leishmania major cytochrome p450-like protein 0.0018 0.0109 0.0326
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0109 0.0326
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1271 0.3481
Schistosoma mansoni sodium/chloride dependent transporter 0.0041 0.0422 0.0406
Echinococcus multilocularis sodium and chloride dependent glycine 0.0041 0.0422 0.0421
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0853 0.524
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0155 0.0117
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0222 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0076 0.0901 0.0885
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0155 0.0138
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0761
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0099 0.0098
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.1574 0.1572
Onchocerca volvulus 0.0026 0.0222 0.0407
Echinococcus granulosus g protein coupled receptor 0.0026 0.0222 0.0221
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.1024 0.1009
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.0083
Schistosoma mansoni hypothetical protein 0.0036 0.0354 0.0338
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0109 0.0107
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0041 0.0422 0.0554
Loa Loa (eye worm) Notch2 0.0017 0.0099 0.0128
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Echinococcus granulosus neurogenic locus notch protein 0.005 0.0544 0.0542
Brugia malayi Protein kinase domain containing protein 0.0031 0.0292 0.0382
Echinococcus granulosus lamin dm0 0.0053 0.0595 0.0594
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.1128 0.1126
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0304 0.1616
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0076 0.0901 0.0885
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0222 0.0221
Schistosoma mansoni rab6-interacting 0.0059 0.0665 0.065
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0222 0.0206
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0155 0.0153
Brugia malayi hypothetical protein 0.0026 0.0222 0.0291
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0161 0.2053 0.2052
Onchocerca volvulus 0.0161 0.2053 0.6475
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0577 0.1583
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0222 0.0221
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0853 0.2279
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0067 0.0047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Echinococcus granulosus epidermal growth factor receptor 0.0148 0.1873 0.1872
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.1121 0.7006
Schistosoma mansoni acetylcholinesterase 0.0022 0.0175 0.0159
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0258 0.3361 0.336
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0259 0.0338
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.1669 0.1655
Brugia malayi EGF-like domain containing protein 0.0017 0.0099 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0189 0.0248
Onchocerca volvulus 0.0026 0.0222 0.0407
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0161 0.2053 0.204
Loa Loa (eye worm) hypothetical protein 0.0161 0.2053 0.2691
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0222 0.0221
Loa Loa (eye worm) hypothetical protein 0.0072 0.0853 0.1117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.0128
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.0901 0.2655
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.0083
Brugia malayi beta-lactamase family protein 0.0072 0.0853 0.1119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0161 0.2053 0.2691
Loa Loa (eye worm) norepinephrine transporter 0.024 0.3117 0.4087
Onchocerca volvulus 0.0072 0.0853 0.2498
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0161 0.2053 0.2693
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0757 0.4609
Schistosoma mansoni biogenic amine receptor 0.0026 0.0222 0.0206
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0175 0.0193
Leishmania major DNA polymerase eta, putative 0.0021 0.0155 0.0627
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0222 0.0221
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0103 0.0011
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0099 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.1271 0.3481
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.1574 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.1271 0.8003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0222 0.0206
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0572 0.7626 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0552
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0668 0.0667
Echinococcus multilocularis 0.0018 0.0109 0.0107
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0017 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0155 0.0273
Schistosoma mansoni opsin-like receptor 0.0026 0.0222 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0109 0.0042
Onchocerca volvulus 0.0026 0.0222 0.0407
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0552
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0222 0.0221
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.2721 0.4352
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0668 0.5192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0222 0.0206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0755
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.1271 0.8003
Schistosoma mansoni jun-related protein 0.0141 0.178 0.1766
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0041 0.0422 0.3674
Echinococcus multilocularis lamin 0.0053 0.0595 0.0594
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0083 0.0082
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0175 0.0159
Trypanosoma brucei unspecified product 0.0014 0.0067 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0422 0.3268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0222 0.0221
Schistosoma mansoni peroxidasin 0.0052 0.0577 0.0561
Loa Loa (eye worm) TK/EGFR protein kinase 0.0148 0.1873 0.2455
Schistosoma mansoni nuclear receptor nhr-48 0.0076 0.0901 0.0885
Loa Loa (eye worm) solute carrier family 6 member 4 0.024 0.3117 0.4087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0175 0.0227
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.021 0.2721 0.8915
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0304 0.1616
Schistosoma mansoni sodium-dependent amino acid transporter 0.0041 0.0422 0.0406
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0222 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0175 0.0173
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0665 0.0664
Brugia malayi Carboxylesterase family protein 0.0022 0.0175 0.0229
Onchocerca volvulus 0.0041 0.0422 0.107
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0083 0.0107
Onchocerca volvulus 0.0026 0.0222 0.0407
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0665 0.0664
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0289
Brugia malayi nuclear hormone receptor 0.0076 0.0901 0.1181
Schistosoma mansoni ankyrin 23/unc44 0.003 0.0273 0.0257
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.1271 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0222 0.0221
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0099 0.013
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0304 0.0303
Brugia malayi cytochrome P450 0.0018 0.0109 0.0143
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0757 0.4609
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0552
Brugia malayi P38 map kinase family protein 2 0.0126 0.1574 0.2064
Loa Loa (eye worm) hypothetical protein 0.0076 0.0901 0.1179
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0155 0.0627
Onchocerca volvulus 0.0026 0.0222 0.0407
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0222 0.0206
Onchocerca volvulus 0.0059 0.0665 0.1876
Brugia malayi hypothetical protein 0.0041 0.0422 0.0554

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.017 uM Inhibition of human CDK2/cyclin A ChEMBL. 17904841
IC50 (binding) = 0.42 uM Inhibition of human GSK3beta ChEMBL. 17904841
IC50 (binding) = 0.42 uM Inhibition of human GSK3beta ChEMBL. 17904841
IC50 (functional) = 0.95 uM Effect on cell proliferation assessed as radiolabelled thymidine incorporation in cell-based assay ChEMBL. 17904841

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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