Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1734 | 0.1249 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.1539 | 0.0589 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.4315 | 1 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.412 | 0.934 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1539 | 0.0589 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 34 % | In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 4*10e -8M. | ChEMBL. | 1901912 |
Inhibition (binding) | = 34 % | In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 4*10e -8M. | ChEMBL. | 1901912 |
Inhibition (binding) | = 71 % | In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 10e -7M. | ChEMBL. | 1901912 |
Inhibition (binding) | = 71 % | In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 10e -7M. | ChEMBL. | 1901912 |
Lowering (functional) | = 54 % | In vivo inhibition of galactitol accumulation in the sciatic nerve of rats fed 20% galactose for 4 day at 115 mg/kg/day dose | ChEMBL. | 1901912 |
Lowering (functional) | = 58 % | In vivo inhibition of galactitol accumulation in the diaphragm of rats fed 20% galactose for 4 day at 115 mg/kg/day dose | ChEMBL. | 1901912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.