TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 597.565 | Formula: C28H22F3N5O5S
H donors: 2 H acceptors: 6 LogP: 3.74 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: OC1CCN(c2c1cc(cc2)c1ccccc1S(=O)(=O)C)C(=O)c1cc(nn1c1ccc2c(c1)c(N)no2)C(F)(F)F
InChi: 1S/C28H22F3N5O5S/c1-42(39,40)24-5-3-2-4-17(24)15-6-8-20-18(12-15)22(37)10-11-35(20)27(38)21-14-25(28(29,30)31)33-36(21)16-7-9-23-19(13-16)26(32)34-41-23/h2-9,12-14,22,37H,10-11H2,1H3,(H2,32,34)
InChiKey: ZXZABNZWYVFDLE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protease, serine, 1 (trypsin 1)		References
Homo sapiens	coagulation factor X	Starlite/ChEMBL	References
Homo sapiens	coagulation factor II (thrombin)	Starlite/ChEMBL	References
Homo sapiens	protease, serine, 2 (trypsin 2)		References
Homo sapiens	protease, serine, 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K09639 transmembrane protease, serine 8, putative	Get druggable targets OG5_126639	All targets in OG5_126639
Onchocerca volvulus		Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Get druggable targets OG5_126639	All targets in OG5_126639
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126639	All targets in OG5_126639
Brugia malayi	Trypsin family protein	Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Get druggable targets OG5_126639	All targets in OG5_126639
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126639	All targets in OG5_126639
Schistosoma japonicum	ko:K09639 transmembrane protease, serine 8, putative	Get druggable targets OG5_126639	All targets in OG5_126639
Onchocerca volvulus		Get druggable targets OG5_126639	All targets in OG5_126639

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Trypsin family protein	protease, serine, 1 (trypsin 1)	247 aa	287 aa	21.6 %
Schistosoma mansoni	cercarial elastase (S01 family)	protease, serine, 2 (trypsin 2)	247 aa	240 aa	25.8 %
Schistosoma mansoni	cercarial elastase (S01 family)	protease, serine, 3	261 aa	234 aa	25.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0277	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0021	0.0029
Schistosoma mansoni	egf-like domain protein	0.0016	0.0001	0.0002
Onchocerca volvulus		0.0019	0.0036	0.005
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0093	0.0131
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0033	0.0181	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0181	0.0254
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0347	0.3609	0.5069
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.0066	0.0066
Trichomonas vaginalis	phosphofructokinase, putative	0.0125	0.1189	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0093	0.05
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Schistosoma mansoni	sodium-bile acid cotransporter	0.0283	0.2904	0.4078
Onchocerca volvulus		0.0041	0.0277	0.039
Toxoplasma gondii	kringle domain-containing protein	0.0021	0.0057	0.2031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Plasmodium falciparum	cysteine repeat modular protein 1	0.0021	0.0057	0.1369
Onchocerca volvulus		0.0031	0.0164	0.023
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0034	0.0195	0.0274
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0022	0.0068	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0181	0.0254
Toxoplasma gondii	protease inhibitor PI2	0.0022	0.0068	0.2423
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0347	0.3609	0.5069
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0133	0.0186
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0034	0.0195	0.0274
Loa Loa (eye worm)	agrin synaptic family protein	0.0022	0.0068	0.0096
Echinococcus multilocularis	fibrillin 1	0.0016	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0181	0.0254
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.0066	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0066	0.0264
Loa Loa (eye worm)	cysteine protease	0.0019	0.0036	0.005
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0036	0.005
Leishmania major	cathepsin L-like protease	0.0073	0.0626	0.5117
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0181	0.0254
Echinococcus multilocularis	laminin	0.0016	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0195	0.0274
Echinococcus multilocularis	expressed protein	0.0022	0.0068	0.0068
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0066	0.0093
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0036	0.005
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0033	0.0181	0.0181
Loa Loa (eye worm)	PXA domain-containing protein	0.0022	0.0066	0.0093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0034	0.0195	0.0274
Echinococcus multilocularis	enteropeptidase	0.0028	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.0096
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0277	0.039
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0033	0.0181	0.0181
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0195	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0511	0.5395	0.7578
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.0096
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0068	0.2423
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0034	0.0195	0.0274
Onchocerca volvulus		0.0034	0.0195	0.0274
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.0066	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0181	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0277	0.039
Brugia malayi	Kringle domain containing protein	0.0021	0.0057	0.0081
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0034	0.0194	0.1373
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0018	0.0021	0.0029
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Brugia malayi	beta-lactamase	0.0041	0.0277	0.039
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0029
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0277	0.1369
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0034	0.0195	0.0274
Schistosoma mansoni	sodium-bile acid cotransporter related	0.067	0.7119	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0181	0.0254
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0066	0.0093
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0387	0.4041	0.5677
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0998	0.1402
Onchocerca volvulus	Arrow homolog	0.0016	0.0001	0.0002
Brugia malayi	Sodium Bile acid symporter family protein	0.067	0.7119	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0067	0.0557	0.4515
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0194	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0277	0.039
Echinococcus granulosus	glycoprotein Antigen 5	0.0028	0.0133	0.0186
Echinococcus multilocularis	lamin	0.0031	0.0164	0.0164
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0195	0.0274
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0195	0.0274
Onchocerca volvulus		0.0028	0.0133	0.0186
Onchocerca volvulus		0.0347	0.3609	0.5069
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Mycobacterium ulcerans	6-phosphofructokinase	0.0125	0.1189	1
Schistosoma mansoni	hypothetical protein	0.0021	0.0057	0.0081
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.0066	0.0093
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0194	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0195	0.0274
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0066	0.0093
Onchocerca volvulus		0.0031	0.0164	0.023
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0181	0.0254
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0036	0.0036
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.0066	0.0066
Schistosoma mansoni	lamin	0.0031	0.0164	0.023
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0022	0.0066	0.0093
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0016	0.0001	0.0002
Schistosoma mansoni	agrin	0.0022	0.0068	0.0096
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0181	0.0254
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0265	0.2712	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0277	0.2095
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0028	0.0133	0.0186
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0626	0.5117
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.0066	0.0093
Brugia malayi	prostaglandin transporter	0.0033	0.0181	0.0254
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0068	0.0096
Brugia malayi	hypothetical protein	0.0033	0.0181	0.0254
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0195	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0066	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0034	0.0195	0.0274
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0034	0.0195	0.0195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0195	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0195	0.0274
Trichomonas vaginalis	phosphofructokinase, putative	0.0125	0.1189	1
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.0066	0.0093
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0007	0.001
Toxoplasma gondii	transporter, major facilitator family protein	0.0033	0.0181	0.6506
Schistosoma mansoni	6-phosphofructokinase	0.0125	0.1189	0.1671
Brugia malayi	phosphofructokinase	0.0125	0.1189	0.1671
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0195	0.0274
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0001	0.0002
Echinococcus granulosus	follistatin	0.0022	0.0068	0.0096
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0277	0.039
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0066	0.0093
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0222
Brugia malayi	regulator of G-protein signaling rgs-7	0.0022	0.0066	0.0093
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0133	0.0186
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0001	0.0002
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0036	0.005
Schistosoma mansoni	hypothetical protein	0.0195	0.1952	0.2741
Onchocerca volvulus		0.0019	0.0036	0.005
Echinococcus multilocularis	Tolloid protein 1	0.0016	0.0001	0.0001
Brugia malayi	regulator of G-protein signaling egl-10	0.0022	0.0066	0.0093
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0034	0.0195	0.0274
Loa Loa (eye worm)	6-phosphofructokinase	0.0125	0.1189	0.1671
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0194	0.1373
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0034	0.0195	0.0274
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0066	0.0264
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0195	0.0195
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0125	0.1189	0.3747
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0181	0.0254
Onchocerca volvulus		0.067	0.7119	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0036	0.005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0133	0.0186
Echinococcus multilocularis	musashi	0.0031	0.0164	0.0164
Onchocerca volvulus		0.0033	0.0181	0.0254
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0034	0.0194	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0195	0.0274
Echinococcus granulosus	intermediate filament protein	0.0031	0.0164	0.023
Brugia malayi	secreted modular calcium-binding protein 1	0.0022	0.0068	0.0096
Loa Loa (eye worm)	hypothetical protein	0.067	0.7119	1
Schistosoma mansoni	hypothetical protein	0.0195	0.1952	0.2741
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0029
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0004	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0347	0.3609	0.5069
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0033	0.0181	0.0254
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0016	0.0001	0.0002
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0037	0.0052
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0277	0.2095
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0195	0.0274
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0022	0.0066	0.0066
Leishmania major	ATP-dependent phosphofructokinase	0.0125	0.1189	1
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0022	0.0066	0.0093
Loa Loa (eye worm)	TK/ROR protein kinase	0.0021	0.0057	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0066	0.0093
Echinococcus multilocularis	ecdysone induced protein 78C	0.0034	0.0195	0.0195
Toxoplasma gondii	6-phosphofructokinase	0.0034	0.0194	0.6983
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0277	0.039
Brugia malayi	hypothetical protein	0.0033	0.0181	0.0254
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0028	0.0133	0.0186
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0277	0.0277
Echinococcus multilocularis	geminin	0.0195	0.1952	0.1952
Onchocerca volvulus		0.0028	0.0133	0.0186
Echinococcus granulosus	enteropeptidase	0.0028	0.0133	0.0186
Onchocerca volvulus		0.0033	0.0181	0.0254
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0028	0.0133	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0066	0.0264
Echinococcus granulosus	sodium bile acid cotransporter	0.067	0.7119	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0007	0.001
Echinococcus multilocularis	agrin	0.0022	0.0068	0.0068
Loa Loa (eye worm)	phosphofructokinase	0.0125	0.1189	0.1671
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0195	0.0274
Onchocerca volvulus		0.0033	0.0181	0.0254
Loa Loa (eye worm)	ctsf protein	0.0019	0.0036	0.005
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0195	0.0274
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0277	0.1369
Loa Loa (eye worm)	6-phosphofructokinase	0.0125	0.1189	0.1671
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0626	0.5117
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0277	0.039
Echinococcus multilocularis	expressed protein	0.043	0.4509	0.4509
Brugia malayi	PXA domain containing protein	0.0022	0.0066	0.0093
Onchocerca volvulus		0.0319	0.3302	0.4638
Schistosoma mansoni	lamin	0.0031	0.0164	0.023
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0001	0.0002
Onchocerca volvulus		0.0022	0.0068	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0029
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0066	0.0093
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0036	0.005
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0022	0.0066	0.0264
Echinococcus granulosus	Tolloid protein 1	0.0016	0.0001	0.0002
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0164	0.023
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0022	0.0066	0.0093
Echinococcus multilocularis	follistatin	0.0022	0.0068	0.0068
Echinococcus multilocularis	6 phosphofructokinase	0.0125	0.1189	0.1189
Brugia malayi	hypothetical protein	0.0018	0.0021	0.0029
Brugia malayi	A-kinase anchor protein 10, precursor	0.0022	0.0066	0.0093
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0018	0.0021	0.0029
Echinococcus multilocularis	cysteine protease	0.0019	0.0036	0.0036
Echinococcus granulosus	laminin	0.0016	0.0001	0.0002
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0277	0.2095
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0195	0.0274
Echinococcus granulosus	expressed protein	0.043	0.4509	0.6333
Onchocerca volvulus		0.0021	0.0057	0.0081
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0034	0.0195	0.0274
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0034	0.0194	0.6983
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0022	0.0068	0.0096
Leishmania major	hypothetical protein, conserved	0.0041	0.0277	0.2095
Onchocerca volvulus	Bile acid receptor homolog	0.0034	0.0195	0.0274
Brugia malayi	Trypsin family protein	0.0028	0.0133	0.0186
Echinococcus multilocularis	Mastin	0.0028	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0001	0.0002
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0036	0.005
Echinococcus granulosus	sodium bile acid cotransporter	0.067	0.7119	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0626	0.5117
Onchocerca volvulus		0.0019	0.0036	0.005
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.0066	0.0093
Echinococcus granulosus	cathepsin l1	0.0019	0.0036	0.005
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0194	0.1373
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0068	0.2423
Onchocerca volvulus		0.0019	0.0036	0.005
Echinococcus multilocularis	sodium bile acid cotransporter	0.067	0.7119	0.7119
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0066	0.0093
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0277	0.2095
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0277	0.2095
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0022	0.0066	0.0093
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.0066	0.0066
Leishmania major	cathepsin L-like protease	0.0073	0.0626	0.5117
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0455	0.3632
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0022	0.0066	0.0066
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0066	0.0264
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0133	0.0186
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0277	0.039
Brugia malayi	Trypsin family protein	0.0028	0.0133	0.0186
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0034	0.0195	0.0274
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0194	1
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0093	0.0093
Trichomonas vaginalis	esterase, putative	0.0041	0.0277	0.2095
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0034	0.0195	0.0274
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0194	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0034	0.0195	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0277	0.039
Echinococcus multilocularis	tissue type plasminogen activator	0.0021	0.0057	0.0057
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0277	0.039
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0195	0.0274
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.0066	0.0066
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0277	0.1369
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0036	0.005
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0195	0.0274
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0028	0.0133	0.0186
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0016	0.0001	0.0002
Schistosoma mansoni	hypothetical protein	0.0028	0.0133	0.0186
Brugia malayi	SPARC precursor	0.0022	0.0068	0.0096
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0066	0.0093
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0093	0.05
Onchocerca volvulus	Phospholipase A2 homolog	0.0108	0.0998	0.1402
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.0057	0.0188
Echinococcus granulosus	6 phosphofructokinase	0.0125	0.1189	0.1671
Schistosoma mansoni	organic anion transporter	0.0033	0.0181	0.0254
Echinococcus multilocularis	lamin dm0	0.0031	0.0164	0.0164
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0036	0.0036
Mycobacterium ulcerans	lipase LipD	0.0041	0.0277	0.1369
Entamoeba histolytica	phosphofructokinase, putative	0.0125	0.1189	1
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0068	0.2423
Brugia malayi	Trypsin family protein	0.0347	0.3609	0.5069
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0125	0.1189	1
Brugia malayi	Trypsin-like protease protein 5	0.0028	0.0133	0.0186
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0022	0.0068	0.0096
Plasmodium vivax	vivapain-2	0.0019	0.0036	0.1073
Brugia malayi	Steroid receptor seven-up type 2	0.0034	0.0195	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0195	0.0274
Brugia malayi	beta-lactamase family protein	0.0041	0.0277	0.039
Schistosoma mansoni	RAR-like nuclear receptor	0.0034	0.0195	0.0274
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0125	0.1189	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0034	0.0195	0.0274
Onchocerca volvulus		0.0019	0.0036	0.005
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0125	0.1189	1
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0022	0.0066	0.0066
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0277	0.039
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0034	0.0195	0.0195
Echinococcus granulosus	lamin dm0	0.0031	0.0164	0.023
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0133	0.0186
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0093	0.0131
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0164	0.023
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0164	0.023
Brugia malayi	beta-lactamase family protein	0.0041	0.0277	0.039
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0194	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0066	0.0093
Brugia malayi	Fibulin-1 precursor	0.0016	0.0001	0.0002
Echinococcus granulosus	FTZ F1 alpha	0.0034	0.0195	0.0274
Plasmodium vivax	vivapain-2	0.0019	0.0036	0.1073
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0036	0.0036
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0036	0.005
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0093	0.0131
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0028	0.0133	0.0186
Onchocerca volvulus		0.0028	0.0133	0.0186
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.0066	0.0093
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0022	0.0068	0.0096
Schistosoma mansoni	coup transcription factor	0.0034	0.0195	0.0274
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0194	0.1373
Schistosoma mansoni	follistatin	0.0022	0.0068	0.0096
Onchocerca volvulus		0.0033	0.0181	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0029
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0194	0.6923
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0277	0.1369
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0194	0.6923
Entamoeba histolytica	phosphofructokinase, putative	0.0125	0.1189	1
Brugia malayi	intermediate filament protein	0.0031	0.0164	0.023
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Loa Loa (eye worm)	steroid hormone receptor	0.0034	0.0195	0.0274
Loa Loa (eye worm)	fibroinase	0.0019	0.0036	0.005
Toxoplasma gondii	ABC1 family protein	0.0041	0.0277	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0034	0.0195	0.0274
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0021	0.0057	0.1874
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0195	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0001	0.0002
Brugia malayi	Trypsin family protein	0.0028	0.0133	0.0186
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0034	0.0195	0.0274
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0022	0.0068	0.2423
Brugia malayi	steroid hormone receptor	0.0034	0.0195	0.0274
Brugia malayi	6-phosphofructokinase	0.0125	0.1189	0.1671
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0036	0.005
Brugia malayi	photoreceptor-specific nuclear receptor	0.0034	0.0195	0.0274
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0022	0.0066	0.0093
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0034	0.0195	0.0274
Brugia malayi	PXA domain containing protein	0.0022	0.0066	0.0093
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.0066	0.0093
Onchocerca volvulus		0.0019	0.0036	0.005
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0181	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0066	0.0264
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0034	0.0195	0.0274
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.0066	0.0093
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0626	0.5117
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0036	0.005
Entamoeba histolytica	hypothetical protein	0.0022	0.0066	0.0264
Leishmania major	hypothetical protein, conserved	0.0021	0.0057	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0133	0.0186
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0034	0.0195	0.0195
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0181	0.0254
Leishmania major	cathepsin L-like protease	0.0073	0.0626	0.5117
Onchocerca volvulus		0.0028	0.0133	0.0186
Echinococcus granulosus	geminin	0.0195	0.1952	0.2741
Echinococcus granulosus	agrin	0.0022	0.0068	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0034	0.0195	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0036	0.005
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0066	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0347	0.3609	0.5069
Echinococcus granulosus	ecdysone induced protein 78C	0.0034	0.0195	0.0274
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0194	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0036	0.005
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0277	0.039
Loa Loa (eye worm)	hypothetical protein	0.002	0.0039	0.0055
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.0066	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0029
Loa Loa (eye worm)	trypsin family protein	0.0028	0.0133	0.0186
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0036	0.005
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.0066	0.0066
Loa Loa (eye worm)	RGS-3 protein	0.0022	0.0066	0.0093
Onchocerca volvulus		0.0019	0.0036	0.005
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0133	0.0186
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0018	0.0021	0.0021
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0277	0.2095
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0061	0.1587
Echinococcus multilocularis	sodium bile acid cotransporter	0.067	0.7119	0.7119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Brugia malayi	hypothetical protein	0.0028	0.0133	0.0186
Schistosoma mansoni	6-phosphofructokinase	0.0125	0.1189	0.1671
Schistosoma mansoni	hypothetical protein	0.0028	0.0133	0.0186
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0195	0.0274
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0036	0.005
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0021	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0057	0.0081
Echinococcus granulosus	Mastin	0.0028	0.0133	0.0186
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0125	0.1189	1
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0033	0.0181	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0164	0.023
Onchocerca volvulus		0.0041	0.0277	0.039
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0195	0.0274
Brugia malayi	hypothetical protein	0.0022	0.0066	0.0093
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0034	0.0195	0.0195
Onchocerca volvulus		0.0033	0.0181	0.0254
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0028	0.0133	0.0186
Echinococcus granulosus	lamin	0.0031	0.0164	0.023
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0016	0.0001	0.0002
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0022	0.0066	0.0093
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0164	0.023
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0036	0.005
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0057	0.0081
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0034	0.0195	0.0274
Onchocerca volvulus	Phospholipase A2 homolog	0.0511	0.5395	0.7578
Echinococcus granulosus	transmembrane protease serine 3	0.0028	0.0133	0.0186
Onchocerca volvulus		0.0028	0.0133	0.0186
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0034	0.0195	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0066	0.0093
Schistosoma mansoni	z-protein (S1r protein)	0.0022	0.0066	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0034	0.0195	0.0274
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0194	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0034	0.0195	0.0274
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0034	0.0195	0.0195
Schistosoma mansoni	retinoic acid receptor RXR	0.0034	0.0195	0.0274
Echinococcus multilocularis	glycoprotein Antigen 5	0.0028	0.0133	0.0133
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.0066	0.0093
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0018	0.0021	0.0029
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0195	0.0274
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0034	0.0195	0.0274
Echinococcus multilocularis	cysteine protease	0.0019	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0001	0.0002
Onchocerca volvulus	Putative organic anion transporter	0.0033	0.0181	0.0254
Brugia malayi	nuclear hormone receptor	0.0034	0.0195	0.0274
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0034	0.0195	0.0274
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0066	0.0093
Brugia malayi	ecdysteroid receptor	0.0034	0.0195	0.0274
Toxoplasma gondii	cathepsin CPL	0.0019	0.0036	0.1246
Brugia malayi	hypothetical protein	0.0022	0.0066	0.0093
Trichomonas vaginalis	phosphofructokinase, putative	0.0125	0.1189	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0133	0.0186
Onchocerca volvulus		0.0041	0.0277	0.039
Schistosoma mansoni	cercarial elastase (S01 family)	0.0028	0.0133	0.0186
Brugia malayi	6-phosphofructokinase	0.0125	0.1189	0.1671
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0016	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0133	0.0186
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0034	0.0195	0.0274
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0036	0.005
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0021	0.0029
Brugia malayi	hypothetical protein	0.0018	0.0021	0.0029
Brugia malayi	sodium-independent organic anion transporter family protein	0.0033	0.0181	0.0254
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0066	0.0093
Echinococcus multilocularis	transmembrane protease serine 3	0.0028	0.0133	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0066	0.0264
Brugia malayi	nuclear receptor RXR	0.0018	0.0021	0.0029
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0022	0.0066	0.0093
Echinococcus granulosus	sodium bile acid cotransporter	0.067	0.7119	1
Echinococcus multilocularis	sodium bile acid cotransporter	0.067	0.7119	0.7119
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0034	0.0195	0.0274
Entamoeba histolytica	hypothetical protein	0.0022	0.0066	0.0264
Brugia malayi	Phospholipase A2 family protein	0.0108	0.0998	0.1402
Trypanosoma cruzi	MFS transporter, putative	0.0033	0.0181	0.1259
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0277	0.2095
Echinococcus granulosus	Regulator of G protein signaling 20	0.0022	0.0066	0.0093
Schistosoma mansoni	organic anion transporter	0.0033	0.0181	0.0254
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0626	0.3823
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0034	0.0195	0.0274
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0034	0.0194	0.1373
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0036	0.005
Entamoeba histolytica	phosphofructokinase, putative	0.0125	0.1189	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0125	0.1189	1
Echinococcus multilocularis	FTZ F1 alpha	0.0034	0.0195	0.0195
Echinococcus multilocularis	regulator of G protein signaling	0.0022	0.0066	0.0066
Onchocerca volvulus	Protein ultraspiracle homolog	0.0034	0.0195	0.0274
Echinococcus granulosus	tissue type plasminogen activator	0.0021	0.0057	0.0081
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0195	0.0195
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.0066	0.0093
Toxoplasma gondii	phosphofructokinase PFKII	0.0034	0.0194	0.6983
Entamoeba histolytica	hypothetical protein	0.0022	0.0066	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0277	0.039

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1400 nM	Inhibition of human factor 10a	ChEMBL.	17933529
Ki (binding)	= 1400 nM	Inhibition of human factor 10a	ChEMBL.	17933529
Ki (binding)	> 4200 nM	Inhibition of human trypsin	ChEMBL.	17933529
Ki (binding)	> 4200 nM	Inhibition of human trypsin	ChEMBL.	17933529
Ki (binding)	> 6300 nM	Inhibition of human thrombin	ChEMBL.	17933529
Ki (binding)	> 6300 nM	Inhibition of human thrombin	ChEMBL.	17933529

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL398518

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 500442