Detailed information for compound 500812

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 615.872 | Formula: C36H49N5O2S
  • H donors: 1 H acceptors: 2 LogP: 6.05 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1cc(C)cc(c1)c1[nH]c2c(c1CCN1CCN(CC1)CC(=O)N1CCCC1)cc(s2)C(C(=O)N1C2CCC1CC2)(C)C
  • InChi: 1S/C36H49N5O2S/c1-24-19-25(2)21-26(20-24)33-29(11-14-38-15-17-39(18-16-38)23-32(42)40-12-5-6-13-40)30-22-31(44-34(30)37-33)36(3,4)35(43)41-27-7-8-28(41)10-9-27/h19-22,27-28,37H,5-18,23H2,1-4H3
  • InChiKey: BRRJNHJWPVIHFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References
Rattus norvegicus Gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni peptide (allatostatin)-like receptor Gonadotropin-releasing hormone receptor   327 aa 272 aa 23.2 %
Brugia malayi ORL1-like opioid receptor Gonadotropin-releasing hormone receptor   327 aa 293 aa 20.8 %
Echinococcus granulosus tm gpcr rhodopsin Gonadotropin-releasing hormone receptor   327 aa 299 aa 23.1 %
Echinococcus multilocularis allatostatin A receptor Gonadotropin-releasing hormone receptor   327 aa 279 aa 23.7 %
Echinococcus multilocularis neuropeptide receptor Gonadotropin-releasing hormone receptor   327 aa 263 aa 20.9 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 292 aa 19.5 %
Echinococcus multilocularis tachykinin peptides receptor 99D Gonadotropin-releasing hormone receptor   327 aa 283 aa 20.1 %
Echinococcus granulosus allatostatin A receptor Gonadotropin-releasing hormone receptor   327 aa 284 aa 22.9 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Gonadotropin-releasing hormone receptor   327 aa 288 aa 24.3 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Gonadotropin-releasing hormone receptor   327 aa 263 aa 23.2 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 271 aa 20.7 %
Loa Loa (eye worm) hypothetical protein Gonadotropin-releasing hormone receptor   327 aa 334 aa 21.6 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 284 aa 19.4 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Gonadotropin-releasing hormone receptor   327 aa 343 aa 21.6 %
Echinococcus granulosus tachykinin peptides receptor 99D Gonadotropin-releasing hormone receptor   327 aa 283 aa 19.1 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Gonadotropin-releasing hormone receptor   327 aa 273 aa 19.8 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 336 aa 19.0 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Gonadotropin-releasing hormone receptor   327 aa 305 aa 24.9 %
Schistosoma mansoni neuropeptide receptor Gonadotropin-releasing hormone receptor   327 aa 263 aa 24.0 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Gonadotropin-releasing hormone receptor   327 aa 290 aa 19.7 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 336 aa 20.8 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Gonadotropin-releasing hormone receptor   327 aa 288 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0478 0.3566 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.006 0.0103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0048 0.0135
Echinococcus multilocularis Rac GTPase activating protein 1 0.0019 0.006 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0183 0.0433
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0514
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.035 0.0922
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.013 0.0363
Echinococcus granulosus uridine 5' monophosphate synthase 0.0131 0.092 0.258
Onchocerca volvulus 0.0478 0.3566 0.3947
Brugia malayi beta-lactamase family protein 0.0035 0.0183 0.0189
Loa Loa (eye worm) hypoxia-induced factor 1 0.0175 0.1257 0.3525
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0135
Schistosoma mansoni cpg binding protein 0.0028 0.013 0.0299
Brugia malayi Pre-SET motif family protein 0.0416 0.3096 0.3635
Schistosoma mansoni atypical protein kinase C 0.0046 0.0265 0.0682
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0048 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0028
Onchocerca volvulus 0.0035 0.0183 0.0178
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0127 0.0885 0.2481
Echinococcus multilocularis protein kinase c iota type 0.0046 0.0265 0.0744
Loa Loa (eye worm) thymidylate synthase 0.0478 0.3566 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0038 0.0023
Echinococcus granulosus geminin 0.0361 0.2675 0.7502
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0027 0.0123 0.0345
Schistosoma mansoni hypothetical protein 0.0042 0.0238 0.0604
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0325 0.0356
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0038 0.0023
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0478 0.1341
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0687 0.1866
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0596 0.0678
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.003 0.0085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0048 0.0069
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0048 0.0069
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0117 0.0327
Onchocerca volvulus 0.0026 0.0117 0.0103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0378 0.1059
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0798 0.2239
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0131 0.092 0.2517
Brugia malayi MH2 domain containing protein 0.0115 0.0798 0.0917
Brugia malayi Hr1 repeat family protein 0.0027 0.0123 0.0117
Schistosoma mansoni hypothetical protein 0.0361 0.2675 0.7485
Onchocerca volvulus 0.0023 0.009 0.0073
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.006 0.0103
Loa Loa (eye worm) hypothetical protein 0.0067 0.0431 0.1208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0378 0.0999
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0321 0.2366 0.5465
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0384 0.1017
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0321 0.2366 0.6585
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0048 0.0135
Brugia malayi p70 ribosomal S6 kinase beta 0.0027 0.0123 0.0117
Echinococcus multilocularis cpg binding protein 0.0029 0.0142 0.0397
Onchocerca volvulus 0.0089 0.0596 0.0638
Echinococcus granulosus RNA directed DNA polymerase 0.0122 0.0847 0.2375
Schistosoma mansoni diacylglycerol kinase theta 0.0019 0.006 0.0103
Brugia malayi diacylglycerol kinase 0.0019 0.006 0.0043
Echinococcus granulosus lamin 0.0026 0.0117 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0048 0.0029
Brugia malayi Protein kinase domain containing protein 0.0015 0.0032 0.001
Schistosoma mansoni tyrosinase precursor 0.0089 0.0596 0.1617
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0048 0.0069
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0238 0.0253
Brugia malayi Cytochrome P450 family protein 0.0018 0.0052 0.0034
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0238 0.0604
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0131 0.092 0.2517
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0378 0.1059
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0236 0.9884
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0478 0.3566 1
Echinococcus multilocularis protein kinase c eta type 0.0019 0.006 0.0169
Onchocerca volvulus 0.0035 0.0183 0.0178
Entamoeba histolytica hypothetical protein 0.0042 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0327
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0236 0.9884
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0236 0.9884
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0048 0.0029
Brugia malayi Ets-domain containing protein 0.0073 0.0478 0.0538
Entamoeba histolytica hypothetical protein 0.0042 0.0238 1
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0024 0.0067
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0321 0.2366 0.6452
Brugia malayi Protein kinase domain containing protein 0.002 0.0068 0.0053
Echinococcus granulosus serine:threonine protein kinase N2 0.0027 0.0123 0.0345
Echinococcus granulosus cpg binding protein 0.0029 0.0142 0.0397
Onchocerca volvulus 0.0042 0.0238 0.0239
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.003 0.0085
Echinococcus multilocularis geminin 0.0361 0.2675 0.7502
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0123 0.028
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0183 0.0514
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0048 0.0135
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.006 0.0378 0.1059
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0052 0.0147
Brugia malayi orotate phosphoribosyltransferase family protein 0.0131 0.092 0.106
Schistosoma mansoni protein kinase C 0.0023 0.009 0.0186
Mycobacterium ulcerans orotidine 5'-phosphate decarboxylase 0.0131 0.092 0.2469
Brugia malayi steroid hormone receptor 0.0017 0.0048 0.0029
Onchocerca volvulus 0.0089 0.0596 0.0638
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Leishmania major protein kinase, putative 0.0016 0.0038 0.0023
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0048 0.0069
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0038 0.0023
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.002 0.0068 0.0191
Brugia malayi hypothetical protein 0.0042 0.0238 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0183 0.045
Entamoeba histolytica protein kinase, putative 0.0027 0.0123 0.3534
Echinococcus multilocularis Diacylglycerol kinase theta 0.0019 0.006 0.0169
Onchocerca volvulus 0.0026 0.0117 0.0103
Loa Loa (eye worm) tyrosinase 1 0.0089 0.0596 0.1673
Brugia malayi Melibiase family protein 0.0067 0.0431 0.0481
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0048 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0069
Brugia malayi Pre-SET motif family protein 0.006 0.0378 0.0419
Loa Loa (eye worm) hypothetical protein 0.0324 0.2389 0.6699
Schistosoma mansoni unc-13 (munc13) 0.0023 0.009 0.0186
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0048 0.0135
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0048 0.0135
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0038 0.0023
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.0027 0.0008
Trichomonas vaginalis esterase, putative 0.0035 0.0183 0.0437
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0439 0.327 0.917
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0183 0.0189
Onchocerca volvulus 0.1189 0.8998 1
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Brugia malayi Ets-domain containing protein 0.0073 0.0478 0.0538
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0019 0.006 0.0169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0345
Onchocerca volvulus 0.0017 0.0048 0.0027
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0135
Trichomonas vaginalis set domain proteins, putative 0.0474 0.3535 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0027 0.0123 0.0345
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Onchocerca volvulus 0.0035 0.0183 0.0178
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0596 0.0678
Brugia malayi C1-like domain containing protein 0.002 0.0068 0.0053
Brugia malayi intermediate filament protein 0.0026 0.0117 0.011
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.003 0.0085
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0378 0.1059
Schistosoma mansoni single-minded 0.0057 0.035 0.0922
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.0085
Toxoplasma gondii AGC kinase 0.0027 0.0123 0.0272
Schistosoma mansoni unc-13 (munc13) 0.0023 0.009 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.006 0.0103
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0183 0.0514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0325 0.091
Brugia malayi hypothetical protein 0.019 0.1369 0.1592
Schistosoma mansoni lamin 0.0026 0.0117 0.0262
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0238 0.0528
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0027 0.0123 0.0345
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0024 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.1224 0.3389
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0478 0.3566 1
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0048 0.0069
Brugia malayi Protein kinase domain containing protein 0.0439 0.327 0.384
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0048 0.0029
Echinococcus granulosus single minded 2 0.0042 0.0238 0.0667
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0183 0.045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0048 0.0135
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0048 0.0135
Echinococcus multilocularis lamin dm0 0.0026 0.0117 0.0327
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0687 0.1926
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0325 0.0849
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0048 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0048 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0478 0.3566 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0596 0.1673
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0024 0.0067
Brugia malayi beta-lactamase 0.0035 0.0183 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0378 0.0999
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0149 0.0417
Brugia malayi hypoxia-induced factor 1 0.0175 0.1257 0.1459
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0019 0.006 0.0169
Schistosoma mansoni ets-related 0.0223 0.162 0.4506
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0461 0.1293
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0027 0.0123 0.0345
Brugia malayi RhoGAP domain containing protein 0.0019 0.006 0.0043
Echinococcus multilocularis Ankyrin 0.0014 0.0025 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0514
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.006 0.0169
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0236 0.9884
Brugia malayi RhoGAP domain containing protein 0.0019 0.006 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0123 0.028
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2935 0.8231
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0048 0.0029
Loa Loa (eye worm) hypothetical protein 0.014 0.0989 0.2774
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0135
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0183 0.0373
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0514
Echinococcus granulosus thymidylate synthase 0.0478 0.3566 1
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0131 0.092 0.258
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0798 0.2239
Echinococcus multilocularis serine:threonine protein kinase N2 0.0027 0.0123 0.0345
Schistosoma mansoni protein kinase C mu 0.0019 0.006 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0048 0.0029
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0049 0.0295 0.0827
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0048 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0048 0.0135
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0478 0.3566 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0183 0.0433
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0687 0.1872
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0068 0.0125
Brugia malayi nuclear hormone receptor 0.0017 0.0048 0.0029
Entamoeba histolytica protein kinase, putative 0.0027 0.0123 0.3534
Trypanosoma brucei RNA helicase, putative 0.0103 0.0702 0.185
Loa Loa (eye worm) AGC/AKT protein kinase 0.0027 0.0123 0.0345
Brugia malayi Protein kinase domain containing protein 0.0027 0.0123 0.0117
Schistosoma mansoni tyrosinase precursor 0.0089 0.0596 0.1617
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0131 0.092 0.2517
Trichomonas vaginalis conserved hypothetical protein 0.0227 0.1653 0.4631
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0048 0.0027
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0027 0.0123 0.0345
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0048 0.0069
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0052 0.0063
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.0103
Schistosoma mansoni hypothetical protein 0.0361 0.2675 0.7485
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0048 0.0029
Loa Loa (eye worm) hypothetical protein 0.0063 0.0397 0.1113
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0135
Schistosoma mansoni lamin 0.0026 0.0117 0.0262
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Loa Loa (eye worm) hypothetical protein 0.019 0.1369 0.384
Brugia malayi Uncoordinated protein 44 0.0014 0.0024 0.000000029837
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0048 0.0027
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0238 0.0667
Echinococcus granulosus death domain containing protein 0.0014 0.0024 0.0067
Echinococcus multilocularis lamin 0.0026 0.0117 0.0327
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Toxoplasma gondii orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase 0.0131 0.092 0.2524
Loa Loa (eye worm) RasGEF domain-containing protein 0.0019 0.006 0.0169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0238 0.0667
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0024 0.0068
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.003 0.0085
Entamoeba histolytica hypothetical protein 0.0042 0.0238 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0048 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0325 0.0849
Loa Loa (eye worm) hypothetical protein 0.0122 0.0847 0.2375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0048 0.0135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0325 0.091
Schistosoma mansoni hypothetical protein 0.0103 0.0702 0.1916
Loa Loa (eye worm) ShTK domain-containing protein 0.0089 0.0596 0.1673
Toxoplasma gondii diacylglycerol kinase, putative 0.0019 0.006 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0048 0.0069
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0183 0.0433
Brugia malayi follicle stimulating hormone receptor 0.0236 0.1719 0.2005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0356 0.0999
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0052 0.0147
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0023 0.009 0.0252
Loa Loa (eye worm) hypothetical protein 0.0089 0.0596 0.1673
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0048 0.0135
Schistosoma mansoni cpg binding protein 0.0029 0.0142 0.0333
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0321 0.2366 1
Brugia malayi Ras association domain family 1 isoform A 0.0019 0.006 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0325 0.091
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0068 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0123 0.028
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0687 0.1872
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0048 0.0029
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0171 0.1224 0.3433
Mycobacterium ulcerans hypothetical protein 0.0035 0.0183 0.0373
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0048 0.0069
Leishmania major hypothetical protein, conserved 0.0035 0.0183 0.0433
Schistosoma mansoni hypothetical protein 0.0395 0.2935 0.822
Loa Loa (eye worm) raf kinase 0.0019 0.006 0.0169
Entamoeba histolytica protein kinase, putative 0.0027 0.0123 0.3534
Brugia malayi ShTK domain containing protein 0.0089 0.0596 0.0678
Echinococcus granulosus Rac GTPase activating protein 1 0.0019 0.006 0.0169
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0019 0.006 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0183 0.0437
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0183 0.0437
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0321 0.2366 0.6452
Schistosoma mansoni vav2 0.0019 0.006 0.0103
Schistosoma mansoni serine/threonine kinase 0.0027 0.0123 0.028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0238 0.0667
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0024 0.0067
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0027 0.0123 0.0345
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0027 0.0123 0.0345
Brugia malayi Protein kinase c protein 2 0.0145 0.1027 0.1187
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0027 0.0123 0.0345
Leishmania major protein kinase, putative 0.0016 0.0038 0.0023
Onchocerca volvulus 0.006 0.0378 0.0394
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0325 0.091
Mycobacterium leprae Probable lipase LipE 0.0035 0.0183 0.0433
Brugia malayi hypothetical protein 0.0227 0.1653 0.1928
Echinococcus granulosus protein kinase c iota type 0.0046 0.0265 0.0744
Echinococcus multilocularis thymidylate synthase 0.0478 0.3566 1
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0478 0.3566 1
Onchocerca volvulus 0.0474 0.3536 0.3913
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0183 0.0437
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0019 0.006 0.0169
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.002 0.0068 0.0191
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0135
Mycobacterium ulcerans beta-lactamase 0.0035 0.0183 0.0373
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0048 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.1224 0.3389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0048 0.0135
Onchocerca volvulus 0.0019 0.006 0.0041
Loa Loa (eye worm) hypothetical protein 0.0089 0.0596 0.1673
Echinococcus multilocularis serine:threonine protein kinase 38 0.0027 0.0123 0.0345
Echinococcus multilocularis unc 13 (munc13) 0.0023 0.009 0.0252
Echinococcus multilocularis protein kinase c epsilon type 0.0049 0.0295 0.0827
Mycobacterium leprae Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) 0.0131 0.092 0.2517
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0048 0.0135
Mycobacterium tuberculosis Hypothetical protein 0.0227 0.1653 0.4346
Echinococcus multilocularis musashi 0.0026 0.0117 0.0327
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0117 0.011
Entamoeba histolytica fatty acid elongase, putative 0.0042 0.0236 0.9884
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0478 0.3566 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0252
Brugia malayi Death domain containing protein 0.0014 0.0024 0.000000029837
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Schistosoma mansoni diacylglycerol kinase theta 0.0019 0.006 0.0103
Schistosoma mansoni rac gtpase activating protein 0.0019 0.006 0.0103
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0687 0.1872
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0131 0.092 0.258
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.002 0.0068 0.0191
Brugia malayi Protein kinase domain containing protein 0.0027 0.0123 0.0117
Onchocerca volvulus 0.0089 0.0596 0.0638
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0026 0.0115 0.0242
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0048 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Brugia malayi nuclear receptor NHR-88 0.0017 0.0048 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0378 0.0999
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0378 0.0999
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0067
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0183 0.0514
Plasmodium vivax orotidine 5'-phosphate decarboxylase, putative 0.0131 0.092 0.2178
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0048 0.0029
Onchocerca volvulus 0.0019 0.006 0.0041
Toxoplasma gondii ABC1 family protein 0.0035 0.0183 0.0443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0325 0.091
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0478 0.1341
Loa Loa (eye worm) AGC/NDR protein kinase 0.0027 0.0123 0.0345
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Echinococcus granulosus Ankyrin 0.0014 0.0025 0.0069
Echinococcus multilocularis N chimaerin 0.0019 0.006 0.0169
Brugia malayi CXXC zinc finger family protein 0.0028 0.013 0.0125
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.1719 0.482
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0514
Brugia malayi protein kinase C II. 0.0049 0.0295 0.0321
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0431 0.1149
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.002 0.0068 0.0053
Brugia malayi RhoGEF domain containing protein 0.0019 0.006 0.0043
Echinococcus granulosus protein kinase c eta type 0.0019 0.006 0.0169
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0321 0.2366 0.6585
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0123 0.028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1615 0.4232
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0461 0.1293
Brugia malayi Pleckstrin Homology Domain 0.0019 0.006 0.0043
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0048 0.0135
Schistosoma mansoni gabp alpha 0.0073 0.0478 0.1283
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0048 0.0029
Brugia malayi GnHR receptor homolog 0.1121 0.8476 1
Echinococcus granulosus protein kinase C gamma type 0.0152 0.1082 0.3033
Schistosoma mansoni cpg binding protein 0.0029 0.0142 0.0333
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0028
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0687 0.1872
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0183 0.0437
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0024 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0052 0.0147
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0025 0.0003
Leishmania major cytochrome p450-like protein 0.0018 0.0052 0.0063
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0048 0.0135
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0048 0.0069
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0048 0.0135
Echinococcus multilocularis serine:threonine protein kinase N2 0.0027 0.0123 0.0345
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0052 0.0063
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0478 0.3566 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.002 0.0068 0.0191
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0122 0.0847 0.2375
Echinococcus granulosus Diacylglycerol kinase theta 0.0019 0.006 0.0169
Brugia malayi ecdysteroid receptor 0.0017 0.0048 0.0029
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0131 0.092 0.2469
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0048 0.0135
Loa Loa (eye worm) fli-1 protein 0.0223 0.162 0.4542
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0183 0.0373
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0336 0.0874
Brugia malayi beta-lactamase family protein 0.0035 0.0183 0.0189
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0027 0.0123 0.0345
Brugia malayi Variant SH3 domain containing protein 0.0019 0.006 0.0043
Brugia malayi Protein kinase domain containing protein 0.0027 0.0123 0.0117
Entamoeba histolytica protein kinase, putative 0.0027 0.0123 0.3534
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0295 0.0765
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0048 0.0135
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0048 0.0135
Mycobacterium ulcerans lipase LipD 0.0035 0.0183 0.0373
Brugia malayi protein kinase C3,putative 0.002 0.0068 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0048 0.0029
Brugia malayi diacylglycerol kinase 0.0019 0.006 0.0043
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0027 0.0123 0.0345
Echinococcus granulosus N chimaerin 0.0019 0.006 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0048 0.0029
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2935 0.8231
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0321 0.2366 0.6585
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0024 0.000000071199
Echinococcus multilocularis raf serine:threonine protein kinase 0.0019 0.006 0.0169
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0131 0.092 0.253
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0023 0.009 0.0252
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0048 0.0135
Echinococcus granulosus unc 13 munc13 0.0023 0.009 0.0252
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0117 0.0327
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0431 0.1143
Onchocerca volvulus 0.0015 0.003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.3096 0.8684
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0089 0.0596 0.0678
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0135
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0378 0.0992
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0514
Brugia malayi thymidylate synthase 0.0478 0.3566 0.4191
Loa Loa (eye worm) AGC/PKN protein kinase 0.0027 0.0123 0.0345
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0048 0.0135
Echinococcus granulosus NDR protein kinase 0.0027 0.0123 0.0345
Brugia malayi Fli-1 protein 0.0223 0.162 0.1888
Mycobacterium ulcerans thymidylate synthase 0.0478 0.3566 1
Brugia malayi hypothetical protein 0.0124 0.0866 0.0996
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0089 0.0596 0.0678
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Brugia malayi Cytochrome P450 family protein 0.0018 0.0052 0.0034
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0131 0.092 0.2517
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0227 0.1653 0.4591
Onchocerca volvulus 0.0028 0.013 0.0118
Trypanosoma brucei rac serine-threonine kinase, putative 0.0027 0.0123 0.02
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0048 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Loa Loa (eye worm) hypothetical protein 0.0017 0.0048 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0048 0.0135
Schistosoma mansoni protein kinase C mu 0.002 0.0068 0.0125
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0514
Echinococcus granulosus lamin dm0 0.0026 0.0117 0.0327
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0183 0.0437
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0325 0.0849
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0478 0.3566 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0687 0.1926
Echinococcus multilocularis myotubularin protein 13 0.0019 0.006 0.0169
Schistosoma mansoni hypothetical protein 0.0051 0.0306 0.0797
Echinococcus granulosus protein kinase c epsilon type 0.0049 0.0295 0.0827
Loa Loa (eye worm) beta-lactamase 0.0035 0.0183 0.0514
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0024 0.0067
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.003 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0169
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0478 0.1341
Schistosoma mansoni coup transcription factor 0.0017 0.0048 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0123 0.0265
Schistosoma mansoni intermediate filament proteins 0.0026 0.0117 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0048 0.0135
Echinococcus granulosus raf serine:threonine protein kinase 0.0019 0.006 0.0169
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0687 0.1926
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0431 0.1149
Brugia malayi Common central domain of tyrosinase family protein 0.0089 0.0596 0.0678
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0048 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0183 0.0373
Brugia malayi PAS domain containing protein 0.0057 0.035 0.0386
Onchocerca volvulus 0.0089 0.0596 0.0638
Brugia malayi Cytochrome P450 family protein 0.003 0.0149 0.0148
Echinococcus granulosus myotubularin protein 13 0.0019 0.006 0.0169
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0014 0.0038
Echinococcus granulosus Protein kinase C brain isozyme 0.0171 0.1224 0.3433
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0048 0.0135
Entamoeba histolytica hypothetical protein 0.0042 0.0238 1
Echinococcus multilocularis serine threonine protein kinase 0.0152 0.1082 0.3033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0048 0.0135
Plasmodium vivax SET domain protein, putative 0.006 0.0378 0.0574
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0048 0.0069
Echinococcus granulosus intermediate filament protein 0.0026 0.0117 0.0327
Echinococcus multilocularis RNA directed DNA polymerase 0.0122 0.0847 0.2375

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 74 nM Displacement of [125I]D-Trp from rat GnRH receptor ChEMBL. 17937987
IC50 (binding) = 74 nM Displacement of [125I]D-Trp from rat GnRH receptor ChEMBL. 17937987
IC50 (functional) = 89 nM Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pitutary cells assessed as inhibition of GnRH stimulated LH release after 24 hrs ChEMBL. 17937987
IC50 (functional) = 89 nM Antagonist activity at GnRH receptor expressed in AP Han Wistar rat primary pitutary cells assessed as inhibition of GnRH stimulated LH release after 24 hrs ChEMBL. 17937987
IC50 (binding) = 195 nM Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells ChEMBL. 17937987
IC50 (binding) = 195 nM Displacement of [125I]D-Trp from human GnRH receptor expressed in HEK cells ChEMBL. 17937987
Solubility = 39 uM Solubility in 0.1 M phosphate buffer at pH 7.4 ChEMBL. 17937987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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