Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | tachykinin receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1236 | 0.3301 | 0.3301 |
Echinococcus multilocularis | protein dispatched 1 | 0.1236 | 0.3301 | 0.3301 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3003 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1236 | 0.3301 | 0.3301 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1409 | 0.3955 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3003 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3003 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3003 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1409 | 0.3955 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3003 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1409 | 0.3955 | 1 |
Echinococcus multilocularis | protein patched | 0.1236 | 0.3301 | 0.3301 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3003 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3003 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1236 | 0.3301 | 0.3301 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3003 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1409 | 0.3955 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1236 | 0.3301 | 0.3301 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1236 | 0.3301 | 0.3301 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3003 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 1 ml/min.kg | Plasma clearance in dog | ChEMBL. | 17637506 |
CL (ADMET) | = 4.5 ml/min.kg | Plasma clearance in rhesus monkey | ChEMBL. | 17637506 |
CL (ADMET) | = 19.6 ml/min.kg | Plasma clearance in rat | ChEMBL. | 17637506 |
F (ADMET) | = 68 % | Oral bioavailability in rhesus monkey | ChEMBL. | 17637506 |
F (ADMET) | = 100 % | Oral bioavailability in rat | ChEMBL. | 17637506 |
F (ADMET) | = 100 % | Oral bioavailability in dog | ChEMBL. | 17637506 |
IC50 (binding) | = 0.11 nM | Displacement of [3H]SP from human NK1 receptor expressed in CHO cells | ChEMBL. | 17637506 |
IC50 (binding) | = 0.11 nM | Displacement of [3H]SP from human NK1 receptor expressed in CHO cells | ChEMBL. | 17637506 |
IC50 (binding) | = 1730 nM | Binding affinity to NK2 receptor | ChEMBL. | 17637506 |
IC50 (binding) | = 1730 nM | Binding affinity to NK2 receptor | ChEMBL. | 17637506 |
IC50 (binding) | > 3000 nM | Binding affinity to NK3 receptor | ChEMBL. | 17637506 |
IC50 (binding) | > 3000 nM | Binding affinity to NK3 receptor | ChEMBL. | 17637506 |
ID50 (functional) | = 0.1 mg kg-1 | Inhibition of GR73632-induced foot tapping in iv dosed gerbils | ChEMBL. | 17637506 |
ID50 (functional) | = 0.17 mg kg-1 | Inhibition of separation-induced vocalizations in po dosed guinea pig after 4 hrs | ChEMBL. | 17637506 |
ID50 (functional) | = 0.25 mg kg-1 | Inhibition of GR73632-induced foot tapping in iv dosed gerbils after 4 hrs | ChEMBL. | 17637506 |
ID50 (functional) | = 0.45 mg kg-1 | Inhibition of GR73632-induced foot tapping in iv dosed gerbils after 24 hrs | ChEMBL. | 17637506 |
ID50 (functional) | = 0.9 mg kg-1 | Inhibition of GR73632-induced foot tapping in iv dosed gerbils after 1 hr | ChEMBL. | 17637506 |
Inhibition (functional) | = 100 % | Inhibition of GR73632-induced foot tapping in gerbils at 1 mg/kg, iv | ChEMBL. | 17637506 |
Inhibition (functional) | = 100 % | Inhibition of GR73632-induced foot tapping in gerbils at 3 mg/kg, iv after 24 hrs | ChEMBL. | 17637506 |
Occ50 (functional) | = 30 ng/ml | Receptor occupancy at NK1 receptor in iv dosed rhesus monkey brain after 4 hrs | ChEMBL. | 17637506 |
Occ90 (functional) | = 300 ng/ml | Receptor occupancy at NK1 receptor in iv dosed rhesus monkey brain after 4 hrs | ChEMBL. | 17637506 |
t1/2 (ADMET) | = 3.6 hr | Half life in rat | ChEMBL. | 17637506 |
t1/2 (ADMET) | = 5.7 hr | Half life in rhesus monkey | ChEMBL. | 17637506 |
t1/2 (ADMET) | = 20 hr | Half life in dog | ChEMBL. | 17637506 |
Vd (ADMET) | = 1.6 L/Kg | Volume of distribution in dog | ChEMBL. | 17637506 |
Vd (ADMET) | = 2.3 L/Kg | Volume of distribution in rhesus monkey | ChEMBL. | 17637506 |
Vd (ADMET) | = 6.2 L/Kg | Volume of distribution in rat | ChEMBL. | 17637506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.