Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | formyl peptide receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | formyl peptide receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | G-protein coupled receptor, putative | formyl peptide receptor 2 | 351 aa | 303 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Echinococcus granulosus | dna polymerase eta | 0.0048 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3151 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.6422 | 0.4775 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.3151 | 0.1904 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.3151 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3151 | 0.1904 |
Echinococcus multilocularis | dna polymerase eta | 0.0048 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.3151 | 0.3151 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3151 | 0.3151 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.3151 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.3151 | 0.3151 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.3151 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3151 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.3151 | 0.3151 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.6422 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.3151 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.6422 | 0.4775 |
Schistosoma mansoni | DNA polymerase eta | 0.0048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3151 | 0.1904 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3151 | 0.3151 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.3151 | 0.3151 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3151 | 0.1904 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.3151 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.3151 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human FPR2 expressed in RBL-2H3 cells assessed as induction of calcium mobilization | ChEMBL. | 20870313 | |
EC50 (functional) | = 0.83 uM | Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay | ChEMBL. | 17920884 |
EC50 (functional) | = 0.83 uM | Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay | ChEMBL. | 17920884 |
EC50 (functional) | > 10 uM | Agonist activity at human recombinant FPR expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay | ChEMBL. | 17920884 |
EC50 (functional) | > 10 uM | Agonist activity at human recombinant FPR expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay | ChEMBL. | 17920884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.