Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Agaricus bisporus | Tyrosinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0018 | 0.0027 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0249 | 0.0552 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 0.1254 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.3048 | 0.6407 |
Onchocerca volvulus | 0.0111 | 0.2758 | 1 | |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0161 | 0.4403 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1037 | 0.1593 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0059 | 0.1037 | 0.157 |
Brugia malayi | bZIP transcription factor family protein | 0.0083 | 0.1815 | 0.277 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.3048 | 0.6407 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.1254 | 0.1906 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0059 | 0.1037 | 0.1778 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.2647 | 0.5345 |
Onchocerca volvulus | 0.0065 | 0.1223 | 0.44 | |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.2647 | 0.5345 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0031 | 0.0103 | 0.0149 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.0103 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1037 | 0.1593 |
Onchocerca volvulus | 0.0111 | 0.2758 | 1 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.0103 | 0.0132 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0631 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0059 | 0.1037 | 0.2432 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0059 | 0.1037 | 0.1778 |
Brugia malayi | follicle stimulating hormone receptor | 0.0224 | 0.6509 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0031 | 0.0103 | 0.0158 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0083 | 0.1815 | 0.429 |
Schistosoma mansoni | tyrosinase precursor | 0.0111 | 0.2758 | 0.478 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0103 | 0.0158 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0083 | 0.1815 | 0.3136 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 1 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.2758 | 0.4221 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.2647 | 0.5345 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0059 | 0.1037 | 0.1778 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.3048 | 0.6407 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0059 | 0.1037 | 0.1778 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 1 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0329 | 0.0544 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0329 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1299 | 0.2235 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2758 | 0.4237 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1037 | 0.1593 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0631 | 0.097 |
Schistosoma mansoni | thyroid hormone receptor | 0.0201 | 0.575 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1254 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0059 | 0.1037 | 0.2432 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0059 | 0.1037 | 0.2432 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0059 | 0.1037 | 0.157 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0201 | 0.575 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0224 | 0.6509 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0155 | 0.4208 | 0.731 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0111 | 0.2758 | 0.4237 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0059 | 0.1037 | 0.157 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0059 | 0.1037 | 0.157 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0142 | 0.3771 | 0.8957 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0059 | 0.1037 | 0.157 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1254 | 0.2952 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0329 | 0.0744 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0631 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0059 | 0.1037 | 0.1778 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0249 | 0.0357 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0059 | 0.1037 | 0.157 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1254 | 0.1927 |
Brugia malayi | nuclear receptor RXR | 0.0031 | 0.0103 | 0.0132 |
Schistosoma mansoni | coup transcription factor | 0.0059 | 0.1037 | 0.1778 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0031 | 0.0103 | 0.0149 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.3771 | 0.6547 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0111 | 0.2758 | 0.4237 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0329 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0059 | 0.1037 | 0.1593 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0059 | 0.1037 | 0.157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0059 | 0.1037 | 0.1593 |
Schistosoma mansoni | nuclear hormone receptor | 0.0059 | 0.1037 | 0.1778 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0155 | 0.4208 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0059 | 0.1037 | 0.1778 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0059 | 0.1037 | 0.2432 |
Brugia malayi | hypothetical protein | 0.0065 | 0.1223 | 0.1857 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1037 | 0.1593 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0059 | 0.1037 | 0.157 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0631 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1254 | 0.2158 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0059 | 0.1037 | 0.1593 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0059 | 0.1037 | 0.1778 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0103 | 0.0132 |
Schistosoma mansoni | thyroid hormone receptor | 0.0201 | 0.575 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0059 | 0.1037 | 0.157 |
Schistosoma mansoni | jun-related protein | 0.0067 | 0.1299 | 0.2235 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0059 | 0.1037 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1037 | 0.1593 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0059 | 0.1037 | 0.157 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0249 | 0.0404 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0059 | 0.1037 | 0.1778 |
Schistosoma mansoni | tyrosinase precursor | 0.0111 | 0.2758 | 0.478 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.2647 | 0.5345 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.174 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1037 | 0.1593 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0059 | 0.1037 | 0.1778 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0123 | 0.3163 | 0.5486 |
Brugia malayi | ecdysteroid receptor | 0.0059 | 0.1037 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0103 | 0.0158 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0142 | 0.3771 | 0.6547 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0631 | 0.097 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.2647 | 0.5345 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0103 | 0.0158 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0631 | 0.1464 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.2758 | 0.4221 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0111 | 0.2758 | 0.4221 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0631 | 0.107 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0018 | 0.0027 |
Echinococcus granulosus | FTZ F1 alpha | 0.0059 | 0.1037 | 0.2432 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0059 | 0.1037 | 0.1778 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0111 | 0.2758 | 0.4221 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.1254 | 0.1031 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0059 | 0.1037 | 0.1593 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1254 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0059 | 0.1037 | 0.1778 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0059 | 0.1037 | 0.1778 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1037 | 0.1593 |
Onchocerca volvulus | 0.0111 | 0.2758 | 1 | |
Brugia malayi | nuclear hormone receptor | 0.0059 | 0.1037 | 0.157 |
Brugia malayi | ShTK domain containing protein | 0.0111 | 0.2758 | 0.4221 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0018 | 0.0027 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0059 | 0.1037 | 0.1778 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0059 | 0.1037 | 0.1778 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0059 | 0.1037 | 0.1778 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.3048 | 0.2281 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0329 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0059 | 0.1037 | 0.1593 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0059 | 0.1037 | 0.2432 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0059 | 0.1037 | 0.372 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0631 | 0.0945 |
Onchocerca volvulus | 0.0111 | 0.2758 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0111 | 0.2758 | 0.4221 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0059 | 0.1037 | 0.157 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0161 | 0.4403 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1254 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0161 | 0.4403 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1254 | 0.2158 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0103 | 0.0158 |
Brugia malayi | nuclear receptor NHR-88 | 0.0059 | 0.1037 | 0.157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0059 | 0.1037 | 0.1593 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0059 | 0.1037 | 0.1593 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0059 | 0.1037 | 0.157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0059 | 0.1037 | 0.1593 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0059 | 0.1037 | 0.372 |
Brugia malayi | steroid hormone receptor | 0.0059 | 0.1037 | 0.157 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0631 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0059 | 0.1037 | 0.157 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0249 | 0.0404 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0103 | 0.0132 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0059 | 0.1037 | 0.157 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0059 | 0.1037 | 0.2432 |
Echinococcus granulosus | jun protein | 0.0083 | 0.1815 | 0.429 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0103 | 0.0158 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0031 | 0.0103 | 0.0204 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0249 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2758 | 0.4237 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0059 | 0.1037 | 0.372 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1037 | 0.1593 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0631 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0083 | 0.1815 | 0.3136 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.2647 | 0.5345 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0631 | 0.0945 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0059 | 0.1037 | 0.157 |
Onchocerca volvulus | 0.0059 | 0.1037 | 0.372 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0111 | 0.2758 | 0.4237 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.0103 | 0.0132 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0059 | 0.1037 | 0.1778 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0059 | 0.1037 | 0.2432 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.