Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 32 ug ml-1 | Concentration of compound required against Mycobacterium avium; Range is 4-32 ug/mL | ChEMBL. | 14998335 |
IC50 (binding) | = 4.4 nM | Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined | ChEMBL. | 15115391 |
IC50 (binding) | = 4.4 nM | Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined | ChEMBL. | 15115391 |
IC50 (binding) | = 5000 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporidium parvum of bovine origin | ChEMBL. | 14998335 |
IC50 (binding) | = 5000 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporidium parvum of bovine origin | ChEMBL. | 14998335 |
IC50 (binding) | = 8000 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporidium parvum of human origin | ChEMBL. | 14998335 |
IC50 (binding) | = 8000 nM | Inhibitory concentration against dihdrofolate reductace enzyme of humans | ChEMBL. | 14998335 |
IC50 (binding) | = 8000 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporidium parvum of human origin | ChEMBL. | 14998335 |
IC50 (binding) | = 8000 nM | Inhibitory concentration against dihdrofolate reductace enzyme of humans | ChEMBL. | 14998335 |
IC50 (binding) | = 0.0058 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from Mycobacterium avium (Ma) | ChEMBL. | 11754594 |
IC50 (binding) | = 0.0058 uM | Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium avium | ChEMBL. | 12699390 |
IC50 (binding) | = 0.0058 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from Mycobacterium avium (Ma) | ChEMBL. | 11754594 |
IC50 (binding) | = 0.0058 uM | Inhibition of Dihydrohydrofolate reductase(DHFR) of Mycobacterium avium | ChEMBL. | 12699390 |
IC50 (binding) | = 0.049 uM | In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase. | ChEMBL. | 11754594 |
IC50 (binding) | = 0.049 uM | In vitro inhibition of Pneumocystis carinii (Pc) dihydrofolate reductase. | ChEMBL. | 11754594 |
IC50 (binding) | = 0.054 uM | Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis carinii | ChEMBL. | 12699390 |
IC50 (binding) | = 0.054 uM | Inhibition of Dihydrohydrofolate reductase(DHFR) of Pneumocystis carinii | ChEMBL. | 12699390 |
IC50 (binding) | = 0.11 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from Toxoplasma gondii (Tg) | ChEMBL. | 11754594 |
IC50 (binding) | = 0.11 uM | Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii | ChEMBL. | 12699390 |
IC50 (binding) | = 0.11 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from Toxoplasma gondii (Tg) | ChEMBL. | 11754594 |
IC50 (binding) | = 0.11 uM | Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii | ChEMBL. | 12699390 |
IC50 (binding) | = 3.9 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liver | ChEMBL. | 11754594 |
IC50 (binding) | = 3.9 uM | Inhibition of partially purified dihydrofolate reductase (DHFR) from rat liver | ChEMBL. | 11754594 |
IC50 (binding) | = 4.6 uM | Inhibition Dihydrohydrofolate reductase(DHFR) of rat liver | ChEMBL. | 12699390 |
IC50 (binding) | = 4.6 uM | Inhibition Dihydrohydrofolate reductase(DHFR) of rat liver | ChEMBL. | 12699390 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC100 | ChEMBL. | 14998335 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC101 | ChEMBL. | 14998335 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC109 | ChEMBL. | 14998335 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC16 | ChEMBL. | 14998335 |
MIC (functional) | > 32 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC108 | ChEMBL. | 14998335 |
MIC50 (functional) | = 16 ug ml-1 | Minimum inhibitory concentration required for 50 percent inhibition of Mycobacterium avium isolate | ChEMBL. | 14998335 |
MIC90 (functional) | = 32 ug ml-1 | Minimum inhibitory concentration required for 90 percent inhibition of Mycobacterium avium isolate | ChEMBL. | 14998335 |
Selectivity index (binding) | = 42 | Selective index for Dihydrofolate reductase was determined by IC50(rat liver) / IC50(T. gondii) | ChEMBL. | 12699390 |
Selectivity index (binding) | = 79 | Relative affinity for Dihydrofolate reductase of rat liver and Mycobacterium avium | ChEMBL. | 12699390 |
Selectivity index (binding) | = 85 | Relative affinity for Dihydrofolate reductase from rat liver and P. carinii | ChEMBL. | 12699390 |
SI (binding) | = 35 | Selective index against dihydrofolate reductase of Rat liver and T. gondii | ChEMBL. | 11754594 |
SI (binding) | = 80 | Selective index against dihydrofolate reductase of Rat liver and dihydrofolate reductase of P. carinii | ChEMBL. | 11754594 |
SI (binding) | = 660 | Selective index for rat liver and M. avium dihydrofolate reductase | ChEMBL. | 11754594 |
SI (binding) | = 1 | Ratio of DHFR inhibition of humans to that of Cryptosporidium parvum of human origin | ChEMBL. | 14998335 |
SI (binding) | = 35 | Selective index against dihydrofolate reductase of Rat liver and T. gondii | ChEMBL. | 11754594 |
SI (binding) | = 80 | Selective index against dihydrofolate reductase of Rat liver and dihydrofolate reductase of P. carinii | ChEMBL. | 11754594 |
SI (binding) | = 660 | Selectivity index was determined by the ratio for IC50 of rat liver DHFR to the IC50 of Mycobacterium avium DHFR | ChEMBL. | 15115391 |
SI (binding) | = 660 | Selective index for rat liver and M. avium dihydrofolate reductase | ChEMBL. | 11754594 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.