TDR Targets

Basic information

Technical information

TDR Targets ID: 501191
Name: 4-[7-(dimethylaminomethyl)-2-(4-fluorophenyl) imidazo[1,2-a]pyridin-3-yl]-N-[(2-fluoropheny l)methyl]pyrimidin-2-amine
MW: 470.516 | Formula: C27H24F2N6
H donors: 1 H acceptors: 3 LogP: 5.25 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CN(Cc1ccn2c(c1)nc(c2c1ccnc(n1)NCc1ccccc1F)c1ccc(cc1)F)C
InChi: 1S/C27H24F2N6/c1-34(2)17-18-12-14-35-24(15-18)33-25(19-7-9-21(28)10-8-19)26(35)23-11-13-30-27(32-23)31-16-20-5-3-4-6-22(20)29/h3-15H,16-17H2,1-2H3,(H,30,31,32)
InChiKey: DUIKAMVHIYZMQU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[7-(dimethylaminomethyl)-2-(4-fluorophenyl)-3-imidazo[1,2-a]pyridinyl]-N-[(2-fluorophenyl)methyl]-2-pyrimidinamine
[3-[2-[(2-fluorobenzyl)amino]pyrimidin-4-yl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methyl-dimethyl-amine
4-[7-(dimethylaminomethyl)-2-(4-fluorophenyl)imidazo[3,2-a]pyridin-3-yl]-N-[(2-fluorophenyl)methyl]pyrimidin-2-amine
4-[7-(dimethylaminomethyl)-2-(4-fluorophenyl)-3-imidazo[3,2-a]pyridinyl]-N-[(2-fluorophenyl)methyl]-2-pyrimidinamine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Eimeria tenella	cGMP-dependent protein kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium knowlesi	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium berghei	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium hominis	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase 2, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Babesia bovis	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127599	All targets in OG5_127599
Theileria parva	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Loa Loa (eye worm)	AGC/PKG protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Brugia malayi	Egg laying defective protein 4	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127599	All targets in OG5_127599
Cryptosporidium parvum	cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding domains and a Ser/Thr kinase domain	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium falciparum	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium yoelii	cGMP-dependent protein kinase-related	Get druggable targets OG5_127599	All targets in OG5_127599
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Neospora caninum	AGC kinase TgPKG1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0347	0.0049
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.0165	0.4209	1
Chlamydia trachomatis	dihydrofolate reductase	0.037	1	1
Brugia malayi	Pre-SET motif family protein	0.0202	0.5242	0.5204
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0197	0.017
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0641	0.0565
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.034	0.9151	0.9145
Schistosoma mansoni	glutaminase	0.0265	0.7034	0.701
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.052	0.0632
Echinococcus multilocularis	inositol monophosphatase 1	0.0146	0.3658	0.3607
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0146	0.3658	0.364
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.052	0.0632
Mycobacterium ulcerans	glutaminase	0.0265	0.7034	0.7026
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.4001	0.3953
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0065	0.1355	0.1833
Echinococcus multilocularis	geminin	0.0164	0.418	0.4133
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0146	0.3658	0.8666
Brugia malayi	Zinc finger, C2H2 type family protein	0.0065	0.1355	0.1285
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0935	0.0862
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0327	0.0718
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0935	0.0862
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.052	0.0632
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0065	0.1355	0.1285
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.5242	0.5229
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.2149	0.2086
Trichomonas vaginalis	glutaminase, putative	0.0265	0.7034	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.052	0.1064
Brugia malayi	Egg laying defective protein 4	0.006	0.1222	0.1151
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.3331	0.3277
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0197	0.017
Brugia malayi	jmjC domain containing protein	0.0093	0.2149	0.2086
Schistosoma mansoni	alpha-glucosidase	0.0136	0.3378	0.3324
Schistosoma mansoni	dihydrofolate reductase	0.037	1	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0347	0.0269
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0141	0.3531	0.838
Loa Loa (eye worm)	hypothetical protein	0.002	0.008	0.0053
Brugia malayi	glutaminase DH11.1	0.0265	0.7034	0.701
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0347	0.032
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.008	0.008
Brugia malayi	Pre-SET motif family protein	0.0029	0.0347	0.0269
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0327	0.0249
Echinococcus granulosus	dihydrofolate reductase	0.037	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0197	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0034	0.049	0.0464
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0935	0.0911
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.037	1	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0146	0.3658	0.5145
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0065	0.1355	0.3088
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0165	0.4209	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0347	0.0269
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.052	0.0443
Onchocerca volvulus		0.023	0.6032	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0316	0.0238
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.052	0.0443
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0146	0.3658	0.5145
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.049	0.0413
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0131	0.3225	0.3089
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0141	0.3531	0.838
Onchocerca volvulus	Alhambra homolog	0.0028	0.0327	0.0224
Schistosoma mansoni	hypothetical protein	0.0028	0.0327	0.0249
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.034	0.9151	0.9145
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0197	0.017
Echinococcus multilocularis	expressed conserved protein	0.006	0.1222	0.1151
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0197	0.017
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0146	0.3658	0.5145
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0065	0.1355	0.1833
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.052	0.1064
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0146	0.3658	0.8581
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.0165	0.4209	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0327	0.0249
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0496	0.0419
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0034	0.049	0.0413
Brugia malayi	Inositol-1	0.0146	0.3658	0.3607
Echinococcus multilocularis	dihydrofolate reductase	0.037	1	1
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0165	0.4209	0.4162
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0065	0.1355	0.1285
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0197	0.0326
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.118	0.1156
Plasmodium vivax	SET domain protein, putative	0.0029	0.0347	0.0763
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.052	0.0632
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0158	0.4001	0.3953
Loa Loa (eye worm)	glutaminase 2	0.0265	0.7034	0.7026
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0158	0.4001	0.3985
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0146	0.3658	0.8666
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0327	0.0301
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0065	0.1355	0.1285
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0197	0.0282
Plasmodium falciparum	dihydroorotate dehydrogenase	0.0165	0.4209	1
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0141	0.3531	0.8255
Giardia lamblia	PHD finger protein 15	0.0028	0.0327	1
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0165	0.4209	1
Brugia malayi	Dihydrofolate reductase	0.037	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.3331	0.3277
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.006	0.1222	0.1151
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0347	0.0269
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.0165	0.4209	1
Brugia malayi	Bromodomain containing protein	0.0028	0.0327	0.0249
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.052	0.0632
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0327	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0197	0.017
Loa Loa (eye worm)	glutaminase	0.0265	0.7034	0.7026
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0197	0.0326
Echinococcus granulosus	cGMP dependent protein kinase	0.006	0.1222	0.1151
Schistosoma mansoni	inositol monophosphatase	0.0146	0.3658	0.3607
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.034	0.9151	0.9145
Echinococcus multilocularis	peregrin	0.0028	0.0327	0.0249
Loa Loa (eye worm)	inositol-1	0.0146	0.3658	0.364
Schistosoma mansoni	hypothetical protein	0.0164	0.418	0.4133
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0197	0.0326
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.008	0.0053
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0347	0.0269
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.052	0.1228
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0065	0.1355	0.1833
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0141	0.3531	0.8359
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0141	0.3531	0.8359
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0197	0.017
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.008	0.0053
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.037	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0347	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0197	0.017
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0134	0.3331	0.3313
Echinococcus granulosus	lysosomal alpha glucosidase	0.0158	0.4001	0.3953
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0496	0.047
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.052	0.0494
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0197	0.0118
Brugia malayi	jmjC domain containing protein	0.0034	0.0496	0.0419
Echinococcus granulosus	inositol monophosphatase 1	0.0146	0.3658	0.3607
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.052	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0197	0.017
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0327	0.0249
Trichomonas vaginalis	set domain proteins, putative	0.023	0.6032	0.8559
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.006	0.1222	0.2305
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.052	0.1064
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.1222	0.1151
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.052	0.0632
Leishmania major	dihydroorotate dehydrogenase	0.0165	0.4209	1
Schistosoma mansoni	hypothetical protein	0.0164	0.418	0.4133
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0065	0.1355	0.1833
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0065	0.1355	0.3563
Schistosoma mansoni	inositol monophosphatase	0.0146	0.3658	0.3607
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0641	0.0565
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0146	0.3658	0.8666
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.052	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0899	0.0874
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0065	0.1355	0.1833
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0134	0.3331	0.3277
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0131	0.3225	0.3225
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0146	0.3658	0.8666
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.008	0.008
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0197	0.017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.3331	0.3277
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.034	0.9151	0.9145
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0141	0.3531	0.8359
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.3331	0.3277
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0146	0.3658	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.006	0.1222	0.1151
Plasmodium falciparum	cGMP-dependent protein kinase	0.006	0.1222	0.2857
Brugia malayi	PHD-finger family protein	0.0028	0.0327	0.0249
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.0165	0.4209	0.4209
Schistosoma mansoni	alpha-glucosidase	0.0136	0.3378	0.3324
Echinococcus granulosus	geminin	0.0164	0.418	0.4133
Trypanosoma brucei	glucosidase, putative	0.0035	0.052	0.1064
Onchocerca volvulus		0.0029	0.0347	0.0257
Schistosoma mansoni	alpha glucosidase	0.0035	0.052	0.0443
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0496	0.0419
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0197	0.0118
Echinococcus granulosus	cGMP dependent protein kinase 1	0.006	0.1222	0.1151
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.0165	0.4209	1
Schistosoma mansoni	dihydroorotate dehydrogenase	0.0165	0.4209	0.4162
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.3331	0.3277
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.034	0.9151	0.9149
Loa Loa (eye worm)	dihydrofolate reductase	0.037	1	1
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0165	0.4209	1
Onchocerca volvulus		0.0091	0.2115	0.3287
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.161	0.1542
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.1222	0.1151
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0347	0.0269
Loa Loa (eye worm)	hypothetical protein	0.005	0.0935	0.0911
Loa Loa (eye worm)	AGC/PKG protein kinase	0.006	0.1222	0.1198
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0065	0.1355	0.1833
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.0165	0.4209	0.4092
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.052	0.1228
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.052	0.0632
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.4001	0.3953
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0197	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0327	0.0301
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0347	0.0269
Mycobacterium ulcerans	hypothetical protein	0.0059	0.1212	0.1187
Echinococcus granulosus	cGMP dependent protein kinase 1	0.006	0.1222	0.1151
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0197	0.017
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0197	0.0282
Echinococcus granulosus	peregrin	0.0028	0.0327	0.0249
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0496	0.0419
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0197	0.0197
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.3331	0.3277
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.052	0.0632
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.0165	0.4209	0.4162
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.2149	0.2086
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.052	0.0495
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0496	0.0419
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.3331	0.3277
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0197	0.017
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.0165	0.4209	0.4193
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.037	1	1
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0065	0.1355	0.1285
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.008	0.0053
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0197	0.0197

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	< 50 %	Anticococcidal activity against Eimeria acervulina in Chick assessed as redution in oocyte at 25 ppm relative to control	ChEMBL.	17433505
Activity (functional)	= 80 %	Anticococcidal activity against Eimeria tenella in Chick assessed as redution in oocyte at 25 ppm relative to control	ChEMBL.	17433505
Activity (functional)	= 80 %	Anticococcidal activity against Eimeria mitis in Chick assessed as redution in oocyte at 25 ppm relative to control	ChEMBL.	17433505
Activity (functional)	= 80 %	Anticococcidal activity against Eimeria maxima in Chick assessed as redution in oocyte at 25 ppm relative to control	ChEMBL.	17433505
IC50 (binding)	= 0.087 nM	Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay	ChEMBL.	17433505
IC50 (binding)	= 0.087 nM	Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay	ChEMBL.	17433505

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL401102
PubChem: 24746543

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 501191