Detailed information for compound 501341

Basic information

Technical information
  • TDR Targets ID: 501341
  • Name: 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenoth iazine-2-carbonitrile
  • MW: 365.492 | Formula: C21H23N3OS
  • H donors: 1 H acceptors: 2 LogP: 3.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1
  • InChi: 1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
  • InChiKey: LUALIOATIOESLM-UHFFFAOYSA-N  

Network

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Synonyms

  • Pericyazine
  • Propericiazine
  • 10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile
  • 10-[3-(4-hydroxy-1-piperidinyl)propyl]-2-phenothiazinecarbonitrile
  • 10-[3-(4-hydroxypiperidino)propyl]phenothiazine-2-carbonitrile
  • 2622-26-6
  • KBio2_004662
  • BSPBio_002336
  • KBio2_007230
  • DivK1c_000874
  • NINDS_000874
  • D01485
  • Neuleptil (TN)
  • Propericiazine (JAN)
  • KBioSS_002094
  • Spectrum3_000748
  • KBioGR_000819
  • KBio1_000874
  • Spectrum2_001604
  • 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile
  • 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine
  • 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine
  • 4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)-
  • 6909 RP
  • Aolept
  • BRN 0576739
  • Bayer 1409
  • Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine [French]
  • EINECS 220-071-3
  • F.I. 6145
  • IC 6002
  • Nemactil
  • Neulactil
  • Neuleptil
  • Periciazina [INN-Spanish]
  • Periciazine
  • Periciazine [INN]
  • Periciazinum [INN-Latin]
  • Phenothiazine-2-carbonitrile, 10-(3-(4-hydroxypiperidino)propyl)-
  • Piperocyanomazine
  • RP 8908
  • SKF 20,716
  • WH 7508
  • NCGC00095086-01
  • Spectrum4_000210
  • Spectrum5_001747
  • NCGC00095086-02
  • Spectrum_001614
  • SPBio_001607
  • IDI1_000874
  • SPECTRUM1503936
  • KBio2_002094
  • KBio3_001556

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Equus caballus Cholinesterase Starlite/ChEMBL References
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi trypanothione reductase, putative Curated by TDR Targets No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Bos taurus Acetylcholinesterase Starlite/ChEMBL References
Trypanosoma cruzi trypanothione reductase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Rattus norvegicus Androgen Receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Get druggable targets OG5_138783 All targets in OG5_138783
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania infantum acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Get druggable targets OG5_138783 All targets in OG5_138783
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Get druggable targets OG5_138783 All targets in OG5_138783
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Get druggable targets OG5_138783 All targets in OG5_138783
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Get druggable targets OG5_138783 All targets in OG5_138783
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_138783 All targets in OG5_138783
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis dihydrolipoamide dehydrogenase Get druggable targets OG5_149690 All targets in OG5_149690
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_138783 All targets in OG5_138783
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei dihydrolipoamide dehydrogenase Get druggable targets OG5_149690 All targets in OG5_149690
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma brucei dihydrolipoamide dehydrogenase Get druggable targets OG5_143064 All targets in OG5_143064
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Leishmania mexicana dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Leishmania donovani acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Get druggable targets OG5_138783 All targets in OG5_138783
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   613 aa 564 aa 30.3 %
Plasmodium falciparum thioredoxin reductase dihydrolipoamide dehydrogenase, putative 550 aa 523 aa 19.5 %
Onchocerca volvulus Galectin homolog Cholinesterase   574 aa 531 aa 39.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Brugia malayi Carboxylesterase family protein Cholinesterase   574 aa 538 aa 31.4 %
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   613 aa 627 aa 33.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 189 aa 197 aa 20.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast dihydrolipoamide dehydrogenase, putative 551 aa 549 aa 22.9 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 492 aa 548 aa 21.5 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   613 aa 573 aa 26.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast dihydrolipoamide dehydrogenase, putative 510 aa 550 aa 25.8 %
Echinococcus granulosus neuroligin Cholinesterase   574 aa 492 aa 24.4 %
Onchocerca volvulus Carnitine O-palmitoyltransferase 2, mitochondrial homolog Acetylcholinesterase   613 aa 511 aa 39.9 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast dihydrolipoamide dehydrogenase, putative 510 aa 550 aa 26.0 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   613 aa 601 aa 23.6 %
Brugia malayi Thioredoxin reductase dihydrolipoamide dehydrogenase, putative 551 aa 497 aa 20.3 %
Schistosoma japonicum ko:K01050 cholinesterase [EC3.1.1.8], putative Cholinesterase   574 aa 577 aa 36.9 %
Onchocerca volvulus Acetylcholinesterase   613 aa 552 aa 31.3 %
Plasmodium falciparum thioredoxin reductase dihydrolipoamide dehydrogenase, putative 550 aa 523 aa 19.5 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   613 aa 534 aa 23.2 %
Schistosoma mansoni gliotactin Cholinesterase   574 aa 587 aa 27.9 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   613 aa 491 aa 26.7 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   613 aa 527 aa 32.3 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   613 aa 627 aa 34.0 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   613 aa 561 aa 24.6 %
Onchocerca volvulus Acetylcholinesterase   613 aa 565 aa 26.0 %
Onchocerca volvulus Putative nuclear protein Acetylcholinesterase   613 aa 572 aa 41.6 %
Onchocerca volvulus Acetylcholinesterase   613 aa 613 aa 26.8 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   613 aa 569 aa 31.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus neuroligin 0.0028 0.005 0.0154
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.006 0.046 0.1427
Trichomonas vaginalis glutathione reductase, putative 0.0224 0.2582 1
Echinococcus multilocularis acetylcholinesterase 0.0164 0.1802 0.5592
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0486 0.1508
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0224 0.2582 0.798
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.006 0.046 0.1427
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0224 0.2582 0.8011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0589 0.7276 0.7145
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.006 0.046 0.1427
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.006 0.046 0.1621
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0486 0.0027
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.006 0.046 0.1427
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.005 0.0154
Schistosoma mansoni lipoxygenase 0.01 0.0976 0.3028
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0224 0.2582 1
Loa Loa (eye worm) thioredoxin reductase 0.0274 0.3223 1
Echinococcus granulosus lamin 0.0033 0.0113 0.035
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0224 0.2582 0.8011
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.006 0.046 0.1293
Onchocerca volvulus 0.0028 0.005 0.1079
Loa Loa (eye worm) carboxylesterase 0.0028 0.005 0.0154
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.006 0.046 0.1427
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0274 0.3223 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.006 0.046 0.1621
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0113 0.035
Plasmodium vivax ferrodoxin reductase, putative 0.006 0.046 0.1427
Trypanosoma brucei protein kinase, putative 0.0062 0.0486 0.0027
Loa Loa (eye worm) programmed cell death 8 0.006 0.046 0.1427
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0154
Plasmodium vivax glutathione reductase, putative 0.0274 0.3223 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0028 0.005 0.0154
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0224 0.2582 0.2224
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0165 0.1815 0.5632
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0224 0.2582 0.2224
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0154
Mycobacterium tuberculosis Putative ferredoxin reductase 0.006 0.046 0.1293
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0224 0.2582 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.006 0.046 0.1293
Schistosoma mansoni sulfide quinone reductase 0.006 0.046 0.1427
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.006 0.046 0.1293
Schistosoma mansoni hypothetical protein 0.0205 0.2329 0.7227
Schistosoma mansoni hypothetical protein 0.0205 0.2329 0.7227
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0113 0.035
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0224 0.2582 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0486 0.1723
Schistosoma mansoni neuroligin 3 (S09 family) 0.0028 0.005 0.0154
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.006 0.046 0.1293
Schistosoma mansoni acetylcholinesterase 0.0028 0.005 0.0154
Mycobacterium ulcerans ferredoxin reductase 0.006 0.046 0.1621
Loa Loa (eye worm) glutathione reductase 0.0274 0.3223 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.006 0.046 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1528 0.4741
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0224 0.2582 0.8011
Echinococcus granulosus lamin dm0 0.0033 0.0113 0.035
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0224 0.2582 0.8011
Echinococcus multilocularis glutamate synthase 0.006 0.046 0.1427
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.005 0.0154
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0224 0.2582 0.8011
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.006 0.046 0.1427
Trypanosoma brucei trypanothione reductase 0.0274 0.3223 0.2896
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0326
Mycobacterium ulcerans hypothetical protein 0.006 0.046 0.1621
Brugia malayi Thioredoxin reductase 0.0274 0.3223 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.006 0.046 0.1427
Plasmodium falciparum ferrodoxin reductase-like protein 0.006 0.046 0.1427
Echinococcus multilocularis geminin 0.0205 0.2329 0.7227
Mycobacterium tuberculosis Probable dehydrogenase 0.006 0.046 0.1293
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0589 0.7276 0.7145
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0224 0.2582 0.8011
Schistosoma mansoni glutamate synthase 0.006 0.046 0.1427
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0224 0.2582 0.8011
Toxoplasma gondii NADPH-glutathione reductase 0.0224 0.2582 0.768
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0154
Plasmodium falciparum thioredoxin reductase 0.0274 0.3223 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.006 0.046 0.1621
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.006 0.046 0.1427
Echinococcus multilocularis musashi 0.0033 0.0113 0.035
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0486 0.0027
Loa Loa (eye worm) carboxylesterase 0.0028 0.005 0.0154
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0224 0.2582 1
Schistosoma mansoni lipoxygenase 0.0142 0.1528 0.4741
Trichomonas vaginalis glutamate synthase, putative 0.006 0.046 0.1621
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.006 0.046 0.1427
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0673 0.8368 0.8289
Trichomonas vaginalis disulfide oxidoreductase, putative 0.006 0.046 0.1621
Schistosoma mansoni BC026374 protein (S09 family) 0.0028 0.005 0.0154
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0113 0.035
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0154
Loa Loa (eye worm) acetylcholinesterase 1 0.0164 0.1802 0.5592
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0028 0.005 0.0154
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.006 0.046 0.1621
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.006 0.046 0.1427
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0486 0.1508
Brugia malayi Carboxylesterase family protein 0.0164 0.1802 0.5592
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0224 0.2582 0.8011
Mycobacterium ulcerans dehydrogenase 0.006 0.046 0.1621
Entamoeba histolytica thioredoxin reductase, putative 0.006 0.046 0.5
Trichomonas vaginalis disulfide oxidoreductase, putative 0.006 0.046 0.1621
Echinococcus granulosus BC026374 protein S09 family 0.0028 0.005 0.0154
Trichomonas vaginalis apoptosis inducing factor, putative 0.006 0.046 0.1621
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0486 0.1508
Brugia malayi Carboxylesterase family protein 0.0028 0.005 0.0154
Onchocerca volvulus 0.006 0.046 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0113 0.035
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.006 0.046 0.5
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1528 0.4741
Brugia malayi Carboxylesterase family protein 0.0028 0.005 0.0154
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0486 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0486 0.1723
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0486 0.1508
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.006 0.046 0.1427
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.006 0.046 0.1293
Echinococcus multilocularis carboxylesterase 5A 0.0164 0.1802 0.5592
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.006 0.046 0.1621
Trichomonas vaginalis mercuric reductase, putative 0.0224 0.2582 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.006 0.046 0.1427
Echinococcus granulosus thioredoxin glutathione reductase 0.0274 0.3223 1
Brugia malayi glutamate synthase 0.006 0.046 0.1427
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0224 0.2582 0.2224
Echinococcus multilocularis para nitrobenzyl esterase 0.0028 0.005 0.0154
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0154
Schistosoma mansoni sulfide quinone reductase 0.006 0.046 0.1427
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0589 0.7276 0.7145
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0224 0.2582 1
Plasmodium falciparum glutathione reductase 0.0274 0.3223 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.006 0.046 0.1427
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.006 0.046 0.1621
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.006 0.046 0.1427
Mycobacterium ulcerans glutamate synthase subunit beta 0.006 0.046 0.1621
Schistosoma mansoni intermediate filament proteins 0.0033 0.0113 0.035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0673 0.8368 0.8289
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.006 0.046 0.1293
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0165 0.1815 0.5632
Onchocerca volvulus 0.0028 0.005 0.1079
Loa Loa (eye worm) hypothetical protein 0.0164 0.1802 0.5592
Schistosoma mansoni glutamate synthase 0.006 0.046 0.1427
Echinococcus multilocularis lamin dm0 0.0033 0.0113 0.035
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.006 0.046 0.1621
Entamoeba histolytica disulphide oxidoreductase, putative 0.006 0.046 0.5
Brugia malayi glutathione reductase 0.0274 0.3223 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0224 0.2582 0.798
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.006 0.046 0.1293
Plasmodium falciparum glutathione reductase 0.0224 0.2582 0.8011
Treponema pallidum NADH oxidase 0.0224 0.2582 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0486 0.0027
Loa Loa (eye worm) hypothetical protein 0.006 0.046 0.1427
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.08 1 1
Brugia malayi Carboxylesterase family protein 0.0028 0.005 0.0154
Echinococcus granulosus acetylcholinesterase 0.0164 0.1802 0.5592
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0224 0.2582 0.798
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0486 0.0094
Plasmodium vivax thioredoxin reductase, putative 0.0274 0.3223 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.006 0.046 0.1621
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.1802 0.5592
Echinococcus granulosus geminin 0.0205 0.2329 0.7227
Mycobacterium ulcerans monoxygenase 0.006 0.046 0.1621
Onchocerca volvulus 0.0033 0.0113 0.2452
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.006 0.046 0.1293
Onchocerca volvulus 0.0033 0.0113 0.2452
Trichomonas vaginalis glutamate synthase, putative 0.006 0.046 0.1621
Onchocerca volvulus 0.0028 0.005 0.1079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0673 0.8368 0.8289
Echinococcus granulosus para nitrobenzyl esterase 0.0028 0.005 0.0154
Leishmania major trypanothione reductase 0.0274 0.3223 0.2896
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.006 0.046 0.1621
Trichomonas vaginalis disulfide oxidoreductase, putative 0.006 0.046 0.1621
Onchocerca volvulus 0.0028 0.005 0.1079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0589 0.7276 0.7145
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0486 0.1508
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.006 0.046 0.1427
Echinococcus granulosus acetylcholinesterase 0.0164 0.1802 0.5592
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.006 0.046 0.1427
Echinococcus multilocularis BC026374 protein (S09 family) 0.0028 0.005 0.0154
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.006 0.046 0.1427
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.006 0.046 0.1427
Echinococcus multilocularis lamin 0.0033 0.0113 0.035
Echinococcus multilocularis thioredoxin glutathione reductase 0.0274 0.3223 1
Brugia malayi hypothetical protein 0.0028 0.005 0.0154
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.08 1 1
Brugia malayi Carboxylesterase family protein 0.0164 0.1802 0.5592
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.006 0.046 0.1621
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.006 0.046 0.5
Plasmodium falciparum thioredoxin reductase 0.0224 0.2582 0.8011
Mycobacterium ulcerans NADH dehydrogenase 0.006 0.046 0.1621
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0486 0.0027
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.005 0.0154
Giardia lamblia NADH oxidase lateral transfer candidate 0.0224 0.2582 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0224 0.2582 0.2224
Toxoplasma gondii thioredoxin reductase 0.0274 0.3223 1
Brugia malayi intermediate filament protein 0.0033 0.0113 0.035
Schistosoma mansoni lamin 0.0033 0.0113 0.035
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0486 0.0027
Trichomonas vaginalis disulfide oxidoreductase, putative 0.006 0.046 0.1621
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0154
Onchocerca volvulus 0.0028 0.005 0.1079
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0486 0.1508
Brugia malayi Carboxylesterase family protein 0.0028 0.005 0.0154
Schistosoma mansoni disulfide oxidoreductase 0.006 0.046 0.1427
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0224 0.2582 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0486 0.1723
Trypanosoma cruzi trypanothione reductase, putative 0.0224 0.2582 0.2224
Echinococcus multilocularis neuroligin 0.0028 0.005 0.0154
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0486 0.0027
Schistosoma mansoni gliotactin 0.0028 0.005 0.0154
Schistosoma mansoni lamin 0.0033 0.0113 0.035
Echinococcus multilocularis acetylcholinesterase 0.0164 0.1802 0.5592
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0224 0.2582 0.768
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.006 0.046 0.1621
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0154
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.006 0.046 0.1293
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.006 0.046 0.1621
Schistosoma mansoni hypothetical protein 0.006 0.046 0.1427
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0224 0.2582 0.798
Entamoeba histolytica glutamate synthase beta subunit, putative 0.006 0.046 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.08 1 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0113 0.035
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.006 0.046 0.1427
Schistosoma mansoni glutamate synthase 0.006 0.046 0.1427
Trypanosoma cruzi trypanothione reductase, putative 0.0274 0.3223 0.2896
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0486 0.0027
Loa Loa (eye worm) hypothetical protein 0.0164 0.1802 0.5592
Echinococcus granulosus glutamate synthase 0.006 0.046 0.1427
Echinococcus granulosus carboxylesterase 5A 0.0164 0.1802 0.5592
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0224 0.2582 1
Loa Loa (eye worm) carboxylesterase 0.0164 0.1802 0.5592
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.006 0.046 0.1427
Trichomonas vaginalis disulfide oxidoreductase, putative 0.006 0.046 0.1621
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0673 0.8368 0.8289
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0486 0.1723
Entamoeba histolytica glutamate synthase beta subunit, putative 0.006 0.046 0.5
Mycobacterium tuberculosis Probable reductase 0.006 0.046 0.1293
Brugia malayi MAP kinase sur-1 0.0062 0.0486 0.1508

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antagonist activity at androgen receptor (unknown origin) expressed in CV1 cells assessed as dihydrotestosterone-stimulated transactivation by CAT reporter gene assay ChEMBL. 17606915
IC50 (functional) = 6562 nM Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay ChEMBL. 20547797
IC50 (binding) = 0.23 uM Inhibition of Equine serum BChE using butyrylthiocholine iodide as a substrate after 20 mins by Ellman's assay ChEMBL. 21459491
IC50 (binding) = 7 uM Inhibition of bovine erythrocyte AChE using acetylthiocholine iodide as a substrate after 20 mins by Ellman's assay ChEMBL. 21459491
Inhibition (ADMET) = 117.1349751 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 132.4558361 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Ki (binding) = 3 uM Displacement of [3H]mibolerone from rat androgen receptor ChEMBL. 17606915
Ki (binding) = 3 uM Displacement of [3H]mibolerone from rat androgen receptor ChEMBL. 17606915
logKd (ADMET) = 4.12 Binding affinity to bovine serum albumin by circular dichroic probe technique ChEMBL. 576620
LogP = 3.52 Partition coefficient, log P of the compound ChEMBL. 18027916
pKa = 8.76 Dissociation constant, pKa of the compound ChEMBL. 18027916
Potency (functional) = 0.0063 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.3332 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.3359 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 40.5334 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 20547797

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 54712  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 38071  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 30042  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 48719  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 54571  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 54642  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 35349  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 50541  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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