Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1787 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.6447 | 0.6271 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0065 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0065 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0065 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0011 | 0.0471 | 0.0471 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1787 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0471 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0065 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0011 | 0.0471 | 0.0471 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0011 | 0.0471 | 0.0471 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0011 | 0.0471 | 0.0471 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6447 | 0.6447 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.1787 | 1 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0011 | 0.0471 | 0.0471 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6447 | 0.6447 |
Echinococcus granulosus | acetylcholinesterase | 0.0065 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0471 | 0.5 | |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.1787 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.6447 | 0.6271 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.1787 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0471 | 0.5 | |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.1787 | 0.1787 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.1787 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0011 | 0.0471 | 0.2635 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0011 | 0.0471 | 0.2635 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1787 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1787 | 0.1787 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0011 | 0.0471 | 0.0471 |
Echinococcus granulosus | carboxylesterase 5A | 0.0065 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0471 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0011 | 0.0471 | 0.0471 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0011 | 0.0471 | 0.0471 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0011 | 0.0471 | 0.0471 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6447 | 0.6447 |
Echinococcus multilocularis | acetylcholinesterase | 0.0065 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1787 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6447 | 0.6447 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.1787 | 0.1381 |
Echinococcus multilocularis | neuroligin | 0.0011 | 0.0471 | 0.0471 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.1787 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0011 | 0.0471 | 0.0471 |
Onchocerca volvulus | 0.0011 | 0.0471 | 0.5 | |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.1787 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0011 | 0.0471 | 0.0471 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.1787 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6447 | 0.6447 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0011 | 0.0471 | 0.0471 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0011 | 0.0471 | 0.0471 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0011 | 0.0471 | 0.2635 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.1787 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0011 | 0.0471 | 0.2635 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6447 | 0.6447 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1787 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.1787 | 0.1787 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0011 | 0.0471 | 0.0471 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1787 | 0.1787 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0.0471 | 0.2635 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.1787 | 0.1381 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1787 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6447 | 0.6447 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.1787 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0.0471 | 0.2635 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 0.95 uM | Antiproliferative activity against human SK-MN-C cells by MTT assay | ChEMBL. | 18159922 |
IC50 (ADMET) | = 2026.85 uM | Cytotoxicity against mouse J774 cells after 24 hrs by resazurin assay | ChEMBL. | 20163897 |
MIC (functional) | = 5.06 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by resazurine microtiter assay | ChEMBL. | 20163897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.