Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.1749 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0019 | 0.1233 | 0.1233 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.1749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1236 | 0.1236 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0019 | 0.1236 | 0.1236 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.7354 | 0.7354 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1236 | 0.1236 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 1 | 1 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0019 | 0.1233 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0019 | 0.1233 | 0.1233 |
Schistosoma mansoni | ferritin | 0.0019 | 0.1233 | 0.1233 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.7354 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.1749 | 0.1749 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.7354 | 0.7354 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.7354 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.1749 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.7354 | 0.7354 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.1749 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.7354 | 0.7354 |
Echinococcus multilocularis | ferritin | 0.0019 | 0.1233 | 0.1233 |
Brugia malayi | Protein kinase domain containing protein | 0.0019 | 0.1236 | 0.1236 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.1749 | 0.1749 |
Schistosoma mansoni | apoferritin-2 | 0.0019 | 0.1233 | 0.1233 |
Echinococcus granulosus | ferritin | 0.0019 | 0.1233 | 0.1233 |
Echinococcus granulosus | expressed protein | 0.0019 | 0.1233 | 0.1233 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.1749 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.1749 | 0.1749 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.1749 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.1749 | 1 |
Schistosoma mansoni | ferritin | 0.0019 | 0.1233 | 0.1233 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.1749 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0019 | 0.1236 | 0.1236 |
Schistosoma mansoni | ferritin | 0.0019 | 0.1233 | 0.1233 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.1749 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.7354 | 0.7354 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.7354 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.0019 | 0.1233 | 0.1233 |
Toxoplasma gondii | kringle domain-containing protein | 0.0019 | 0.1236 | 0.7066 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.1749 | 0.1749 |
Onchocerca volvulus | 0.0019 | 0.1236 | 1 | |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.1749 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.1749 | 0.1749 |
Brugia malayi | Kringle domain containing protein | 0.0019 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0019 | 0.1236 | 0.1236 |
Schistosoma mansoni | apoferritin-2 | 0.0019 | 0.1233 | 0.1233 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.1749 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.1749 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.1749 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.1749 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.7354 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.1749 | 0.1749 |
Schistosoma mansoni | ferritin | 0.0019 | 0.1233 | 0.1233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Antagonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium 45 uptake | ChEMBL. | 18072720 |
Activity (functional) | = 40 % | Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium 45 uptake relative to 300 nM capsaicin | ChEMBL. | 18072720 |
Activity (functional) | = 40 % | Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium 45 uptake relative to 300 nM capsaicin | ChEMBL. | 18072720 |
Ki (binding) | = 24 nM | Displacement of [3H]RTX from rat TRPV1 receptor expressed in CHO cells | ChEMBL. | 18072720 |
Ki (binding) | = 24 nM | Displacement of [3H]RTX from rat TRPV1 receptor expressed in CHO cells | ChEMBL. | 18072720 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.