Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thymidylate synthase | 0.0195 | 1 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0106 | 0.1327 | 0.0733 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0106 | 0.1327 | 0.0733 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0106 | 0.1327 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.0106 | 0.1327 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0106 | 0.1327 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0099 | 0.0641 | 0.0207 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0106 | 0.1327 | 0.0924 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0106 | 0.1327 | 0.0733 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0106 | 0.1327 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0106 | 0.1327 | 0.0733 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0099 | 0.0641 | 0.0641 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0106 | 0.1327 | 0.0733 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0106 | 0.1327 | 0.1327 |
Entamoeba histolytica | protein kinase, putative | 0.0106 | 0.1327 | 1 |
Onchocerca volvulus | 0.0195 | 1 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Brugia malayi | intracellular kinase | 0.0106 | 0.1327 | 0.1327 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0106 | 0.1327 | 1 |
Echinococcus granulosus | protein kinase shaggy | 0.0106 | 0.1327 | 0.0733 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 1 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0099 | 0.0641 | 0.0641 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0099 | 0.0641 | 0.0641 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0106 | 0.1327 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0106 | 0.1327 | 0.0924 |
Echinococcus multilocularis | protein kinase shaggy | 0.0106 | 0.1327 | 0.0733 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 uM | Inhibition of Toxoplasma gondii DHFR | ChEMBL. | 18072727 |
IC50 (binding) | = 5.4 uM | Inhibition of human thymidylate synthase | ChEMBL. | 18072727 |
IC50 (binding) | = 5.4 uM | Inhibition of human thymidylate synthase | ChEMBL. | 18072727 |
IC50 (binding) | = 27 uM | Inhibition of Escherichia coli thymidylate synthase | ChEMBL. | 18072727 |
IC50 (binding) | = 27 uM | Inhibition of Toxoplasma gondii thymidylate synthase | ChEMBL. | 18072727 |
IC50 (binding) | = 27 uM | Inhibition of Escherichia coli thymidylate synthase | ChEMBL. | 18072727 |
IC50 (binding) | > 32 uM | Inhibition of human recombinant DHFR | ChEMBL. | 18072727 |
IC50 (binding) | > 32 uM | Inhibition of Escherichia coli DHFR | ChEMBL. | 18072727 |
IC50 (binding) | > 32 uM | Inhibition of human recombinant DHFR | ChEMBL. | 18072727 |
Inhibition (binding) | = 0 % | Inhibition of human recombinant DHFR at >32 uM | ChEMBL. | 18072727 |
Inhibition (binding) | = 0 % | Inhibition of Escherichia coli DHFR at >32 uM | ChEMBL. | 18072727 |
Inhibition (binding) | = 0 % | Inhibition of human recombinant DHFR at >32 uM | ChEMBL. | 18072727 |
Ratio IC50 (binding) | > 20 | Selectivity ratio of IC50 for Toxoplasma gondii DHFR over IC50 for human recombinant DHFR | ChEMBL. | 18072727 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.