Detailed information for compound 501769

Basic information

Technical information
  • TDR Targets ID: 501769
  • Name: 1,2,3-trimethoxy-5-[[(E)-2-(2,4,6-trimethoxyp henyl)ethenyl]sulfonylmethyl]benzene
  • MW: 438.491 | Formula: C21H26O8S
  • H donors: 0 H acceptors: 2 LogP: 2.91 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c(c(c1)OC)/C=C/S(=O)(=O)Cc1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C21H26O8S/c1-24-15-11-17(25-2)16(18(12-15)26-3)7-8-30(22,23)13-14-9-19(27-4)21(29-6)20(10-14)28-5/h7-12H,13H2,1-6H3/b8-7+
  • InChiKey: HVCSNRBEYZDBMD-BQYQJAHWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1,2,3-trimethoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonylmethyl]benzene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0086 0.0944
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0086 0.0944
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0086 0.0545
Schistosoma mansoni hypothetical protein 0.0146 0.0441 0.4819
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0162 0.2606
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0162 0.1783
Echinococcus multilocularis jun protein 0.0085 0.0214 0.3432
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0086 0.1384
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0214 0.3432
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0162 0.1777
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0086 0.0545
Loa Loa (eye worm) carbonic anhydrase 3 0.0031 0.0018 0.0111
Schistosoma mansoni ATP-citrate synthase 0.0136 0.0403 0.4405
Trypanosoma cruzi squalene synthase, putative 0.0252 0.083 1
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.5432
Brugia malayi Cytochrome P450 family protein 0.0048 0.008 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0086 0.0545
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0031 0.0163
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0091 0.0239 1
Brugia malayi glutaminase DH11.1 0.0275 0.0914 0.5772
Brugia malayi hypothetical protein 0.0159 0.0488 0.3083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0086 0.0545
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0457 0.1584 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0055 0.0464
Loa Loa (eye worm) hypothetical protein 0.0079 0.0192 0.1214
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Schistosoma mansoni hypothetical protein 0.0079 0.0192 0.2103
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0086 0.1958
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0091 0.0239 0.1511
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0086 0.0545
Brugia malayi ecdysteroid receptor 0.005 0.0086 0.0545
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0055 0.0023
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0061 0.0955
Schistosoma mansoni thyroid hormone receptor 0.0196 0.0624 0.6819
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0061 0.0955
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0091 0.0239 0.2618
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0032 0.052
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.3839
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0282
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0036 0.0398
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0086 0.3367
Brugia malayi polk-prov protein 0.0031 0.0018 0.0116
Echinococcus granulosus Squalene phytoene synthase 0.0079 0.0192 0.4365
Brugia malayi hypothetical protein 0.0066 0.0147 0.093
Schistosoma mansoni glutaminase 0.0275 0.0914 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0048 0.1367
Trypanosoma cruzi squalene synthase, putative 0.0252 0.083 1
Brugia malayi steroid hormone receptor 0.005 0.0086 0.0545
Leishmania major squalene synthase, putative 0.0252 0.083 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0439 0.4806
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0398
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0162 0.1777
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.008 0.0506
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.0441 1
Echinococcus granulosus single minded 2 0.0035 0.0032 0.0736
Brugia malayi hypoxia-induced factor 1 0.0147 0.0443 0.2797
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0031 0.0018 0.0111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0086 0.0944
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0424 0.9632
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0048 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0036 0.0584
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0078 0.085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0086 0.1958
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0061 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0086 0.0545
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0086 0.1384
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0086 0.1958
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Toxoplasma gondii ATP-citrate lyase, putative 0.0155 0.0473 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0036 0.0827
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0055 0.0464
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0091 0.0239 0.2618
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0086 0.0545
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0086 0.1384
Loa Loa (eye worm) acetyltransferase 0.0146 0.0439 0.2774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0086 0.0545
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0031 0.0018 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.4875
Loa Loa (eye worm) hypothetical protein 0.0159 0.0488 0.3083
Echinococcus granulosus carbonic anhydrase II 0.0031 0.0018 0.0399
Schistosoma mansoni hypothetical protein 0.0034 0.0029 0.0312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0086 0.0545
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2747 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0086 0.0545
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Schistosoma mansoni nuclear hormone receptor 0.005 0.0086 0.0944
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0086 0.1384
Brugia malayi nuclear hormone receptor 0.005 0.0086 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0018 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0086 0.0545
Leishmania major fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.2729
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.5432
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0086 0.0545
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0055 0.0886
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.0441 0.7067
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0086 0.0545
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0086 0.1958
Leishmania major hypothetical protein, conserved 0.0079 0.0192 0.215
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0031 0.0018 0.0111
Trypanosoma cruzi phytoene synthase, putative 0.0079 0.0192 0.215
Echinococcus granulosus jun protein 0.0085 0.0214 0.4856
Loa Loa (eye worm) hypothetical protein 0.0082 0.0205 0.1297
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0031 0.0018 0.0192
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0086 0.1384
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0086 0.0546
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0086 0.0944
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0086 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0086 0.0545
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi hypothetical protein 0.0036 0.0036 0.023
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0399
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0086 0.0545
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0031 0.0018 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0031 0.0018 0.0111
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0091 0.0239 0.3839
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0086 0.0546
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.0443 0.2797
Echinococcus multilocularis carbonic anhydrase 0.0031 0.0018 0.0282
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0439 0.7048
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0061 0.1385
Loa Loa (eye worm) glutaminase 2 0.0275 0.0914 0.5772
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0162 0.3688
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Schistosoma mansoni carbonic anhydrase-related 0.0031 0.0018 0.0192
Mycobacterium ulcerans phytoene synthase, CrtB 0.0079 0.0192 0.016
Brugia malayi bZIP transcription factor family protein 0.0085 0.0214 0.135
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0091 0.0239 0.5432
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0086 0.1958
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0086 0.0545
Trypanosoma brucei squalene synthase, putative 0.0252 0.083 1
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0032 0.0205
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0546
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Schistosoma mansoni hypothetical protein 0.0069 0.0156 0.1704
Brugia malayi ATP-citrate synthase 0.0155 0.0473 0.2983
Brugia malayi PAS domain containing protein 0.0047 0.0078 0.0491
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0086 0.0944
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.3839
Echinococcus granulosus FTZ F1 alpha 0.005 0.0086 0.1958
Echinococcus multilocularis carbonic anhydrase II 0.0031 0.0018 0.0282
Schistosoma mansoni hypothetical protein 0.0031 0.0018 0.0192
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0031 0.0018 0.0111
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2747 1 1
Plasmodium falciparum fructose-bisphosphate aldolase 0.0091 0.0239 1
Mycobacterium ulcerans glutaminase 0.0275 0.0914 0.0885
Loa Loa (eye worm) ATP-citrate synthase 0.0155 0.0473 0.2983
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Brugia malayi nuclear receptor NHR-88 0.005 0.0086 0.0545
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0399
Echinococcus multilocularis thyroid hormone receptor alpha 0.0196 0.0624 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0061 0.0067
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0086 0.0944
Schistosoma mansoni thyroid hormone receptor 0.0196 0.0624 0.6819
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0086 0.1958
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0086 0.3367
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0029 0.018
Echinococcus granulosus dna polymerase kappa 0.0041 0.0055 0.1254
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0079 0.0192 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0086 0.0944
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0091 0.0239 0.3839
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0086 0.0545
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0214 0.4856
Schistosoma mansoni single-minded 0.0047 0.0078 0.085
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0086 0.1958
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0162 0.3185
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0086 0.3367
Onchocerca volvulus 0.005 0.0086 0.3367
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0086 0.0545
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0031 0.0018 0.0192
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0086 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0055 0.0023
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0091 0.0239 0.1511
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Trypanosoma brucei unspecified product 0.0035 0.0031 0.0163
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0086 0.1384
Onchocerca volvulus 0.0066 0.0147 0.7182
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0086 0.0944
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0091 0.0239 0.4875
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0086 0.1384
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0086 0.0545
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0091 0.0239 0.4875
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0545
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0086 0.0545
Echinococcus granulosus carbonic anhydrase 0.0031 0.0018 0.0399
Brugia malayi fructose-bisphosphate aldolase 2 0.0091 0.0239 0.1511
Brugia malayi follicle stimulating hormone receptor 0.0457 0.1584 1
Loa Loa (eye worm) glutaminase 0.0275 0.0914 0.5772
Schistosoma mansoni carbonic anhydrase 0.0031 0.0018 0.0192
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0079 0.0192 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0018 0.0009
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0091 0.0239 0.5432
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0086 0.1384
Brugia malayi fructose-bisphosphate aldolase 1 0.0091 0.0239 0.1511
Loa Loa (eye worm) hypothetical protein 0.0031 0.0018 0.0111
Echinococcus multilocularis Squalene phytoene synthase 0.0079 0.0192 0.3084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0162 0.013
Schistosoma mansoni jun-related protein 0.0069 0.0156 0.1704
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0086 0.1958
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0048 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0086 0.0944
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0055 0.0464
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0091 0.0239 0.2729
Loa Loa (eye worm) hypothetical protein 0.0034 0.0029 0.018
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0439 0.2774
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0086 0.0545
Schistosoma mansoni coup transcription factor 0.005 0.0086 0.0944
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0086 0.0545
Trichomonas vaginalis glutaminase, putative 0.0275 0.0914 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0086 0.0546

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 20 uM Antitumor activity against human BT20 cells by trypan blue exclusion assay ChEMBL. 18088089
IC50 (functional) > 20 uM Antitumor activity against AR-negative human DU145 cells by tryphan blue exclusion assay ChEMBL. 18088089
IC50 (functional) > 20 uM Antitumor activity against human H157 cells by tryphan blue exclusion assay ChEMBL. 18088089
IC50 (functional) > 20 uM Antitumor activity against human DLD1 cells by tryphan blue exclusion assay ChEMBL. 18088089
IC50 (functional) > 20 uM Antitumor activity against human BT20 cells by trypan blue exclusion assay ChEMBL. 18088089
IC50 (functional) > 20 uM Antitumor activity against AR-negative human DU145 cells by tryphan blue exclusion assay ChEMBL. 18088089
IC50 (functional) > 20 uM Antitumor activity against human DLD1 cells by tryphan blue exclusion assay ChEMBL. 18088089

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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