Detailed information for compound 50199

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.211 | Formula: C17H14Cl2N2O3
  • H donors: 1 H acceptors: 3 LogP: 3.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CN1Cc2ccccc2N(C1=O)Cc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C17H14Cl2N2O3/c18-13-6-5-11(7-14(13)19)8-21-15-4-2-1-3-12(15)9-20(17(21)24)10-16(22)23/h1-7H,8-10H2,(H,22,23)
  • InChiKey: JFEIHCIXFVDOKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.005 0.0198
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0069 0.0425
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0022 0.0089 0.01
Loa Loa (eye worm) RecQ helicase 0.0022 0.0089 0.0503
Schistosoma mansoni phosphoglucomutase 0.0223 0.1618 0.1618
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0069 0.0262
Echinococcus granulosus ribonuclease H1 0.0223 0.1618 0.6406
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0153 0.2335
Loa Loa (eye worm) glutathione reductase 0.0049 0.0296 0.1667
Brugia malayi phosphofructokinase 0.0114 0.0786 0.4419
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0069 0.008
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0153 0.0368
Giardia lamblia CDC8 0.0075 0.0493 0.1151
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0069 0.0152
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0779 0.8837
Trichomonas vaginalis thymidylate kinase, putative 0.0075 0.0493 0.1242
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0022 0.0089 0.0089
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0786 0.3111
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.003 0.0145 0.0345
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0153 0.2596
Schistosoma mansoni ap endonuclease 0.002 0.0069 0.0069
Brugia malayi reverse transcriptase 0.0022 0.0089 0.0499
Trypanosoma brucei trypanothione reductase 0.0049 0.0296 0.0388
Loa Loa (eye worm) hypothetical protein 0.0028 0.013 0.0734
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0069 0.0152
Echinococcus granulosus lamin dm0 0.0028 0.0134 0.0532
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0153 0.2335
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.005 0.0102
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0786 0.1995
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0022 0.0089 0.0351
Trypanosoma brucei ingi protein (ORF1) 0.0245 0.1787 0.2408
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3897 1
Echinococcus granulosus geminin 0.0342 0.2525 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0022 0.0089 0.0351
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0022 0.0089 0.0106
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0875 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0089 0.0204
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0069 0.039
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0786 0.8918
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0296 0.1173
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0786 0.7663
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.013
Trypanosoma brucei hypothetical protein, conserved 0.0245 0.1787 0.2408
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0035 0.0195
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0022 0.0089 0.0202
Onchocerca volvulus Ribonuclease H1 homolog 0.0223 0.1618 1
Schistosoma mansoni thymidylate kinase 0.0075 0.0493 0.0493
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.005 0.0107
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0022 0.0089 0.0351
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0786 0.1995
Schistosoma mansoni lamin 0.0028 0.0134 0.0134
Plasmodium vivax glutathione reductase, putative 0.0049 0.0296 0.5709
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0069 0.0152
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0223 0.1618 1
Leishmania major ribonuclease H1, putative 0.0223 0.1618 0.4135
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.005 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.005 0.0102
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.005 0.0102
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Schistosoma mansoni thymidylate kinase 0.0075 0.0493 0.0493
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0296 0.0736
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.005 0.0102
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.003 0.0145 0.0345
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0022 0.0089 0.0351
Plasmodium falciparum thymidylate kinase 0.0075 0.0493 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0153 0.066
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0089 0.0089
Plasmodium falciparum thioredoxin reductase 0.0049 0.0296 0.5558
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0786 0.4419
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0786 0.0786
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0153 0.0368
Treponema pallidum thymidylate kinase (tmk) 0.0075 0.0493 0.2826
Giardia lamblia Thymidine kinase 0.0521 0.3897 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0875 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.005 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.005 0.0102
Schistosoma mansoni ap endonuclease 0.002 0.0069 0.0069
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0069 0.0234
Brugia malayi thymidylate kinase 0.0075 0.0493 0.2773
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0779 0.7488
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0069 0.0152
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0875 1
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0786 0.1995
Echinococcus granulosus lamin 0.0028 0.0134 0.0532
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0015 0.0087
Brugia malayi hypothetical protein 0.0022 0.0089 0.0499
Trichomonas vaginalis reverse transcriptases, putative 0.0022 0.0089 0.0202
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Echinococcus granulosus thymidylate kinase 0.0075 0.0493 0.1953
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3897 1
Onchocerca volvulus 0.0028 0.0134 0.0831
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0756
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0022 0.0089 0.01
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.005 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.005 0.0102
Echinococcus multilocularis lamin dm0 0.0028 0.0134 0.0532
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0069 0.0436
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0069 0.0123
Toxoplasma gondii ribonuclease HI protein 0.0223 0.1618 1
Trichomonas vaginalis ribonuclease H1, putative 0.0223 0.1618 0.4135
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0779 0.8837
Brugia malayi reverse transcriptase 0.0022 0.0089 0.0499
Schistosoma mansoni hypothetical protein 0.0342 0.2525 0.2525
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0153 0.2596
Brugia malayi follicle stimulating hormone receptor 0.0244 0.1778 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0153 0.0269
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0296 0.5709
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0075 0.0493 0.5371
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Trypanosoma brucei RNA helicase, putative 0.0979 0.7387 1
Schistosoma mansoni hypothetical protein 0.0022 0.0089 0.0089
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0786 0.1995
Trypanosoma cruzi thymidylate kinase, putative 0.0075 0.0493 0.1242
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0069 0.0275
Trypanosoma brucei ingi protein (ORF1) 0.0245 0.1787 0.2408
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0786 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0786 0.1995
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Echinococcus multilocularis lamin 0.0028 0.0134 0.0532
Brugia malayi hypothetical protein 0.0022 0.0089 0.0499
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0108
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0069 0.039
Echinococcus granulosus RNA directed DNA polymerase 0.0022 0.0089 0.0351
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0245 0.1787 0.2408
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0153 0.0368
Toxoplasma gondii thioredoxin reductase 0.0049 0.0296 0.1661
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0153 0.076
Brugia malayi RNase H family protein 0.0223 0.1618 0.91
Trypanosoma brucei unspecified product 0.0245 0.1787 0.2408
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0069 0.0761
Toxoplasma gondii exonuclease III APE 0.002 0.0069 0.0229
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0296 0.2985
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.005 0.0102
Schistosoma mansoni hypothetical protein 0.0979 0.7387 0.7387
Brugia malayi Zinc knuckle family protein 0.0022 0.0089 0.0499
Echinococcus multilocularis musashi 0.0028 0.0134 0.0532
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0069 0.0152
Leishmania major trypanothione reductase 0.0049 0.0296 0.0736
Brugia malayi hypothetical protein 0.0022 0.0089 0.0499
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0153 0.0368
Treponema pallidum ribonuclease H (rnhA) 0.0223 0.1618 1
Onchocerca volvulus 0.0022 0.0089 0.0548
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0296 0.1173
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0022 0.0089 0.0202
Brugia malayi RNase H family protein 0.0223 0.1618 0.91
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.005 0.0054
Schistosoma mansoni protein kinase 0.0022 0.0089 0.0089
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.005 0.0054
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0786 0.3111
Mycobacterium tuberculosis Probable reductase 0.0113 0.0779 0.8837
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0153 0.0368
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0022 0.0089 0.0106
Brugia malayi Thioredoxin reductase 0.0049 0.0296 0.1667
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.005 0.0102
Brugia malayi RNase H family protein 0.0223 0.1618 0.91
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0153 0.2335
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0153 0.2335
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0035 0.0195
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0153 0.0368
Trypanosoma brucei thymidylate kinase, putative 0.0075 0.0493 0.0654
Brugia malayi 6-phosphofructokinase 0.0114 0.0786 0.4419
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.005 0.005
Plasmodium vivax thymidylate kinase, putative 0.0075 0.0493 1
Schistosoma mansoni hypothetical protein 0.0075 0.0493 0.0493
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.005 0.0102
Giardia lamblia Ribonuclease H 0.0223 0.1618 0.4075
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0153 0.0368
Trypanosoma cruzi ribonuclease H1, putative 0.0223 0.1618 0.4135
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0296 0.1667
Brugia malayi reverse transcriptase 0.0022 0.0089 0.0499
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0069 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0089 0.0202
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0786 0.1051
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Leishmania major thymidine kinase, putative 0.0521 0.3897 1
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0153 0.076
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Entamoeba histolytica Thymidylate kinase, putative 0.0075 0.0493 0.1242
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0022 0.0089 0.0548
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Trypanosoma brucei thymidine kinase 0.0521 0.3897 0.5269
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0022 0.0089 0.01
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0779 0.8837
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0134 0.0756
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0089 0.0503
Brugia malayi 6-phosphofructokinase 0.0114 0.0786 0.4419
Brugia malayi hypothetical protein 0.0022 0.0089 0.0499
Echinococcus multilocularis geminin 0.0342 0.2525 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0022 0.0089 0.01
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0779 0.8837
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Echinococcus multilocularis ribonuclease H1 0.0223 0.1618 0.6406
Entamoeba histolytica thymidine kinase, putative 0.0521 0.3897 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.024 0.1752 0.1752
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0069 0.0123
Onchocerca volvulus 0.0022 0.0089 0.0548
Schistosoma mansoni intermediate filament proteins 0.0028 0.0134 0.0134
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.005 0.034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0108
Loa Loa (eye worm) thymidylate kinase 0.0075 0.0493 0.2773
Chlamydia trachomatis thymidylate kinase 0.0075 0.0493 1
Brugia malayi glutathione reductase 0.0049 0.0296 0.1667
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0786 0.1995
Trichomonas vaginalis reverse transcriptases, putative 0.0022 0.0089 0.0202
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.005 0.0107
Brugia malayi intermediate filament protein 0.0028 0.0134 0.0756
Trypanosoma cruzi thymidylate kinase, putative 0.0075 0.0493 0.1242
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0089 0.0204
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.005 0.0102
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0134 0.0756
Mycobacterium ulcerans thymidylate kinase 0.0075 0.0493 0.6022
Plasmodium falciparum glutathione reductase 0.0049 0.0296 0.5558
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0075 0.0493 0.2826
Schistosoma mansoni phosphoglucomutase 0.0223 0.1618 0.1618
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0022 0.0089 0.0106
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0054 0.0054
Onchocerca volvulus 0.0028 0.0134 0.0831
Trypanosoma brucei ribonuclease H1 0.0223 0.1618 0.2179
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0022 0.0089 0.0351
Trypanosoma cruzi thymidine kinase, putative 0.0521 0.3897 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0069 0.0275
Toxoplasma gondii thymidylate kinase 0.0075 0.0493 0.2903
Onchocerca volvulus Putative thymidylate kinase 0.0075 0.0493 0.3048
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.005 0.0102
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0875 1
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0786 0.1995
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.005 0.0054
Trichomonas vaginalis thymidylate kinase, putative 0.0075 0.0493 0.1242
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.005 0.0054
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0015 0.0087
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0786 0.1995
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0153 0.076
Trypanosoma cruzi ribonuclease H1, putative 0.0223 0.1618 0.4135
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.005 0.034
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0153 0.0368
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0786 0.4692
Brugia malayi Pao retrotransposon peptidase family protein 0.0022 0.0089 0.0499
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0786 0.4419
Echinococcus granulosus bloom syndrome protein 0.0022 0.0089 0.0354
Schistosoma mansoni phosphoglucomutase 0.0223 0.1618 0.1618
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.005 0.0102
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0022 0.0089 0.0351
Mycobacterium tuberculosis Possible maturase 0.0022 0.0089 0.0468
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0779 0.8837
Trypanosoma cruzi thymidine kinase, putative 0.0521 0.3897 1
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0786 0.1995
Echinococcus granulosus KRAB A domain containing protein 0.0022 0.0089 0.0351
Echinococcus granulosus intermediate filament protein 0.0028 0.0134 0.0532
Leishmania major thymidylate kinase-like protein 0.0075 0.0493 0.1242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.031
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0786 0.4419
Schistosoma mansoni lamin 0.0028 0.0134 0.0134
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0089 0.0354
Brugia malayi Zinc knuckle family protein 0.0022 0.0089 0.0499
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.1778 1
Trichomonas vaginalis thymidine kinase, putative 0.0521 0.3897 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.005 0.0198
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0786 0.0786
Trypanosoma brucei thymidylate kinase, putative 0.0075 0.0493 0.0654
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.005 0.0102
Schistosoma mansoni hypothetical protein 0.0022 0.0089 0.0089
Giardia lamblia Reverse transcriptase/endonuclease 0.0022 0.0089 0.01
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0022 0.0089 0.0351
Schistosoma mansoni hypothetical protein 0.0342 0.2525 0.2525
Echinococcus multilocularis thymidylate kinase 0.0075 0.0493 0.1953
Leishmania major hypothetical protein, conserved 0.003 0.0145 0.0345
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0134 0.0756
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0069 0.005

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 41 % In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 4*10e -8M. ChEMBL. 1901912
Inhibition (binding) = 41 % In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 4*10e -8M. ChEMBL. 1901912
Inhibition (binding) = 68 % In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 10e -7M. ChEMBL. 1901912
Inhibition (binding) = 68 % In vitro inhibition of aldose reductase in partially purified bovine lens preparation at a concentration of 10e -7M. ChEMBL. 1901912
Lowering (functional) NA 0 % In vivo inhibition of galactitol accumulation in the sciatic nerve of rats fed 20% galactose for 4 day at 95 mg/kg/day dose; NS= No Significant inhibition of polyol accumulation ChEMBL. 1901912
Lowering (functional) = 38 % In vivo inhibition of galactitol accumulation in the diaphragm of rats fed 20% galactose for 4 day at 81 mg/kg/day dose ChEMBL. 1901912

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.