EC50 (functional)
|
= 1.5 uM
|
Growth inhibition of the FaDu Human Squamous Cell carcinoma cell line
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
|
Inhibition of Toxoplasma gondii DHFR
|
ChEMBL.
|
18800768
|
IC50 (binding)
|
|
Inhibition of Toxoplasma gondii thymidylate synthase
|
ChEMBL.
|
18800768
|
IC50 (binding)
|
|
Inhibition of human recombinant DHFR
|
ChEMBL.
|
18800768
|
IC50 (binding)
|
0
|
Inhibition of Toxoplasma gondii thymidylate synthase
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
0
|
Inhibition of Escherichia coli DHFR
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
0
|
Inhibition of Toxoplasma gondii DHFR
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
= 0.00000015 M
|
Inhibitory concentration against human thymidylate synthase
|
ChEMBL.
|
15837298
|
IC50 (binding)
|
= 0.00000015 M
|
Inhibitory concentration against human thymidylate synthase
|
ChEMBL.
|
15837298
|
IC50 (binding)
|
= 0.13 uM
|
Inhibition of human thymidylate synthase
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
= 0.13 uM
|
Inhibition of human thymidylate synthase
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
= 0.15 uM
|
The inhibitory concentration of compound was evaluated on Human Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 0.15 uM
|
The inhibitory concentration of compound was evaluated on Human Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 0.15 uM
|
Inhibition of human thymidylate synthase
|
ChEMBL.
|
18800768
|
IC50 (binding)
|
= 2 uM
|
The inhibitory concentration of compound was evaluated on Pneumocystis carini Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 2 uM
|
The inhibitory concentration of compound was evaluated on Pneumocystis carini Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 5.1 uM
|
The inhibitory concentration of compound was evaluated on Lactobacillus casei Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 5.1 uM
|
The inhibitory concentration of compound was evaluated on Lactobacillus casei Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 13 uM
|
The inhibitory concentration of compound was evaluated on Escherichia coli Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 13 uM
|
The inhibitory concentration of compound was evaluated on Escherichia coli Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 13 uM
|
Inhibition of Escherichia coli thymidylate synthase
|
ChEMBL.
|
18800768
|
IC50 (binding)
|
= 15 uM
|
The inhibitory concentration of compound was evaluated on Streptococcus faecium Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
> 15 uM
|
The inhibitory concentration of compound against Dihydrofolate reductases on Pneumocystis carini
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 15 uM
|
The inhibitory concentration of compound was evaluated on Streptococcus faecium Thymidylate synthase
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
> 15 uM
|
The inhibitory concentration of compound against Dihydrofolate reductases on Pneumocystis carini
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 45 uM
|
Inhibition of Escherichia coli thymidylate synthase
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
= 45 uM
|
Inhibition of Escherichia coli thymidylate synthase
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
> 54 uM
|
Inhibition of human recombinant DHFR
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
> 54 uM
|
Inhibition of human recombinant DHFR
|
ChEMBL.
|
18072727
|
IC50 (binding)
|
= 244 uM
|
The inhibitory concentration of compound against Dihydrofolate reductases on T. gondii
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 244 uM
|
The inhibitory concentration of compound against Dihydrofolate reductases on T. gondii
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 7470 uM
|
The inhibitory concentration of compound against Dihydrofolate reductases on rat liver
|
ChEMBL.
|
8917644
|
IC50 (binding)
|
= 7470 uM
|
The inhibitory concentration of compound against Dihydrofolate reductases on rat liver
|
ChEMBL.
|
8917644
|
Ratio (binding)
|
= 30.6
|
Selectivity ratio of IC50 values of rl / tg .
|
ChEMBL.
|
8917644
|
Ratio IC50 (binding)
|
0
|
Selectivity ratio of IC50 for Toxoplasma gondii DHFR over IC50 for human recombinant DHFR
|
ChEMBL.
|
18072727
|