Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | free fatty acid receptor 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at FFAR1 (unknown origin) expressed in HEK-EM293 cells assessed as linoleic acid-stimulated calcium influx after 30 mins by FLIPR assay | ChEMBL. | 18193825 | |
Activity (functional) | 0 | Antagonist activity at FFAR1 (unknown origin) expressed in HEK-EM293 cells assessed as linoleic acid-stimulated calcium influx after 30 mins by FLIPR assay | ChEMBL. | 18193825 |
IC50 (functional) | = 2.8 uM | Antagonist activity at FFAR1 (unknown origin) expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assay | ChEMBL. | 18193825 |
IC50 (functional) | = 2.8 uM | Antagonist activity at FFAR1 (unknown origin) expressed in HEK-EM293 cells assessed as inhibition calcium influx by FLIPR assay | ChEMBL. | 18193825 |
Inhibition (functional) | = 30 % | Antagonist activity at TRH receptor 1 (unknown origin) expressed in HEK-EM293 cells assessed as inhibition of thyrotropin-releaseing hormone-stimulated calcium influx at 30 uM by FLIPR assay | ChEMBL. | 18193825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.