Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0107 | 0.2838 | 0.5 | |
Trypanosoma brucei | thymidine kinase | 0.0249 | 1 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0249 | 1 | 1 |
Giardia lamblia | Thymidine kinase | 0.0249 | 1 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0249 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0107 | 0.2838 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0249 | 1 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0249 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0151 | 0.5046 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0107 | 0.2838 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0107 | 0.2838 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0249 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0107 | 0.2838 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0107 | 0.2838 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.5046 | 0.5046 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.5046 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.0249 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.5046 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0107 | 0.2838 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0107 | 0.2838 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0107 | 0.2838 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 41 % | Inhibition of Mouse Active Arthus reaction following 150 mg/Kg i.p.; 41-60% inhibition. | ChEMBL. | 6218302 |
Inhibition (functional) | = 41 % | Inhibition of Mouse Active Arthus reaction following 150 mg/Kg i.p.; 41-60% inhibition. | ChEMBL. | 6218302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.