Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | RUN | 0.0019 | 0.2733 | 0.2613 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.1911 | 0.1638 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0.2733 | 0.4884 |
Echinococcus granulosus | lamin | 0.003 | 0.4737 | 0.4992 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.2733 | 0.2733 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.4737 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.1911 | 0.1638 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4619 | 0.4619 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.8854 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4737 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.4737 | 0.4992 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.4737 | 1 |
Echinococcus multilocularis | musashi | 0.003 | 0.4737 | 0.4992 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.2733 | 0.4858 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4619 | 0.4619 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Onchocerca volvulus | 0.003 | 0.4737 | 1 | |
Onchocerca volvulus | 0.003 | 0.4737 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.2733 | 0.2613 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.2733 | 0.2613 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4619 | 0.4853 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0.2733 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.8956 | 0.8956 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.4737 | 0.4992 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4331 | 0.8965 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.4737 | 1 |
Schistosoma mansoni | lamin | 0.003 | 0.4737 | 0.4737 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2733 | 0.4858 |
Schistosoma mansoni | polycystin 1-related | 0.0019 | 0.2733 | 0.2733 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0366 |
Schistosoma mansoni | loxhd1 | 0.0019 | 0.2733 | 0.2733 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.8956 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4331 | 0.4331 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4619 | 0.4853 |
Schistosoma mansoni | lipoxygenase | 0.0019 | 0.2733 | 0.2733 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.2201 | 0.3493 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.042 | 0.5 |
Echinococcus multilocularis | lamin | 0.003 | 0.4737 | 0.4992 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.2733 | 0.4884 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0531 | 0.0531 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.2201 | 0.3527 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.8956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1911 | 0.2749 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2733 | 0.2733 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0019 | 0.2733 | 0.2613 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.4637 | 0.9744 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2733 | 0.4858 |
Echinococcus granulosus | RUN | 0.0019 | 0.2733 | 0.2613 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0.2733 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.4737 | 0.4737 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0019 | 0.2733 | 0.2613 |
Schistosoma mansoni | lamin | 0.003 | 0.4737 | 0.4737 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0.2733 | 0.4884 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0019 | 0.2733 | 0.2613 |
Brugia malayi | intermediate filament protein | 0.003 | 0.4737 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1811 | 0.2493 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0019 | 0.2733 | 0.2733 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1811 | 0.2493 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4331 | 0.896 |
Onchocerca volvulus | 0.0028 | 0.4331 | 0.7977 | |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0019 | 0.2733 | 0.2613 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0366 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.4737 | 0.4992 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 333 uM | Inhibition of recombinant HIV1 integrase-mediated 3'-processing activity in prescence of magnesium | ChEMBL. | 18095643 |
IC50 (binding) | > 333 uM | Inhibition of recombinant HIV1 integrase strand transfer activity in prescence of magnesium | ChEMBL. | 18095643 |
IC50 (binding) | > 333 uM | Inhibition of recombinant HIV1 integrase-mediated 3'-processing activity in prescence of magnesium | ChEMBL. | 18095643 |
IC50 (binding) | > 333 uM | Inhibition of recombinant HIV1 integrase strand transfer activity in prescence of magnesium | ChEMBL. | 18095643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.