Detailed information for compound 502530

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 880.046 | Formula: C46H61N11O7
  • H donors: 10 H acceptors: 7 LogP: 1.46 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3c(c2)cccc3)NC(=O)[C@@H](N)CCCCC(=O)CCC(=O)NCCCC[C@H](NC(=O)[C@@H](NC1=O)Cc1c[nH]c2c1cccc2)C(=O)N
  • InChi: 1S/C46H61N11O7/c47-34-14-5-3-12-32(58)20-21-40(59)51-22-8-7-16-36(41(48)60)54-45(64)39(26-31-27-53-35-15-6-4-13-33(31)35)57-43(62)37(17-9-23-52-46(49)50)55-44(63)38(56-42(34)61)25-28-18-19-29-10-1-2-11-30(29)24-28/h1-2,4,6,10-11,13,15,18-19,24,27,34,36-39,53H,3,5,7-9,12,14,16-17,20-23,25-26,47H2,(H2,48,60)(H,51,59)(H,54,64)(H,55,63)(H,56,61)(H,57,62)(H4,49,50,52)/t34-,36-,37-,38+,39-/m0/s1
  • InChiKey: KDTZLQMUHBEBMZ-OUBWENQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Starlite/ChEMBL References
Homo sapiens melanocortin 5 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References
Homo sapiens melanocortin 3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melanocortin 5 receptor 325 aa 311 aa 20.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) solute carrier family 6 member 4 0.0273 0.1074 0.396
Trypanosoma brucei beta tubulin 0.0027 0.0044 0.0294
Leishmania major ion transport protein-like protein 0.0029 0.0053 0.0355
Echinococcus granulosus biogenic amine 5HT receptor 0.0424 0.1707 0.1947
Brugia malayi beta-tubulin, identical 0.0027 0.0044 0.0176
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0284 0.1176
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0082 0.0297
Echinococcus granulosus potassium channel subfamily K 8 0.0029 0.0053 0.006
Echinococcus granulosus hypothetical protein 0.0187 0.0714 0.0814
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0044 0.0044
Brugia malayi glutaminase DH11.1 0.0569 0.2318 0.9654
Echinococcus granulosus neuropeptide Y receptor 0.0187 0.0714 0.0814
Schistosoma mansoni biogenic amine receptor 0.0187 0.0714 0.0814
Leishmania major calcium/potassium channel (CAKC), putative 0.0029 0.0053 0.0355
Echinococcus granulosus intermediate filament protein 0.0081 0.0269 0.0307
Brugia malayi G-protein coupled receptor 0.0187 0.0714 0.297
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0029 0.019
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0037 0.0037
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0125 0.0142
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0029 0.0053 0.006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1134 0.794
Onchocerca volvulus 0.0046 0.0124 0.0546
Onchocerca volvulus 0.0077 0.0252 0.1241
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0152 0.0152
Brugia malayi MH2 domain containing protein 0.0378 0.1515 0.6306
Trypanosoma cruzi ion transport protein, putative 0.0029 0.0053 0.0355
Brugia malayi Pre-SET motif family protein 0.0058 0.0175 0.072
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0067 0.0271
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0269 0.0987
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1134 0.4889
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0536 0.0536
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0046 0.0124 0.0124
Trypanosoma brucei calcium-activated potassium channel, putative 0.0029 0.0053 0.0355
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0008 0.0046
Echinococcus granulosus geminin 0.088 0.3623 0.4131
Brugia malayi mbt repeat family protein 0.0047 0.0125 0.0512
Onchocerca volvulus 0.0029 0.0053 0.0164
Schistosoma mansoni hypothetical protein 0.088 0.3623 0.4131
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0252 0.1082
Loa Loa (eye worm) hypothetical protein 0.0145 0.0536 0.1975
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0172 0.0653 0.4544
Schistosoma mansoni ap endonuclease 0.0057 0.017 0.0194
Brugia malayi beta-lactamase family protein 0.0077 0.0252 0.1045
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0039 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1134 0.4889
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Loa Loa (eye worm) norepinephrine transporter 0.0273 0.1074 0.396
Schistosoma mansoni amine GPCR 0.0507 0.2057 0.2345
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0033 0.0214
Echinococcus multilocularis dro:myosuppressin receptor 0.0187 0.0714 0.0714
Echinococcus granulosus pyruvate kinase 0.0033 0.0067 0.0076
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0125 0.0125
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0156 0.107
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0022 0.0089
Loa Loa (eye worm) tubulin beta-1 chain 0.0027 0.0044 0.0156
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0093 0.0106
Brugia malayi Dopamine receptor protein 1 0.0589 0.2401 1
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0029 0.0053 0.0189
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0022 0.0084
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0124 0.0508
Loa Loa (eye worm) hypothetical protein 0.0088 0.0297 0.109
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0082 0.0335
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0029 0.0053 0.0213
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Schistosoma mansoni flap endonuclease-1 0.0023 0.0026 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0061 0.0248
Brugia malayi beta-lactamase 0.0077 0.0252 0.1045
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1073 0.4623
Onchocerca volvulus 0.0187 0.0714 0.3734
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Schistosoma mansoni smad 0.0026 0.0037 0.0043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0346 0.1434
Onchocerca volvulus 0.0029 0.0053 0.0164
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0269 0.1114
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.017 0.0725
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) beta-tubulin 0.0027 0.0044 0.0156
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0008 0.0028
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Schistosoma mansoni neuropeptide F-like receptor 0.0187 0.0714 0.0814
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1134 0.4889
Echinococcus granulosus caspase 8 0.0017 0.0002 0.0002
Schistosoma mansoni sodium/chloride dependent transporter 0.0273 0.1074 0.1224
Brugia malayi putative neuropeptide receptor NPR1 0.0187 0.0714 0.297
Onchocerca volvulus 0.0187 0.0714 0.3734
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0029 0.0053 0.0213
Giardia lamblia DNA repair protein RAD52 0.0357 0.1427 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.0747 0.0852
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.072 0.31
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0187 0.0714 0.0814
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Echinococcus multilocularis small conductance calcium activated potassium 0.0662 0.2709 0.2709
Loa Loa (eye worm) hypothetical protein 0.0272 0.1069 0.3943
Echinococcus multilocularis g-protein coupled receptor 0.0187 0.0714 0.0714
Onchocerca volvulus 0.0187 0.0714 0.3734
Brugia malayi GnHR receptor homolog 0.0187 0.0714 0.297
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0219
Schistosoma mansoni twik family of potassium channels-related 0.0029 0.0053 0.006
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0046 0.0124 0.0508
Plasmodium vivax potassium channel, putative 0.0029 0.0053 0.2096
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0156 0.0664
Schistosoma mansoni hypothetical protein 0.0187 0.0714 0.0814
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0187 0.0714 0.0714
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0187 0.0714 0.0814
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0103 0.0721
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0037 0.0132
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.036 0.144 0.5312
Echinococcus multilocularis serotonin transporter 0.0273 0.1074 0.1074
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0273 0.1074 0.1224
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus granulosus neuropeptide receptor A26 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Schistosoma mansoni tubulin subunit beta 0.0027 0.0044 0.005
Echinococcus multilocularis beta tubulin 0.0027 0.0044 0.0044
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0518 0.2587
Brugia malayi Dopamine receptor 0.0187 0.0714 0.297
Schistosoma mansoni Smad4 0.0026 0.0037 0.0043
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0076
Brugia malayi ERG2 and Sigma1 receptor like protein 0.036 0.144 0.5992
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0059 0.0175 0.0641
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.0714 0.0814
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0076
Onchocerca volvulus 0.0187 0.0714 0.3734
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0044 0.005
Loa Loa (eye worm) hypothetical protein 0.0039 0.0093 0.0338
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0029 0.1153
Schistosoma mansoni glutaminase 0.0569 0.2318 0.2643
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1073 0.4623
Schistosoma mansoni histamine h1 receptor 0.0187 0.0714 0.0814
Brugia malayi Tachykinin-like peptides receptor 99D 0.0187 0.0714 0.297
Plasmodium falciparum transporter, putative 0.0046 0.0124 0.7285
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Schistosoma mansoni hypothetical protein 0.007 0.0224 0.0256
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0008 0.001
Schistosoma mansoni acetylcholinesterase 0.0022 0.0022 0.0026
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0037 0.0132
Echinococcus multilocularis neuropeptide FF receptor 2 0.0187 0.0714 0.0714
Plasmodium vivax potassium channel, putative 0.0029 0.0053 0.2096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.034 0.034
Leishmania major DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Schistosoma mansoni microtubule-associated protein tau 0.2107 0.8772 1
Loa Loa (eye worm) TWK-7 protein 0.0029 0.0053 0.0189
Entamoeba histolytica hypothetical protein 0.0071 0.0229 0.1555
Plasmodium falciparum pyruvate kinase 0.0033 0.0067 0.3944
Schistosoma mansoni intermediate filament proteins 0.0081 0.0269 0.0307
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0518 0.2224
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.045
Brugia malayi Carboxylesterase family protein 0.0022 0.0022 0.0086
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0156 0.107
Loa Loa (eye worm) hypothetical protein 0.0424 0.1707 0.6301
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0119 0.4699
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0003 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.017 0.0837
Loa Loa (eye worm) hypothetical protein 0.0077 0.0252 0.0926
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0076
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0067 0.0453
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0187 0.0714 0.0814
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0152 0.0173
Echinococcus multilocularis allatostatin A receptor 0.0187 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0063 0.0196 0.0837
Echinococcus granulosus tm gpcr rhodopsin 0.0187 0.0714 0.0814
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.034 0.1409
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0002 0.0072
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0187 0.0714 0.0714
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0102 0.0355 0.2447
Echinococcus granulosus twik family of potassium channels 0.0029 0.0053 0.006
Leishmania major pyruvate kinase 0.0033 0.0067 0.0453
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.017 0.119
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0043
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0156 0.107
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0029 0.0053 0.0213
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0029 0.0053 0.0213
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0156 0.0664
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0008 0.0046
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.017 0.0194
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.017 0.0725
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0022 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0187 0.0714 0.0714
Trypanosoma cruzi beta tubulin, putative 0.0027 0.0044 0.0294
Schistosoma mansoni tubulin subunit beta 0.0027 0.0044 0.005
Echinococcus multilocularis sodium and chloride dependent glycine 0.0046 0.0124 0.0124
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0044 0.0182
Echinococcus granulosus serotonin transporter 0.0273 0.1074 0.1224
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.034 0.1249
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0124 0.4898
Plasmodium vivax amine transporter, putative 0.0046 0.0124 0.4898
Schistosoma mansoni smad1 5 8 and 0.0026 0.0037 0.0043
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0044 0.0156
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0187 0.0714 0.297
Brugia malayi G-protein coupled receptor 0.0187 0.0714 0.297
Echinococcus multilocularis lamin dm0 0.0081 0.0269 0.0269
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0156 0.0156
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0044 0.0044
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0046 0.0124 0.045
Echinococcus granulosus lamin dm0 0.0081 0.0269 0.0307
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0087
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0025 0.0087
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0008 0.0024
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Loa Loa (eye worm) hypothetical protein 0.0589 0.2401 0.8864
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.017 0.1272
Brugia malayi MH1 domain containing protein 0.0026 0.0037 0.0148
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0096 0.011
Echinococcus granulosus microtubule associated protein 2 0.2107 0.8772 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0229 0.0229
Echinococcus multilocularis caspase 8 0.0017 0.0002 0.0002
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0036 0.0195
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0025 0.0119
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0036 0.0147
Echinococcus multilocularis tubulin subunit beta 0.0027 0.0044 0.0044
Brugia malayi Serotonin receptor 0.0187 0.0714 0.297
Onchocerca volvulus 0.0187 0.0714 0.3734
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0046 0.0124 0.0141
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0029 0.0053 0.0355
Entamoeba histolytica hypothetical protein 0.0071 0.0229 0.1555
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Loa Loa (eye worm) Smad1 0.0026 0.0037 0.0132
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Brugia malayi jmjC domain containing protein 0.0057 0.017 0.0701
Trichomonas vaginalis esterase, putative 0.0077 0.0252 0.1082
Schistosoma mansoni twik family of potassium channels-related 0.0029 0.0053 0.006
Plasmodium falciparum potassium channel 0.0029 0.0053 0.3118
Loa Loa (eye worm) G-protein coupled receptor 0.0187 0.0714 0.2632
Trypanosoma brucei beta tubulin 0.0027 0.0044 0.0294
Schistosoma mansoni biogenic amine (5HT) receptor 0.0424 0.1707 0.1947
Echinococcus granulosus potassium channel subfamily K 8 0.0029 0.0053 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0252 0.1082
Loa Loa (eye worm) hypothetical protein 0.0273 0.1074 0.396
Echinococcus multilocularis beta tubulin 0.0027 0.0044 0.0044
Echinococcus multilocularis dna polymerase eta 0.0019 0.0008 0.0008
Schistosoma mansoni neuropeptide f receptor 76f 0.0187 0.0714 0.0814
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0252 0.0288
Loa Loa (eye worm) MBCTL1 0.0053 0.0152 0.0553
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0061 0.0061
Leishmania major hypothetical protein, conserved 0.0025 0.0033 0.0214
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0008 0.0046
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0175 0.6917
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0029 0.0053 0.0314
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0518 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.1074 0.396
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0119 0.4699
Brugia malayi MH2 domain containing protein 0.0026 0.0037 0.0148
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0039 0.0258
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0029 0.0506
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0187 0.0714 0.0814
Onchocerca volvulus 0.0029 0.0053 0.0164
Toxoplasma gondii ABC1 family protein 0.0077 0.0252 1
Echinococcus multilocularis neuropeptide receptor A26 0.0187 0.0714 0.0714
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0037 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.017 0.0622
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1134 0.4889
Loa Loa (eye worm) hypothetical protein 0.0077 0.0252 0.0926
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0081 0.0293
Echinococcus granulosus caspase 2 0.0088 0.0297 0.0338
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0036 0.0252
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0156 0.0156
Echinococcus granulosus flap endonuclease 1 0.0025 0.0036 0.0041
Plasmodium falciparum flap endonuclease 1 0.0025 0.0036 0.212
Schistosoma mansoni caspase-3 (C14 family) 0.0017 0.0002 0.0002
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0119 0.0504
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0187 0.0714 0.0814
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0166 0.0189
Schistosoma mansoni tubulin subunit beta 0.0027 0.0044 0.005
Echinococcus multilocularis potassium channel subfamily K 8 0.0029 0.0053 0.0053
Echinococcus granulosus small conductance calcium activated potassium 0.0662 0.2709 0.3088
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0124 0.0141
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.0573 0.0653
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0125 0.0142
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.0573 0.0573
Brugia malayi hypothetical protein 0.0125 0.0452 0.1875
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0036 0.0238
Schistosoma mansoni amine GPCR 0.0187 0.0714 0.0814
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0029 0.0053 0.0213
Echinococcus granulosus neuropeptide receptor 0.0187 0.0714 0.0814
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0103 0.6061
Loa Loa (eye worm) hypothetical protein 0.0099 0.0346 0.1271
Loa Loa (eye worm) hypothetical protein 0.0172 0.0653 0.2405
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0067 0.2651
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0029 0.0113
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.017 0.6723
Brugia malayi mbt repeat family protein 0.0047 0.0125 0.0512
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0252 0.0926
Schistosoma mansoni myosin xvIII 0.0187 0.0714 0.0814
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Onchocerca volvulus 0.0187 0.0714 0.3734
Echinococcus multilocularis lamin 0.0081 0.0269 0.0269
Plasmodium falciparum amino acid transporter, putative 0.0046 0.0124 0.7285
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.0714 0.0714
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0096 0.011
Onchocerca volvulus 0.0081 0.0269 0.1331
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0061 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0187 0.0714 0.2632
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0679 0.2925
Echinococcus granulosus g protein coupled receptor 0.0187 0.0714 0.0814
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0152 0.0173
Brugia malayi neuropeptide F receptor 0.0187 0.0714 0.297
Echinococcus granulosus dro:myosuppressin receptor 0.0187 0.0714 0.0814
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0073 0.0308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0067 0.024
Schistosoma mansoni lamin 0.0081 0.0269 0.0307
Schistosoma mansoni gliotactin 0.0022 0.0022 0.0026
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0252 0.1253
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.0714 0.0714
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0156 0.0177
Toxoplasma gondii hypothetical protein 0.0046 0.0124 0.4898
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Mycobacterium ulcerans transmembrane cation transporter 0.0029 0.0053 0.0215
Loa Loa (eye worm) hypothetical protein 0.0424 0.1707 0.6301
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Echinococcus multilocularis potassium channel subfamily K 0.0029 0.0053 0.0053
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0029 0.0053 0.0213
Onchocerca volvulus 0.0187 0.0714 0.3734
Schistosoma mansoni pyruvate kinase 0.0033 0.0067 0.0076
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0119 0.0504
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0044 0.005
Onchocerca volvulus 0.0081 0.0269 0.1331
Echinococcus multilocularis sodium and chloride dependent glycine 0.0046 0.0124 0.0124
Echinococcus granulosus caspase 0.0017 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.034 0.0387
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0114
Echinococcus multilocularis neuropeptide s receptor 0.0187 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Mycobacterium ulcerans lipase LipD 0.0077 0.0252 0.1077
Onchocerca volvulus 0.0187 0.0714 0.3734
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1073 0.4623
Echinococcus granulosus potassium channel subfamily K 0.0029 0.0053 0.006
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0229 0.0261
Brugia malayi Carboxylesterase family protein 0.0022 0.0022 0.0086
Loa Loa (eye worm) MH2 domain-containing protein 0.0378 0.1515 0.559
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0029 0.0053 0.0189
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0125 0.0142
Brugia malayi follicle stimulating hormone receptor 0.0187 0.0714 0.297
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0022 0.0026
Brugia malayi AKH receptor 0.0187 0.0714 0.297
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0252 0.1253
Onchocerca volvulus 0.0187 0.0714 0.3734
Echinococcus granulosus allatostatin A receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Schistosoma mansoni twik family of potassium channels-related 0.0029 0.0053 0.006
Mycobacterium tuberculosis Conserved protein 0.0077 0.0252 0.1253
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0124 0.0508
Brugia malayi hypothetical protein 0.0071 0.0229 0.0947
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Onchocerca volvulus 0.0029 0.0053 0.0164
Echinococcus granulosus acetylcholinesterase 0.0131 0.048 0.0547
Echinococcus multilocularis Smad4 0.0026 0.0037 0.0037
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0039 0.0155
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0067 0.0241
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Brugia malayi Flap endonuclease-1 0.0025 0.0036 0.0142
Mycobacterium tuberculosis Conserved protein 0.0077 0.0252 0.1253
Schistosoma mansoni biogenic amine receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0273 0.1074 0.396
Onchocerca volvulus Neuropeptide F receptor homolog 0.0187 0.0714 0.3734
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus granulosus neuropeptide Y receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0187 0.0714 0.297
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0029 0.0053 0.0213
Brugia malayi Carboxylesterase family protein 0.0131 0.048 0.1994
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0187 0.0714 0.0814
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0008 0.0046
Onchocerca volvulus 0.0077 0.0252 0.1241
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0029 0.0053 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Schistosoma mansoni ap endonuclease 0.0057 0.017 0.0194
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0044 0.0182
Echinococcus granulosus sex peptide receptor 0.0187 0.0714 0.0814
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0003 0.0009
Schistosoma mansoni twik family of potassium channels-related 0.0029 0.0053 0.006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0124 0.4898
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0252 0.1253
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0044 0.0182
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0029 0.0131
Onchocerca volvulus 0.0187 0.0714 0.3734
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0067 0.0453
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0175 0.0175
Onchocerca volvulus 0.0029 0.0053 0.0164
Loa Loa (eye worm) hypothetical protein 0.0077 0.0252 0.0926
Echinococcus multilocularis carboxylesterase 5A 0.0131 0.048 0.048
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.0714 0.0814
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0252 0.0288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0175 0.0199
Brugia malayi putative neuropeptide receptor 0.0187 0.0714 0.297
Echinococcus granulosus 7tm_1 domain containing protein 0.0187 0.0714 0.0814
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0156 0.107
Loa Loa (eye worm) TWK-28 protein 0.0029 0.0053 0.0189
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0036 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.034 0.034
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0008 0.0027
Schistosoma mansoni hypothetical protein 0.0029 0.0053 0.006
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0214 0.0885
Schistosoma mansoni hypothetical protein 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Schistosoma mansoni hypothetical protein 0.0294 0.1165 0.1328
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0187 0.0714 0.2632
Schistosoma mansoni neuropeptide receptor 0.0187 0.0714 0.0814
Brugia malayi hypothetical protein 0.0046 0.0124 0.0508
Schistosoma mansoni amine GPCR 0.0187 0.0714 0.0814
Giardia lamblia Beta tubulin 0.0027 0.0044 0.0309
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0029 0.0053 0.0213
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0284 0.0324
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0357 0.1427 1
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0029 0.0053 0.0213
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0679 0.2925
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0252 0.0288
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0067 0.0271
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Schistosoma mansoni amine GPCR 0.0187 0.0714 0.0814
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0022 0.0026
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0027 0.0044 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0175 0.0199
Brugia malayi hypothetical protein 0.007 0.0224 0.0928
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0119 0.4699
Onchocerca volvulus 0.0187 0.0714 0.3734
Trypanosoma brucei unspecified product 0.0019 0.0008 0.0046
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Loa Loa (eye worm) melatonin receptor type 1A 0.0187 0.0714 0.2632
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.0714 0.0714
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.1134 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0187 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1134 0.4889
Trypanosoma brucei beta tubulin 0.0027 0.0044 0.0294
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0408 0.1639 0.6049
Echinococcus granulosus tm gpcr rhodopsin 0.0187 0.0714 0.0814
Echinococcus multilocularis microtubule associated protein 2 0.2107 0.8772 0.8772
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0252 0.1253
Brugia malayi hypothetical protein 0.0025 0.0033 0.0128
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.017 0.072
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0284 0.0284
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0124 0.0141
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.0555 0.0633
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Onchocerca volvulus 0.0187 0.0714 0.3734
Schistosoma mansoni caspase-7 (C14 family) 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0252 0.1253
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0346 0.1434
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Mycobacterium ulcerans hypothetical protein 0.0077 0.0252 0.1077
Echinococcus multilocularis 0.0018 0.0003 0.0003
Mycobacterium ulcerans beta-lactamase 0.0077 0.0252 0.1077
Onchocerca volvulus 0.0084 0.0284 0.1411
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0008 0.0027
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0046 0.0124 0.0141
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0029 0.0053 0.0213
Loa Loa (eye worm) hypothetical protein 0.0662 0.2709 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0263 0.0964
Treponema pallidum sodium- and chloride- dependent transporter 0.0273 0.1074 0.9451
Plasmodium vivax tubulin beta chain, putative 0.0027 0.0044 0.1744
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0156 0.107
Brugia malayi MAP kinase sur-1 0.0054 0.0156 0.0641
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Giardia lamblia Hypothetical protein 0.0029 0.0053 0.0371
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0022 0.0098
Echinococcus multilocularis geminin 0.088 0.3623 0.3623
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0156 0.107
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0187 0.0714 0.3734
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0061 0.007
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0046 0.0124 0.0141
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0022 0.0022
Echinococcus multilocularis twik family of potassium channels 0.0029 0.0053 0.0053
Echinococcus multilocularis g protein coupled receptor 0.0187 0.0714 0.0714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0175 0.0199
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0033 0.1918
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0029 0.0113
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0068 0.0214 0.0785
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0125 0.0142
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0022 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0187 0.0714 0.0814
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0061 0.0061
Onchocerca volvulus 0.0029 0.0053 0.0164
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0273 0.1074 0.4467
Loa Loa (eye worm) hypothetical protein 0.0131 0.048 0.1767
Echinococcus granulosus calcium activated potassium channel variant 0.0029 0.0053 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.0714 0.0814
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1134 0.4889
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0039 0.0258
Echinococcus granulosus GPCR family 2 0.0031 0.0061 0.007
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0046 0.0124 0.0141
Brugia malayi G protein-coupled receptor F59B2.13 0.0187 0.0714 0.297
Schistosoma mansoni hypothetical protein 0.0068 0.0214 0.0244
Echinococcus multilocularis orexin receptor type 2 0.0187 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Brugia malayi Smad1 0.0026 0.0037 0.0148
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0046 0.0124 0.0124
Echinococcus multilocularis neuropeptides capa receptor 0.0187 0.0714 0.0714
Echinococcus multilocularis neuropeptide Y receptor 0.0187 0.0714 0.0714
Schistosoma mansoni neuropeptide receptor 0.0187 0.0714 0.0814
Onchocerca volvulus 0.0046 0.0124 0.0546
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.045
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.017 0.1138
Loa Loa (eye worm) hypothetical protein 0.0058 0.0175 0.0638
Trypanosoma cruzi ion transport protein, putative 0.0029 0.0053 0.0355
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0175 0.0199
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.017 0.1168
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.017 0.017
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0067 0.024
Loa Loa (eye worm) hypothetical protein 0.007 0.0224 0.0822
Onchocerca volvulus 0.0187 0.0714 0.3734
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0124 0.0141
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Trypanosoma brucei beta tubulin 0.0027 0.0044 0.0294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0252 0.1077
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0187 0.0714 0.0814
Schistosoma mansoni opsin-like receptor 0.0187 0.0714 0.0814
Echinococcus multilocularis acetylcholinesterase 0.0131 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Giardia lamblia DINP protein human, muc B family 0.0019 0.0008 0.0059
Echinococcus multilocularis serotonin receptor 0.0424 0.1707 0.1707
Brugia malayi hypothetical protein 0.0029 0.0053 0.0213
Echinococcus granulosus twik family of potassium channels 0.0029 0.0053 0.006
Loa Loa (eye worm) carboxylesterase 0.0131 0.048 0.1767
Schistosoma mansoni calcium-activated potassium channel 0.0029 0.0053 0.006
Schistosoma mansoni hypothetical protein 0.0031 0.0061 0.007
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0017 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0252 0.1743
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0073 0.0308
Leishmania major hypothetical protein, conserved 0.0077 0.0252 0.1743
Loa Loa (eye worm) tubulin beta-2A chain 0.0027 0.0044 0.0156
Onchocerca volvulus 0.0187 0.0714 0.3734
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0252 0.1253
Schistosoma mansoni sodium/chloride dependent transporter 0.0046 0.0124 0.0141
Schistosoma mansoni twik family of potassium channels-related 0.0029 0.0053 0.006
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0022 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus multilocularis neuroligin 0.0022 0.0022 0.0022
Brugia malayi hypothetical protein 0.0022 0.0022 0.0086
Entamoeba histolytica hypothetical protein 0.0071 0.0229 0.1555
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0024
Brugia malayi MH1 domain containing protein 0.0026 0.0037 0.0148
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0124 0.0141
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0003 0.0121
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0187 0.0714 0.0714
Echinococcus granulosus beta tubulin 0.0027 0.0044 0.005
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0125 0.0454
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Onchocerca volvulus Huntingtin homolog 0.0125 0.0452 0.2317
Loa Loa (eye worm) hypothetical protein 0.0145 0.0536 0.1975
Plasmodium vivax SET domain protein, putative 0.0058 0.0175 0.6917
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0187 0.0714 0.0714
Leishmania major cytochrome p450-like protein 0.0018 0.0003 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0252 0.1082
Brugia malayi Dopamine receptor protein 2 0.0187 0.0714 0.297
Echinococcus granulosus g-protein coupled receptor 0.0187 0.0714 0.0814
Onchocerca volvulus 0.0464 0.1875 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0029 0.0053 0.0213
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0044 0.0044
Echinococcus multilocularis pyruvate kinase 0.0033 0.0067 0.0067
Schistosoma mansoni calcium-activated potassium channel 0.0029 0.0053 0.006
Toxoplasma gondii beta tubulin 0.0027 0.0044 0.1744
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Schistosoma mansoni jumonji domain containing protein 0.0057 0.017 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Onchocerca volvulus 0.0058 0.0175 0.0821
Echinococcus multilocularis acetylcholinesterase 0.0131 0.048 0.048
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0252 0.4843
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0252 0.1253
Toxoplasma gondii exonuclease III APE 0.0057 0.017 0.6723
Schistosoma mansoni hypothetical protein 0.088 0.3623 0.4131
Loa Loa (eye worm) TYRA-2 protein 0.0187 0.0714 0.2632
Entamoeba histolytica tubulin family protein 0.0027 0.0044 0.0251
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.017 1
Brugia malayi Carboxylesterase family protein 0.0022 0.0022 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.017 0.0194
Brugia malayi jmjC domain containing protein 0.0057 0.017 0.0701
Schistosoma mansoni opsin-like receptor 0.0187 0.0714 0.0814
Brugia malayi Carboxylesterase family protein 0.0131 0.048 0.1994
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0067 0.2651
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0252 0.1082
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0152 0.0152
Echinococcus granulosus dna polymerase kappa 0.0019 0.0008 0.001
Echinococcus granulosus dna polymerase eta 0.0019 0.0008 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0131 0.048 0.0547
Echinococcus granulosus biogenic amine 5HT receptor 0.0187 0.0714 0.0814
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0029 0.0053 0.0213
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0003 0.0009
Giardia lamblia Pyruvate kinase 0.0033 0.0067 0.0469
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0252 0.1743
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Brugia malayi MH2 domain containing protein 0.0026 0.0037 0.0148
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0187 0.0714 0.0714
Loa Loa (eye worm) acetyltransferase 0.0153 0.0573 0.211
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.0053 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1073 0.4623
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0679 0.2925
Echinococcus multilocularis fmrfamide receptor 0.0187 0.0714 0.0714
Plasmodium falciparum tubulin beta chain 0.0027 0.0044 0.2595
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0492 0.1993 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0272 0.1073 0.4463
Trichomonas vaginalis tubulin gamma chain, putative 0.0027 0.0044 0.0182
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0062 0.0222
Schistosoma mansoni growth hormone secretagogue receptor 0.0187 0.0714 0.0814
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0022 0.0098
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.0714 0.0714
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0046 0.0124 0.0124
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.017 0.017
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0187 0.0714 0.297
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.045
Loa Loa (eye worm) G-protein coupled receptor 0.0187 0.0714 0.2632
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0008 0.0027
Schistosoma mansoni hypothetical protein 0.0187 0.0714 0.0814
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0272 0.1073 0.3956
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0029 0.0053 0.0355
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0008 0.0028
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0029 0.0053 0.0213
Echinococcus granulosus g protein coupled receptor 0.0187 0.0714 0.0814
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0022 0.0089
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0008 0.0046
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Loa Loa (eye worm) carboxylesterase 0.0022 0.0022 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Echinococcus multilocularis sex peptide receptor 0.0187 0.0714 0.0714
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0187 0.0714 0.0814
Brugia malayi Carboxylesterase family protein 0.0022 0.0022 0.0086
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0067 0.0321
Schistosoma mansoni adenoreceptor 0.0187 0.0714 0.0814
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0252 0.1077
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.017 0.0194
Echinococcus granulosus neuropeptide s receptor 0.0187 0.0714 0.0814
Brugia malayi Serotonin receptor 0.0187 0.0714 0.297
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0067 0.0241
Loa Loa (eye worm) hypothetical protein 0.0053 0.0152 0.0553
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.0714 0.0714
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0187 0.0714 0.0714
Schistosoma mansoni cytochrome P450 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Leishmania major C-8 sterol isomerase-like protein 0.036 0.144 1
Entamoeba histolytica hypothetical protein 0.0102 0.0355 0.2447
Loa Loa (eye worm) beta-lactamase 0.0077 0.0252 0.0926
Plasmodium falciparum metacaspase 1 0.0017 0.0002 0.0107
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Brugia malayi Tubulin beta-1 chain 0.0027 0.0044 0.0176
Schistosoma mansoni hypothetical protein 0.0662 0.2709 0.3088
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.072 0.31
Schistosoma mansoni tubulin subunit beta 0.0027 0.0044 0.005
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0187 0.0714 0.0714
Trichomonas vaginalis tubulin, putative 0.0027 0.0044 0.0182
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0029 0.1153
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Trichomonas vaginalis set domain proteins, putative 0.0464 0.1875 0.8088
Onchocerca volvulus Huntingtin homolog 0.0125 0.0452 0.2317
Schistosoma mansoni hypothetical protein 0.0187 0.0714 0.0814
Loa Loa (eye worm) carboxylesterase 0.0022 0.0022 0.0076
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1662
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0029 0.0053 0.0213
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0022 0.0026
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0152 0.0624
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1073 0.4623
Echinococcus granulosus fmrfamide receptor 0.0187 0.0714 0.0814
Onchocerca volvulus 0.0295 0.1166 0.6172
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0039 0.0258
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0156 0.1091
Schistosoma mansoni calcium-activated potassium channel 0.0662 0.2709 0.3088
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0029 0.0053 0.0355
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0111 0.0405
Echinococcus multilocularis neuropeptide receptor 0.0187 0.0714 0.0714
Onchocerca volvulus 0.0029 0.0053 0.0164
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0044 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.0714 0.0814
Brugia malayi hypothetical protein 0.0029 0.0053 0.0213
Schistosoma mansoni DNA polymerase eta 0.0019 0.0008 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0033 0.1918
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0039 0.0137
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0125 0.0142
Loa Loa (eye worm) tubulin beta chain 0.0027 0.0044 0.0156
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0002 0.0072
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0029 0.0053 0.0053
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0044 0.0156
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1662
Echinococcus multilocularis somatostatin receptor 0.0187 0.0714 0.0714
Leishmania major hypothetical protein, conserved 0.0029 0.0053 0.0355
Echinococcus granulosus muscleblind protein 0.0145 0.0536 0.0611
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0679 0.2925
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0067 0.0453
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0156 0.0177
Giardia lamblia Beta tubulin 0.0027 0.0044 0.0309
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.017 0.07
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0187 0.0714 0.2632
Echinococcus multilocularis twik family of potassium channels 0.0029 0.0053 0.0053
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0036 0.0238
Echinococcus granulosus neuropeptide receptor 0.0187 0.0714 0.0814
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0125 0.0551
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0061 0.0248
Loa Loa (eye worm) hypothetical protein 0.0131 0.048 0.1767
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0029 0.1715
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0346 0.1271
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.017 0.0194
Loa Loa (eye worm) uncoordinated protein 58 0.0029 0.0053 0.0189
Brugia malayi Cytochrome P450 family protein 0.0026 0.0039 0.0155
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0008 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Brugia malayi Pre-SET motif family protein 0.0408 0.1639 0.6824
Onchocerca volvulus 0.0187 0.0714 0.3734
Loa Loa (eye worm) hypothetical protein 0.0303 0.1199 0.4425
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Onchocerca volvulus 0.007 0.0224 0.109
Echinococcus multilocularis apoptotic protease activating factor 1 0.007 0.0224 0.0224
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0082 0.0082
Leishmania major pyruvate kinase 0.0033 0.0067 0.0453
Echinococcus multilocularis potassium channel subfamily K 8 0.0029 0.0053 0.0053
Echinococcus granulosus 7TM GPCR rhodopsin 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Brugia malayi Muscleblind-like protein 0.0145 0.0536 0.2228
Loa Loa (eye worm) hypothetical protein 0.0081 0.0269 0.0987
Echinococcus multilocularis G-protein coupled receptor, putative 0.0187 0.0714 0.0714
Echinococcus granulosus pyruvate kinase 0.0033 0.0067 0.0076
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0187 0.0714 0.0714
Echinococcus granulosus carboxylesterase 5A 0.0131 0.048 0.0547
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.1134 0.794
Onchocerca volvulus 0.0273 0.1074 0.5674
Echinococcus multilocularis musashi 0.0081 0.0269 0.0269
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0156 0.0664
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0187 0.0714 0.297
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0679 0.2925
Echinococcus granulosus acetylcholinesterase 0.0131 0.048 0.0547
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Brugia malayi neuropeptide F receptor 0.0187 0.0714 0.297
Trichomonas vaginalis glutaminase, putative 0.0569 0.2318 1
Loa Loa (eye worm) hypothetical protein 0.0295 0.1166 0.4301
Schistosoma mansoni calcium-activated potassium channel 0.0574 0.2339 0.2667
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0053 0.0355
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.0714 0.0714
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0036 0.0036
Schistosoma mansoni twik family of potassium channels-related 0.0029 0.0053 0.006
Toxoplasma gondii beta-1 tubulin, putative 0.0027 0.0044 0.1744
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0022 0.0098
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0111 0.0457
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.1073 0.4623
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Echinococcus granulosus G protein coupled receptor 139 0.0187 0.0714 0.0814
Brugia malayi Cytochrome P450 family protein 0.0036 0.0081 0.0331
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0033 0.0214
Echinococcus multilocularis GPCR, family 2 0.0031 0.0061 0.0061
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0124 0.4898
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0029 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0077 0.0252 0.0926
Brugia malayi hypothetical protein 0.0295 0.1166 0.4852
Schistosoma mansoni biogenic amine receptor 0.0187 0.0714 0.0814
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0033 0.0214
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0033 0.129
Schistosoma mansoni tubulin subunit beta 0.0027 0.0044 0.005
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0252 0.1082
Echinococcus granulosus beta tubulin 0.0027 0.0044 0.005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0187 0.0714 0.0714
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0037 0.0043
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0029 0.0053 0.0213
Loa Loa (eye worm) hypothetical protein 0.0084 0.0284 0.1042
Brugia malayi beta-lactamase family protein 0.0077 0.0252 0.1045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Leishmania major hypothetical protein, conserved 0.0029 0.0053 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0679 0.2925
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0187 0.0714 0.0814
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Schistosoma mansoni hypothetical protein 0.0031 0.0061 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0187 0.0714 0.0714
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.017 0.1168
Mycobacterium tuberculosis Conserved protein 0.0077 0.0252 0.1253
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.0679 0.3546
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0003 0.0009
Echinococcus multilocularis neuropeptide Y receptor 0.0187 0.0714 0.0714
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0029 0.0053 0.0189
Trypanosoma cruzi C-8 sterol isomerase, putative 0.036 0.144 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0046 0.0124 0.0141
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0061 0.0219
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0156 0.6164
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0187 0.0714 0.0714
Loa Loa (eye worm) neuropeptide F receptor 0.0187 0.0714 0.2632
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Loa Loa (eye worm) glutaminase 2 0.0569 0.2318 0.8558
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0046 0.0124 0.4898
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0029 0.1153
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Brugia malayi larval opioid receptor 0.0187 0.0714 0.297
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0033 0.129
Echinococcus granulosus sodium and chloride dependent glycine 0.0046 0.0124 0.0141
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0187 0.0714 0.0814
Echinococcus granulosus g protein coupled receptor 0.0187 0.0714 0.0814
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Schistosoma mansoni sodium-dependent amino acid transporter 0.0046 0.0124 0.0141
Echinococcus multilocularis smad 0.0026 0.0037 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.0714 0.0814
Echinococcus multilocularis pyruvate kinase 0.0026 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0037 0.0037
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0017 0.0002 0.0002
Echinococcus multilocularis serotonin receptor 0.0424 0.1707 0.1707
Echinococcus multilocularis tubulin beta 1 chain 0.0027 0.0044 0.0044
Onchocerca volvulus 0.0077 0.0252 0.1241
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0187 0.0714 0.0814
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0029 0.0053 0.0355
Toxoplasma gondii ion channel protein 0.0029 0.0053 0.2096
Schistosoma mansoni amine GPCR 0.0187 0.0714 0.0814
Echinococcus granulosus peptide allatostatin:somatostatin 0.0187 0.0714 0.0814
Loa Loa (eye worm) cytochrome P450 0.0018 0.0003 0.0005
Onchocerca volvulus 0.0047 0.0125 0.0551
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0679 0.2925
Loa Loa (eye worm) hypothetical protein 0.0047 0.0125 0.0454
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0284 0.0324
Brugia malayi Melatonin receptor type 1A 0.0187 0.0714 0.297
Loa Loa (eye worm) tubulin beta-4 chain 0.0027 0.0044 0.0156
Brugia malayi cytochrome P450 0.0018 0.0003 0.0005
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Schistosoma mansoni opsin-like receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0184 0.0701 0.2584
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0029 0.0053 0.0213
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0046 0.0124 1
Mycobacterium leprae Probable lipase LipE 0.0077 0.0252 0.4843
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0067 0.024
Echinococcus granulosus Smad4 0.0026 0.0037 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.034 0.0387
Onchocerca volvulus 0.0046 0.0124 0.0546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.034 0.0387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.034 0.0387
Echinococcus multilocularis muscleblind protein 0.0145 0.0536 0.0536
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0029 0.0053 0.0355
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0044 0.0044
Brugia malayi RE15519p 0.0187 0.0714 0.297
Plasmodium falciparum potassium channel 0.0029 0.0053 0.3118
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0002 0.0072
Onchocerca volvulus Cell death protein 3 homolog 0.0088 0.0297 0.1481
Echinococcus multilocularis neuropeptides capa receptor 0.0187 0.0714 0.0714
Entamoeba histolytica hypothetical protein 0.0071 0.0229 0.1555
Echinococcus multilocularis G protein coupled receptor 139 0.0187 0.0714 0.0714
Onchocerca volvulus 0.0029 0.0053 0.0164
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus granulosus tubulin subunit beta 0.0027 0.0044 0.005
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0152 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Plasmodium falciparum metacaspase-like protein 0.0017 0.0002 0.0107
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.1134 0.7952
Schistosoma mansoni pyruvate kinase 0.0033 0.0067 0.0076
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0067 0.1241
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0103 0.0666
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0187 0.0714 0.0714
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1134 0.4889
Schistosoma mansoni caspase-7 (C14 family) 0.0088 0.0297 0.0338
Schistosoma mansoni neuropeptide F-like receptor 0.0187 0.0714 0.0814
Trypanosoma brucei C-8 sterol isomerase, putative 0.036 0.144 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0036 0.1425
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0269 0.0987
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0187 0.0714 0.0814
Echinococcus granulosus tm gpcr rhodopsin 0.0187 0.0714 0.0814
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0037 0.0043
Loa Loa (eye worm) hypothetical protein 0.0077 0.0252 0.0926
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0172 0.0653 0.4544
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.0714 0.2632
Echinococcus multilocularis caspase 2 0.0088 0.0297 0.0297
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0175 0.0175
Schistosoma mansoni twik family of potassium channels-related 0.0029 0.0053 0.006
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0126 0.0143
Brugia malayi Cytochrome P450 family protein 0.0018 0.0003 0.0005
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0187 0.0714 0.0714
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0187 0.0714 0.2632
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0046 0.0124 0.0141
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0067 0.0281
Mycobacterium ulcerans glutaminase 0.0569 0.2318 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0187 0.0714 0.0814
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0252 0.1045
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0156 0.107
Mycobacterium ulcerans ion transport protein 0.0029 0.0053 0.0215
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0039 0.0137
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0008 0.0023
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0029 0.0053 0.0213
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0029 0.0053 0.006
Brugia malayi intermediate filament protein 0.0081 0.0269 0.1114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0229 0.0261
Echinococcus granulosus apoptotic protease activating factor 1 0.007 0.0224 0.0256
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0008 0.0008
Leishmania major cytochrome p450-like protein 0.0026 0.0039 0.0258
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0044 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0187 0.0714 0.0814
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0187 0.0714 0.0814
Entamoeba histolytica hypothetical protein 0.0024 0.0029 0.0146
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0046 0.0124 0.0508
Toxoplasma gondii beta-tubulin, putative 0.0027 0.0044 0.1744
Loa Loa (eye worm) glutaminase 0.0569 0.2318 0.8558
Loa Loa (eye worm) acetylcholinesterase 1 0.0131 0.048 0.1767
Schistosoma mansoni lamin 0.0081 0.0269 0.0307
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0008 0.0023
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0082 0.0094
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.034 0.0387
Echinococcus multilocularis pyruvate kinase 0.0033 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0087 0.0315
Leishmania major DNA polymerase eta, putative 0.0019 0.0008 0.0046
Brugia malayi sulfakinin receptor protein 0.0187 0.0714 0.297
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.017 0.1168
Leishmania major potassium channel subunit-like protein 0.0029 0.0053 0.0355
Loa Loa (eye worm) hypothetical protein 0.0038 0.0087 0.0315
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0046 0.0124 0.0141
Echinococcus granulosus neuropeptide FF receptor 2 0.0187 0.0714 0.0814
Brugia malayi Cytochrome P450 family protein 0.0026 0.0039 0.0155
Echinococcus granulosus smad 0.0026 0.0037 0.0043
Brugia malayi Cell death protein 3 precursor 0.0088 0.0297 0.123
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0187 0.0714 0.0814
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.017 0.017
Schistosoma mansoni neuropeptide receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.045
Giardia lamblia Beta tubulin 0.0027 0.0044 0.0309
Echinococcus granulosus alpha 1A adrenergic receptor 0.0187 0.0714 0.0814
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0156 0.0664
Toxoplasma gondii hypothetical protein 0.0046 0.0124 0.4898
Echinococcus multilocularis calcium activated potassium channel variant 0.0029 0.0053 0.0053
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0093 0.0093
Trypanosoma brucei protein kinase, putative 0.0054 0.0156 0.107
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0187 0.0714 0.2632
Echinococcus multilocularis g protein coupled receptor 0.0187 0.0714 0.0714
Echinococcus multilocularis caspase 0.0017 0.0002 0.0002
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0036 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0046 0.0124 0.0141
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.017 0.1168
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Onchocerca volvulus 0.0157 0.0586 0.3042
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0119 0.0135
Echinococcus granulosus orexin receptor type 2 0.0187 0.0714 0.0814
Leishmania major beta tubulin 0.0027 0.0044 0.0294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Leishmania major cytochrome p450-like protein 0.0018 0.0003 0.0009
Entamoeba histolytica tubulin family protein 0.0027 0.0044 0.0251
Echinococcus multilocularis neuropeptide receptor 0.0187 0.0714 0.0714
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0044 0.005
Plasmodium vivax metacaspase 1, putative 0.0017 0.0002 0.0072
Loa Loa (eye worm) neuropeptide F receptor 0.0187 0.0714 0.2632
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0036 0.1425
Loa Loa (eye worm) transcription factor SMAD2 0.0378 0.1515 0.559
Toxoplasma gondii ion channel protein 0.0029 0.0053 0.2096
Echinococcus multilocularis fmrfamide receptor 0.0187 0.0714 0.0714
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0046 0.0124 0.045
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0175 0.0199
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0156 0.0177
Schistosoma mansoni hypothetical protein 0.0071 0.0229 0.0261
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0156 0.0568
Echinococcus granulosus neuroligin 0.0022 0.0022 0.0026
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Echinococcus granulosus tubulin beta 4A class IVa 0.0027 0.0044 0.005
Brugia malayi ORL1-like opioid receptor 0.0187 0.0714 0.297
Echinococcus granulosus neuropeptides capa receptor 0.0187 0.0714 0.0814
Brugia malayi hypothetical protein 0.0187 0.0714 0.297
Schistosoma mansoni hypothetical protein 0.0031 0.0061 0.007
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.0044 0.0182
Onchocerca volvulus 0.0187 0.0714 0.3734
Loa Loa (eye worm) hypothetical protein 0.0077 0.0252 0.0926
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.017 1
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0003 0.0003
Schistosoma mansoni twik family of potassium channels-related 0.0029 0.0053 0.006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0063 0.0196 0.0837
Schistosoma mansoni neuropeptide receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0189
Onchocerca volvulus 0.0187 0.0714 0.3734
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0187 0.0714 0.297
Echinococcus granulosus lamin 0.0081 0.0269 0.0307
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0067 0.0453
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.0573 0.238
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0029 0.019
Echinococcus granulosus neuropeptides capa receptor 0.0187 0.0714 0.0814
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0187 0.0714 0.0714
Echinococcus granulosus sodium and chloride dependent glycine 0.0046 0.0124 0.0141
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.017 0.062
Loa Loa (eye worm) serotonin transporter b 0.0273 0.1074 0.396
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.045
Schistosoma mansoni tubulin subunit beta 0.0027 0.0044 0.005
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0067 0.0276
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0067 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0008 0.0046
Echinococcus granulosus somatostatin receptor 0.0187 0.0714 0.0814
Echinococcus granulosus serotonin receptor 0.0187 0.0714 0.0814
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0252 0.1743
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.017 0.0194
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0187 0.0714 0.0814
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0022 0.0026
Schistosoma mansoni hypothetical protein 0.0031 0.0061 0.007
Chlamydia trachomatis pyruvate kinase 0.0033 0.0067 0.4001
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0067 0.0241
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0017 0.0002 0.0072
Loa Loa (eye worm) hypothetical protein 0.0033 0.0067 0.0241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.1134 0.4889
Brugia malayi G protein-coupled receptor 0.0187 0.0714 0.297
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0008 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0053 0.0355
Echinococcus granulosus tubulin beta 1 chain 0.0027 0.0044 0.005
Schistosoma mansoni alpha-1 adrenergic receptor 0.0187 0.0714 0.0814
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.045

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM relative to MT2 ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM relative to MT2 ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM relative to MT2 ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM relative to MT2 ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM relative to MT2 ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM relative to MT2 ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM ChEMBL. 18088090
Activity (functional) = 0 % Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM ChEMBL. 18088090
Activity (functional) = 20 % Agonist activity at human MC1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM relative to MT2 ChEMBL. 18088090
Activity (functional) = 20 % Agonist activity at human MC1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM relative to MT2 ChEMBL. 18088090
EC50 (functional) > 1000 nM Agonist activity at human MC1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation ChEMBL. 18088090
EC50 (functional) > 1000 nM Agonist activity at human MC1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation ChEMBL. 18088090
IC50 (binding) = 12 nM Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells ChEMBL. 18088090
IC50 (binding) = 12 nM Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells ChEMBL. 18088090
IC50 (binding) = 17 nM Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells ChEMBL. 18088090
IC50 (binding) = 17 nM Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC5 receptor expressed in HEK293 cells ChEMBL. 18088090
IC50 (binding) = 300 nM Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC4 receptor expressed in HEK293 cells ChEMBL. 18088090
IC50 (binding) = 300 nM Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC4 receptor expressed in HEK293 cells ChEMBL. 18088090
IC50 (binding) = 2000 nM Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC1 receptor expressed in HEK293 cells ChEMBL. 18088090
IC50 (binding) = 2000 nM Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC1 receptor expressed in HEK293 cells ChEMBL. 18088090
Kd (functional) = 8.3 Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation ChEMBL. 18088090
Kd (functional) = 8.7 Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation ChEMBL. 18088090
pA2 (functional) = 8.3 Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation ChEMBL. 18088090
pA2 (functional) = 8.7 Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as inhibition of MT2 induced intracellular cAMP accumulation ChEMBL. 18088090

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.