Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0118 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0088 | 0.2801 | 0.2801 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0185 | 0.8321 | 0.8185 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0185 | 0.8321 | 0.8321 |
Schistosoma mansoni | tar DNA-binding protein | 0.0118 | 0.4527 | 0.4527 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.3537 | 0.3537 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0749 | 0.0749 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0088 | 0.2801 | 0.2801 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0185 | 0.8321 | 0.8321 |
Schistosoma mansoni | tar DNA-binding protein | 0.0118 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0118 | 0.4527 | 0.4527 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0185 | 0.8321 | 0.8185 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.3537 | 0.3537 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1013 | 0.1013 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.8321 | 0.8321 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.3537 | 0.3537 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.3537 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 1 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.3537 | 0.3537 |
Schistosoma mansoni | tar DNA-binding protein | 0.0118 | 0.4527 | 0.4527 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0185 | 0.8321 | 0.8185 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.3537 | 0.3014 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1013 | 0.1013 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.3537 | 0.3014 |
Brugia malayi | TAR-binding protein | 0.0118 | 0.4527 | 0.4527 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3537 | 0.3537 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1013 | 0.1013 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.3537 | 0.3014 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.3537 | 0.3014 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3537 | 0.3537 |
Echinococcus multilocularis | tar DNA binding protein | 0.0118 | 0.4527 | 0.4084 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.3537 | 0.3537 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0749 | 0.0749 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0185 | 0.8321 | 0.8185 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0749 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3537 | 0.3537 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0185 | 0.8321 | 0.8185 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.3537 | 0.3537 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.3537 | 0.3537 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0749 | 0.0749 |
Echinococcus granulosus | tar DNA binding protein | 0.0118 | 0.4527 | 0.4084 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0118 | 0.4527 | 0.4527 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0185 | 0.8321 | 0.8185 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.3537 | 0.3537 |
Brugia malayi | MH2 domain containing protein | 0.0088 | 0.2801 | 0.2801 |
Brugia malayi | RNA binding protein | 0.0118 | 0.4527 | 0.4527 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.3537 | 0.3014 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.011 | 0.406 | 0.406 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.3537 | 0.3014 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0075 | 0.2073 | 0.2073 |
Loa Loa (eye worm) | RNA binding protein | 0.0118 | 0.4527 | 0.4527 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0749 | 0.0749 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1013 | 0.1013 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0118 | 0.4527 | 0.4527 |
Onchocerca volvulus | 0.0185 | 0.8321 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0118 | 0.4527 | 0.4527 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.3537 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 10 nM | Inhibition of bovin carbonic anhydrase 4 | ChEMBL. | 17475500 |
Ki (binding) | = 10 nM | Inhibition of bovin carbonic anhydrase 4 | ChEMBL. | 17475500 |
Ki (binding) | = 12 nM | Inhibition of human carbonic anhydrase 2 | ChEMBL. | 17475500 |
Ki (binding) | = 12 nM | Inhibition of human carbonic anhydrase 2 | ChEMBL. | 17475500 |
Ki (binding) | = 620 nM | Inhibition of human carbonic anhydrase 1 | ChEMBL. | 17475500 |
Ki (binding) | = 620 nM | Inhibition of human carbonic anhydrase 1 | ChEMBL. | 17475500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.