Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1713 | 0.3721 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1094 | 0.2377 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0224 | 0.0487 |
Schistosoma mansoni | lamin | 0.0032 | 0.1135 | 0.0931 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1713 | 0.3558 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.4603 | 0.4603 |
Echinococcus multilocularis | lamin | 0.0032 | 0.1135 | 0.1135 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.1135 | 0.2465 |
Schistosoma mansoni | thyroid hormone receptor | 0.016 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.4603 | 1 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.1135 | 0.2269 |
Echinococcus granulosus | lamin | 0.0032 | 0.1135 | 0.1236 |
Onchocerca volvulus | 0.0032 | 0.1135 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.1135 | 0.1236 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0224 | 0.024 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.2995 | 0.6416 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.1135 | 0.0931 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.4603 | 0.4479 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2995 | 0.6507 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0224 | 0.0244 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.2995 | 0.6507 |
Echinococcus multilocularis | musashi | 0.0032 | 0.1135 | 0.1135 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.4603 | 0.4603 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1713 | 0.1523 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0224 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0148 | 0.9178 | 0.9159 |
Onchocerca volvulus | 0.0032 | 0.1135 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4603 | 1 |
Schistosoma mansoni | lamin | 0.0032 | 0.1135 | 0.0931 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.4603 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0224 | 0.024 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0224 | 0.0244 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.4603 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.1135 | 0.1135 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.1135 | 0.2465 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.4603 | 0.4603 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.4603 | 0.5015 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.4603 | 0.5015 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.1135 | 0.1236 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0148 | 0.9178 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.4603 | 0.5015 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.4603 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.4603 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0224 | 0.0244 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0116 | 0.0253 |
Schistosoma mansoni | thyroid hormone receptor | 0.016 | 1 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0148 | 0.9178 | 0.9178 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1135 | 0.2465 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.1135 | 0.2269 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.2995 | 0.6416 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0224 | 0.0487 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.92 | Inhibition of AChE (unknown origin) using acetylthiocholine chloride as substrate after 15 min by Ellman's method | ChEMBL. | No reference |
logRA (binding) | = -0.824 | Inhibition of AchE (unknown origin) relative to tacrine | ChEMBL. | 17158047 |
logRA (binding) | = -0.824 | Inhibition of AchE (unknown origin) relative to tacrine | ChEMBL. | 17158047 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.