Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0644 | 0.9492 | 0.9492 |
Echinococcus granulosus | dihydrofolate reductase | 0.0676 | 1 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0083 | 0.0415 | 0.0415 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0644 | 0.9492 | 0.947 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0075 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0421 | 0.5879 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5879 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5879 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0083 | 0.0415 | 0.0415 |
Schistosoma mansoni | dihydrofolate reductase | 0.0676 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0676 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0676 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0676 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0676 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0676 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0676 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1175 | 0.0793 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1175 | 0.1175 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.0075 | 0.0075 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0075 | 0.0075 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1175 | 0.1175 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5879 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5879 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0676 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1175 | 0.1175 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0083 | 0.0415 | 0.0415 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0083 | 0.0415 | 0.0415 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1175 | 0.1175 |
Onchocerca volvulus | 0.013 | 0.1175 | 1 | |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1175 | 0.1175 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1175 | 0.1175 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5879 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.5 nM | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | ChEMBL. | 14998335 |
IC50 (binding) | = 1.5 nM | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | ChEMBL. | 14998335 |
IC50 (binding) | = 5.5 nM | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | ChEMBL. | 14998335 |
IC50 (binding) | = 5.5 nM | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | ChEMBL. | 14998335 |
IC50 (binding) | = 23 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis carinii | ChEMBL. | 14998335 |
IC50 (binding) | = 23 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis carinii | ChEMBL. | 14998335 |
IC50 (binding) | = 650 nM | Inhibitory concentration against dihydrofolate reductase of rat liver | ChEMBL. | 14998335 |
IC50 (binding) | = 650 nM | Inhibitory concentration against dihydrofolate reductase of rat liver | ChEMBL. | 14998335 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC100 | ChEMBL. | 14998335 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC101 | ChEMBL. | 14998335 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC108 | ChEMBL. | 14998335 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC109 | ChEMBL. | 14998335 |
MIC (functional) | > 64 ug ml-1 | Minimum inhibitory concentration required against Mycobacterium avium isolate from patient number MAC16 | ChEMBL. | 14998335 |
SI (binding) | = 28 | Ratio of DHFR inhibition of rat liver to that of Pneumocystis carinii | ChEMBL. | 14998335 |
SI (binding) | = 120 | Ratio of DHFR inhibition of rat liver to that of Toxoplasma gondii | ChEMBL. | 14998335 |
SI (binding) | = 430 | Ratio of DHFR inhibition of rat liver to that of Mycobacterium avium | ChEMBL. | 14998335 |
SI (binding) | = 28 | Ratio of DHFR inhibition of rat liver to that of Pneumocystis carinii | ChEMBL. | 14998335 |
SI (binding) | = 120 | Ratio of DHFR inhibition of rat liver to that of Toxoplasma gondii | ChEMBL. | 14998335 |
SI (binding) | = 430 | Ratio of DHFR inhibition of rat liver to that of Mycobacterium avium | ChEMBL. | 14998335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.