Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0118471 | 1 | 0.5 |
Brugia malayi | Adenosylhomocysteinase | 0.0118471 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0118471 | 1 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0118471 | 1 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0118471 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0118471 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0118471 | 1 | 0.5 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0118471 | 1 | 0.5 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0118471 | 1 | 0.5 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0118471 | 1 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0118471 | 1 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0118471 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0118471 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0118471 | 1 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0118471 | 1 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0118471 | 1 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0118471 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0118471 | 1 | 0.5 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0118471 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.25 uM | Concentration required to reduce incorporation of [3H]-hypoxanthine by P. falciparum strain K1 to 50% of controls, determined using a 24 hr continuous exposure | ChEMBL. | 8182707 |
IC50 (functional) | = 0.25 uM | Concentration required to reduce incorporation of [3H]-hypoxanthine by P. falciparum strain K1 to 50% of controls, determined using a 24 hr continuous exposure | ChEMBL. | 8182707 |
IC50 (functional) | = 2.5 uM | Concentration required to reduce growth of human jurkat leukemia cells to 50% of control cultures, determined using a 72 hr continuous exposure | ChEMBL. | 8182707 |
IC50 (functional) | = 2.5 uM | Concentration required to reduce growth of human jurkat leukemia cells to 50% of control cultures, determined using a 72 hr continuous exposure | ChEMBL. | 8182707 |
TI (ADMET) | = 10 | In vitro therapeutic index value is the ratio between IC50 values of [J] and [P] | ChEMBL. | 8182707 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8182707 | |
Plasmodium falciparum | ChEMBL23 | 8182707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.