Detailed information for compound 503187

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 530.745 | Formula: C36H42N4
  • H donors: 1 H acceptors: 1 LogP: 6.42 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 2
  • SMILES: C1/C=C\C/C=C\2/C=C(C3CCN(CCC1)C[C@@]13[C@H]2N2CCCCC=C[C@H]2C1)c1nccc2c1[nH]c1c2cccc1
  • InChi: 1S/C36H42N4/c1-2-5-11-20-39-22-18-31-30(33-34-29(17-19-37-33)28-15-9-10-16-32(28)38-34)23-26(13-7-3-1)35-36(31,25-39)24-27-14-8-4-6-12-21-40(27)35/h1,3,8-10,13-17,19,23,27,31,35,38H,2,4-7,11-12,18,20-22,24-25H2/b3-1-,14-8-,26-13-/t27-,31?,35-,36-/m0/s1
  • InChiKey: XJPQQKQCGFEXKO-SGYLFFKUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lamin dm0 0.003 0.0223 0.0179
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.078 0.1286
Brugia malayi nuclear receptor NHR-67 0.0015 0.0053 0.0057
Loa Loa (eye worm) DR-78 0.0015 0.0053 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0454 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0475 0.6067
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0053 0.0057
Brugia malayi ecdysteroid receptor 0.0032 0.0248 0.0586
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0074 0.0031
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0248 0.0204
Toxoplasma gondii thioredoxin reductase 0.0052 0.048 0.6139
Schistosoma mansoni smad1 5 8 and 0.0017 0.0082 0.0032
Mycobacterium ulcerans lipase LipD 0.0077 0.078 0.3861
Schistosoma mansoni hypothetical protein 0.0049 0.0456 0.0438
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0063 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0353 0.4494
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0248 0.0204
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0198
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0475 0.1137
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0207 0.0555
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.078 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.078 0.1286
Brugia malayi nuclear receptor NHR-88 0.0032 0.0248 0.0586
Loa Loa (eye worm) hypothetical protein 0.0077 0.078 0.2093
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1677 0.4464
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0321 0.3591
Schistosoma mansoni Smad4 0.0017 0.0082 0.0032
Brugia malayi glutathione reductase 0.0052 0.048 0.1215
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.1251 0.2132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0666
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0087 0.0481
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0321 0.1302
Echinococcus granulosus tumor protein p63 0.0725 0.8343 0.9004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0248 0.0204
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0223 0.06
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0078 0.0036
Onchocerca volvulus 0.0077 0.078 0.198
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0078 0.0211
Brugia malayi hypothetical protein 0.0017 0.0074 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.078 0.1981
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0248 0.0586
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.1251 0.2132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0087 0.0066
Onchocerca volvulus 0.0077 0.078 0.198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0248 0.0204
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.078 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0063 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0248 0.0204
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0082 0.0041
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0248 0.0212
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Echinococcus granulosus lamin 0.003 0.0223 0.0194
Entamoeba histolytica hypothetical protein 0.0112 0.1191 1
Schistosoma mansoni intermediate filament proteins 0.003 0.0223 0.0185
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0087 0.0066
Entamoeba histolytica protein kinase, putative 0.0058 0.0556 0.2706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0078 0.0958
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.1705 0.4532
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0666
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0087 0.015
Mycobacterium tuberculosis Probable reductase 0.0118 0.1251 0.2132
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0556 0.1493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0322 0.4097
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0053 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0321 0.0462
Entamoeba histolytica hypothetical protein 0.0112 0.1191 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0087 0.0066
Echinococcus multilocularis geminin 0.0181 0.1994 0.1957
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0248 0.0212
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0087 0.1069
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0126 0.0174
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0475 0.0466
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0456 0.115
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.078 0.0797
Loa Loa (eye worm) hypothetical protein 0.0329 0.3724 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0078 0.0034
Loa Loa (eye worm) hypothetical protein 0.0106 0.1117 0.3001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0322 0.4097
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0074 0.0023
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0078 0.0042
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0475 0.0458
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0121
Loa Loa (eye worm) hypothetical protein 0.0077 0.078 0.2093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.2531
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0248 0.0666
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.1191 0.1236
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.048 0.582
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0475 0.1137
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0248 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.2531
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0321 0.0299
Loa Loa (eye worm) transcription factor SMAD2 0.0256 0.2869 0.7704
Brugia malayi hypothetical protein 0.0329 0.3724 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0063 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0078 0.0958
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0248 0.022
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0053 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.1191 0.1151
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0053 0.0008
Mycobacterium ulcerans beta-lactamase 0.0077 0.078 0.3861
Loa Loa (eye worm) Smad1 0.0017 0.0082 0.0221
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0063 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0248 0.0586
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0074 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0454 0.0444
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0321 0.4978
Schistosoma mansoni thyroid hormone receptor 0.0301 0.339 0.3624
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0053 0.0009
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.078 0.1286
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0456 0.0413
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.048 0.1153
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0053 0.0057
Brugia malayi Thioredoxin reductase 0.0052 0.048 0.1215
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0087 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0087 0.0066
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0248 0.0532
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0248 0.0212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.016 0.0269
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0248 0.0532
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0321 1
Echinococcus multilocularis smad 0.0017 0.0082 0.0038
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0053 0.0009
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0078 0.0028
Brugia malayi hypothetical protein 0.0015 0.0053 0.0057
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0248 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0387 0.4943
Loa Loa (eye worm) MH2 domain-containing protein 0.0256 0.2869 0.7704
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0058 0.0556 0.0546
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0575 0.0567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.1705 0.4579
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.053 0.129
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0063 0.017
Brugia malayi tailless protein 0.0015 0.0053 0.0057
Schistosoma mansoni hypothetical protein 0.0269 0.3021 0.3223
Echinococcus granulosus intermediate filament protein 0.003 0.0223 0.0194
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0248 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0248 0.0666
Loa Loa (eye worm) hypothetical protein 0.0029 0.0217 0.0583
Plasmodium falciparum glycogen synthase kinase 3 0.0058 0.0556 1
Echinococcus multilocularis microtubule associated protein 2 0.0804 0.9261 0.9258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0353 0.4494
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0666
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0087 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0078 0.0958
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.048 0.0748
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0053 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0248 0.0586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0248 0.0666
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Leishmania major hypothetical protein, conserved 0.0077 0.078 0.1981
Schistosoma mansoni cpg binding protein 0.003 0.0225 0.0187
Echinococcus granulosus GPCR family 2 0.0049 0.0456 0.0447
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0053 0.0009
Toxoplasma gondii hypothetical protein 0.0053 0.0492 0.6286
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0248 0.0586
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1677 0.4464
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0053 0.0008
Schistosoma mansoni hypothetical protein 0.0049 0.0456 0.0438
Echinococcus multilocularis protein kinase shaggy 0.0058 0.0556 0.0513
Brugia malayi nuclear hormone receptor 0.0015 0.0053 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0454 0.0411
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0053 0.0008
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0053 0.0008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0456 0.1226
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.1881 0.3262
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0666
Echinococcus multilocularis Smad4 0.0017 0.0082 0.0038
Schistosoma mansoni lamin 0.003 0.0223 0.0185
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0321 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0248 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0248 0.0586
Onchocerca volvulus 0.0077 0.078 0.198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0087 0.0066
Brugia malayi MH2 domain containing protein 0.0017 0.0082 0.0137
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.078 0.0789
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.048 0.0472
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0063 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0454 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0235 0.2973
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0058 0.0556 0.0555
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0666
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0087 0.0066
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.1705 0.4532
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0248 0.0586
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0556 0.2706
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0058 0.0556 0.7118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0248 0.0212
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0556 0.2706
Loa Loa (eye worm) hypothetical protein 0.0077 0.078 0.2093
Mycobacterium tuberculosis Conserved protein 0.0077 0.078 0.1286
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0248 0.0586
Loa Loa (eye worm) hypothetical protein 0.0077 0.078 0.2093
Loa Loa (eye worm) hypothetical protein 0.0077 0.078 0.2093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.2531
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0248 0.0212
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0087 0.0331
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.1404 0.2406
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.1677 0.4464
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0058 0.0556 0.0513
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0556 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0321 0.0861
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0248 0.0666
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0198
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.078 0.1286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0454 0.0436
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0087 0.0066
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0456 0.0447
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0104
Schistosoma mansoni cpg binding protein 0.0028 0.0207 0.0167
Echinococcus granulosus microtubule associated protein 2 0.0804 0.9261 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 0.0556 0.1363
Schistosoma mansoni hypothetical protein 0.0049 0.0456 0.0438
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0078 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.078 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0063 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0248 0.0586
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0454 0.122
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0475 0.177
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0454 0.1144
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0082 0.0038
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0456 0.1226
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0321 0.408
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.5635 1
Toxoplasma gondii ABC1 family protein 0.0077 0.078 1
Plasmodium vivax glutathione reductase, putative 0.0052 0.048 0.582
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0413 0.0967
Entamoeba histolytica hypothetical protein 0.0112 0.1191 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0353 0.4494
Onchocerca volvulus 0.003 0.0223 0.0464
Echinococcus multilocularis thyroid hormone receptor alpha 0.0301 0.339 0.336
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0456 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0231 0.2928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0078 0.0958
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0475 0.1137
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.078 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0353 0.4494
Mycobacterium ulcerans hypothetical protein 0.0171 0.1881 1
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0053 0.0142
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.3679 1
Schistosoma mansoni hypothetical protein 0.0181 0.1994 0.2108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0322 0.4097
Giardia lamblia GTOR 0.0051 0.0475 0.8263
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0078 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0074 0.0114
Brugia malayi conserved hypotetical protein 0.0015 0.0053 0.0057
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0475 0.1137
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0475 0.12
Brugia malayi nuclear receptor RXR 0.0015 0.0053 0.0057
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0248 0.0212
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0063 0.0018
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0248 0.0586
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0063 0.0018
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.078 0.1286
Giardia lamblia Kinase, CMGC GSK 0.0058 0.0556 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.078 0.3861
Loa Loa (eye worm) hypothetical protein 0.003 0.0223 0.06
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0198
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0248 0.0212
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.078 0.0738
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0087 0.1069
Trypanosoma brucei protein kinase, putative 0.0058 0.0556 0.1363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0248 0.0666
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0082 0.0038
Plasmodium falciparum thioredoxin reductase 0.0052 0.048 0.846
Echinococcus multilocularis lamin 0.003 0.0223 0.0179
Mycobacterium tuberculosis Conserved protein 0.0077 0.078 0.1286
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0322 0.4097
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0556 0.7118
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0321 0.522
Mycobacterium tuberculosis Conserved protein 0.0077 0.078 0.1286
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0074 0.0114
Entamoeba histolytica hypothetical protein 0.0112 0.1191 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.1127 0.3027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0454 0.0436
Brugia malayi Smad1 0.0017 0.0082 0.0137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0053 0.0008
Echinococcus granulosus protein kinase shaggy 0.0058 0.0556 0.0555
Schistosoma mansoni smad1 5 8 and 0.0017 0.0082 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0248 0.0586
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.078 0.3861
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0063 0.0763
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.3679 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.1251 0.2132
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0082 0.0221
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0248 0.022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0248 0.0212
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0248 0.0532
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0321 0.0711
Brugia malayi nuclear receptor RXR 0.0017 0.0074 0.0114
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.078 0.1286
Trichomonas vaginalis esterase, putative 0.0077 0.078 1
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.078 0.1286
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.1251 0.2132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0322 0.4097
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0087 0.0481
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0087 0.0066
Loa Loa (eye worm) glutathione reductase 0.0052 0.048 0.1289
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0248 0.0586
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0413 0.0967
Echinococcus multilocularis GPCR, family 2 0.0049 0.0456 0.0413
Schistosoma mansoni cpg binding protein 0.003 0.0225 0.0187
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0063 0.0018
Brugia malayi MH1 domain containing protein 0.0017 0.0082 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0248 0.0586
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0321 0.0711
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0223 0.0519
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0053 0.0009
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0053 0.0057
Loa Loa (eye worm) beta-lactamase 0.0077 0.078 0.2093
Onchocerca volvulus 0.0329 0.3724 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0087 0.0331
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0475 0.1137
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0475 0.177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.2524
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0321 0.0277
Echinococcus granulosus lamin dm0 0.003 0.0223 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0248 0.0586
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0666
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0475 0.1274
Schistosoma mansoni smad1 5 8 and 0.0017 0.0082 0.0032
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0321 0.0782
Brugia malayi CXXC zinc finger family protein 0.0028 0.0207 0.0474
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0087 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0265 0.337
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0078 0.0042
Schistosoma mansoni hypothetical protein 0.0181 0.1994 0.2108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.2531
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0198
Echinococcus granulosus smad 0.0017 0.0082 0.0041
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0248 0.022
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0248 0.022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.1404 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.078 0.2026
Loa Loa (eye worm) intermediate filament protein 0.003 0.0223 0.06
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0353 0.0801
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0326 0.3679 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0078 0.0042
Plasmodium falciparum glutathione reductase 0.0052 0.048 0.846
Brugia malayi MH2 domain containing protein 0.0256 0.2869 0.7685
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0053 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 0.0556 0.1493
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0248 0.0586
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.078 0.1981
Mycobacterium ulcerans hypothetical protein 0.0077 0.078 0.3861
Schistosoma mansoni ap endonuclease 0.0038 0.0321 0.0291
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0053 0.0142
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0321 0.0711
Schistosoma mansoni microtubule-associated protein tau 0.0804 0.9261 1
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.1127 0.2967
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0074 0.0198
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0078 0.0127
Brugia malayi nuclear receptor NHR-88 0.0015 0.0053 0.0057
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0087 0.0046
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0053 0.0057
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0087 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0078 0.0958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0235 0.2973
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0087 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.078 0.2093
Onchocerca volvulus 0.0032 0.0248 0.0532
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0087 0.0066
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0269 0.3021 0.2989
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0078 0.0042
Schistosoma mansoni hypothetical protein 0.0112 0.1191 0.1236
Brugia malayi MH1 domain containing protein 0.0017 0.0082 0.0137
Plasmodium vivax hypothetical protein, conserved 0.0077 0.078 1
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0456 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0038 0.0443
Trypanosoma brucei trypanothione reductase 0.0052 0.048 0.1153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0322 0.4097
Brugia malayi hypothetical protein 0.0015 0.0053 0.0057
Echinococcus multilocularis musashi 0.003 0.0223 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0248 0.0586
Toxoplasma gondii exonuclease III APE 0.0038 0.0321 0.408
Brugia malayi intermediate filament protein 0.003 0.0223 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0475 0.6067
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.1404 0.2406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0454 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0278 0.3536
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0087 0.0066
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0087 0.1069
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.1404 0.2406
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0556 0.7118
Onchocerca volvulus 0.003 0.0223 0.0464
Onchocerca volvulus 0.0028 0.0207 0.0419
Schistosoma mansoni smad 0.0017 0.0082 0.0032
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0074 0.0029
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 0.0556 0.1363
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.1191 0.1244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0322 0.4097
Plasmodium vivax glycogen synthase kinase 3, putative 0.0058 0.0556 0.688
Brugia malayi steroid hormone receptor 0.0032 0.0248 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.2524
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0087 0.1069
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.078 0.1981
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0248 0.0666
Brugia malayi nuclear hormone receptor 0.0032 0.0248 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.02 0.2524
Schistosoma mansoni lamin 0.003 0.0223 0.0185
Brugia malayi beta-lactamase family protein 0.0077 0.078 0.2026
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.078 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0321 0.0711
Schistosoma mansoni cellular tumor antigen P53 0.0106 0.1117 0.1156
Leishmania major trypanothione reductase 0.0052 0.048 0.1153
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0666
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.05 0.64
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0063 0.0763
Echinococcus granulosus Smad4 0.0017 0.0082 0.0041
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0053 0.0142
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0353 0.0801
Brugia malayi intracellular kinase 0.0058 0.0556 0.142
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.048 0.0437
Echinococcus multilocularis cpg binding protein 0.003 0.0225 0.0181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0087 0.0066
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0248 0.0204
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0082 0.0032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0104
Brugia malayi ecdysone receptor 0.0015 0.0053 0.0057
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.048 0.1289
Onchocerca volvulus 0.0058 0.0556 0.1371
Onchocerca volvulus 0.0106 0.1117 0.29
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0248 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0235 0.2973
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0087 0.0037
Brugia malayi hypothetical protein 0.0017 0.0074 0.0114
Schistosoma mansoni ap endonuclease 0.0038 0.0321 0.0291
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0063 0.017
Echinococcus multilocularis tumor protein p63 0.0725 0.8343 0.8335
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0269 0.3021 0.3229
Leishmania major mitochondrial DNA polymerase beta 0.0326 0.3679 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0475 0.6067
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0353 0.0801
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.1251 0.2132
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0321 0.408
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0475 0.0432
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0248 0.022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0248 0.022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.078 0.0789
Brugia malayi beta-lactamase family protein 0.0077 0.078 0.2026
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0087 0.0066
Schistosoma mansoni hypothetical protein 0.0107 0.1127 0.1167
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0082 0.0221
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0248 0.0212
Schistosoma mansoni thyroid hormone receptor 0.0301 0.339 0.3624
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0248 0.0212
Schistosoma mansoni hypothetical protein 0.0049 0.0456 0.0438
Brugia malayi MH2 domain containing protein 0.0017 0.0082 0.0137
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.1251 0.7548
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0087 0.0066
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0666
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0082 0.0041
Loa Loa (eye worm) hypothetical protein 0.0077 0.078 0.2093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0322 0.4097
Brugia malayi hypothetical protein 0.0112 0.1191 0.314
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0087 0.0042
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0475 0.1137
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0231 0.2928
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0248 0.0666
Brugia malayi beta-lactamase 0.0077 0.078 0.2026
Echinococcus granulosus cpg binding protein 0.003 0.0225 0.0196
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0087 0.0066
Echinococcus granulosus geminin 0.0181 0.1994 0.2114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0353 0.4494
Brugia malayi isocitrate dehydrogenase 0.0016 0.0063 0.0086
Loa Loa (eye worm) hypothetical protein 0.0156 0.1705 0.4579
Plasmodium falciparum glutathione reductase 0.0018 0.0087 0.0481
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0413 0.0967
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0413 0.0967
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0456 0.0447
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0053 0.0009
Schistosoma mansoni coup transcription factor 0.0032 0.0248 0.0212
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0248 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0248 0.0666
Plasmodium falciparum thioredoxin reductase 0.0018 0.0087 0.0481

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.4 uM Inhibition of human recombinant GSKbeta ChEMBL. 17708655
IC50 (binding) = 5.4 uM Inhibition of human recombinant GSKbeta ChEMBL. 17708655
Inhibition (binding) = 71.2 % Inhibition of human recombinant GSKbeta at 25 uM ChEMBL. 17708655
Inhibition (binding) = 71.2 % Inhibition of human recombinant GSKbeta at 25 uM ChEMBL. 17708655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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