TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 405.491 | Formula: C20H31N5O4
H donors: 4 H acceptors: 3 LogP: 1.34 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: O=C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCC(C)C)CCCN=C(N)N
InChi: 1S/C20H31N5O4/c1-14(2)13-29-20(28)25-17(11-15-7-4-3-5-8-15)18(27)24-16(12-26)9-6-10-23-19(21)22/h3-5,7-8,12,14,16-17H,6,9-11,13H2,1-2H3,(H,24,27)(H,25,28)(H4,21,22,23)/t16-,17+/m1/s1
InChiKey: NNDNCQMSFNKZNC-SJORKVTESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Carica papaya	Papain	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	cysteine protease, putative	Papain	345 aa	344 aa	30.8 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	343 aa	25.4 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	324 aa	32.1 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	357 aa	26.9 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	302 aa	24.8 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Plasmodium vivax	unspecified product	Papain	345 aa	358 aa	30.2 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Papain	345 aa	280 aa	29.6 %
Onchocerca volvulus		Papain	345 aa	326 aa	31.9 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Papain	345 aa	355 aa	30.4 %
Onchocerca volvulus		Papain	345 aa	324 aa	32.1 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	318 aa	22.3 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Dictyostelium discoideum	cathepsin L-like proteinase	Papain	345 aa	330 aa	37.3 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	350 aa	29.4 %
Plasmodium vivax	vivapain-1	Papain	345 aa	360 aa	30.0 %
Echinococcus granulosus	cathepsin L	Papain	345 aa	316 aa	29.1 %
Brugia malayi	Papain family cysteine protease containing protein	Papain	345 aa	308 aa	27.6 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	321 aa	29.3 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Papain	345 aa	328 aa	33.5 %
Onchocerca volvulus	Cathepsin L homolog	Papain	345 aa	317 aa	33.8 %
Onchocerca volvulus		Papain	345 aa	312 aa	35.6 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Papain	345 aa	320 aa	28.4 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	351 aa	25.1 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Papain	345 aa	281 aa	26.0 %
Trypanosoma cruzi	cysteine proteinase, putative	Papain	345 aa	298 aa	29.2 %
Neospora caninum	hypothetical protein	Papain	345 aa	297 aa	23.2 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	392 aa	23.0 %
Plasmodium yoelii	cysteine proteinase precursor	Papain	345 aa	346 aa	30.6 %
Trypanosoma cruzi	cysteine proteinase, putative	Papain	345 aa	299 aa	30.1 %
Brugia malayi	cathepsin B-like cysteine proteinase	Papain	345 aa	306 aa	26.1 %
Onchocerca volvulus		Papain	345 aa	307 aa	35.5 %
Theileria parva	cysteine proteinase, putative	Papain	345 aa	307 aa	29.0 %
Plasmodium berghei	berghepain-1	Papain	345 aa	345 aa	29.9 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	361 aa	24.9 %
Schistosoma japonicum	Disco-interacting protein 2 homolog B, putative	Papain	345 aa	342 aa	30.7 %
Onchocerca volvulus	Protein MCM10 homolog	Papain	345 aa	294 aa	34.7 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	373 aa	27.3 %
Plasmodium knowlesi	knowpain-1	Papain	345 aa	396 aa	29.8 %
Echinococcus granulosus	cathepsin L	Papain	345 aa	356 aa	36.0 %
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Papain	345 aa	323 aa	26.3 %
Echinococcus multilocularis	cathepsin L	Papain	345 aa	355 aa	27.3 %
Babesia bovis	papain family cysteine protease containing protein	Papain	345 aa	342 aa	31.0 %
Entamoeba histolytica	cysteine protease, putative	Papain	345 aa	291 aa	24.1 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Papain	345 aa	313 aa	29.7 %
Echinococcus multilocularis	cathepsin L	Papain	345 aa	352 aa	36.4 %
Echinococcus granulosus	cathepsin b	Papain	345 aa	321 aa	25.9 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Papain	345 aa	324 aa	35.2 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Papain	345 aa	328 aa	33.5 %
Onchocerca volvulus		Papain	345 aa	344 aa	23.3 %
Plasmodium vivax	vivapain-3	Papain	345 aa	340 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Papain	345 aa	376 aa	30.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Schistosoma mansoni	thymidylate kinase	0.0072	0.0539	0.0489
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0106	0.0898	0.085
Giardia lamblia	CDC8	0.0072	0.0539	0.5
Brugia malayi	thymidylate kinase	0.0072	0.0539	0.0489
Trichomonas vaginalis	thymidylate kinase, putative	0.0072	0.0539	0.1063
Loa Loa (eye worm)	thymidylate kinase	0.0072	0.0539	0.0539
Onchocerca volvulus	Putative thymidylate kinase	0.0072	0.0539	0.0489
Leishmania major	hypothetical protein, conserved	0.0028	0.0067	0.0015
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0106	0.0898	0.0898
Trypanosoma cruzi	thymidylate kinase, putative	0.0072	0.0539	0.0489
Echinococcus granulosus	voltage dependent calcium channel	0.0106	0.0898	0.0898
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0028	0.0067	0.0015
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0045	0.0244	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0052	0.0052
Echinococcus granulosus	thymidylate synthase	0.0953	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0898	0.0898
Plasmodium vivax	thymidylate kinase, putative	0.0072	0.0539	0.0489
Echinococcus multilocularis	thymidylate synthase	0.0953	1	1
Loa Loa (eye worm)	thymidylate synthase	0.0953	1	1
Trypanosoma brucei	thymidylate kinase, putative	0.0072	0.0539	0.0489
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0106	0.0898	0.085
Loa Loa (eye worm)	cysteine protease	0.0027	0.0052	0.0052
Loa Loa (eye worm)	fibroinase	0.0027	0.0052	0.0052
Trypanosoma brucei	thymidylate kinase, putative	0.0072	0.0539	0.0489
Leishmania major	thymidylate kinase-like protein	0.0072	0.0539	0.0489
Echinococcus multilocularis	voltage dependent calcium channel	0.0106	0.0898	0.085
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0052	0.0052
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0072	0.0539	0.5
Echinococcus multilocularis	sodium channel protein	0.0045	0.0244	0.0193
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0052	0.0052
Entamoeba histolytica	Thymidylate kinase, putative	0.0072	0.0539	1
Echinococcus granulosus	cathepsin l1	0.0027	0.0052	0.0052
Loa Loa (eye worm)	ctsf protein	0.0027	0.0052	0.0052
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0052	0.0052
Onchocerca volvulus		0.0953	1	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0106	0.0898	0.0898
Echinococcus multilocularis	thymidylate kinase	0.0072	0.0539	0.0489
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Brugia malayi	hypothetical protein	0.0453	0.4633	0.4605
Echinococcus granulosus	thymidylate kinase	0.0072	0.0539	0.0539
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0064	0.0453	0.0403
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0028	0.0067	0.0015
Plasmodium falciparum	thymidylate kinase	0.0072	0.0539	0.0489
Loa Loa (eye worm)	calcium channel	0.0106	0.0898	0.0898
Chlamydia trachomatis	thymidylate kinase	0.0072	0.0539	0.5
Mycobacterium tuberculosis	Hypothetical protein	0.0453	0.4633	0.4327
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0953	1	1
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0106	0.0898	0.085
Trypanosoma cruzi	thymidylate kinase, putative	0.0072	0.0539	0.0489
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0953	1	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0106	0.0898	0.085
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0106	0.0898	0.0898
Trichomonas vaginalis	conserved hypothetical protein	0.0453	0.4633	1
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0106	0.0898	0.085
Trichomonas vaginalis	thymidylate kinase, putative	0.0072	0.0539	0.1063
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0052	0.0052
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0453	0.4633	0.4605
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0064	0.0453	0.0403
Mycobacterium ulcerans	thymidylate synthase	0.0953	1	1
Toxoplasma gondii	cathepsin CPL	0.0027	0.0052	0.0052
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0953	1	1
Toxoplasma gondii	thymidylate kinase	0.0072	0.0539	0.0539
Schistosoma mansoni	thymidylate kinase	0.0072	0.0539	0.0489
Schistosoma mansoni	hypothetical protein	0.0072	0.0539	0.0489
Echinococcus multilocularis	voltage dependent calcium channel	0.0106	0.0898	0.085
Schistosoma mansoni	voltage-gated cation channel	0.0106	0.0898	0.085
Treponema pallidum	thymidylate kinase (tmk)	0.0072	0.0539	0.5
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0106	0.0898	0.085
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0953	1	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0106	0.0898	0.085
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0953	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12.5 uM	Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substrates	ChEMBL.	9873373
IC50 (binding)	= 12.5 uM	Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substrates	ChEMBL.	9873373

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 50324