Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.004 | 0.3278 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0059 | 0.6093 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.004 | 0.3278 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0033 | 0.235 | 0.1584 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0059 | 0.6093 | 0.5 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0026 | 0.1262 | 0.0742 |
Trypanosoma brucei | unspecified product | 0.0053 | 0.5164 | 0.822 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0033 | 0.235 | 0.1245 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0033 | 0.235 | 0.1584 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.235 | 0.2252 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0059 | 0.6093 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0026 | 0.1262 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.1803 | 0.178 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.2814 | 0.3718 |
Schistosoma mansoni | eyes absent homolog | 0.0086 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0059 | 0.6093 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0033 | 0.235 | 0.1584 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0033 | 0.235 | 0.2252 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.004 | 0.3278 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.2814 | 0.3718 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0059 | 0.6093 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0053 | 0.5164 | 0.822 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0059 | 0.6093 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0033 | 0.235 | 0.1245 |
Brugia malayi | polk-prov protein | 0.0036 | 0.2814 | 0.1777 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.235 | 0.1245 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0059 | 0.6093 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0059 | 0.6093 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.235 | 0.5396 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.3278 | 0.4607 |
Giardia lamblia | DINP protein human, muc B family | 0.004 | 0.3278 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0033 | 0.235 | 0.2252 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.1803 | 0.178 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2814 | 0.1777 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0033 | 0.235 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0033 | 0.235 | 0.2252 |
Echinococcus multilocularis | dna polymerase eta | 0.0033 | 0.235 | 0.2252 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.1803 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0059 | 0.6093 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0033 | 0.235 | 0.1245 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0026 | 0.1262 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0033 | 0.235 | 0.2827 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0026 | 0.1262 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2.1 | Activation of SMN2 promoter in mouse NSC34 cells assessed as induction of beta-lactamase activity relative to nonactivated cells | ChEMBL. | 18205293 |
EC50 (functional) | = 897 nM | Activation of SMN2 promoter in mouse NSC34 cells assessed as induction of beta-lactamase activity | ChEMBL. | 18205293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.