TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 536.649 | Formula: C28H35F3N2O3S
H donors: 2 H acceptors: 3 LogP: 7.62 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCN(C1Cc2c(C1)ccc(c2)SC(C(=O)O)(C)C)C(=O)Nc1cccc(c1)C(F)(F)F
InChi: 1S/C28H35F3N2O3S/c1-4-5-6-7-8-14-33(26(36)32-22-11-9-10-21(18-22)28(29,30)31)23-15-19-12-13-24(17-20(19)16-23)37-27(2,3)25(34)35/h9-13,17-18,23H,4-8,14-16H2,1-3H3,(H,32,36)(H,34,35)
InChiKey: MOSXKNXXSVFGPW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Peroxisome proliferator-activated receptor alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma japonicum	IPR008946,Nuclear receptor, ligand-binding,domain-containing	Get druggable targets OG5_137778	All targets in OG5_137778
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	Get druggable targets OG5_137778	All targets in OG5_137778

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	hypothetical protein	Peroxisome proliferator-activated receptor alpha	468 aa	376 aa	27.9 %
Echinococcus granulosus	ecdysone induced protein 78C	Peroxisome proliferator-activated receptor alpha	468 aa	409 aa	30.8 %
Schistosoma mansoni	retinoic acid receptor RXR	Peroxisome proliferator-activated receptor alpha	468 aa	398 aa	28.4 %
Brugia malayi	ecdysteroid receptor	Peroxisome proliferator-activated receptor alpha	468 aa	375 aa	25.1 %
Echinococcus multilocularis	ecdysone induced protein 78C	Peroxisome proliferator-activated receptor alpha	468 aa	409 aa	30.8 %
Brugia malayi	Steroid receptor seven-up type 2	Peroxisome proliferator-activated receptor alpha	468 aa	381 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.008	0.0898
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.006	0.067
Loa Loa (eye worm)	ATP-citrate synthase	0.0135	0.0479	0.5368
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.006	0.5
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0027	0.0024	0.0271
Echinococcus granulosus	ecdysone induced protein 78C	0.004	0.008	0.0898
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0169	0.011
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0024	0.0271
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.008	0.0898
Onchocerca volvulus	Bile acid receptor homolog	0.004	0.008	0.6591
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.004	0.008	0.0898
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.004	0.008	0.0898
Brugia malayi	nuclear receptor NHR-88	0.004	0.008	0.0898
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0111	0.0635
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.004	0.008	0.0898
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0235	0.2634
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.006	0.1768
Plasmodium falciparum	carbonic anhydrase	0.0027	0.0024	0.0096
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.004	0.008	0.0898
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0173	0.1943
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0123	0.138
Echinococcus multilocularis	lamin dm0	0.0026	0.0021	0.0237
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.0866	0.0811
Echinococcus granulosus	geminin	0.0167	0.0614	0.6881
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0019	0.0214
Toxoplasma gondii	hypothetical protein	0.0027	0.0024	0.0045
Schistosoma mansoni	hypothetical protein	0.0048	0.0111	0.0635
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0027	0.0024	0.0271
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.0893	1
Echinococcus granulosus	intermediate filament protein	0.0026	0.0021	0.0237
Toxoplasma gondii	ABC1 family protein	0.0036	0.006	0.0824
Brugia malayi	photoreceptor-specific nuclear receptor	0.004	0.008	0.0898
Brugia malayi	RNA binding protein	0.0063	0.0173	0.1943
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.004	0.008	0.0898
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0168	0.0617	0.6913
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.004	0.008	0.0898
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.004	0.008	0.0898
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0173	0.0995
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0027	0.0024	0.0271
Onchocerca volvulus		0.0036	0.006	0.4326
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.008	0.0898
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.006	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.004	0.008	0.046
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0169	0.0971
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0235	0.0213
Echinococcus multilocularis	carbonic anhydrase II	0.0027	0.0024	0.0271
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.004	0.008	0.0898
Brugia malayi	beta-lactamase family protein	0.0036	0.006	0.067
Brugia malayi	Probable ClpP-like protease	0.0077	0.0235	0.2634
Schistosoma mansoni	carbonic anhydrase-related	0.0027	0.0024	0.0139
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.004	0.008	0.0898
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.008	0.0898
Mycobacterium tuberculosis	3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase)	0.24	1	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.006	0.067
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.008	0.0898
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.004	0.008	0.0898
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0169	0.1896
Schistosoma mansoni	nuclear hormone receptor	0.004	0.008	0.046
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0436	0.1742	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.008	0.0898
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0027	0.0024	0.0271
Echinococcus multilocularis	ecdysone induced protein 78C	0.004	0.008	0.0898
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0235	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0229	0.0872	0.9774
Schistosoma mansoni	hypothetical protein	0.0167	0.0614	0.3525
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0024	0.0271
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.004	0.008	0.0898
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.008	0.0898
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0169	0.011
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.006	0.5
Echinococcus granulosus	lamin	0.0026	0.0021	0.0237
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.004	0.008	0.046
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0027	0.0024	0.0271
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.006	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0169	0.3218
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.008	0.0898
Brugia malayi	ATP-citrate synthase	0.0135	0.0479	0.5368
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.006	0.067
Echinococcus granulosus	lamin dm0	0.0026	0.0021	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0036	0.006	0.067
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0169	0.1896
Schistosoma mansoni	hypothetical protein	0.0027	0.0024	0.0139
Brugia malayi	intermediate filament protein	0.0026	0.0021	0.0237
Echinococcus multilocularis	musashi	0.0026	0.0021	0.0237
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0024	0.0271
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0173	0.0995
Brugia malayi	beta-lactamase	0.0036	0.006	0.067
Brugia malayi	Steroid receptor seven-up type 2	0.004	0.008	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0024	0.0271
Schistosoma mansoni	thyroid hormone receptor	0.0168	0.0617	0.3542
Schistosoma mansoni	carbonic anhydrase	0.0027	0.0024	0.0139
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.0235	0.135
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.0235	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.004	0.008	0.0898
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0027	0.0024	0.0271
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.004	0.008	0.0898
Mycobacterium ulcerans	3-dehydroquinate dehydratase	0.24	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0169	0.011
Echinococcus multilocularis	FTZ F1 alpha	0.004	0.008	0.0898
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.006	0.067
Schistosoma mansoni	carbonic anhydrase-related	0.0027	0.0024	0.0139
Schistosoma mansoni	hypothetical protein	0.0128	0.0447	0.2567
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0128	0.0447	0.501
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0021	0.0237
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.004	0.008	0.046
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0021	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.008	0.0898
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.006	0.0038
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0024	0.0271
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.008	0.0898
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.006	0.5
Mycobacterium leprae	Probable lipase LipE	0.0036	0.006	0.0038
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.004	0.008	0.0898
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.004	0.008	0.0898
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.0893	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.006	1
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0024	0.0271
Onchocerca volvulus		0.0036	0.006	0.4326
Brugia malayi	follicle stimulating hormone receptor	0.0229	0.0872	0.9774
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0024	0.0271
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0024	0.0271
Echinococcus granulosus	carbonic anhydrase II	0.0027	0.0024	0.0271
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0111	0.1239
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0235	0.5
Brugia malayi	steroid hormone receptor	0.004	0.008	0.0898
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0128	0.0447	0.501
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0235	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.006	0.0343
Echinococcus granulosus	FTZ F1 alpha	0.004	0.008	0.0898
Schistosoma mansoni	thyroid hormone receptor	0.0168	0.0617	0.3542
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0027	0.0024	0.0271
Onchocerca volvulus		0.0036	0.006	0.4326
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0235	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.006	0.067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.004	0.008	0.0898
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.004	0.008	0.046
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0123	0.0064
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0169	1
Brugia malayi	beta-lactamase family protein	0.0036	0.006	0.067
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0173	0.1943
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0173	0.1943
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0123	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0036	0.006	0.067
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0027	0.0024	0.0139
Schistosoma mansoni	retinoic acid receptor RXR	0.004	0.008	0.046
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.008	0.0898
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0173	0.1943
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0173	0.0995
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.004	0.008	0.0898
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.006	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0123	0.138
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.004	0.008	0.6591
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0235	0.0176
Loa Loa (eye worm)	hypothetical protein	0.004	0.008	0.0898
Schistosoma mansoni	steroid hormone receptor ad4bp	0.004	0.008	0.046
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.004	0.008	0.0898
Schistosoma mansoni	ATP-citrate synthase	0.0119	0.0409	0.235
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0027	0.0024	0.0139
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.004	0.008	0.0898
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0169	0.011
Loa Loa (eye worm)	hypothetical protein	0.004	0.008	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0024	0.0271
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0173	0.1943
Loa Loa (eye worm)	hypothetical protein	0.0036	0.006	0.067
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0173	0.0995
Brugia malayi	nuclear hormone receptor	0.004	0.008	0.0898
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0027	0.0024	0.0271
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.004	0.008	0.0898
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0021	0.0237
Schistosoma mansoni	hypothetical protein	0.0167	0.0614	0.3525
Loa Loa (eye worm)	hypothetical protein	0.0234	0.0893	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.006	0.067
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0021	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.008	0.0898
Leishmania major	hypothetical protein, conserved	0.0036	0.006	0.2456
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0173	0.0995
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.004	0.008	0.0898
Loa Loa (eye worm)	hypothetical protein	0.004	0.008	0.0898
Brugia malayi	ecdysteroid receptor	0.004	0.008	0.0898
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.004	0.008	0.046
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.004	0.008	0.046
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0173	0.1943
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.006	0.5
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0235	0.2634
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.004	0.008	0.0898
Schistosoma mansoni	carbonic anhydrase-related	0.0027	0.0024	0.0139
Schistosoma mansoni	lamin	0.0026	0.0021	0.0121
Echinococcus multilocularis	lamin	0.0026	0.0021	0.0237
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0021	0.0121
Loa Loa (eye worm)	hypothetical protein	0.004	0.008	0.0898
Loa Loa (eye worm)	hypothetical protein	0.004	0.008	0.0898
Toxoplasma gondii	ATP-citrate lyase, putative	0.0135	0.0479	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.004	0.008	0.6591
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0027	0.0024	0.0271
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0169	0.0971
Onchocerca volvulus		0.004	0.008	0.6591
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.006	0.067
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.008	0.0898
Loa Loa (eye worm)	carbonic anhydrase 3	0.0027	0.0024	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0036	0.006	0.067
Trichomonas vaginalis	esterase, putative	0.0036	0.006	0.5
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0235	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.008	0.046
Echinococcus multilocularis	geminin	0.0167	0.0614	0.6881
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0235	0.466
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.008	0.0898
Onchocerca volvulus		0.0048	0.0111	1
Schistosoma mansoni	lamin	0.0026	0.0021	0.0121
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.006	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0235	0.2634
Brugia malayi	hypothetical protein	0.0234	0.0893	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.004	0.008	0.0898
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0235	0.0176
Schistosoma mansoni	coup transcription factor	0.004	0.008	0.046
Brugia malayi	TAR-binding protein	0.0063	0.0173	0.1943
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0235	0.466
Loa Loa (eye worm)	steroid hormone receptor	0.004	0.008	0.0898
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0123	0.0064

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 2.73 uM	Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction	ChEMBL.	18029176
EC50 (functional)	= 2.73 uM	Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction	ChEMBL.	18029176

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 503480