Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Peroxisome proliferator-activated receptor alpha | 468 aa | 376 aa | 27.9 % |
Echinococcus granulosus | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Schistosoma mansoni | retinoic acid receptor RXR | Peroxisome proliferator-activated receptor alpha | 468 aa | 398 aa | 28.4 % |
Brugia malayi | ecdysteroid receptor | Peroxisome proliferator-activated receptor alpha | 468 aa | 375 aa | 25.1 % |
Brugia malayi | Steroid receptor seven-up type 2 | Peroxisome proliferator-activated receptor alpha | 468 aa | 381 aa | 24.1 % |
Echinococcus multilocularis | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0056 | 0.0481 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0056 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.0481 | 0.0481 | |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0406 | 0.8678 | 0.8612 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0056 | 0.0481 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Leishmania major | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0462 | 1 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0462 | 1 | 1 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0462 | 1 | 1 |
Leishmania major | d-xylulose reductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0462 | 1 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0056 | 0.0481 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0462 | 1 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | quinone oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0056 | 0.0481 | 0.0481 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0462 | 1 | 1 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0406 | 0.8678 | 0.8612 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0422 | 0.9069 | 0.9022 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.146 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
EC50 (functional) | = 0.146 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.