Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Peroxisome proliferator-activated receptor alpha | 468 aa | 376 aa | 27.9 % |
Echinococcus granulosus | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Brugia malayi | Steroid receptor seven-up type 2 | Peroxisome proliferator-activated receptor alpha | 468 aa | 381 aa | 24.1 % |
Schistosoma mansoni | retinoic acid receptor RXR | Peroxisome proliferator-activated receptor alpha | 468 aa | 398 aa | 28.4 % |
Brugia malayi | ecdysteroid receptor | Peroxisome proliferator-activated receptor alpha | 468 aa | 375 aa | 25.1 % |
Echinococcus multilocularis | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0056 | 0.0481 | 0.0481 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.0481 | 0.0481 | |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0406 | 0.8678 | 0.8612 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0056 | 0.0481 | 0.0481 |
Leishmania major | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0056 | 0.0481 | 0.5 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0462 | 1 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0056 | 0.0481 | 0.5 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0462 | 1 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0462 | 1 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0462 | 1 | 1 |
Leishmania major | d-xylulose reductase, putative | 0.0056 | 0.0481 | 1 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0462 | 1 | 1 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0406 | 0.8678 | 0.8612 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0056 | 0.0481 | 0.0481 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0422 | 0.9069 | 0.9022 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0056 | 0.0481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0481 | 0.0481 |
Trypanosoma brucei | oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Leishmania major | quinone oxidoreductase, putative | 0.0056 | 0.0481 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0056 | 0.0481 | 1 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0462 | 1 | 1 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0462 | 1 | 1 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0056 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0462 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.85 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
EC50 (functional) | = 2.85 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.