Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | jun protein | 0.0098 | 0.1914 | 0.1899 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0027 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0866 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.0442 | 0.0423 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0057 | 0.0816 | 0.0798 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0833 | 0.1233 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.4614 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.4614 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.017 | 0.3877 | 0.3865 |
Echinococcus granulosus | geminin | 0.0197 | 0.4614 | 0.4604 |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.3877 | 0.8233 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0732 | 0.108 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0031 | 0.0102 | 0.0126 |
Mycobacterium leprae | conserved hypothetical protein | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.0442 | 0.0423 |
Onchocerca volvulus | 0.0077 | 0.1344 | 0.6756 | |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0043 | 0.0442 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.3575 | 0.5385 |
Echinococcus granulosus | intermediate filament protein | 0.0058 | 0.0831 | 0.0814 |
Echinococcus multilocularis | lamin | 0.0058 | 0.0831 | 0.0814 |
Echinococcus granulosus | lamin | 0.0058 | 0.0831 | 0.0814 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.0442 | 0.0423 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0057 | 0.0816 | 0.0798 |
Trypanosoma brucei | cytochrome P450, putative | 0.0054 | 0.0732 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0043 | 0.0442 | 0.5098 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.0442 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0057 | 0.0816 | 0.0798 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.3238 | 0.6702 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.0816 | 0.0897 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.0816 | 0.1094 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0098 | 0.1914 | 0.1899 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0098 | 0.1914 | 0.1899 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0866 | 0.1018 |
Echinococcus multilocularis | jun protein | 0.0098 | 0.1914 | 0.1899 |
Schistosoma mansoni | intermediate filament proteins | 0.0058 | 0.0831 | 0.0934 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0866 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0732 | 0.0966 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0732 | 0.108 |
Echinococcus multilocularis | tumor protein p63 | 0.0396 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.1417 | 0.2338 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1888 | 0.283 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.0213 | 0.2458 |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 0.0816 | 0.0897 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.0442 | 0.0423 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0442 | 0.6031 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0027 | 0 | 0.5 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0043 | 0.0442 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0442 | 0.064 |
Leishmania major | cytochrome p450-like protein | 0.0054 | 0.0732 | 0.8454 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.0213 | 0.0194 |
Echinococcus multilocularis | musashi | 0.0058 | 0.0831 | 0.0814 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.0213 | 0.017 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0866 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0057 | 0.0816 | 0.0798 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0054 | 0.0732 | 1 |
Echinococcus multilocularis | geminin | 0.0197 | 0.4614 | 0.4604 |
Brugia malayi | follicle stimulating hormone receptor | 0.0271 | 0.6622 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0442 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0058 | 0.0831 | 0.123 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.0213 | 0.0194 |
Schistosoma mansoni | lamin | 0.0058 | 0.0831 | 0.0934 |
Onchocerca volvulus | 0.0058 | 0.0831 | 0.3691 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0866 | 0.0849 |
Onchocerca volvulus | 0.0058 | 0.0833 | 0.3703 | |
Brugia malayi | hypothetical protein | 0.0159 | 0.3575 | 0.5326 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0732 | 0.0966 |
Onchocerca volvulus | 0.0097 | 0.1888 | 1 | |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0147 | 0.3241 | 0.4879 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0802 | 0.1187 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0054 | 0.0732 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0146 | 0.3238 | 0.3225 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.0547 | 0.0682 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0866 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0058 | 0.0831 | 0.0814 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.0833 | 0.0938 |
Brugia malayi | hypothetical protein | 0.0077 | 0.1344 | 0.1905 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0309 | 0.0439 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0043 | 0.0442 | 0.0423 |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.3877 | 0.8233 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0097 | 0.1888 | 0.3466 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.0547 | 0.0253 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0271 | 0.6622 | 1 |
Onchocerca volvulus | 0.0058 | 0.0831 | 0.3691 | |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0057 | 0.0816 | 0.1207 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.0442 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0097 | 0.1888 | 0.1872 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.0816 | 0.1094 |
Schistosoma mansoni | single-minded | 0.0047 | 0.0547 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1841 | 0.276 |
Brugia malayi | intermediate filament protein | 0.0058 | 0.0831 | 0.1118 |
Brugia malayi | bZIP transcription factor family protein | 0.0098 | 0.1914 | 0.2779 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0866 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0831 | 0.123 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0058 | 0.0831 | 0.1118 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0054 | 0.0732 | 0.108 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0043 | 0.0442 | 1 |
Schistosoma mansoni | lamin | 0.0058 | 0.0831 | 0.0934 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0866 | 0.1018 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0097 | 0.1888 | 0.2738 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0146 | 0.3238 | 0.3225 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.0816 | 0.0897 |
Schistosoma mansoni | jun-related protein | 0.0079 | 0.1417 | 0.2338 |
Brugia malayi | hypoxia-induced factor 1 | 0.0147 | 0.3241 | 0.4814 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0866 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0054 | 0.0732 | 0.8454 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0043 | 0.0442 | 0.0423 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0058 | 0.0831 | 0.123 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0866 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0058 | 0.0831 | 0.0814 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0097 | 0.1888 | 0.1872 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.