Detailed information for compound 503541

Basic information

Technical information
  • TDR Targets ID: 503541
  • Name: 5-[(8Z,11Z)-heptadeca-8,11-dienyl]benzene-1,3 -diol
  • MW: 344.531 | Formula: C23H36O2
  • H donors: 2 H acceptors: 2 LogP: 8.51 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C/C=C\CCCCCCCc1cc(O)cc(c1)O
  • InChi: 1S/C23H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21-18-22(24)20-23(25)19-21/h6-7,9-10,18-20,24-25H,2-5,8,11-17H2,1H3/b7-6-,10-9-
  • InChiKey: LQLSZSURMCEKFF-HZJYTTRNSA-N  

Network

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Synonyms

  • 5-[(8Z,11Z)-heptadeca-8,11-dienyl]resorcinol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0027 0.0073 0.0073
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Schistosoma mansoni hypothetical protein 0.0336 0.1474 0.1474
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0436 0.0365
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0189 0.0189
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0077 0.0077
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0037 0.0037
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0074 0.0071
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0204 0.0874 0.0862
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0136 0.0136
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0597 0.0597
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.0849 0.0849
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0997 0.2905
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0436 0.0365
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0074 0.0214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0768 0.3432 0.343
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0084 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0204 0.0874 0.0862
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0204 0.0874 0.0874
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.116 0.3378
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0052 0.0185 0.0185
Mycobacterium tuberculosis Probable oxidoreductase 0.0768 0.3432 0.3384
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0204 0.0874 0.2384
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0037 0.0037
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0189 0.0344
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Entamoeba histolytica thioredoxin reductase, putative 0.0204 0.0874 1
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0045 0.0131
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0037 0.0037
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.009 0.009
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0136 0.0136
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0564 0.2508 0.2508
Brugia malayi chromobox protein homolog 3 0.0038 0.0122 0.0122
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0105 0.0092
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0084 0.0084
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0768 0.3432 0.3432
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0204 0.0874 0.2547
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0105 0.0102
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0204 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0189 0.0186
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0768 0.3432 0.3432
Brugia malayi nuclear receptor NHR-88 0.0041 0.0136 0.0136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0192 0.0192
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0007 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0135 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0136 0.0136
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0074 0.006
Brugia malayi isocitrate dehydrogenase 0.0031 0.009 0.009
Plasmodium falciparum importin beta, putative 0.0062 0.0231 0.0231
Echinococcus granulosus intermediate filament protein 0.0054 0.0192 0.0192
Trichomonas vaginalis glutathione reductase, putative 0.0768 0.3432 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0231 0.0228
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0136 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0768 0.3432 0.3424
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0204 0.0874 0.0874
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0038 0.0038
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0768 0.3432 1
Echinococcus multilocularis endoplasmin 0.0027 0.0074 0.0074
Onchocerca volvulus 0.0107 0.0436 0.4375
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0204 0.0874 0.0874
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0013 0.0135
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0136 0.0136
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0105 0.0092
Schistosoma mansoni inositol monophosphatase 0.004 0.0131 0.0131
Echinococcus multilocularis cpg binding protein 0.003 0.0084 0.0084
Leishmania major NADH dehydrogenase, putative 0.0204 0.0874 0.0871
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0436 0.1271
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0204 0.0874 0.2384
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0062
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0436 0.108
Loa Loa (eye worm) programmed cell death 8 0.0204 0.0874 0.0874
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0038 0.0038
Mycobacterium tuberculosis Probable dehydrogenase 0.0204 0.0874 0.0807
Onchocerca volvulus 0.0047 0.0162 0.1629
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0204 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0015 0.0045
Trypanosoma brucei heat shock protein, putative 0.0034 0.0105 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0597 0.0597
Schistosoma mansoni hypothetical protein 0.0136 0.0564 0.0564
Schistosoma mansoni chromobox protein 0.0068 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0107 0.0436 0.0436
Brugia malayi hypothetical protein 0.023 0.0993 0.0993
Brugia malayi nuclear hormone receptor 0.0041 0.0136 0.0136
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0136 0.0136
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0007 0.0007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.009 0.0087
Schistosoma mansoni nuclear receptor 0.0019 0.0038 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0597 0.0597
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0204 0.0874 0.0862
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0038 0.0038
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0136 0.0136
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0157 0.0154
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0084 0.0084
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0052 0.0185 0.0185
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0193 0.0193
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0105 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.116 0.3378
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0105 0.0105
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0204 0.0874 0.0874
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0768 0.3432 0.343
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0136 0.0136
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0038 0.0038
Brugia malayi intermediate filament protein 0.0054 0.0192 0.0192
Echinococcus granulosus Chromobox protein 3 0.0011 0.0000000055152 0.0000000055152
Plasmodium falciparum heat shock protein 90 0.0034 0.0105 0.0105
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0178 0.0519
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0204 0.0874 0.2384
Mycobacterium ulcerans lipase LipD 0.0107 0.0436 0.108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Onchocerca volvulus 0.0054 0.0192 0.1929
Onchocerca volvulus 0.0107 0.0436 0.4375
Trichomonas vaginalis ran, putative 0.0046 0.0157 0.0457
Loa Loa (eye worm) hypothetical protein 0.0027 0.0073 0.0073
Brugia malayi nuclear receptor RXR 0.0019 0.0038 0.0038
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0013 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0136 0.0136
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0038 0.0038
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.0257 0.0244
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0063 0.0234 0.0234
Leishmania major trypanothione reductase 0.2217 1 1
Trypanosoma brucei NADH dehydrogenase 0.0204 0.0874 0.0871
Trypanosoma brucei heat shock protein, putative 0.0034 0.0105 0.0102
Schistosoma mansoni endoplasmin 0.0034 0.0105 0.0105
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0048 0.0048
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0204 0.0874 0.0871
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Brugia malayi nuclear receptor NHR-67 0.0019 0.0038 0.0038
Mycobacterium ulcerans ferredoxin reductase 0.0204 0.0874 0.2384
Loa Loa (eye worm) hypothetical protein 0.0026 0.0067 0.0067
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0768 0.3432 0.343
Brugia malayi kap beta 3 protein 0.0012 0.0003 0.0003
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0768 0.3432 0.343
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0005 0.0005
Trypanosoma brucei protein kinase, putative 0.0053 0.0189 0.0186
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.0257 0.0257
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0005
Trichomonas vaginalis importin beta-1, putative 0.005 0.0178 0.0519
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0189 0.0176
Brugia malayi hypothetical protein 0.0019 0.0038 0.0038
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0993 0.0993
Entamoeba histolytica hypothetical protein 0.005 0.0178 0.2036
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0048 0.0048
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0136 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.116 0.3378
Schistosoma mansoni glutamate synthase 0.0204 0.0874 0.0874
Leishmania major heat shock protein, putative 0.0014 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0136 0.0136
Loa Loa (eye worm) endoplasmin 0.0034 0.0105 0.0105
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0515 0.0515
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Brugia malayi nuclear receptor NHR-88 0.0019 0.0038 0.0038
Loa Loa (eye worm) hepatopoietin HPO2 0.0068 0.0257 0.0257
Brugia malayi steroid hormone receptor 0.0041 0.0136 0.0136
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0204 0.0874 0.2384
Giardia lamblia Glutamate synthase 0.0204 0.0874 0.2384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0136 0.0136
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.2217 1 1
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0013 0.001
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0204 0.0874 0.2384
Brugia malayi beta-lactamase family protein 0.0107 0.0436 0.0436
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0073 0.0073
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0037
Plasmodium vivax endoplasmin, putative 0.0034 0.0105 0.0105
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0189 0.0189
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0063 0.0234 0.0234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0768 0.3432 0.3424
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0768 0.3432 0.3424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0084
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0157 0.0144
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0204 0.0874 0.0874
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0038 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0744 0.2166
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.0257 0.0255
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0136 0.0136
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0768 0.3432 0.3384
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0131 0.0131
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0204 0.0874 0.2547
Plasmodium falciparum thioredoxin reductase 0.0768 0.3432 0.3432
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0157 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0136 0.0136
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0053 0.0188 0.0188
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0073 0.0073
Schistosoma mansoni importin-beta 2 0.0012 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.116 0.3378
Echinococcus granulosus cpg binding protein 0.003 0.0084 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0204 0.0874 0.0871
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0768 0.3432 0.3424
Toxoplasma gondii selenide, water dikinase 0.0204 0.0874 0.0874
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0686 0.3059 0.3007
Brugia malayi conserved hypotetical protein 0.0019 0.0038 0.0038
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0204 0.0874 0.0874
Plasmodium vivax transportin, putative 0.0012 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.0849 0.0849
Brugia malayi nuclear hormone receptor 0.0019 0.0038 0.0038
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0768 0.3432 0.3432
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0436 0.1271
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0768 0.3432 0.3424
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0204 0.0874 0.0874
Echinococcus granulosus transportin 1 0.0012 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0112 0.0114
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0037 0.0037
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0204 0.0874 0.2547
Plasmodium vivax heat shock protein, putative 0.0014 0.0013 0.0013
Echinococcus multilocularis heat shock protein 0.0034 0.0105 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0436 0.0434
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0768 0.3432 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0131 0.0128
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0045 0.0131
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0204 0.0874 0.0874
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0048 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0136 0.0136
Schistosoma mansoni loxhd1 0.0019 0.0037 0.0037
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0131 0.0131
Schistosoma mansoni glutamate synthase 0.0204 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0136
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0564 0.0564
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0067 0.0067
Echinococcus multilocularis heat shock protein 90 0.0034 0.0105 0.0105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0768 0.3432 0.343
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0136 0.0136
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.009 0.009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0198 0.0849 0.0849
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0003 0.0003
Brugia malayi glutamate synthase 0.0204 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0107 0.0436 0.0436
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0436 0.0436
Echinococcus granulosus snurportin 1 0.0663 0.2955 0.2955
Loa Loa (eye worm) hypothetical protein 0.0136 0.0564 0.0564
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0073 0.0073
Schistosoma mansoni heat shock protein 0.0034 0.0105 0.0105
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.009 0.009
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.007 0.0267 0.0267
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0136 0.0136
Toxoplasma gondii NADPH-glutathione reductase 0.0768 0.3432 0.3432
Loa Loa (eye worm) hypothetical protein 0.0107 0.0436 0.0436
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0131 0.0381
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0105 0.1204
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0204 0.0874 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0062
Onchocerca volvulus 0.0011 0.0000000055152 0.000000055302
Schistosoma mansoni hypothetical protein 0.0398 0.1754 0.1754
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0192
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0162 0.0162
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0189 0.0551
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0038 0.0038
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.1754 0.1754
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0786 0.2291
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0436 0.1271
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0136 0.0136
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0178 0.0519
Brugia malayi SET domain containing protein 0.0013 0.0008 0.0008
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0068 0.0257 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0136 0.0136
Giardia lamblia NADH oxidase lateral transfer candidate 0.0768 0.3432 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0136 0.1365
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0204 0.0874 0.0874
Onchocerca volvulus 0.0028 0.0076 0.0766
Schistosoma mansoni lipoxygenase 0.0019 0.0037 0.0037
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Echinococcus multilocularis snurportin 1 0.0663 0.2955 0.2955
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.009 0.0016
Echinococcus multilocularis GPCR, family 2 0.0063 0.0234 0.0234
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0189 0.0551
Echinococcus multilocularis chromobox protein 1 0.0068 0.0257 0.0257
Loa Loa (eye worm) thioredoxin reductase 0.2217 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0189 0.0189
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0131 0.0381
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0189 0.0186
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0257 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0136 0.0136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0084
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0037 0.0037
Echinococcus multilocularis translational activator gcn1 0.0012 0.0003 0.0003
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0041 0.0028
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0067 0.0067
Leishmania major GTP-binding protein, putative 0.0046 0.0157 0.0154
Echinococcus granulosus dnaJ subfamily B 0.0398 0.1754 0.1754
Schistosoma mansoni importin beta-1 0.0062 0.0231 0.0231
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0136 0.0136
Plasmodium vivax ferrodoxin reductase, putative 0.0204 0.0874 0.0874
Schistosoma mansoni microtubule-associated protein tau 0.2048 0.9234 0.9234
Schistosoma mansoni cpg binding protein 0.0028 0.0076 0.0076
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0131 0.0118
Plasmodium vivax importin-beta 2, putative 0.0062 0.0231 0.0231
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0038 0.0038
Brugia malayi nuclear receptor RXR 0.0022 0.0048 0.0048
Onchocerca volvulus 0.0231 0.0997 1
Brugia malayi RNA, U transporter 1 0.0177 0.075 0.075
Schistosoma mansoni polycystin 1-related 0.0019 0.0037 0.0037
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0204 0.0874 0.2384
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0204 0.0874 0.2547
Echinococcus multilocularis geminin 0.0336 0.1474 0.1474
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0131 0.0131
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0204 0.0874 0.2547
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0003 0.0003
Plasmodium falciparum endoplasmin, putative 0.0021 0.0045 0.0045
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.009 0.0087
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Brugia malayi Endoplasmin precursor 0.0034 0.0105 0.0105
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0257 0.0257
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0257 0.0257
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0204 0.0874 0.2384
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0037
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.116 0.116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0136
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0038 0.0038
Echinococcus multilocularis importin 5 0.0012 0.0003 0.0003
Brugia malayi beta-lactamase family protein 0.0107 0.0436 0.0436
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0744 0.2166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Echinococcus granulosus chromobox protein 1 0.0068 0.0257 0.0257
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0048 0.0048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0195 0.0195
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.0257 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0136 0.0136
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0131 0.017
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0204 0.0874 0.2384
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0000000055152 0.0000000055152
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0135 0.1354
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0005 0.0005
Mycobacterium ulcerans glutamate synthase subunit beta 0.0204 0.0874 0.2384
Schistosoma mansoni chromobox protein 0.0068 0.0257 0.0257
Brugia malayi Doublecortin family protein 0.0019 0.0037 0.0037
Schistosoma mansoni lamin 0.0054 0.0192 0.0192
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.009 0.009
Echinococcus granulosus geminin 0.0336 0.1474 0.1474
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0105 0.0105
Onchocerca volvulus 0.0019 0.0038 0.0377
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0234 0.0234
Schistosoma mansoni sulfide quinone reductase 0.0204 0.0874 0.0874
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0204 0.0874 0.2547
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.0209
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0768 0.3432 0.3432
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0204 0.0874 0.0807
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0768 0.3432 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0597 0.0597
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0136 0.0136
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0136 0.0136
Leishmania major hypothetical protein, conserved 0.0204 0.0874 0.0871
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.116 0.116
Schistosoma mansoni survival motor neuron protein 0.0047 0.0162 0.0162
Leishmania major hypothetical protein, conserved 0.0107 0.0436 0.0434
Schistosoma mansoni lipoxygenase 0.0054 0.0193 0.0193
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0189 0.0189
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0189 0.0176
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0136 0.0136
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0074 0.0074
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.009 0.009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0136 0.0136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0084
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0768 0.3432 0.3432
Mycobacterium tuberculosis Conserved protein 0.0107 0.0436 0.0365
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0107 0.0436 0.0436
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0204 0.0874 0.0807
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0136 0.0136
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0204 0.0874 0.2384
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0768 0.3432 0.343
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0436 0.0436
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0084
Trypanosoma cruzi NADH dehydrogenase, putative 0.0204 0.0874 0.0862
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0204 0.0874 0.0874
Echinococcus multilocularis conserved hypothetical protein 0.0052 0.0185 0.0185
Leishmania major hypothetical protein, conserved 0.0204 0.0874 0.0871
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0204 0.0874 0.0807
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0768 0.3432 0.3424
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0768 0.3432 0.3432
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1586 0.7138 0.7138
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0436 0.0436
Brugia malayi beta-lactamase 0.0107 0.0436 0.0436
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0768 0.3432 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.087 0.087
Entamoeba histolytica disulphide oxidoreductase, putative 0.0204 0.0874 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0768 0.3432 0.3424
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0204 0.0874 0.0807
Brugia malayi ecdysone receptor 0.0019 0.0038 0.0038
Echinococcus multilocularis heat shock protein 90 0.0027 0.0074 0.0074
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0768 0.3432 0.3432
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0073 0.007
Onchocerca volvulus 0.0019 0.0038 0.0377
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0204 0.0874 0.0874
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0136 0.0136
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0768 0.3432 0.3432
Schistosoma mansoni cpg binding protein 0.003 0.0084 0.0084
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0136 0.0136
Schistosoma mansoni inositol monophosphatase 0.004 0.0131 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0744 0.2166
Trypanosoma brucei heat shock protein, putative 0.0034 0.0105 0.0102
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0189 0.0176
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0189 0.0551
Echinococcus granulosus lamin 0.0054 0.0192 0.0192
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0136 0.1365
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0131 0.0381
Brugia malayi Inositol-1 0.004 0.0131 0.0131
Echinococcus granulosus GPCR family 2 0.0063 0.0234 0.0234
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0122
Entamoeba histolytica Ran family GTPase 0.0046 0.0157 0.1795
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0436 0.108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0436 0.0365
Mycobacterium tuberculosis Probable reductase 0.0204 0.0874 0.0807
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0436 0.0436
Trichomonas vaginalis hypothetical protein 0.0012 0.0003 0.0009
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0204 0.0874 0.0871
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0134 0.0134
Entamoeba histolytica HEAT repeat domain containing protein 0.0012 0.0003 0.0034
Onchocerca volvulus 0.0041 0.0136 0.1365
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0204 0.0874 0.0871
Mycobacterium leprae Probable lipase LipE 0.0107 0.0436 0.108
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0157 0.0157
Trypanosoma cruzi trypanothione reductase, putative 0.0768 0.3432 0.3424
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0436 0.1271
Schistosoma mansoni ran 0.0046 0.0157 0.0157
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0013 0.0013
Onchocerca volvulus 0.0054 0.0192 0.1929
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0189 0.0189
Giardia lamblia Thioredoxin reductase 0.0204 0.0874 0.2384
Brugia malayi hypothetical protein 0.0018 0.0029 0.0029
Onchocerca volvulus 0.0019 0.0037 0.0368
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0204 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0136
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0136 0.1365
Echinococcus granulosus thioredoxin glutathione reductase 0.2217 1 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0204 0.0874 0.0874
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0204 0.0874 0.2384
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.0209
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0204 0.0874 0.0874
Trypanosoma brucei heat shock protein, putative 0.0034 0.0105 0.0102
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0234 0.0234
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0436 0.0365
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0157 0.0157
Onchocerca volvulus 0.0019 0.0037 0.0368
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0136 0.0136
Onchocerca volvulus 0.0041 0.0134 0.1348
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0234 0.0234
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0436 0.0365
Loa Loa (eye worm) hypothetical protein 0.0107 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0136
Echinococcus multilocularis lamin dm0 0.0054 0.0192 0.0192
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0136 0.0136
Echinococcus multilocularis Glycosyl transferase, family 8 0.007 0.0267 0.0267
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0073 0.006
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0112 0.0039
Brugia malayi Thioredoxin reductase 0.2217 1 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0204 0.0874 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0084
Schistosoma mansoni hypothetical protein 0.0663 0.2955 0.2955
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0038 0.0038
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.008 0.008
Brugia malayi ecdysteroid receptor 0.0041 0.0136 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.116 0.3378
Brugia malayi Heterochromatin protein 1 0.0068 0.0257 0.0257
Brugia malayi heat shock protein 90 0.0034 0.0105 0.0105
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0234 0.0234
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0204 0.0874 0.2547
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0007 0.0007
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0204 0.0874 0.0874
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0204 0.0874 0.0874
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.009 0.0087
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0038 0.0038
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0038 0.0038
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Brugia malayi hypothetical protein 0.0022 0.0048 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0515 0.0515
Brugia malayi Hsp90 protein 0.0014 0.0013 0.0013
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0157 0.0157
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0136 0.0136
Loa Loa (eye worm) glutathione reductase 0.2217 1 1
Mycobacterium ulcerans dehydrogenase 0.0204 0.0874 0.2384
Loa Loa (eye worm) beta-lactamase 0.0107 0.0436 0.0436
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.009 0.009
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0204 0.0874 0.2547
Echinococcus granulosus endoplasmin 0.0027 0.0074 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0038 0.0038
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0204 0.0874 0.2384
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0105 0.0307
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0204 0.0874 0.0807
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0038 0.0377
Trypanosoma brucei heat shock protein, putative 0.0034 0.0105 0.0102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0436 0.0436
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0744 0.2166
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.009 0.009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.009 0.009
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0204 0.0874 0.0874
Echinococcus granulosus RUN 0.0019 0.0037 0.0037
Loa Loa (eye worm) DR-78 0.0019 0.0038 0.0038
Echinococcus granulosus chromobox protein 1 0.0068 0.0257 0.0257
Brugia malayi Isocitrate dehydrogenase 0.0031 0.009 0.009
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0136 0.0136
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0178 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0436 0.0423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0204 0.0874 0.0874
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0768 0.3432 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0597 0.0597
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.009 0.0076
Echinococcus granulosus microtubule associated protein 2 0.2048 0.9234 0.9234
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0768 0.3432 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0257 0.0749
Treponema pallidum thioredoxin reductase (trxB) 0.0204 0.0874 0.2384
Echinococcus granulosus importin subunit beta 1 0.0062 0.0231 0.0231
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0204 0.0874 0.2547
Schistosoma mansoni heat shock protein 0.0014 0.0013 0.0013
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0231 0.0228
Echinococcus granulosus heat shock protein 90 0.0034 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0136
Brugia malayi hypothetical protein 0.0019 0.0037 0.0037
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0436 0.0436
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0768 0.3432 0.3384
Brugia malayi Pre-SET motif family protein 0.003 0.0084 0.0084
Schistosoma mansoni heat shock protein 0.0034 0.0105 0.0105
Mycobacterium ulcerans hypothetical protein 0.0107 0.0436 0.108
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0204 0.0874 0.0807
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0013 0.0013
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0204 0.0874 0.0862
Echinococcus granulosus lamin dm0 0.0054 0.0192 0.0192
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0136 0.0136
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0597 0.0597
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0135 0.0393
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0136 0.0136
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0105 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.116 0.3378
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0105 0.0105
Brugia malayi Glycosyl transferase family 8 protein 0.007 0.0267 0.0267
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0136 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0744 0.2166
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0136 0.0136
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0038 0.0377
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0013 0.0013
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0204 0.0874 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0768 0.3432 0.343
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0013 0.0039
Brugia malayi Augmenter of liver regeneration 0.0068 0.0257 0.0257
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0074 0.0214
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0204 0.0874 1
Trichomonas vaginalis glutamate synthase, putative 0.0204 0.0874 0.2547
Schistosoma mansoni hypothetical protein 0.0204 0.0874 0.0874
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0189 0.0189
Mycobacterium ulcerans monoxygenase 0.0204 0.0874 0.2384
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Echinococcus multilocularis lamin 0.0054 0.0192 0.0192
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0068 0.0257 0.0257
Schistosoma mansoni endoplasmin 0.0034 0.0105 0.0105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0744 0.7455
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0038 0.0038
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0157 0.0144
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0037 0.0037
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0029 0.0084
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0157 0.0248
Trichomonas vaginalis glutamate synthase, putative 0.0204 0.0874 0.2547
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0013 0.0039
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.0257 0.0257
Toxoplasma gondii ABC1 family protein 0.0107 0.0436 0.0436
Trypanosoma brucei trypanothione reductase 0.2217 1 1
Echinococcus multilocularis musashi 0.0054 0.0192 0.0192
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0204 0.0874 0.0871
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0131 0.0128
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0027 0.0073 0.007
Mycobacterium ulcerans NADH dehydrogenase 0.0204 0.0874 0.2384
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0189 0.0189
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0204 0.0874 0.2547
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0122 0.1223
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0768 0.3432 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.009 0.009
Leishmania major heat shock protein 83-1 0.0034 0.0105 0.0102
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0038 0.0038
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0768 0.3432 0.343
Loa Loa (eye worm) hypothetical protein 0.0204 0.0874 0.0874
Mycobacterium ulcerans beta-lactamase 0.0107 0.0436 0.108
Schistosoma mansoni rab6-interacting 0.0019 0.0037 0.0037
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0436 0.108
Brugia malayi Importin beta-1 subunit 0.0062 0.0231 0.0231
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0204 0.0874 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0136 0.0136
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0204 0.0874 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0084 0.0084
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0204 0.0874 0.0862
Loa Loa (eye worm) inositol-1 0.004 0.0131 0.0131
Trypanosoma brucei heat shock protein, putative 0.0034 0.0105 0.0102
Brugia malayi CHD4 protein 0.0013 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0204 0.0874 0.2384
Brugia malayi MAP kinase sur-1 0.0053 0.0189 0.0189
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0157 0.0157
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Echinococcus granulosus heat shock protein 90 0.0027 0.0074 0.0074
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0136 0.0136
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0029 0.0084
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0231 0.0231
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0131 0.017
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0068 0.0257 0.0257
Echinococcus multilocularis glutamate synthase 0.0204 0.0874 0.0874
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0189 0.0186
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0136 0.0136
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.008 0.008
Trypanosoma brucei heat shock protein, putative 0.0034 0.0105 0.0102
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0038 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0597 0.0597
Treponema pallidum oxidoreductase 0.0204 0.0874 0.2384
Schistosoma mansoni zinc finger protein 0.0019 0.0038 0.0038
Plasmodium falciparum glutathione reductase 0.0768 0.3432 0.3432
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0136 0.0136
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0136 0.0136
Plasmodium vivax glutathione reductase, putative 0.2217 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0204 0.0874 0.0807
Onchocerca volvulus 0.0107 0.0436 0.4375
Brugia malayi tailless protein 0.0019 0.0038 0.0038
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0564 0.2508 0.2508
Plasmodium falciparum transportin 0.0012 0.0003 0.0003
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0014 0.0013 0.0154
Schistosoma mansoni nuclear receptor 0.0019 0.0038 0.0038
Echinococcus granulosus translational activator gcn1 0.0012 0.0003 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0038 0.0038
Schistosoma mansoni rab6-interacting 0.0019 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0047 0.0162 0.0162
Mycobacterium ulcerans hypothetical protein 0.0204 0.0874 0.2384
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0204 0.0874 0.2384
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0105 0.0092
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0122 0.0355
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0204 0.0874 0.0874
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0038 0.0038
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0105 0.0092
Trichomonas vaginalis mercuric reductase, putative 0.0768 0.3432 1
Echinococcus granulosus heat shock protein 0.0034 0.0105 0.0105
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0136
Trichomonas vaginalis apoptosis inducing factor, putative 0.0204 0.0874 0.2547
Toxoplasma gondii thioredoxin reductase 0.2217 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0136 0.0136
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0436 0.0436
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0436 0.0423
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0204 0.0874 0.0874
Brugia malayi hypothetical protein 0.0022 0.0048 0.0048
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0204 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0063 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0063 0.0234 0.0234
Trypanosoma cruzi trypanothione reductase, putative 0.2217 1 1
Schistosoma mansoni hypothetical protein 0.0063 0.0234 0.0234
Brugia malayi CXXC zinc finger family protein 0.0028 0.0076 0.0076
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.0257 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0136 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0786 0.2291
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0257 0.0257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0768 0.3432 0.3424
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.0257 0.0244
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0204 0.0874 0.0871
Echinococcus granulosus importin 5 0.0012 0.0003 0.0003
Schistosoma mansoni coup transcription factor 0.0041 0.0136 0.0136
Schistosoma mansoni cpg binding protein 0.003 0.0084 0.0084
Plasmodium vivax thioredoxin reductase, putative 0.2217 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0157 0.0157
Onchocerca volvulus 0.0204 0.0874 0.8765
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0068 0.0257 0.0257
Echinococcus multilocularis thioredoxin glutathione reductase 0.2217 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.009 0.009
Trypanosoma cruzi NADH dehydrogenase, putative 0.0204 0.0874 0.0862
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0204 0.0874 0.2384
Plasmodium falciparum ferrodoxin reductase-like protein 0.0204 0.0874 0.0874
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0037 0.0037
Echinococcus granulosus Glycosyl transferase family 8 0.007 0.0267 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0204 0.0874 0.0862
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0048 0.0048
Echinococcus multilocularis transportin 1 0.0012 0.0003 0.0003
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0136 0.0136
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0204 0.0874 0.0862
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0062 0.0231 0.0231
Mycobacterium tuberculosis Conserved protein 0.0107 0.0436 0.0365
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0204 0.0874 0.0871
Schistosoma mansoni ran 0.0046 0.0157 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0744 0.2166
Schistosoma mansoni glutamate synthase 0.0204 0.0874 0.0874
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.0849 0.0849
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0189 0.0551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0136 0.0136
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0204 0.0874 0.2384
Brugia malayi AT16019p 0.0018 0.0031 0.0031
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0204 0.0874 0.2384
Schistosoma mansoni hypothetical protein 0.0336 0.1474 0.1474
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0136 0.0136
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.009 0.0076
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0192 0.0192
Plasmodium falciparum thioredoxin reductase 0.2217 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0136 0.0136
Schistosoma mansoni glycosyltransferase-related 0.007 0.0267 0.0267
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0204 0.0874 0.0807
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0597 0.0597
Echinococcus multilocularis RUN 0.0019 0.0037 0.0037
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0013 0.0013
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0037 0.0037
Trichomonas vaginalis esterase, putative 0.0107 0.0436 0.1271
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0038 0.0038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0084 0.0084
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.009 0.009
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0074 0.006
Echinococcus granulosus glutamate synthase 0.0204 0.0874 0.0874
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0436 0.0365
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0074 0.0214
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0105 0.0094
Schistosoma mansoni intermediate filament proteins 0.0054 0.0192 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0136 0.0136
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0131 0.1496
Leishmania major importin beta-1 subunit, putative 0.005 0.0178 0.0175
Schistosoma mansoni lamin 0.0054 0.0192 0.0192
Onchocerca volvulus 0.003 0.0085 0.085
Loa Loa (eye worm) hypothetical protein 0.023 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0136
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0131 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0136 0.0136
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0105 0.0102
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0204 0.0874 0.0874
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0122 0.0355
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0597 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0015 0.0045
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0204 0.0874 0.0807
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0073 0.006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0038 0.0038
Treponema pallidum NADH oxidase 0.0768 0.3432 1
Echinococcus multilocularis microtubule associated protein 2 0.2048 0.9234 0.9234
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0768 0.3432 0.3384
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0105 0.0092
Brugia malayi MH2 domain containing protein 0.0125 0.0515 0.0515
Brugia malayi hypothetical protein 0.0019 0.0037 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0136 0.0136
Mycobacterium tuberculosis Conserved protein 0.0107 0.0436 0.0365
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0005 0.0002
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0007 0.0007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0663 0.2955 0.2955
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0436 0.0365
Plasmodium falciparum glutathione reductase 0.2217 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0231 0.0231
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0136 0.0136
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0993 0.0993
Brugia malayi hypothetical protein 0.0019 0.0038 0.0038
Plasmodium vivax SET domain protein, putative 0.003 0.0084 0.0084
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0076 0.0076
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0768 0.3432 0.3432
Loa Loa (eye worm) hypothetical protein 0.0107 0.0436 0.0436
Echinococcus multilocularis chromobox protein 1 0.0068 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0136
Trypanosoma brucei heat shock protein, putative 0.0034 0.0105 0.0102
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0204 0.0874 0.0871
Schistosoma mansoni sulfide quinone reductase 0.0204 0.0874 0.0874
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0105 0.1204
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0436 0.1271
Brugia malayi Pre-SET motif family protein 0.0203 0.087 0.087
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0189 0.0176
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0136 0.0136
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0048 0.0048
Schistosoma mansoni disulfide oxidoreductase 0.0204 0.0874 0.0874
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0038 0.0038
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0204 0.0874 0.0807
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0744 0.2166
Leishmania major hypothetical protein, conserved 0.0068 0.0257 0.0255
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0038 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0136 0.0136
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0048 0.0048

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of PTP1B at 50 uM ChEMBL. 17125236
Activity (binding) Inhibition of thrombin at 50 uM ChEMBL. 17125236
IC50 (functional) = 0.6 uM Antileishmanial activity against Leishmania donovani ChEMBL. 17629327
IC50 (functional) = 0.6 uM Antileishmanial activity against Leishmania donovani ChEMBL. 17629327
IC50 (functional) = 1.42 uM Cytotoxicity against human A549 cells after 96 hrs by MTT assay ChEMBL. 17125236
IC50 (functional) = 1.54 uM Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay ChEMBL. 17125236
IC50 (functional) = 1.57 uM Cytotoxicity against human A2780 cells after 96 hrs by MTT assay ChEMBL. 17125236
IC50 (functional) = 1.79 uM Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay ChEMBL. 17125236
IC50 (functional) = 1.91 uM Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay ChEMBL. 17125236
IC50 (functional) = 8.7 uM Cytotoxicity against human MCF7 cells ChEMBL. 17629327
IC50 (functional) = 8.7 uM Cytotoxicity against human NCI-H460 ChEMBL. 17629327
IC50 (functional) = 8.7 uM Cytotoxicity against human MCF7 cells ChEMBL. 17629327
IC50 (functional) = 8.7 uM Cytotoxicity against human NCI-H460 ChEMBL. 17629327
IC50 (functional) = 30 uM Antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 17629327
IC50 (functional) = 30 uM Antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 17629327
IC50 (ADMET) = 148 uM Cytotoxicity against human Vero cells by MTT assay ChEMBL. 17629327

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Leishmania donovani ChEMBL23 17629327
Homo sapiens ChEMBL23 17125236

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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