Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0396 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0289 | 0.5018 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0289 | 0.5018 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0228 | 0.2209 | 0.4402 |
Brugia malayi | Dihydrofolate reductase | 0.0289 | 0.5018 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0289 | 0.5018 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0289 | 0.5018 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0396 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0289 | 0.5018 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0396 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0289 | 0.5018 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0289 | 0.5018 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0289 | 0.5018 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0289 | 0.5018 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0396 | 1 | 0.5 |
Onchocerca volvulus | 0.0228 | 0.2209 | 0.5 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0228 | 0.2209 | 0.4402 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0396 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0228 | 0.2209 | 0.4402 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.029 uM | Antiplasmoidal activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH assay | ChEMBL. | 17533134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.